Gene: SSTR5

6755
SS-5-R
somatostatin receptor 5
protein-coding
16p13.3
Ensembl:ENSG00000162009 MIM:182455 Vega:OTTHUMG00000047842 UniprotKB:P35346
NG_016744.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.752e-1 (AD)  2.756e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GLT6D10.493
GAGE12H0.491
NPW0.456
CCL3L30.443
ATF7IP20.42
CDX10.416
ASTL0.412
EGR40.41
PTH20.406
NPAS10.404

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYH15-0.296
PARD3B-0.286
APOBEC3H-0.284
FMO4-0.28
FMO5-0.278
RAD51B-0.273
ANXA9-0.266
HFE-0.264
WISP2-0.258
ADRB2-0.257

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00104OctreotideSmall Molecule83150-76-9Approved|InvestigationalTarget
DB04894VapreotideSmall Molecule103222-11-3Approved|InvestigationalTarget
DB06663PasireotideSmall Molecule396091-73-9ApprovedTarget
DB06791LanreotideSmall Molecule108736-35-2ApprovedTarget
DB13985Lutetium Lu 177 dotatateSmall Molecule437608-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SSTR5 mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of SSTR5 mRNA29067470
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SSTR5 mRNA16483693
C110845AN 238AN 238 binds to SSTR5 protein16047355
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SSTR5 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SSTR5 promoter]19654925
C519496BIM 23206[BIM 23206 results in increased activity of SSTR5 protein] which results in decreased expression of CCND1 protein16954443
C519496BIM 23206[BIM 23206 results in increased activity of SSTR5 protein] which results in increased expression of CDKN1B protein16954443
C519496BIM 23206BIM 23206 results in increased activity of SSTR5 protein16954443
C006780bisphenol Abisphenol A results in decreased expression of SSTR5 protein15811591
C006780bisphenol Abisphenol A results in decreased expression of SSTR5 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of SSTR5 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of SSTR5 promoter22457795
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of SSTR5 mRNA26033743
D003300CopperCopper deficiency results in increased expression of SSTR5 mRNA26033743
D016572CyclosporineCyclosporine results in decreased methylation of SSTR5 promoter27989131
C014347decitabine[decitabine co-treated with trichostatin A] affects the expression of SSTR5 mRNA18575731
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SSTR5 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of SSTR5 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of SSTR5 mRNA25016146
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of SSTR5 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of SSTR5 mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with lanreotide] results in increased expression of SSTR5 mRNA19874807
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SSTR5 mRNA27392435
C121853L 817818L 817818 binds to and results in increased activity of SSTR5 protein15811591
C060347lanreotide[Diethylnitrosamine co-treated with lanreotide] results in increased expression of SSTR5 mRNA19874807
C500085muraglitazarmuraglitazar results in increased expression of SSTR5 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SSTR5 mRNA"25926378
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of SSTR5 mRNA24888373
C517782pasireotidepasireotide binds to SSTR5 protein16625840
D010862PilocarpinePilocarpine results in decreased expression of SSTR5 protein18951627
D010862PilocarpinePilocarpine results in increased expression of SSTR5 protein18951627
D010936Plant ExtractsPlant Extracts results in decreased expression of SSTR5 mRNA23557933
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of SSTR5 mRNA24888373
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SSTR5 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of SSTR5 gene28589171
D013004SomatostatinSomatostatin results in increased expression of SSTR5 mRNA18575731
C501413tesaglitazartesaglitazar results in increased expression of SSTR5 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SSTR5 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SSTR5 mRNA19969065
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the expression of SSTR5 mRNA18575731
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SSTR5 mRNA29024780
D014520UrethaneUrethane results in decreased expression of SSTR5 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of SSTR5 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of SSTR5 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004994somatostatin receptor activity-IBA21873635  
GO:0042277peptide binding-IBA21873635  
GO:0042923neuropeptide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-TAS7908405  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0008285negative regulation of cell proliferation-TAS9892014  
GO:0032467positive regulation of cytokinesis-IMP22888021  
GO:0038170somatostatin signaling pathway-IEA-  
GO:0042593glucose homeostasis-IEA-  
GO:0050796regulation of insulin secretion-IBA21873635  
GO:0071385cellular response to glucocorticoid stimulus-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS7908405  
GO:0043005neuron projection-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21110926[Expression and their clinical significance of SSTR2A, SSTR5 and EGFR in non-small cell lung cancer]. (2007 Feb 20)Liu XZhongguo Fei Ai Za Zhi
21692047Association between somatostatin receptor 5 gene polymorphisms and pancreatic cancer risk and survival. (2011 Jul 1)Li DCancer