Gene: STAT1

6772
CANDF7|IMD31A|IMD31B|IMD31C|ISGF-3|STAT91
signal transducer and activator of transcription 1
protein-coding
2q32.2
Ensembl:ENSG00000115415 MIM:600555 Vega:OTTHUMG00000132699 UniprotKB:P42224
NG_008294.1
PubMed
ND
14   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.157e-1 (AD)  9.653e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF2AK20.849
TAP20.834
MX10.834
USP150.833
WDFY10.828
CMPK20.821
WARS0.813
IFIT50.812
OGFOD10.805
PATL10.803

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.461
OR4F29-0.449
DIAPH3-0.286
PLA2G5-0.267
HPR-0.243
PYGM-0.241
ARSF-0.233
TPPP2-0.23
ADAMTSL5-0.227
NXNL1-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]"26609140
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of STAT1 mRNA"19162173
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]"12847270
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of [STAT1 protein binds to STAT1 protein]]"12847270
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]"12847270
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [peroxyvanadate results in increased phosphorylation of STAT1 protein]"12847270
C09724015-deoxy-delta(12,14)-prostaglandin J2"Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]"12847270
C09724015-deoxy-delta(12,14)-prostaglandin J2"CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]"12847270
C09724015-deoxy-delta(12,14)-prostaglandin J2"Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]"12847270
C09724015-deoxy-delta(12,14)-prostaglandin J2"Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]"12847270
C09724015-deoxy-delta(12,14)-prostaglandin J2"peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]"12847270
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]"12584205
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]"12584205
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]21268089
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of STAT1 mRNA19933214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dasatinib results in increased phosphorylation of STAT1 protein]23825585
C00358522-hydroxycholesterol[22-hydroxycholesterol co-treated with alitretinoin] inhibits the reaction [IFNG promotes the reaction [STAT1 protein binds to CCL2 promoter]]21268089
C00358522-hydroxycholesterol[22-hydroxycholesterol co-treated with alitretinoin] inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]21268089
C00358522-hydroxycholesterol22-hydroxycholesterol inhibits the reaction [IFNG results in increased phosphorylation of and results in increased localization of STAT1 protein]21268089
C5859122,4-dihydroxy-N-(4-hydroxyphenyl)benzamide"2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide results in decreased phosphorylation of STAT1 protein"24144632
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of STAT1 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Azoxymethane] results in increased expression of STAT1 mRNA"18424890
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]26609140
C0038982-anisidine2-anisidine results in decreased expression of STAT1 mRNA28089782
C0194992-nitrofluorene2-nitrofluorene results in increased expression of STAT1 mRNA14600272
C5240632-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [OSM protein results in increased phosphorylation of STAT1 protein]"21548952
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of STAT1 mRNA"22262711
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of STAT1 mRNA16788091
C1125284-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene-1-imidazolylacetonitrile"4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene-1-imidazolylacetonitrile inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]"24471457
C0006020014-(3,5-dimethoxystyryl)phenyl acetate"4-(3,5-dimethoxystyryl)phenyl acetate inhibits the reaction [EGF protein results in increased phosphorylation of STAT1 protein]"26138072
C5239344(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester"4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester inhibits the reaction [AGT protein modified form results in increased phosphorylation of STAT1 protein]"24456201
C5239344(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester"4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester results in decreased phosphorylation of STAT1 protein"24456201
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT1 mRNA"27188386
C5692924-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine"4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [Biological Products results in increased activity of STAT1 protein]]"24471457
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of STAT1 mRNA19191707
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of STAT1 mRNA]"26546572
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein16582591
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of STAT1 mRNA16582591|1683574
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneBungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein]16582591
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneBungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of STAT1 mRNA]16835749
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneMecamylamine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein]16582591
C1052604-tert-octylphenol4-tert-octylphenol results in decreased expression of STAT1 mRNA17011747
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of STAT1 mRNA17011747
C1073645,6,7-trimethoxyflavone"5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein]"24161485
C1073645,6,7-trimethoxyflavone"5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]"24161485
C0806695,7-dihydroxy-6-methoxy-2-phenylchromen-4-one"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]"23236370
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT1 mRNA"27188386
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of STAT1 protein modified form]29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased phosphorylation of STAT1 protein]29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [Interferon beta-1b results in increased phosphorylation of STAT1 protein]29031523
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranosideSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of STAT1 protein modified form]]29031523
C0413987,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester"[Amantadine co-treated with Ursodeoxycholic Acid co-treated with 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester] results in increased activity of STAT1"15918519
D000082AcetaminophenAcetaminophen results in decreased expression of STAT1 mRNA21420995|2776149
D000082AcetaminophenAcetaminophen results in increased expression of STAT1 mRNA22230336
D000082AcetaminophenAcetaminophen results in increased expression of STAT1 protein18835260
D000082AcetaminophenPlant Preparations inhibits the reaction [Acetaminophen results in increased expression of STAT1 protein]18835260
C056165acetovanilloneacetovanillone inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein]18322232
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D000111AcetylcysteineAcetylcysteine inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein]20525893
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]19061877
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]"12847270
D000111AcetylcysteineAcetylcysteine promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]12847270
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of STAT1 protein]17607690
D000255Adenosine Triphosphate[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased phosphorylation of STAT1 protein26431797
C016601afimoxifeneafimoxifene results in decreased expression of STAT1 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 affects the expression of STAT1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of STAT1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of STAT1 mRNA19770486
D000393Air PollutantsAir Pollutants inhibits the reaction [IFNG results in increased phosphorylation of STAT1 protein]19269302
D000393Air PollutantsAir Pollutants results in decreased expression of STAT1 protein19269302
D000393Air PollutantsIFNG protein inhibits the reaction [Air Pollutants results in decreased expression of STAT1 protein]19269302
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of STAT1 mRNA"23195993
C103303alitretinoin[22-hydroxycholesterol co-treated with alitretinoin] inhibits the reaction [IFNG promotes the reaction [STAT1 protein binds to CCL2 promoter]]21268089
C103303alitretinoin[22-hydroxycholesterol co-treated with alitretinoin] inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]21268089
C103303alitretinoinalitretinoin inhibits the reaction [IFNG results in increased phosphorylation of and results in increased localization of STAT1 protein]21268089
C103303alitretinoinalitretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein16085646
D000493AllopurinolAllopurinol inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein]18322232
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [IFNA1 protein results in increased phosphorylation of STAT1 protein]"15937643
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [IFNB1 protein results in increased phosphorylation of STAT1 protein]"15937643
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]"15937643|2157204
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]"19061877
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]"22454431
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]"22454431
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein]"18039960
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]"23236370
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 Toxin results in increased expression of STAT1 mRNA]"22454431
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT1 protein]"22454431
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [CTF1 results in increased expression of STAT1 protein]"16534557
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Glucose results in increased phosphorylation of STAT1 protein]"20060012
