Gene: ST5

6764
DENND2B|HTS1|p126
suppression of tumorigenicity 5
protein-coding
11p15.4
Ensembl:ENSG00000166444 MIM:140750 Vega:OTTHUMG00000165835 UniprotKB:P78524
NG_029450.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.595e-1 (AD)  1.115e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAPK70.818
SEC61A10.8
FGFR10.799
WDR10.789
STAT30.785
WBP1L0.783
TM9SF10.78
CCNK0.779
PTPN90.771
SORBS10.771

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.511
OR4F29-0.479
C10orf67-0.236
CETP-0.224
LYPD8-0.213
SULT2B1-0.212
EDN3-0.209
C17orf112-0.207
LCN1-0.206
FOXR1-0.203

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of ST5 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ST5 mRNA"21354444
D000082AcetaminophenAcetaminophen results in decreased expression of ST5 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of ST5 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of ST5 mRNA28959563
D001151ArsenicArsenic affects the methylation of ST5 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of ST5 mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ST5 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ST5 mRNA21839799
C038328BEP protocolBEP protocol results in increased expression of ST5 mRNA18987330
D004958EstradiolEstradiol results in decreased expression of ST5 mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ST5 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of ST5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ST5 mRNA26364221
C006780bisphenol Abisphenol A affects the expression of ST5 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ST5 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of ST5 mRNA25181051
D002922CiguatoxinsCiguatoxins affects the expression of ST5 mRNA18353800
D016572CyclosporineCyclosporine results in decreased expression of ST5 mRNA20106945|2798913
D003907DexamethasoneDexamethasone results in increased expression of ST5 mRNA23946490
D003907DexamethasoneValproic Acid inhibits the reaction [Dexamethasone results in increased expression of ST5 mRNA]23946490
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ST5 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ST5 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of ST5 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of ST5 mRNA18042831
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ST5 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ST5 mRNA17555576
C540355fenamidonefenamidone results in increased expression of ST5 mRNA27029645
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ST5 mRNA27392435
C544151jinfukangjinfukang results in increased expression of ST5 mRNA27392435
D007649KetamineKetamine results in increased expression of ST5 mRNA20080153
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ST5 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ST5 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ST5 mRNA"25620056
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ST5 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ST5 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of ST5 mRNA18042831
C016030pantogabpantogab results in increased expression of ST5 mRNA17379144
D010634PhenobarbitalPhenobarbital results in decreased expression of ST5 mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ST5 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ST5 mRNA18301758|1844570
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ST5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ST5 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ST5 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of ST5 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ST5 mRNA27029645
D012643SeleniumSelenium results in increased expression of ST5 mRNA19244175
D012969Sodium FluorideSodium Fluoride results in increased expression of ST5 mRNA27862939
D013629TamoxifenTamoxifen affects the expression of ST5 mRNA17555576|2093736
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of ST5 mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ST5 mRNA21496263
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ST5 mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ST5 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ST5 mRNA15328365|1661135
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ST5 mRNA21215274
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ST5 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ST5 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of ST5 mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of ST5 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of ST5 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of ST5 mRNA29154799
D014635Valproic AcidValproic Acid inhibits the reaction [Dexamethasone results in increased expression of ST5 mRNA]23946490
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ST5 gene25560391
D014810Vitamin EVitamin E results in increased expression of ST5 mRNA19244175
D015032ZincZinc results in increased expression of ST5 mRNA16870260
C016837zinc chloridezinc chloride results in increased expression of ST5 mRNA16870260
C088658zoledronic acidzoledronic acid results in increased expression of ST5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017112Rab guanyl-nucleotide exchange factor activity-IDA20937701  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26003281Staphylococcus aureus in former Portuguese colonies from Africa and the Far East: missing data to help fill the world map. (2015 Sep)Conceicao TClin Microbiol Infect