Gene: STAT4

6775
SLEB11
signal transducer and activator of transcription 4
protein-coding
2q32.2-q32.3
Ensembl:ENSG00000138378 MIM:600558 Vega:OTTHUMG00000132700 UniprotKB:Q14765
NG_012852.1
PubMed
0   ANCO-SNPs
ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.602e-1 (AD)  2.183e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15636519chr2:191894418STAT41.500e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA2D30.953
KCNIP40.948
MAGEE10.947
HTR5A0.946
RBFOX10.946
FAM81A0.944
LRFN50.944
GABRG20.944
GLS20.944
ADAM230.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.568
YES1-0.555
HEY2-0.545
MYL3-0.542
REST-0.538
WWTR1-0.533
RAB13-0.523
CNN2-0.522
CSAG1-0.506
RNF135-0.504

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of STAT4 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT4 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to STAT4 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to STAT4 protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of STAT4 mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of STAT4 mRNA28959563
C499366Active Hexose Correlated CompoundActive Hexose Correlated Compound results in decreased phosphorylation of STAT4 protein25186628
D000393Air PollutantsAir Pollutants analog results in decreased expression of STAT4 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STAT4 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of STAT4 mRNA12205029
D003913DextroamphetamineSOD1 inhibits the reaction [Dextroamphetamine results in decreased expression of STAT4 mRNA]12205029
D000941Antigens[deoxynivalenol results in increased susceptibility to Antigens] which results in increased expression of STAT4 mRNA28935500
D000941Antigens[ochratoxin A results in increased susceptibility to Antigens] which results in increased expression of STAT4 mRNA28935500
D001151ArsenicArsenic results in increased methylation of STAT4 promoter21291286
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to STAT4 protein]26598702
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of STAT4 mRNA"18687144
D001554BenzeneBenzene results in increased expression of STAT4 mRNA16188087|1916216
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STAT4 mRNA22228805
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of STAT4 mRNA20404318
C006780bisphenol Abisphenol A affects the expression of STAT4 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of STAT4 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of STAT4 mRNA25181051|2717856
C007020chlorophyllinchlorophyllin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT4 protein]16275627
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of STAT4 mRNA20938992
D003474CurcuminCurcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein]17979888
D003474CurcuminCurcumin results in decreased expression of STAT418462866
C038459curdlancurdlan results in increased expression of STAT4 mRNA23543010
D016572CyclosporineCyclosporine results in decreased expression of STAT4 mRNA27989131
C017160cypermethrincypermethrin results in decreased expression of STAT4 mRNA22528246
C007262deoxynivalenol[deoxynivalenol results in increased susceptibility to Antigens] which results in increased expression of STAT4 mRNA28935500
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of STAT4 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of STAT4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of STAT4 mRNA27392435
D004008DiclofenacDiclofenac results in decreased expression of STAT4 mRNA19192274
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of STAT4 mRNA"19480007
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of STAT4 mRNA17374397
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STAT4 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAT4 mRNA17942748
D005054EugenolEugenol results in increased expression of STAT4 mRNA17374397
D005485FlutamideFlutamide results in decreased expression of STAT4 mRNA21126777
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of STAT4 mRNA20938992
D005839GentamicinsGentamicins results in increased expression of STAT4 mRNA22061828
C054591hachimijioganhachimijiogan results in decreased phosphorylation of STAT4 protein12022442
D007213IndomethacinIndomethacin results in increased expression of STAT4 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of STAT4 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of STAT4 mRNA27392435
C038753leptomycin Bleptomycin B affects the localization of STAT4 protein15004198
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of STAT4 mRNA"24972896
D008070Lipopolysaccharideschlorophyllin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT4 protein]16275627
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA23963992
D008344ManebMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]23963992
D008344ManebSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]23963992
D008550MelatoninMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]23963992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of STAT4 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of STAT4 mRNA17400583