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of STAT1 protein]"17607690
C064176alpha-viniferinalpha-viniferin inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]20424383
C064176alpha-viniferinalpha-viniferin inhibits the reaction [MAPK9 protein results in increased phosphorylation of and results in increased activity of STAT1 protein]20424383
C068073Am 580Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein16085646
C068073Am 580Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein]16085646
D000547Amantadine"[Amantadine co-treated with Ursodeoxycholic Acid co-treated with 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester] results in increased activity of STAT1"15918519
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STAT1 mRNA16483693
C038974amorolfineamorolfine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
D000941Antigens[deoxynivalenol results in increased susceptibility to Antigens] which results in increased expression of STAT1 mRNA28935500
D000941Antigens[ochratoxin A results in increased susceptibility to Antigens] which results in increased expression of STAT1 mRNA28935500
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of STAT1 mRNA24449571
C071942arctigenin"arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and affects the localization of STAT1 protein]"21426947
D001151ArsenicArsenic results in increased expression of STAT1 mRNA27838757
C006632arsenic trioxidearsenic trioxide promotes the reaction [IFNG protein results in increased activity of STAT1 protein]14668793
C006632arsenic trioxidearsenic trioxide promotes the reaction [[IFNG protein results in increased activity of STAT1 protein] which results in increased expression of IRF1 mRNA]14668793
C006632arsenic trioxidearsenic trioxide promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]16914093
C006632arsenic trioxidearsenic trioxide results in decreased phosphorylation of and results in decreased activity of STAT1 protein17121903
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]23106696
C015001arsenitearsenite affects the expression of STAT1 mRNA22959463
C015001arsenitearsenite results in decreased expression of STAT1 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of STAT1 mRNA]18929588
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D001379AzathioprineAzathioprine results in decreased expression of STAT1 mRNA19192274
D001397Azoxymethane"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Azoxymethane] results in increased expression of STAT1 mRNA"18424890
D001554BenzeneBenzene results in increased expression of STAT1 mRNA15120971|1512265
C030233benzo(a)pyrene-1,6-quinone"benzo(a)pyrene-1,6-quinone results in increased phosphorylation of STAT1 protein"19166869
C018003benzo(a)pyrene-3,6-quinone"benzo(a)pyrene-3,6-quinone results in increased phosphorylation of STAT1 protein"19166869
D001564Benzo(a)pyreneBenzo(a)pyrene affects the activity of STAT1 protein20624995
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STAT1 mRNA19152381
D001564Benzo(a)pyrenechlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of STAT1 mRNA]19152381
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STAT1 mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STAT1 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in increased expression of and results in increased phosphorylation of STAT1 protein]20945414
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in increased expression of STAT1 mRNA]20945414
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of STAT1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of STAT1 mRNA23373633
D004958EstradiolEstradiol results in increased expression of STAT1 mRNA16514628|1961957
D004958EstradiolEstradiol results in increased expression of STAT1 protein21185374
D004958EstradiolEstradiol results in increased phosphorylation of STAT1 protein21185374
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of STAT1 mRNA18192240
D001688Biological Products15-deoxyprostaglandin J2 inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
D001688Biological Products"4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene-1-imidazolylacetonitrile inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]"24471457
D001688Biological Products"4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [Biological Products results in increased activity of STAT1 protein]]"24471457
D001688Biological Productsamorolfine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
D001688Biological ProductsBiological Products results in increased expression of and results in increased phosphorylation of and results in increased activity of STAT1 protein24471457
D001688Biological Productsbutenafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
D001688Biological ProductsItraconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
D001688Biological ProductsKetoconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
D001688Biological ProductsProtein Kinase Inhibitors inhibits the reaction [Biological Products results in increased expression of and results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
D001688Biological Productsterbinafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
D001688Biological ProductsVPC32183 inhibits the reaction [Biological Products results in increased expression of and results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
C006780bisphenol Abisphenol A results in increased expression of STAT1 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of STAT1 promoter27334623
C006780bisphenol Abisphenol A affects the expression of STAT1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of STAT1 gene28505145
D002038BungarotoxinsBungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein]16582591
D002038BungarotoxinsBungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of STAT1 mRNA]16835749
D002038BungarotoxinsBungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased activity of STAT1 protein]16582591
D002065BuspironeBuspirone results in decreased expression of STAT1 mRNA24136188
C067594butenafine"4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [Biological Products results in increased activity of STAT1 protein]]"24471457
C067594butenafinebutenafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of STAT1 mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of STAT1 mRNA14729362|1500399
D002104CadmiumCadmium inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]16843830
D002104CadmiumCadmium inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]16843830
D002104CadmiumCadmium results in increased phosphorylation of STAT1 protein21783819
D002104CadmiumSB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT1 protein]21783819
D019256Cadmium Chloride"2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]"19635391
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]16843830
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]19635391
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]16843830
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of STAT1 mRNA18560533
D019256Cadmium ChlorideThioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
D002118CalciumCalcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]26609140
D002187Cannabinol"Cannabinol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased activity of STAT1 protein]"19910459
D002211CapsaicinCapsaicin inhibits the reaction [IFNG results in increased activity of STAT1 protein]14530214
D002211CapsaicinCapsaicin results in increased phosphorylation of and results in increased activity of STAT1 protein20712533
D002211CapsaicinCapsaicin results in increased expression of STAT1 mRNA20712533
D002211CapsaicinCapsaicin results in increased expression of STAT1 protein20712533
D002211CapsaicinCapsaicin results in increased phosphorylation of and results in increased activity of STAT1 protein20712533
D002211CapsaicinNOX2 mutant form inhibits the reaction [Capsaicin results in increased expression of STAT1 protein]20712533
D002211CapsaicinSTAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of NOS2 mRNA]20712533
D002211CapsaicinSTAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of NOS2 protein]20712533
D002211CapsaicinSTAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of NOX3 mRNA]20712533
D002211CapsaicinSTAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of NOX3 protein]20712533
D002211CapsaicinSTAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of PTGS2 mRNA]20712533
D002211CapsaicinSTAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of PTGS2 protein]20712533
D002211CapsaicinSTAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of TNF mRNA]20712533
D002211CapsaicinSTAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of TNF protein]20712533
D002211CapsaicinSTAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of TRPV1 protein]20712533
D002211CapsaicinSTAT1 results in increased susceptibility to Capsaicin20712533
C071423capsazepinecapsazepine inhibits the reaction [IFNG results in increased activity of STAT1 protein]14530214
D002220CarbamazepineCarbamazepine affects the expression of STAT1 mRNA24752500
D002229CarbenoxoloneCarbenoxolone affects the expression of STAT1 mRNA23678415
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased phosphorylation of STAT1 protein28428136
D002251Carbon Tetrachloridehesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT1 protein]28428136
D002251Carbon TetrachlorideSilymarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT1 protein]28428136
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of STAT1 protein25858767
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of STAT1 mRNA16644059
C024714caryophyllenecaryophyllene inhibits the reaction [TNF protein results in increased phosphorylation of STAT1 protein]28624443
D002392CatechinCatechin results in decreased expression of STAT1 mRNA15465739
D002392CatechinCatechin results in decreased expression of STAT1 protein15465739
C007020chlorophyllinchlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of STAT1 mRNA]19152381
D002737ChloropreneChloroprene results in decreased expression of STAT1 mRNA23125180
