Gene: STAT5A

6776
MGF|STAT5
signal transducer and activator of transcription 5A
protein-coding
17q21.2
Ensembl:ENSG00000126561 MIM:601511 Vega:OTTHUMG00000150725 UniprotKB:P42229
NC_000017.11
PubMed
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.309e-1 (AD)  5.899e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SERPINB10.909
IFI160.884
MYD880.883
MVP0.877
CLIC10.872
DRAM10.871
TRIP100.866
TIMP10.863
LTBR0.859
PSMB80.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.557
KCNB2-0.546
NEUROD6-0.536
ABCC12-0.532
CALHM1-0.525
CHRNB2-0.516
SLC1A6-0.516
SLC7A4-0.515
NDST3-0.51
GRIN2B-0.509

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of STAT5A mRNA"20826375
C0359762,4,2',4'-tetrachlorobiphenyl"2,4,2',4'-tetrachlorobiphenyl results in increased phosphorylation of STAT5A protein"12711418
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of STAT5A protein"12711418
C5859122,4-dihydroxy-N-(4-hydroxyphenyl)benzamide"2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide results in decreased phosphorylation of STAT5A protein"24144632
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased activity of STAT5A protein"11751460
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of STAT5A protein modified form"11751460
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of STAT5A mRNA"12376462
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of STAT5A protein"12376462
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased activity of STAT5A protein] which results in increased expression of CTNNB1 mRNA"11751460
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of STAT5A protein modified form] which results in increased expression of CTNNB1 mRNA"11751460
C0005892902-hydroxy-1-(2-((9-(4-methylcyclohexyl)-9H-pyrido(4',3'-4,5)pyrrolo(2,3-d)pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone"2-hydroxy-1-(2-((9-(4-methylcyclohexyl)-9H-pyrido(4',3'-4,5)pyrrolo(2,3-d)pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone results in decreased phosphorylation of STAT5A protein"24526162
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of STAT5A protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5A mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of STAT5A mRNA19191707
C5843684'-methoxy licoflavanone4'-methoxy licoflavanone results in decreased phosphorylation of and results in decreased activity of STAT5A protein23850732
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5A mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of STAT5A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of STAT5A mRNA19770486
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [GH1 protein results in increased phosphorylation of STAT5A protein]"18388193
C000154alpinumisoflavonealpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT5A protein23850732
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STAT5A mRNA16483693
D001151ArsenicArsenic results in increased expression of STAT5A mRNA27838757
C006632arsenic trioxidearsenic trioxide results in decreased expression of STAT5A protein18349030
C006632arsenic trioxidearsenic trioxide results in decreased phosphorylation of and results in decreased activity of STAT5A protein17121903
C015001arsenitearsenite results in decreased expression of STAT5A mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of STAT5A mRNA]18929588
C545606AZD 1480AZD 1480 results in decreased phosphorylation of STAT5A protein21138246
C545606AZD 1480AZD 1480 results in decreased phosphorylation of STAT5A protein21138246
C030233benzo(a)pyrene-1,6-quinone"benzo(a)pyrene-1,6-quinone affects the localization of STAT5A protein"19166869
C030233benzo(a)pyrene-1,6-quinone"benzo(a)pyrene-1,6-quinone results in increased phosphorylation of STAT5A protein"19166869
C018003benzo(a)pyrene-3,6-quinone"benzo(a)pyrene-3,6-quinone affects the localization of STAT5A protein"19166869
C018003benzo(a)pyrene-3,6-quinone"benzo(a)pyrene-3,6-quinone results in increased phosphorylation of STAT5A protein"19166869
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of STAT5A mRNA18164116
D004958Estradiol[bisphenol A results in increased susceptibility to Estradiol] which results in decreased expression of STAT5A mRNA27312807
D004958EstradiolESR1 protein mutant form inhibits the reaction [Estradiol results in increased expression of STAT5A mRNA]19920132
D004958EstradiolEstradiol affects the expression of STAT5A mRNA15598610
D004958EstradiolEstradiol affects the localization of STAT5A protein19920132
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of STAT5A protein17884938
D004958EstradiolEstradiol promotes the reaction [[ESR1 protein binds to STAT5A promoter] which results in increased expression of STAT5A mRNA]19920132|1992013
D004958EstradiolEstradiol results in increased expression of STAT5A mRNA19920132|2082637
C006780bisphenol Abisphenol A affects the methylation of STAT5A promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of STAT5A promoter27312807
C006780bisphenol Abisphenol A results in increased expression of STAT5A mRNA20826375
C006780bisphenol A[bisphenol A results in increased susceptibility to Estradiol] which results in decreased expression of STAT5A mRNA27312807
C006780bisphenol Abisphenol A results in decreased phosphorylation of STAT5A protein15242752
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of STAT5A mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of STAT5A mRNA25181051
D001971BromocriptineBromocriptine affects the localization of STAT5A protein17884938
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of STAT5A mRNA12766906
D002273CarcinogensCarcinogens results in increased expression of STAT5A mRNA16316942
C016299chelerythrinechelerythrine results in decreased phosphorylation of and results in decreased activity of STAT5A protein15746188
C018021cobaltous chloridecobaltous chloride results in decreased expression of STAT5A mRNA22941251