D008770MethylnitrosoureaSTAT4 gene mutant form results in increased susceptibility to Methylnitrosourea11418001
D008775MethylprednisoloneMethylprednisolone results in decreased expression of STAT4 mRNA19192274
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of STAT4 mRNA"25554681
D009532NickelNickel results in increased expression of STAT4 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of STAT4 mRNA16780908|1737439
C025589ochratoxin A[ochratoxin A results in increased susceptibility to Antigens] which results in increased expression of STAT4 mRNA28935500
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA23963992
D010269ParaquatMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]23963992
D010269ParaquatSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]23963992
D052638Particulate MatterParticulate Matter results in increased expression of STAT4 mRNA22178795
D052638Particulate MatterParticulate Matter results in increased expression of STAT4 mRNA23638009
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased activity of STAT4 protein27589886
D010672PhenytoinPhenytoin results in decreased expression of STAT4 mRNA14741686
D010894PiroxicamPiroxicam results in decreased expression of STAT4 mRNA19192274
D011239PrednisolonePrednisolone results in decreased expression of STAT4 mRNA19192274
D011374ProgesteroneProgesterone results in decreased expression of STAT4 mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of STAT4 mRNA26079696
C059514resveratrolresveratrol inhibits the reaction [IL1B protein results in increased activity of STAT4 protein]19011540
C059514resveratrolresveratrol results in decreased expression of STAT4 mRNA23419489
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of STAT4 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of STAT4 mRNA25895662
D012838SilymarinSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]23963992
D018038Sodium SeleniteSodium Selenite results in increased expression of STAT4 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STAT4 mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAT4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STAT4 mRNA18684927
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of STAT4 protein18684927
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of STAT4 mRNA25613284
D014050TolueneToluene results in increased expression of STAT4 mRNA21601613
D014118Toxins, Biological"Toxins, Biological affects the expression of STAT4 mRNA"19682533
C012589trichostatin Atrichostatin A results in increased expression of STAT4 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of STAT4 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of STAT4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of STAT4 mRNA26272509
D014635Valproic AcidValproic Acid results in increased expression of STAT4 mRNA24935251
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of STAT4 gene25560391
D015032ZincZinc deficiency results in increased activity of STAT4 protein18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS9284918  
GO:0005515protein binding-IPI22740693  
GO:0042802identical protein binding-IPI18591661  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0007259JAK-STAT cascade-TAS9284918  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0038114interleukin-21-mediated signaling pathway-TAS-  
GO:0038155interleukin-23-mediated signaling pathway-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0070757interleukin-35-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-447115Interleukin-12 family signalingIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-8854691Interleukin-20 family signalingTAS
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsTAS
R-HSA-8863678Neurodegenerative DiseasesTAS
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-8984722Interleukin-35 SignallingTAS
R-HSA-9020591Interleukin-12 signalingTAS
R-HSA-9020591Interleukin-12 signalingIEA
R-HSA-9020933Interleukin-23 signalingTAS
R-HSA-9020958Interleukin-21 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24489016Association of rheumatoid arthritis susceptibility gene with lipid profiles in patients with rheumatoid arthritis. (2014 Jun)Davis LARheumatology (Oxford)
25104439Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. (2014 Aug)Slattery MLBreast Cancer Res Treat
25182674Strategies for evaluating idiopathic inflammatory myopathy disease susceptibility genes. (2014 Oct)Rothwell SCurr Rheumatol Rep
23288628Genetics of rheumatoid arthritis - a comprehensive review. (2013 Oct)Kurko JClin Rev Allergy Immunol
19684152Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population. (2009 Oct)Kiyohara CJ Rheumatol
20046016[Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?]. (2009 Dec)Ohmura KNihon Rinsho Meneki Gakkai Kaishi
15744455Association analysis of signal transducer and activator of transcription 4 (STAT4) polymorphisms with asthma. (2005)Park BLJ Hum Genet
22121102JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)Slattery MLMol Carcinog
20439292Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)van der Helm-van Mil AHAnn Rheum Dis