Gene: STAT2

6773
IMD44|ISGF-3|P113|STAT113
signal transducer and activator of transcription 2
protein-coding
12q13.3
Ensembl:ENSG00000170581 MIM:600556 Vega:OTTHUMG00000170760 UniprotKB:P52630
NG_046314.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.350e-1 (AD)  8.613e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTC170.893
FKBP150.892
MAU20.884
STX160.884
DIDO10.879
ZFYVE260.879
SRRM10.874
ASXL10.873
SUPT20H0.868
RBM50.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.559
OR4F29-0.529
KLRC2-0.295
PLA2G5-0.24
OR4F16-0.234
GSDMC-0.22
NANOGNB-0.215
KCNJ16-0.205
TRDN-0.205
DIO2-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of STAT2 mRNA"24680724
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of STAT2 mRNA"19114083
C0059753,4-dihydroxyphenylethanol"[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNA"16797527
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of STAT2 mRNA"18648102
C0006253616-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased phosphorylation of STAT2 protein]29031523
C0413987,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester"7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester results in increased expression of STAT2 protein"16756086
D000082AcetaminophenAcetaminophen results in decreased expression of STAT2 mRNA21420995
D020106AcrylamideAcrylamide results in increased expression of STAT2 mRNA28959563
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of STAT2 mRNA"23195993
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of STAT2 mRNA18247414
D001151ArsenicArsenic affects the expression of STAT2 mRNA18414638
D001151ArsenicArsenic results in increased expression of STAT2 mRNA27838757
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of STAT2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STAT2 mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STAT2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STAT2 mRNA23735875
D004958EstradiolEstradiol results in increased expression of STAT2 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of STAT2 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of STAT2 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of STAT2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of STAT2 promoter22457795
C055162clopidogrelclopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of STAT2 mRNA]19172522
C038459curdlancurdlan results in increased expression of STAT2 mRNA23543010
D016572CyclosporineCyclosporine results in increased expression of STAT2 mRNA22147139
C007262deoxynivalenoldeoxynivalenol results in increased expression of STAT2 mRNA22454431
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of STAT2 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of STAT2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of STAT2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of STAT2 mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of STAT2 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of STAT2 mRNA21658437
D004317DoxorubicinDoxorubicin results in increased expression of STAT2 mRNA16001973
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STAT2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STAT2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of STAT2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAT2 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of STAT2 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of STAT2 mRNA23649840
C039281furanfuran results in increased methylation of STAT2 gene22079235
D005839GentamicinsGentamicins results in increased expression of STAT2 mRNA22061828
C412815GW 4064GW 4064 promotes the reaction [NR1H4 protein binds to STAT2 gene]20091679
C540383INCB018424INCB018424 inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT2 protein]22941906
C540383INCB018424INCB018424 inhibits the reaction [IFNB1 protein results in increased expression of STAT2 mRNA]28365849
C540383INCB018424INCB018424 inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT2 protein]22941906
C554043interferon alfa-2a6-hydroxy-3-O-methylkaempferol 6-O-glucopyranoside promotes the reaction [interferon alfa-2a results in increased phosphorylation of STAT2 protein]29031523
C554043interferon alfa-2ainterferon alfa-2a results in increased phosphorylation of STAT2 protein29031523
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of STAT2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of STAT2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of STAT2 mRNA26387944
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of STAT2 mRNA21889194
C006552kaempferol"[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNA"16797527
D008070LipopolysaccharidesAHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]22273745
D008070LipopolysaccharidesCASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]]22273745
D008070LipopolysaccharidesCASP1 protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]22273745
D008070Lipopolysaccharidesclopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of STAT2 mRNA]19172522
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of STAT2 mRNA17321000|2658214
D008070Lipopolysaccharides[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA22273745
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of STAT2 mRNA26378955
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of STAT2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of STAT2 mRNA"20188158
C406082monomethylarsonous acidmonomethylarsonous acid affects the expression of STAT2 mRNA25177542
D009151Mustard GasMustard Gas results in increased expression of STAT2 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of STAT2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of STAT2 mRNA"25554681|2562005