D002784CholesterolCholesterol results in increased expression of STAT1 protein17507688
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of STAT1 mRNA27344345
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STAT1 gene20938992
C074702chromium hexavalent ion[chromium hexavalent ion results in increased activity of FYN protein] which results in increased activity of STAT1 protein19994902
C074702chromium hexavalent ionchromium hexavalent ion results in increased phosphorylation of and affects the localization of STAT1 protein17078813
C074702chromium hexavalent ionFYN protein promotes the reaction [chromium hexavalent ion results in increased phosphorylation of STAT1 protein]19994902
C074702chromium hexavalent ionSTAT1 protein affects the reaction [chromium hexavalent ion inhibits the reaction [Nickel results in increased expression of VEGFA mRNA]]19403854
C074702chromium hexavalent ionSTAT1 protein affects the reaction [chromium hexavalent ion inhibits the reaction [Nickel results in increased stability of and results in increased expression of HIF1A protein]]19403854
C074702chromium hexavalent ionSTAT1 protein affects the reaction [chromium hexavalent ion results in decreased expression of VEGFA mRNA]19403854
C074702chromium hexavalent ionSTAT1 protein affects the reaction [chromium hexavalent ion results in increased expression of IRF7 mRNA]19994902
C074702chromium hexavalent ionSTAT1 protein affects the susceptibility to chromium hexavalent ion19403854
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of STAT1 mRNA28472532
C074702chromium hexavalent ionchromium hexavalent ion results in increased phosphorylation of and results in increased activity of STAT1 protein19994902
C074702chromium hexavalent ionSTAT1 protein affects the reaction [chromium hexavalent ion results in increased activity of SP1 protein]19994902
D002922CiguatoxinsCiguatoxins affects the expression of STAT1 mRNA18353800
C007095cobaltiprotoporphyrincobaltiprotoporphyrin results in decreased phosphorylation of STAT1 protein22237591
D003078ColchicineColchicine deficiency results in decreased activity of and affects the localization of STAT1 protein28086195
C075384coniferaldehydeconiferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]27378624
C075384coniferaldehyde"coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form]"27378624
C075384coniferaldehyde"coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]"27378624
D019327Copper SulfateCopper Sulfate inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]16896058
D003471CuprizoneCuprizone results in increased expression of STAT1 mRNA27523638
D003474CurcuminCurcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein]16959222
D003474CurcuminCurcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]21811692
D003474CurcuminCurcumin results in decreased expression of STAT118462866
C038459curdlancurdlan results in increased expression of STAT1 mRNA23543010
D003520CyclophosphamideCyclophosphamide results in increased expression of STAT1 mRNA21041162
D016572CyclosporineCyclosporine results in increased expression of STAT1 mRNA22147139
D016572CyclosporineCyclosporine results in decreased expression of STAT1 mRNA19770486
D015638Cytochalasin DCytochalasin D deficiency results in decreased activity of and affects the localization of STAT1 protein28086195
D003609DactinomycinDactinomycin results in increased expression of STAT1 mRNA16001973
C004742daidzeindaidzein inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form]18274639
C004742daidzeindaidzein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]21972936
D000069439Dasatinib2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dasatinib results in increased phosphorylation of STAT1 protein]23825585
D000069439DasatinibDasatinib results in increased phosphorylation of and affects the localization of STAT1 protein23825585
D000069439DasatinibSTAT1 mutant form inhibits the reaction [Dasatinib results in increased expression of ITGAM protein]23825585
D000069439DasatinibU 0126 inhibits the reaction [Dasatinib results in increased phosphorylation of STAT1 protein]23825585
D003634DDTDDT results in increased phosphorylation of STAT1 protein9070211
C556733dechlorane 602dechlorane 602 results in decreased expression of STAT1 mRNA27081854
C014347decitabine[decitabine affects the methylation of STAT1 gene] which affects the expression of STAT1 mRNA18649362|1864936
C014347decitabinedecitabine results in increased expression of STAT1 mRNA27923600
D013759Dronabinol"Dronabinol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased activity of STAT1 protein]"19910459
C007262deoxynivalenol"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]"22454431
C007262deoxynivalenol"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]"22454431
C007262deoxynivalenoldeoxynivalenol results in increased expression of STAT1 mRNA22454431
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of STAT1 protein22454431
C007262deoxynivalenol[deoxynivalenol results in increased susceptibility to Antigens] which results in increased expression of STAT1 mRNA28935500
C007262deoxynivalenolstattic inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]22454431
C007262deoxynivalenolstattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]22454431
D003907DexamethasoneDexamethasone results in increased expression of STAT1 mRNA21041162
D002945Cisplatin[HDAC4 results in increased activity of STAT1] which results in decreased susceptibility to Cisplatin21571862
D002945Cisplatin[IFNG protein results in increased phosphorylation of STAT1 protein] which results in decreased susceptibility to Cisplatin20814891
D002945CisplatinSTAT1 protein modified form results in increased susceptibility to Cisplatin21571862
D002945CisplatinSTAT1 results in decreased susceptibility to Cisplatin21571862
D002945Cisplatin"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of STAT1 mRNA]"26546572
D002945CisplatinCisplatin results in decreased expression of STAT1 mRNA21151649
D002945CisplatinCisplatin results in increased expression of STAT1 mRNA26546572
D004008Diclofenac"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]"26609140
D004008Diclofenac2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]26609140
D004008DiclofenacCalcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]26609140
D004008DiclofenacDiclofenac affects the expression of STAT1 mRNA24752500
D004008Diclofenac[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein26609140
D004008DiclofenacDiclofenac results in decreased expression of STAT1 mRNA19192274
D004008Diclofenacpyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]26609140
D004008DiclofenacDiclofenac results in decreased expression of STAT1 mRNA22285467
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of STAT1 mRNA26924002
C058705diethyl malatediethyl malate affects the expression of STAT1 mRNA24814887
C014476diethyl maleatediethyl maleate results in decreased expression of STAT1 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of STAT1 mRNA27048571
D004052DiethylnitrosamineDMU-212 affects the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of STAT1 mRNA]27048571
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of STAT1 mRNA15766595
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of STAT1 mRNA21041162
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of STAT1 mRNA17011747
C012621dimemorfandimemorfan affects the activity of STAT1 protein18173806
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of STAT1 mRNA20886546
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of STAT1 mRNA14600272
C024629dimethyl phthalatedimethyl phthalate affects the expression of STAT1 mRNA26924002
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of STAT1 mRNA17374397
D004237DiuronDiuron results in increased expression of STAT1 mRNA21551480
C521792DMU-212DMU-212 affects the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of STAT1 mRNA]27048571
C521792DMU-212DMU-212 results in decreased expression of STAT1 mRNA27048571
D004317DoxorubicinDoxorubicin results in increased expression of STAT1 mRNA16001973
D004317DoxorubicinSTAT1 protein results in decreased susceptibility to Doxorubicin17072862
D004317Doxorubicin[IFNG protein co-treated with Doxorubicin] results in increased phosphorylation of STAT1 protein27155237
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STAT1 mRNA22079256
D000431EthanolEthanol inhibits the reaction [IFNG protein results in increased activity of STAT1 protein]18166357
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of STAT1 mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STAT1 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of STAT1 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of STAT1 gene16688530|1672432
D005047Etoposide[STAT1 protein results in increased activity of CASP3 protein] which results in increased susceptibility to Etoposide18649362
D005047Etoposide[STAT1 protein results in increased activity of CASP7 protein] which results in increased susceptibility to Etoposide18649362
D005054EugenolEugenol results in decreased expression of STAT1 mRNA17374397
C020748ferrous sulfateferrous sulfate results in increased phosphorylation of STAT1 protein17607690
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of STAT1 mRNA17347304
D005419FlavonoidsFlavonoids results in decreased expression of STAT1 mRNA15465739
D005419FlavonoidsFlavonoids results in decreased expression of STAT1 protein15465739
C024352fludarabinefludarabine results in decreased activity of STAT1 protein17072862
D005485FlutamideFlutamide results in decreased expression of STAT1 mRNA11509743
D005485FlutamideFlutamide results in decreased expression of STAT1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of STAT1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STAT1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of STAT1 mRNA23649840
C070081fulvestrantfulvestrant results in decreased expression of STAT1 mRNA16514628
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of STAT1 protein]20884965
D019833GenisteinGenistein results in decreased expression of STAT1 protein20884965
