Gene: BRDT

676
BRD6|CT9|SPGF21
bromodomain testis associated
protein-coding
1p22.1
Ensembl:ENSG00000137948 MIM:602144 Vega:OTTHUMG00000010113 UniprotKB:Q58F21
NC_000001.11
PubMed
0   ANCO-SNPs
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.107e-1 (AD)  9.710e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR10A50.483
ASB120.46
CYP3A40.459
DDX530.451
C9orf1310.434
FAM186A0.428
UGT2B110.426
IFNK0.411
PRDM140.407
PPIAP100.406

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCSK6-0.323
GPD1-0.31
SRGAP2C-0.295
PTPRH-0.282
ICOSLG-0.274
DNAJC22-0.268
MCAM-0.265
SRGAP2B-0.263
KLHL33-0.26
ZDHHC20-0.258

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of BRDT mRNA17562736
D000487AllethrinAllethrin results in decreased expression of BRDT mRNA28181402
C006780bisphenol Abisphenol A results in decreased methylation of BRDT promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of BRDT mRNA25181051
D004041Dietary FatsDietary Fats results in increased expression of BRDT mRNA25016146
D017313FenretinideFenretinide results in decreased expression of BRDT mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound binds to BRDT protein20871596
D011794QuercetinQuercetin results in increased expression of BRDT mRNA15309432
D013853ThioacetamideThioacetamide results in increased expression of BRDT mRNA23411599
D014635Valproic AcidValproic Acid results in increased expression of BRDT mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of BRDT mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-TAS10365964  
GO:0042393histone binding-IDA22464331  
GO:0070577lysine-acetylated histone binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001207histone displacement-ISS-  
GO:0006338chromatin remodeling-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IMP28199965  
GO:0006397mRNA processing-IEA-  
GO:0007140male meiotic nuclear division-ISS-  
GO:0007141male meiosis I-ISS-  
GO:0007283spermatogenesis-ISS-  
GO:0008380RNA splicing-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0043484regulation of RNA splicing-ISS-  
GO:0051039positive regulation of transcription involved in meiotic cell cycle-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29762635An Epigenome-Wide Association Study (EWAS) of Obesity-Related Traits. (2018 May 14)Dhana KAm J Epidemiol
26558777Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity. (2015 Nov 11)Sartor GCJ Neurosci