Gene: STAC

6769
STAC1
SH3 and cysteine rich domain
protein-coding
3p22.3-p22.2
Ensembl:ENSG00000144681 MIM:602317 Vega:OTTHUMG00000130798 UniprotKB:Q99469
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.549e-1 (AD)  8.045e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYO3A0.744
IRX60.719
PRLR0.68
GPR10.67
TNFRSF80.668
DGKK0.665
GPR1010.657
AMBN0.65
ENTHD10.648
KL0.645

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYBPHL-0.38
MOXD1-0.356
TBR1-0.353
SLC17A7-0.307
TNNT2-0.305
CYP3A43-0.294
RASL11B-0.292
NTNG2-0.288
TESPA1-0.286
C3orf35-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of STAC mRNA"28073004
D000082AcetaminophenAcetaminophen results in increased expression of STAC mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of STAC gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to STAC promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STAC mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of STAC mRNA21179406
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of STAC mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of STAC mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of STAC mRNA26079696
C028031cadmium acetatecadmium acetate results in increased expression of STAC mRNA18155341
D002220CarbamazepineCarbamazepine affects the expression of STAC mRNA25979313
D002922CiguatoxinsCiguatoxins affects the expression of STAC mRNA18353800
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of STAC mRNA26033743
D003300CopperCopper deficiency results in increased expression of STAC mRNA26033743
D016572CyclosporineCyclosporine results in increased expression of STAC mRNA20106945
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of STAC mRNA27392435
D002945CisplatinCisplatin results in decreased expression of STAC mRNA27392435
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of STAC mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of STAC mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of STAC mRNA27405655
D002117CalcitriolCalcitriol results in increased expression of STAC mRNA26485663
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of STAC mRNA27392435
D008558MelphalanMelphalan results in decreased expression of STAC mRNA22363485
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of STAC mRNA"29244179
C029938nickel sulfatenickel sulfate results in decreased expression of STAC mRNA22714537
D009538NicotineNicotine results in increased expression of STAC mRNA23825647
D011441PropylthiouracilPropylthiouracil results in decreased expression of STAC mRNA24780913
D012834SilverSilver results in decreased expression of STAC mRNA27131904
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of STAC mRNA26496021
C012589trichostatin Atrichostatin A results in increased expression of STAC mRNA27188386
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of STAC mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of STAC mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of STAC gene29154799
C111237vorinostatvorinostat results in increased expression of STAC mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16260042  21812934  
GO:0044325ion channel binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-IEA-  
GO:0007165signal transduction-NAS8954993  
GO:0034605cellular response to heat-IEA-  
GO:0035556intracellular signal transduction-IEA-  
GO:1901387positive regulation of voltage-gated calcium channel activity-ISS-  
GO:1903078positive regulation of protein localization to plasma membrane-ISS-  
GO:2001259positive regulation of cation channel activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-NAS8954993  
GO:0030315T-tubule-IEA-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29532581Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway. (2018 Mar 13)Hallfors JAddict Biol