D019833GenisteinGenistein inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form]18274639
D005839GentamicinsGentamicins results in increased expression of STAT1 mRNA22061828
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]17507688
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]17507688
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate results in increased expression of STAT1 protein17507688
C102521GGTI 298GGTI 298 results in decreased expression of STAT1 mRNA17507688
C102521GGTI 298GGTI 298 results in decreased expression of STAT1 protein17507688
D005944GlucosamineGlucosamine inhibits the reaction [IFNG results in increased localization of STAT1 protein modified form]17238806
D005944GlucosamineGlucosamine inhibits the reaction [IFNG results in increased phosphorylation of and results in increased localization of STAT1 protein]16431966
D005947Glucose"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Glucose results in increased phosphorylation of STAT1 protein]"20060012
D005947GlucoseGlucose results in increased phosphorylation of STAT1 protein20060012
D005978GlutathioneGlutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D005978GlutathioneGlutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]16896058
D005978Glutathione"Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]"12847270
D005978GlutathioneGlutathione promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]12847270
D006046Gold[Gold co-treated with Silicon Dioxide] results in increased expression of STAT1 mRNA22155353
D006046GoldGold results in increased expression of STAT1 mRNA22155353
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of STAT1 mRNA19192274
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]11882386
C020754herbimycinherbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]10825233
C020754herbimycinherbimycin results in decreased activity of STAT1 protein10825233
C013015hesperetinhesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]28428136
C013015hesperetinhesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT1 protein]28428136
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of STAT1 mRNA15159207
D017313FenretinideFenretinide results in decreased expression of STAT1 mRNA28973697
C029424hydrazinehydrazine results in decreased expression of STAT1 mRNA15282401
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of STAT1 protein10364193
D006861Hydrogen PeroxideHydrogen Peroxide affects the reaction [vanadium pentoxide results in increased phosphorylation of and results in increased activity of STAT1 protein]18322232
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]15748169
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]19635391
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [IFNG protein affects the localization of STAT1 protein]15748169
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]15748169
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]12847270
D006861Hydrogen Peroxide"Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]"12847270
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of STAT1 protein]17607690
D006861Hydrogen Peroxide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of STAT1 protein]"17607690
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of STAT1 protein17607690
C436346I-152 compoundI-152 compound promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of IRF1 protein]23536773
C492448ICG 001ICG 001 results in decreased expression of STAT1 mRNA26191083
D000068877Imatinib MesylateImatinib Mesylate inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]21935477
C540383INCB018424INCB018424 inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT1 protein]22941906
C540383INCB018424INCB018424 inhibits the reaction [IFNB1 protein results in increased expression of STAT1 mRNA]28365849
C540383INCB018424INCB018424 inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT1 protein]22941906
C540383INCB018424INCB018424 inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of STAT1 protein]22941906
C540383INCB018424INCB018424 results in decreased expression of STAT1 mRNA22941906
C540383INCB018424INCB018424 results in decreased phosphorylation of STAT1 protein28365849
D007213IndomethacinIndomethacin results in decreased expression of and results in decreased phosphorylation of STAT1 protein16572323
D007213IndomethacinIndomethacin results in decreased expression of STAT1 protein15631656
D007213IndomethacinIndomethacin results in decreased expression of STAT1 protein modified form16572323
C554043interferon alfa-2a6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of STAT1 protein modified form]29031523
C554043interferon alfa-2a6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased phosphorylation of STAT1 protein]29031523
C554043interferon alfa-2ainterferon alfa-2a results in increased expression of STAT1 protein modified form29031523
C554043interferon alfa-2ainterferon alfa-2a results in increased phosphorylation of STAT1 protein29031523
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased expression of STAT1 protein modified form]]29031523
C554043interferon alfa-2aSOCS3 protein inhibits the reaction [interferon alfa-2a results in increased expression of STAT1 protein modified form]29031523
D000068576Interferon beta-1b6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [Interferon beta-1b results in increased phosphorylation of STAT1 protein]29031523
D000068576Interferon beta-1bInterferon beta-1b results in increased phosphorylation of STAT1 protein29031523
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of STAT1 mRNA25613284
C051890irinotecanirinotecan results in increased phosphorylation of STAT1 protein16204068
C051890irinotecanSTAT1 protein promotes the reaction [irinotecan results in increased localization of FAS protein]16204068
C051890irinotecanTP53 protein inhibits the reaction [irinotecan results in increased phosphorylation of STAT1 protein]16204068
C051890irinotecan[irinotecan co-treated with Lipopolysaccharides] results in increased phosphorylation of STAT1 protein26431797
D017964ItraconazoleItraconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of STAT1 mRNA23086925|2382885
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein results in increased expression of STAT1 mRNA]23589332
C006552kaempferolkaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form]18274639
D007654KetoconazoleKetoconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
D007654KetoconazoleKetoconazole results in increased expression of STAT1 mRNA25787151
D007657Ketone BodiesKetone Bodies results in decreased expression of STAT1 mRNA16807920
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of STAT1 mRNA"23090859
C482199lipopolysaccharide, E coli O55-B5"Cannabinol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased activity of STAT1 protein]"19910459
C482199lipopolysaccharide, E coli O55-B5"Dronabinol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased activity of STAT1 protein]"19910459
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased activity of STAT1 protein"19910459
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of STAT1 protein"17630198|2565184
C482199lipopolysaccharide, E coli O55-B5"resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of STAT1 protein]"25651848
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein"26298005
C440499lipopolysaccharide, Escherichia coli O111 B4"Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]"26298005
C440499lipopolysaccharide, Escherichia coli O111 B4"[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased degradation of STAT1 protein modified form"19549798
C440499lipopolysaccharide, Escherichia coli O111 B4"5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein]"24161485
C440499lipopolysaccharide, Escherichia coli O111 B4"5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]"24161485
C440499lipopolysaccharide, Escherichia coli O111 B4"arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and affects the localization of STAT1 protein]"21426947
C440499lipopolysaccharide, Escherichia coli O111 B4"coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form]"27378624
C440499lipopolysaccharide, Escherichia coli O111 B4"coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]"27378624
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein"24161485
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form"27378624
C440499lipopolysaccharide, Escherichia coli O111 B4"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein"20060843
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and affects the localization of STAT1 protein"21426947
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein"21469130|2416148
C440499lipopolysaccharide, Escherichia coli O111 B4"Quercetin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]"20060843
D008070LipopolysaccharidesLipopolysaccharides affects the expression of STAT1 mRNA28070326
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of STAT1 mRNA23724058
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of STAT1 protein23724058
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT1 protein21135123
D008070Lipopolysaccharidesphenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]23724058
D008070Lipopolysaccharidesphenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]23724058
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of STAT1 mRNA]28070326
D008070Lipopolysaccharides"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]"23236370
D008070LipopolysaccharidesADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT1 protein]20861358
D008070Lipopolysaccharides"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein]"18039960
D008070Lipopolysaccharides"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]"23236370
D008070Lipopolysaccharidesarsenic trioxide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]23106696
D008070LipopolysaccharidesCurcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]21811692
D008070Lipopolysaccharidesdaidzein inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form]18274639
