Gene: SSTR4

6754
SS-4-R|SS4-R|SS4R
somatostatin receptor 4
protein-coding
20p11.21
Ensembl:ENSG00000132671 MIM:182454 Vega:OTTHUMG00000032054 UniprotKB:P31391
NC_000020.11
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.509e-1 (AD)  1.656e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLX10.809
PTHLH0.801
SDK10.797
DLX20.796
IGF10.792
TAC30.79
SLC10A40.79
BTBD110.784
SIAH30.782
PRLHR0.78

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.513
SEPT10-0.512
TGFB3-0.509
SNHG18-0.509
WIPF1-0.509
LITAF-0.508
HBA2-0.505
BAZ1A-0.501
TGIF1-0.497
HEBP2-0.497

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB13985Lutetium Lu 177 dotatateSmall Molecule437608-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C499293(1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide"SSTR4 results in increased susceptibility to (1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide"19622729
D000082AcetaminophenAcetaminophen affects the expression of SSTR4 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of SSTR4 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SSTR4 mRNA16483693
D001151ArsenicArsenic results in decreased expression of SSTR4 mRNA19654921
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SSTR4 mRNA21569818
D002351CarrageenanSSTR4 results in decreased susceptibility to Carrageenan19622729
D002994ClofibrateClofibrate results in decreased expression of SSTR4 mRNA17585979
D003471CuprizoneCuprizone results in decreased expression of SSTR4 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SSTR4 mRNA23640034
D003976DiazinonDiazinon results in increased methylation of SSTR4 gene22964155
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of SSTR4 gene23968726
C008261lead acetatelead acetate results in decreased expression of SSTR4 mRNA21829687
D008070LipopolysaccharidesSSTR4 gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IFNG protein]19622729
D008070LipopolysaccharidesSSTR4 gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]19622729
D008070LipopolysaccharidesSSTR4 results in decreased susceptibility to Lipopolysaccharides19622729
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SSTR4 mRNA"19285098
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SSTR4 mRNA"23845593
D010081OxazoloneSSTR4 gene mutant form promotes the reaction [Oxazolone results in increased expression of IL1B protein]19622729
D010081OxazoloneSSTR4 gene mutant form promotes the reaction [Oxazolone results in increased expression of TNF protein]19622729
D010081OxazoloneSSTR4 results in decreased susceptibility to Oxazolone19622729
C517782pasireotidepasireotide binds to SSTR4 protein16625840
D010862PilocarpinePilocarpine results in decreased expression of SSTR4 protein18951627
D010862PilocarpinePilocarpine results in increased expression of SSTR4 protein18951627
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of SSTR4 gene23968726
D010936Plant ExtractsPlant Extracts results in decreased expression of SSTR4 mRNA23557933
C005556propionaldehydepropionaldehyde results in decreased expression of SSTR4 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of SSTR4 mRNA24780913
D013004SomatostatinSomatostatin results in increased expression of SSTR4 mRNA18575731
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SSTR4 mRNA24680724
C009495titanium dioxidetitanium dioxide results in decreased expression of SSTR4 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SSTR4 mRNA20133372
D014050TolueneToluene results in decreased expression of SSTR4 mRNA22967744
D014635Valproic AcidValproic Acid results in increased methylation of SSTR4 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SSTR4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004994somatostatin receptor activity-IBA21873635  
GO:0042277peptide binding-IBA21873635  
GO:0042923neuropeptide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-TAS8405411  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0008285negative regulation of cell proliferation-TAS9892014  
GO:0016477cell migration-IEA-  
GO:0019369arachidonic acid metabolic process-IEA-  
GO:0030900forebrain development-IEA-  
GO:0038170somatostatin signaling pathway-IEA-  
GO:0043410positive regulation of MAPK cascade-IEA-  
GO:0071385cellular response to glucocorticoid stimulus-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8100352  
GO:0043005neuron projection-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29104801Childhood Adversities are not a Predictors of SSTR4met in Alcoholics. (2017)Berent DTransl Neurosci
23857790Genome-wide DNA methylation patterns in discordant sib pairs with alcohol dependence. (2013 Mar)Zhao RAsia Pac Psychiatry
28924491SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics. (2017)Berent DTransl Neurosci