C051752nefazodonenefazodone results in decreased expression of STAT2 mRNA24136188
D009532NickelNickel results in decreased expression of STAT2 mRNA23195993
D009538NicotineNicotine results in decreased expression of STAT2 mRNA18247414
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of STAT2 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of STAT2 mRNA21893156
C016030pantogabpantogab results in decreased expression of STAT2 mRNA17379144
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of STAT2 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of STAT2 mRNA23892564
C006253pirinixic acidpirinixic acid results in decreased expression of STAT2 mRNA17321000
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of STAT2 mRNA]17321000
C006253pirinixic acidpirinixic acid results in decreased expression of STAT2 mRNA19162173
D010936Plant ExtractsPlant Extracts results in increased expression of STAT2 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STAT2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of STAT2 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of STAT2 protein23718831
D011205Povidone[Silver analog co-treated with Povidone] results in decreased expression of STAT2 mRNA25194297
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of STAT2 mRNA25626140
D011794Quercetin"[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNA"16797527
D012822Silicon DioxideAHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]22273745
D012822Silicon DioxideCASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]]22273745
D012822Silicon DioxideCASP1 protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]22273745
D012822Silicon Dioxide[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA22273745
D012834SilverSilver results in decreased expression of STAT2 mRNA27131904
D012834Silver[Silver analog co-treated with Povidone] results in decreased expression of STAT2 mRNA25194297
D012969Sodium FluorideSodium Fluoride results in decreased expression of STAT2 mRNA21340527
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of STAT2 mRNA26378955
D013605T-2 ToxinT-2 Toxin results in increased expression of STAT2 mRNA22454431
D013605T-2 ToxinT-2 Toxin results in decreased expression of STAT2 mRNA26141394
D013629TamoxifenTamoxifen affects the expression of STAT2 mRNA17555576
D013739TestosteroneTestosterone results in decreased expression of STAT2 mRNA15788153
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of STAT2 mRNA27914987
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAT2 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of STAT2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STAT2 mRNA17942748|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STAT2 mRNA21215274
C009495titanium dioxidetitanium dioxide results in increased expression of STAT2 mRNA23557971
C479163tofacitinibtofacitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT2 protein]22941906
C479163tofacitinibtofacitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT2 protein]22941906
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of STAT2 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of STAT2 mRNA"19682533
D014212TretinoinSTAT1 protein affects the reaction [Tretinoin results in increased expression of STAT2 protein]16918696
C012589trichostatin Atrichostatin A affects the expression of STAT2 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of STAT2 mRNA21893156
D014635Valproic AcidValproic Acid results in increased expression of STAT2 mRNA19101580
D014635Valproic AcidValproic Acid results in increased methylation of STAT2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of STAT2 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of STAT2 mRNA20546886
C025643vinclozolinvinclozolin results in decreased expression of STAT2 mRNA23034163
D014810Vitamin E"[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNA"16797527
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT2 mRNA20370541
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of STAT2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI8605876  8605877  9121453  9677371  12220192  15825084  
16227264  17923090  18579593  20404187  21903422  24065129  
26966684  
GO:0042802identical protein binding-IPI8605877  
GO:0044389ubiquitin-like protein ligase binding-IPI27782195  
GO ID GO Term Qualifier Evidence PubMed
GO:0001932regulation of protein phosphorylation-IMP26122121  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS9020188  
GO:0007259JAK-STAT cascade-TAS9020188  
GO:0016032viral process-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0051607defense response to virus-IMP23391734  
GO:0060337type I interferon signaling pathway-IMP23391734  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0090140regulation of mitochondrial fission-IMP26122121  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04380Osteoclast differentiation
hsa04630Jak-STAT signaling pathway
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-8854691Interleukin-20 family signalingTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-909733Interferon alpha/beta signalingIEA
R-HSA-912694Regulation of IFNA signalingTAS
R-HSA-912694Regulation of IFNA signalingIEA
R-HSA-913531Interferon SignalingTAS
R-HSA-913531Interferon SignalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22121102JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)Slattery MLMol Carcinog
19345260Acrolein, a ubiquitous pollutant and lipid hydroperoxide product, inhibits antiviral activity of interferon-alpha: relevance to hepatitis C. (2009 Jul 1)Joshi-Barve SFree Radic Biol Med
27113098CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer. (2017 Feb)Wu YYJ Formos Med Assoc