D008070Lipopolysaccharidesdaidzein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]21972936
D008070LipopolysaccharidesGenistein inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form]18274639
D008070Lipopolysaccharideshesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]28428136
D008070LipopolysaccharidesI-152 compound promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of IRF1 protein]23536773
D008070LipopolysaccharidesIFNB1 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]18323514
D008070Lipopolysaccharideskaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form]18274639
D008070LipopolysaccharidesLipopolysaccharides affects the localization of and results in increased activity of STAT1 protein18039960
D008070LipopolysaccharidesLipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form18274639
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein23536773
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT1 protein22118570
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of STAT1 mRNA12057914
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of and results in increased localization of STAT1 protein17891158
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of STAT1 protein21158907|2130971
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of and results in increased phosphorylation of STAT1 protein20423518
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of STAT1 mRNA10975854|2042351
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT1 protein20861358
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein21396905
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of STAT1 protein18323514|2126233
D008070Lipopolysaccharideslycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]22155741
D008070LipopolysaccharidesMelatonin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein]21158907
D008070LipopolysaccharidesMelatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]22225513
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]24056979
D008070LipopolysaccharidesNCL protein inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein]21309717
D008070Lipopolysaccharidesorazipone analog inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein]18039960
D008070Lipopolysaccharidesorazipone inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein]18039960
D008070Lipopolysaccharidesphenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of STAT1 protein]20423518
D008070Lipopolysaccharidesphenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]20423518
D008070Lipopolysaccharidespitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]18323514
D008070LipopolysaccharidesPPARA affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]21262334
D008070LipopolysaccharidesPPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]28428136
D008070LipopolysaccharidesPravastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]18323514
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form]18274639
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]24040572
D008070Lipopolysaccharidesresveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT1 protein]22118570
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein]22118570
D008070LipopolysaccharidesSTAT1 protein promotes the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]23106696
D008070LipopolysaccharidesSTAT1 protein results in increased susceptibility to Lipopolysaccharides21131441
D008070Lipopolysaccharideswithaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein]21396905
D008070Lipopolysaccharides"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]"12584205
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of STAT1 protein12584205
D008070Lipopolysaccharidesrosiglitazone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]12584205
D008070Lipopolysaccharides[irinotecan co-treated with Lipopolysaccharides] results in increased phosphorylation of STAT1 protein26431797
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased phosphorylation of STAT1 protein26431797
C015330lycorinelycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]22155741
D008464MecamylamineMecamylamine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein]16582591
D008464MecamylamineMecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased activity of STAT1 protein]16582591
D008464MecamylamineMecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of STAT1 mRNA]16835749
D008550MelatoninMelatonin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein]21158907
D008550MelatoninMelatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]22225513
C545385MequindoxMequindox results in increased expression of STAT1 mRNA21146578
D008627Mercuric ChlorideAcetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D008627Mercuric ChlorideAscorbic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D008627Mercuric ChlorideGlutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D008627Mercuric ChlorideGlutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]16896058
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]16896058
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]19635391
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]16896058
D008627Mercuric ChlorideThioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STAT1 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of STAT1 mRNA19192274
D008727MethotrexateMethotrexate results in increased expression of STAT1 mRNA21678067
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]24056979
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of STAT1 mRNA28001369
D008775MethylprednisoloneMethylprednisolone results in decreased expression of STAT1 mRNA19192274
D008779Methylthiouracil"Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]"26298005
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT1 protein]18453621
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]17507688
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]17507688
D008798Mevalonic AcidMevalonic Acid results in increased expression of STAT1 protein17507688
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]16534557
C406082monomethylarsonous acidmonomethylarsonous acid affects the expression of STAT1 mRNA25177542
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of STAT1 mRNA20886546|2210804
C517284monomethyl phthalatemonomethyl phthalate affects the expression of STAT1 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of STAT1 mRNA18955075
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of STAT1 mRNA"29244179
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in decreased phosphorylation of STAT1 protein"25487280
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of STAT1 mRNA"25554681
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of STAT1 mRNA27344345
D009532NickelNickel results in decreased expression of STAT1 mRNA23195993
D009532NickelNickel results in increased expression of STAT1 mRNA24768652|2558310
D009532NickelSTAT1 protein affects the reaction [chromium hexavalent ion inhibits the reaction [Nickel results in increased expression of VEGFA mRNA]]19403854
D009532NickelSTAT1 protein affects the reaction [chromium hexavalent ion inhibits the reaction [Nickel results in increased stability of and results in increased expression of HIF1A protein]]19403854
C022838nickel chloridenickel chloride affects the expression of STAT1 mRNA22110744
C029938nickel sulfateAcetylcysteine inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein]20525893
C029938nickel sulfatenickel sulfate results in decreased expression of STAT1 mRNA17374397
C029938nickel sulfatenickel sulfate results in increased phosphorylation of STAT1 protein20525893
C029938nickel sulfateSB 203580 inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein]20525893
C029938nickel sulfatenickel sulfate results in increased phosphorylation of STAT1 protein25957741
C029938nickel sulfateQuercetin inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein]25957741
D009569Nitric OxideSTAT1 protein promotes the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]23106696
D009582NitrofurantoinNitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]15748169
D009582NitrofurantoinRotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]15748169
D009609Nitrous OxideNitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]15748169
C008655N'-nitrosonornicotineBungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased activity of STAT1 protein]16582591
C008655N'-nitrosonornicotineMecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased activity of STAT1 protein]16582591
C008655N'-nitrosonornicotineMecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of STAT1 mRNA]16835749
C008655N'-nitrosonornicotineN'-nitrosonornicotine results in increased activity of STAT1 protein16582591
C008655N'-nitrosonornicotineN'-nitrosonornicotine results in increased expression of STAT1 mRNA16582591|1683574
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of STAT1 mRNA"19013360
C025256nonylphenolnonylphenol results in increased expression of STAT1 mRNA22982499
C069741norcantharidinnorcantharidin results in increased expression of STAT1 protein19616522
C025589ochratoxin A[ochratoxin A results in increased susceptibility to Antigens] which results in increased expression of STAT1 mRNA28935500
C502617oraziponeorazipone analog inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein]18039960
C502617oraziponeorazipone inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein]18039960
D010081OxazoloneOxazolone results in decreased expression of STAT1 mRNA17374397
D010081OxazoloneOxazolone results in increased expression of STAT1 mRNA21893156
C029341oxophenylarsineoxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]11882386
D010121OxytocinSTAT1 protein inhibits the reaction [GHRL protein results in increased secretion of Oxytocin]19528263
D010121OxytocinSTAT1 protein results in increased secretion of Oxytocin19528263
D010126OzoneAcetylcysteine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]19061877
D010126Ozone"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]"19061877
D010126OzoneOzone results in increased phosphorylation of STAT1 protein19061877
D010126Ozonepimagedine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]19061877
D010126Ozonezinc protoporphyrin inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]19061877
D010126OzoneOzone results in increased expression of and results in increased activity of STAT1 protein12162464
D052638Particulate MatterParticulate Matter results in increased expression of STAT1 mRNA22178795
D052638Particulate MatterParticulate Matter results in increased expression of STAT1 mRNA22134058
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of STAT1 mRNA23948077
D010416PentachlorophenolPentachlorophenol results in increased expression of STAT1 mRNA23892564
C500599peroxyvanadate"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [peroxyvanadate results in increased phosphorylation of STAT1 protein]"12847270
C500599peroxyvanadate"peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]"12847270
C500599peroxyvanadateperoxyvanadate promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]12847270
C500599peroxyvanadateperoxyvanadate results in increased phosphorylation of STAT1 protein12847270
C554945PF 956980PF 956980 inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of STAT1 protein]23968543
C058305phenethyl isothiocyanatephenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]23724058
C058305phenethyl isothiocyanatephenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]23724058
C058305phenethyl isothiocyanatephenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of STAT1 protein]20423518
C058305phenethyl isothiocyanatephenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]20423518
D010634PhenobarbitalPhenobarbital affects the expression of STAT1 mRNA23091169
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of STAT1 mRNA27048571
D010634PhenobarbitalDMU-212 affects the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of STAT1 mRNA]27048571
D010656PhenylephrinePhenylephrine results in decreased expression of STAT1 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of STAT1 mRNA26272509
D010712Phosphatidic AcidsPhosphatidic Acids results in increased phosphorylation of and affects the localization of STAT1 protein16354768
C004479pimagedinepimagedine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]19061877
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of STAT1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of STAT1 mRNA17426115
C108475pitavastatinpitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]18323514
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of STAT1 mRNA]28070326
D010936Plant ExtractsPlant Extracts results in decreased expression of STAT1 mRNA15465739
D010936Plant ExtractsPlant Extracts results in decreased expression of STAT1 protein15465739
D010936Plant ExtractsPlant Extracts results in increased expression of STAT1 mRNA23557933
D028321Plant PreparationsPlant Preparations affects the expression of STAT1 mRNA16046712
D028321Plant PreparationsPlant Preparations inhibits the reaction [Acetaminophen results in increased expression of STAT1 protein]18835260
D059808PolyphenolsPolyphenols results in decreased expression of STAT1 mRNA15465739
D059808PolyphenolsPolyphenols results in decreased expression of STAT1 protein15465739
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STAT1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of STAT1 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased phosphorylation of and affects the localization of STAT1 protein17078813
D017035PravastatinPravastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]18323514
D011374ProgesteroneSTAT1 protein inhibits the reaction [GHRL protein results in decreased secretion of Progesterone]19528263
D011441PropylthiouracilPropylthiouracil results in decreased expression of STAT1 mRNA24780913
D015237DinoprostSTAT1 protein inhibits the reaction [GHRL protein results in increased secretion of Dinoprost]19528263
D015237DinoprostSTAT1 protein results in increased secretion of Dinoprost19528263
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [Biological Products results in increased expression of and results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]26609140
D011794QuercetinQuercetin inhibits the reaction [STAT1 protein modified form binds to TRADD protein]16077199
D011794QuercetinQuercetin results in decreased expression of STAT1 mRNA15309432|2163298
D011794QuercetinQuercetin results in decreased phosphorylation of STAT1 protein16077199
D011794QuercetinQuercetin inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]16171798
D011794Quercetin"Quercetin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]"20060843
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form]18274639
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]24040572
D011794QuercetinQuercetin inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein]25957741
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of STAT1 mRNA16514628
C068874raltitrexedraltitrexed results in increased phosphorylation of STAT1 protein16204068
C068874raltitrexedSTAT1 protein promotes the reaction [raltitrexed results in increased localization of FAS protein]16204068
C068874raltitrexedTP53 protein inhibits the reaction [raltitrexed results in increased phosphorylation of STAT1 protein]16204068
C024353resiniferatoxinresiniferatoxin inhibits the reaction [IFNG results in increased activity of STAT1 protein]14530214
C059514resveratrolresveratrol results in decreased expression of STAT1 mRNA18089832
C059514resveratrolresveratrol results in decreased expression of STAT1 protein18089832
C059514resveratrolresveratrol results in decreased expression of STAT1 protein modified form19397895
C059514resveratrolresveratrol inhibits the reaction [APP protein results in increased phosphorylation of STAT1 protein]22118570
C059514resveratrol"resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of STAT1 protein]"25651848
C059514resveratrolresveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT1 protein]22118570
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein]22118570
C059514resveratrolresveratrol inhibits the reaction [IFNG protein results in increased activity of and results in increased phosphorylation of STAT1 protein]21189227
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein]16085646
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein]16085646
C084904Ro 41-5253Ro 41-5253 results in decreased expression of STAT1 protein16007204
C089730rosiglitazonerosiglitazone inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]21268089
C089730rosiglitazonerosiglitazone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]12584205
C089730rosiglitazonerosiglitazone inhibits the reaction [Taurocholic Acid results in increased phosphorylation of STAT1 protein]19563079
C089730rosiglitazonerosiglitazone inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]12584205
D012402RotenoneRotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]15748169
D012402RotenoneRotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]19635391
D012402RotenoneRotenone inhibits the reaction [IFNG protein affects the localization of STAT1 protein]15748169
D012402RotenoneRotenone inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]15748169
D012402RotenoneRotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]15748169
D012402RotenoneThioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
C410958sauchinonesauchinone inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]21167929
C410958sauchinonesauchinone inhibits the reaction [IL1B protein results in increased phosphorylation of STAT1 protein]21167929
C093642SB 203580SB 203580 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]16355272
C093642SB 203580SB 203580 inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein]20525893
C093642SB 203580SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT1 protein]21783819
D012822Silicon Dioxide[Gold co-treated with Silicon Dioxide] results in increased expression of STAT1 mRNA22155353
D012838SilymarinSilymarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT1 protein]28428136
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT1 protein]18453621
D019821SimvastatinSimvastatin inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]21268089
D019821SimvastatinSimvastatin results in decreased activity of STAT1 protein19886038
D019821SimvastatinSimvastatin results in decreased expression of STAT1 mRNA21268089
D019821SimvastatinSimvastatin results in decreased phosphorylation of STAT1 protein18453621
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]17507688
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]17507688
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]17507688
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]17507688
D019821SimvastatinSimvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]]17507688
D019821SimvastatinSimvastatin inhibits the reaction [IFNG results in increased phosphorylation of STAT1 protein]17507688
D019821SimvastatinSimvastatin results in decreased activity of STAT1 protein19886038
D019821SimvastatinSimvastatin results in decreased expression of STAT1 mRNA17507688
D019821SimvastatinSimvastatin results in decreased expression of STAT1 protein17507688
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]16534557
D019821SimvastatinSimvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]16534557
D012906SmokeSmoke analog results in increased phosphorylation of STAT1 protein26546778
D012906SmokeSmoke results in decreased expression of STAT1 mRNA23693141
C009277sodium arsenatesodium arsenate results in increased expression of STAT1 mRNA16882884
C017947sodium arsenitesodium arsenite results in decreased expression of STAT117224793
C017947sodium arsenitesodium arsenite results in increased phosphorylation of STAT1 protein19168569
D0150862,6-Dichloroindophenol"2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]"19635391
D012999SomanSoman results in increased expression of STAT1 mRNA19281266
D053260Soot[Soot co-treated with Sulfates] affects the methylation of STAT1 promoter25395096
C517409statticstattic inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]22454431
C517409statticstattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]22454431
C517409statticstattic inhibits the reaction [T-2 Toxin results in increased expression of STAT1 mRNA]22454431
C517409statticstattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT1 protein]22454431
D013431Sulfates[Soot co-treated with Sulfates] affects the methylation of STAT1 promoter25395096
D013431SulfatesSulfates affects the methylation of STAT1 promoter25395096
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of STAT1 mRNA"26680231
D014284TriiodothyronineTriiodothyronine inhibits the reaction [FGF2 protein results in increased phosphorylation of STAT1 protein]16150908
D013605T-2 Toxin"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 Toxin results in increased expression of STAT1 mRNA]"22454431
D013605T-2 Toxin"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT1 protein]"22454431
D013605T-2 Toxinstattic inhibits the reaction [T-2 Toxin results in increased expression of STAT1 mRNA]22454431
D013605T-2 Toxinstattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT1 protein]22454431
D013605T-2 ToxinT-2 Toxin results in increased expression of STAT1 mRNA22454431
D013605T-2 ToxinT-2 Toxin results in increased phosphorylation of STAT1 protein22454431
D013605T-2 ToxinT-2 Toxin results in decreased expression of STAT1 mRNA26141394
C061133tamibarotenetamibarotene results in increased expression of STAT1 mRNA15498508
D013629TamoxifenTamoxifen results in increased expression of STAT1 mRNA19155303
D013629TamoxifenTamoxifen affects the expression of STAT1 mRNA17555576|2093736
D013656Taurocholic Acidrosiglitazone inhibits the reaction [Taurocholic Acid results in increased phosphorylation of STAT1 protein]19563079
D013656Taurocholic AcidTaurocholic Acid results in increased phosphorylation of STAT1 protein19563079
C003377taxifolintaxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]12044887
C041359terbinafineterbinafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
C004648testosterone enanthatetestosterone enanthate affects the expression of STAT1 mRNA17440010
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of STAT1 mRNA27914987
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of STAT1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STAT1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STAT1 mRNA12377990|1670473
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STAT1 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STAT1 mRNA14708085
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of STAT1 mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in increased expression of STAT1 protein20109541
D013853ThioacetamideThioacetamide results in decreased expression of STAT1 mRNA23411599
D008063Thioctic AcidThioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]28086195
D008063Thioctic AcidThioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
D008063Thioctic AcidThioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
D008063Thioctic AcidThioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
D008063Thioctic AcidThioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein]28086195
D013876ThiophenesThiophenes analog promotes the reaction [Tretinoin results in increased expression of STAT1 mRNA]16140955
C009495titanium dioxidetitanium dioxide results in decreased expression of STAT1 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of STAT1 mRNA23557971
C423915TO-901317TO-901317 inhibits the reaction [IFNG promotes the reaction [STAT1 protein binds to CCL2 promoter]]21268089
C423915TO-901317TO-901317 inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]21268089
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of STAT1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution inhibits the reaction [IFNB1 protein results in increased expression of STAT1 protein]18722370
D014028Tobacco Smoke PollutionTobacco Smoke Pollution inhibits the reaction [IFNG protein results in increased expression of STAT1 protein]18722370
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of and results in decreased phosphorylation of STAT1 protein18722370
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of STAT1 mRNA28111298
C479163tofacitinibtofacitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT1 protein]22941906
C479163tofacitinibtofacitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT1 protein]22941906
C479163tofacitinibtofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]21383241|2212113
C479163tofacitinibtofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of STAT1 protein]23968543
C479163tofacitinibtofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of STAT1 protein]21548952
C479163tofacitinibtofacitinib inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of STAT1 protein]22941906
C479163tofacitinibtofacitinib inhibits the reaction [TNF protein results in increased phosphorylation of STAT1 protein]22121136
C479163tofacitinibtofacitinib results in decreased expression of STAT1 mRNA22941906
C479163tofacitinibtofacitinib results in decreased expression of STAT1 protein modified form25398374|2705972
C479163tofacitinibtofacitinib results in decreased phosphorylation of STAT1 protein25487280|2836584
C479163tofacitinibtofacitinib inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]21383241
C479163tofacitinibtofacitinib inhibits the reaction [IL21 protein results in increased phosphorylation of STAT1 protein]21383241
C479163tofacitinibtofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]21383241
D014118Toxins, Biological"Toxins, Biological affects the expression of STAT1 mRNA"19682533
D014212Tretinoinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in increased expression of and results in increased phosphorylation of STAT1 protein]20945414
D014212Tretinoinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in increased expression of STAT1 mRNA]20945414
D014212TretinoinRo 41-5253 inhibits the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein]16085646
D014212TretinoinSTAT1 protein affects the reaction [Tretinoin results in increased expression of CEBPE protein]16918696
D014212TretinoinSTAT1 protein affects the reaction [Tretinoin results in increased expression of IRF8 protein]16918696
D014212TretinoinSTAT1 protein affects the reaction [Tretinoin results in increased expression of STAT2 protein]16918696
D014212TretinoinSTAT1 protein promotes the reaction [Tretinoin results in increased expression of CLIP1 mRNA]16574066
D014212TretinoinThiophenes analog promotes the reaction [Tretinoin results in increased expression of STAT1 mRNA]16140955
D014212TretinoinTretinoin inhibits the reaction [IFNG protein results in increased expression of STAT1 protein]16007204
D014212TretinoinTretinoin inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]16636311
D014212TretinoinTretinoin promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]16085646
D014212TretinoinTretinoin results in decreased expression of STAT1 protein16007204
D014212TretinoinTretinoin results in increased expression of and results in increased phosphorylation of STAT1 protein20945414
D014212TretinoinTretinoin results in increased expression of STAT1 mRNA16140955|2094541
D014212TretinoinTretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein16085646
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of STAT1 mRNA17982090
C057693troglitazonetroglitazone results in increased expression of STAT1 mRNA12732648
C057693troglitazone[troglitazone co-treated with TNF protein] results in increased expression of STAT1 mRNA12732648
C113580U 0126U 0126 inhibits the reaction [Dasatinib results in increased phosphorylation of STAT1 protein]23825585
D014580Ursodeoxycholic Acid"[Amantadine co-treated with Ursodeoxycholic Acid co-treated with 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester] results in increased activity of STAT1"15918519
D000068756ValsartanValsartan inhibits the reaction [AGT protein affects the localization of STAT1 protein]12846741
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased activity of STAT1 protein]12846741
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT1 protein]12846741
C066075vanadium pentoxideacetovanillone inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein]18322232
C066075vanadium pentoxideAllopurinol inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein]18322232
C066075vanadium pentoxideHydrogen Peroxide affects the reaction [vanadium pentoxide results in increased phosphorylation of and results in increased activity of STAT1 protein]18322232
C066075vanadium pentoxideIFNB1 protein affects the reaction [vanadium pentoxide results in increased activity of STAT1 protein]18322232
C066075vanadium pentoxideJAK1 protein affects the reaction [vanadium pentoxide results in increased activity of STAT1 protein]18322232
C066075vanadium pentoxidevanadium pentoxide results in decreased expression of STAT1 mRNA17459161
C066075vanadium pentoxidevanadium pentoxide results in increased activity of and results in increased phosphorylation of STAT1 protein18322232
D014640VancomycinVancomycin results in decreased expression of STAT1 mRNA18930951
D014747VinblastineVinblastine deficiency results in decreased activity of and affects the localization of STAT1 protein28086195
C025643vinclozolinvinclozolin affects the expression of STAT1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of STAT1 mRNA18042343
C025643vinclozolinvinclozolin results in increased expression of STAT1 mRNA22570695
D014750VincristineVincristine results in increased expression of STAT1 mRNA16001973
C017963vinyl carbamatevinyl carbamate results in decreased expression of STAT1 mRNA17849452
D014800VitalliumVitallium analog results in decreased expression of STAT1 mRNA23825117
D014810Vitamin EVitamin E results in decreased expression of STAT1 mRNA19244175
C529824VPC32183VPC32183 inhibits the reaction [Biological Products results in increased expression of and results in increased phosphorylation of and results in increased activity of STAT1 protein]24471457
C009684withaferin Awithaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein]21396905
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT1 mRNA20370541
D015032ZincThioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]28086195
D015032ZincThioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein]28086195
D015032ZincZinc deficiency affects the phosphorylation of and results in increased expression of STAT1 protein28086195
D015032ZincZinc deficiency results in decreased activity of and affects the localization of STAT1 protein28086195
D015032ZincZinc deficiency affects the phosphorylation of and results in increased expression of STAT1 protein28086195
D015032ZincZinc deficiency results in decreased activity of and affects the localization of STAT1 protein28086195
D015034Zinc OxideZinc Oxide analog results in decreased expression of STAT1 mRNA27185063
C017803zinc protoporphyrinzinc protoporphyrin inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]19061877
D019287Zinc SulfateZinc Sulfate inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]16896058
D019287Zinc SulfateZinc Sulfate results in increased expression of STAT1 mRNA19013360
C088658zoledronic acidzoledronic acid results in increased expression of STAT1 mRNA24714768
D015054ZymosanIL6 protein affects the reaction [Zymosan results in increased phosphorylation of and results in increased activity of STAT1 protein]15188379
D015054ZymosanSTAT1 protein affects the reaction [Zymosan results in increased expression of SOCS1 mRNA]15188379
D015054ZymosanSTAT1 protein affects the susceptibility to Zymosan15188379
D015054ZymosanZymosan results in increased phosphorylation of and results in increased activity of STAT1 protein15188379

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA18035482  21268089  
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding-IDA23386060  28753426  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000982transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA21268089  
GO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding-IDA28753426  
GO:0003690double-stranded DNA binding-IDA9630226  
GO:0003700DNA-binding transcription factor activity-IDA10973496  23386060  
GO:0005164tumor necrosis factor receptor binding-IPI10848577  
GO:0005515protein binding-IPI8156998  8605877  8662591  9121453  9881977  10848577  
11238845  12070153  12788789  12867595  15780933  15825084  
16189514  16273093  16306601  16531398  16940534  17275127  
17923090  20195357  21903422  21988832  24065129  24360797  
24658140  25241761  25416956  25609649  26479788  26504087  
26889034  26966684  28753426  
GO:0019899enzyme binding-IPI22002246  26479788  
GO:0031730CCR5 chemokine receptor binding-IEA-  
GO:0035035histone acetyltransferase binding-IPI26479788  
GO:0035257nuclear hormone receptor binding-IPI26504087  
GO:0042393histone binding-IPI26479788  
GO:0042802identical protein binding-IPI8605877  9630226  
GO:0042803protein homodimerization activity-IDA9630226  28753426  
GO:0044389ubiquitin-like protein ligase binding-IPI26479788  
GO:0045296cadherin binding-HDA25468996  
GO:0051721protein phosphatase 2A binding-IEA-  
GO:0070491repressing transcription factor binding-IPI23386060  
GO:1990841promoter-specific chromatin binding-IDA26479788  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0001937negative regulation of endothelial cell proliferation-IMP16585190  
GO:0002053positive regulation of mesenchymal cell proliferation-ISS-  
GO:0002230positive regulation of defense response to virus by host-IGI26479788  
GO:0002230positive regulation of defense response to virus by host-IMP26479788  
GO:0003340negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007221positive regulation of transcription of Notch receptor target-TAS-  
GO:0007259JAK-STAT cascade-IDA22002246  
GO:0007584response to nutrient-IEA-  
GO:0008015blood circulation-ISS-  
GO:0009612response to mechanical stimulus-IEA-  
GO:0010742macrophage derived foam cell differentiation-IDA26504087  
GO:0016032viral process-IEA-  
GO:0016525negative regulation of angiogenesis-IMP16585190  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032727positive regulation of interferon-alpha production-IDA28753426  
GO:0032869cellular response to insulin stimulus-IEA-  
GO:0033209tumor necrosis factor-mediated signaling pathway-IDA10848577  
GO:0034097response to cytokine-ISS-  
GO:0035456response to interferon-beta-IMP24882218  
GO:0035458cellular response to interferon-beta-IMP18035482  
GO:0038114interleukin-21-mediated signaling pathway-TAS-  
GO:0042542response to hydrogen peroxide-IEA-  
GO:0042981regulation of apoptotic process-TAS12108949  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IMP10848577  
GO:0043434response to peptide hormone-ISS-  
GO:0043542endothelial cell migrationNOTIMP16585190  
GO:0045648positive regulation of erythrocyte differentiation-IMP28283061  
GO:0045893positive regulation of transcription, DNA-templated-IDA10973496  
GO:0045893positive regulation of transcription, DNA-templated-IGI26479788  
GO:0045893positive regulation of transcription, DNA-templated-IMP26479788  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP18035482  
GO:0046725negative regulation by virus of viral protein levels in host cell-IMP15825084  
GO:0048661positive regulation of smooth muscle cell proliferation-ISS-  
GO:0051591response to cAMP-ISS-  
GO:0051607defense response to virus-IDA28753426  
GO:0051770positive regulation of nitric-oxide synthase biosynthetic process-IEA-  
GO:0060333interferon-gamma-mediated signaling pathway-IDA21268089  
GO:0060333interferon-gamma-mediated signaling pathway-IMP26479788  
GO:0060333interferon-gamma-mediated signaling pathway-ISS-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060334regulation of interferon-gamma-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-IDA23386060  
GO:0060337type I interferon signaling pathway-ISS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0061326renal tubule development-IMP20861313  
GO:0070102interleukin-6-mediated signaling pathway-TAS-  
GO:0070106interleukin-27-mediated signaling pathway-TAS-  
GO:0070757interleukin-35-mediated signaling pathway-TAS-  
GO:0071346cellular response to interferon-gamma-IDA23386060  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO:0072136metanephric mesenchymal cell proliferation involved in metanephros development-ISS-  
GO:0072162metanephric mesenchymal cell differentiation-ISS-  
GO:0072308negative regulation of metanephric nephron tubule epithelial cell differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA18035482  
GO:0005634nucleus-IDA10692450  10973496  15825084  16306601  21268089  23386060  28753426  
GO:0005634nucleuscolocalizes_withIDA26479788  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IDA10692450  10973496  15825084  17275127  23386060  26479788  27796300  28753426  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0032991protein-containing complex-IDA26479788  
GO:0048471perinuclear region of cytoplasm-IDA17275127  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
Reactome ID Reactome Term Evidence
R-HSA-1059683Interleukin-6 signalingTAS
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-1839117Signaling by cytosolic FGFR1 fusion mutantsTAS
R-HSA-1839124FGFR1 mutant receptor activationTAS
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6783589Interleukin-6 family signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-877300Interferon gamma signalingTAS
R-HSA-877312Regulation of IFNG signalingTAS
R-HSA-8854691Interleukin-20 family signalingTAS
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8939902Regulation of RUNX2 expression and activityIEA
R-HSA-8984722Interleukin-35 SignallingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionTAS
R-HSA-9020956Interleukin-27 signalingTAS
R-HSA-9020958Interleukin-21 signalingTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-912694Regulation of IFNA signalingTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-982772Growth hormone receptor signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19345260Acrolein, a ubiquitous pollutant and lipid hydroperoxide product, inhibits antiviral activity of interferon-alpha: relevance to hepatitis C. (2009 Jul 1)Joshi-Barve SFree Radic Biol Med
27228072Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors. (2016)Schaal CPLoS One
25104439Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. (2014 Aug)Slattery MLBreast Cancer Res Treat
22121102JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)Slattery MLMol Carcinog
24285265Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers. (2014 Feb)Meyer MAm J Physiol Lung Cell Mol Physiol
19662102The Epithelial Cell in Lung Health and Emphysema Pathogenesis. (2006 May)Mercer BACurr Respir Med Rev
17558024Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3. (2007 Aug 3)Wu ZJ Biol Chem
22537161Nicotine, IFN-gamma and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades. (2012 Apr 26)Kunigal SMol Cancer
23708675Molecular genetic characterization of p53 mutated oropharyngeal squamous cell carcinoma cells transformed with human papillomavirus E6 and E7 oncogenes. (2013 Aug)Oh JEInt J Oncol
26546778Cigarette smoke-mediated oxidative stress induces apoptosis via the MAPKs/STAT1 pathway in mouse lung fibroblasts. (2016 Jan 5)Lee HToxicol Lett
27994590Cigarette Smoke Induction of Interleukin-27/WSX-1 Regulates the Differentiation of Th1 and Th17 Cells in a Smoking Mouse Model of Emphysema. (2016)Qiu SLFront Immunol
18930547Cigarette smoke attenuation of poly I:C-induced innate antiviral responses in human PBMC is mainly due to inhibition of IFN-beta production. (2009 Feb)Mian MFMol Immunol
24894179Lyn regulates cytotoxicity in respiratory epithelial cells challenged by cigarette smoke extracts. (2014)Wang WCurr Mol Med
27003425Inflammatory and Immune Response Genes Polymorphisms are Associated with Susceptibility to Chronic Obstructive Pulmonary Disease in Tatars Population from Russia. (2016 Aug)Korytina GFBiochem Genet