C060728cobalt oxidecobalt oxide analog results in decreased expression of STAT5A mRNA24821434
D019327Copper SulfateCopper Sulfate results in decreased expression of STAT5A mRNA19549813
D003474CurcuminCurcumin results in decreased expression of STAT5A protein16959222
D003474CurcuminCurcumin results in increased cleavage of STAT5A protein16959222
D003474CurcuminCurcumin results in decreased expression of STAT5A18462866
C038459curdlancurdlan results in increased expression of STAT5A mRNA23543010
D016572CyclosporineCyclosporine results in increased expression of STAT5A mRNA25562108
C017160cypermethrincypermethrin results in decreased expression of STAT5A mRNA22528246
D013759DronabinolDronabinol results in increased phosphorylation of STAT5A protein16434616|1704100
D013759DronabinolSTAT5A affects the reaction [Dronabinol results in increased expression of CNR1 mRNA]17041005
D013759DronabinolSTAT5A affects the reaction [Dronabinol results in increased expression of GATA3 mRNA]16434616
D013759DronabinolSTAT5A affects the reaction [Dronabinol results in increased expression of IL4 mRNA]16434616
D013759DronabinolSTAT5A affects the reaction [Dronabinol results in increased expression of OPRM1 mRNA]16434616
D003907DexamethasoneDexamethasone affects the activity of STAT5A protein14632786
D003907Dexamethasone"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased activity of STAT5A protein"11751460
D003907Dexamethasone"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of STAT5A protein modified form"11751460
D003907DexamethasoneDexamethasone results in decreased expression of STAT5A mRNA21041162
D003907Dexamethasone[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5A protein26972250
D003907Dexamethasone(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5A protein]26972250
D003907DexamethasoneDexamethasone promotes the reaction [STAT5A protein binds to SLC30A2 promoter]20133611
D003907Dexamethasone"[[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased activity of STAT5A protein] which results in increased expression of CTNNB1 mRNA"11751460
D003907Dexamethasone"[[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of STAT5A protein modified form] which results in increased expression of CTNNB1 mRNA"11751460
D002945CisplatinCisplatin results in increased expression of STAT5A mRNA21151649
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of STAT5A mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of STAT5A protein25242112
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of STAT5A mRNA15591538
D004054DiethylstilbestrolDiethylstilbestrol affects the phosphorylation of STAT5A protein15242752
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of STAT5A mRNA21658437
D002117CalcitriolCalcitriol results in increased expression of STAT5A mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of STAT5A mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of STAT5A mRNA"12376462
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of STAT5A protein"12376462
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT5A protein]20523355
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [THPO protein results in increased phosphorylation of STAT5A protein]20523355
D004964EstriolEstriol results in increased expression of STAT5A mRNA25575267
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STAT5A mRNA14976129
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of STAT5A mRNA12072388|1646718
D019833GenisteinGenistein results in decreased expression of STAT5A mRNA21048042
C081021Go 6976Go 6976 results in decreased phosphorylation of and results in decreased activity of STAT5A protein15746188
C081021Go 6976Go 6976 results in decreased phosphorylation of and results in decreased activity of STAT5A protein15746188
D000068877Imatinib Mesylate[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of STAT5A protein15604220
D0150561-Methyl-3-isobutylxanthine[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5A protein26972250
D0150561-Methyl-3-isobutylxanthine(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5A protein]26972250
D007545IsoproterenolIsoproterenol results in decreased expression of STAT5A mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides promotes the reaction [STAT5A protein binds to CSF2RA promoter]]25725100
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT5A protein]25725100
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of STAT5A protein]25053825
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of STAT5A mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased phosphorylation of STAT5A protein25053825
C561695(+)-JQ1 compoundponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5A protein]25053825
C561695(+)-JQ1 compoundquizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5A protein]25053825
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5A protein]26972250
C410337K 7174K 7174 results in decreased expression of STAT5A mRNA24086573
D008070LipopolysaccharidesCSF2 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT5A protein]25725100
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides promotes the reaction [STAT5A protein binds to CSF2RA promoter]]25725100
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT5A protein]25725100
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [STAT5A protein binds to CSF2RA promoter]25725100
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of and affects the localization of STAT5A protein25725100
D008070LipopolysaccharidesAHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of STAT5A mRNA]22273745
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of STAT5A mRNA10975854|2405697
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT5A mRNA]24056979
D008070Lipopolysaccharides[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of STAT5A mRNA22273745
D008727MethotrexateMethotrexate results in decreased expression of STAT5A mRNA17400583
C013598methoxyacetic acidmethoxyacetic acid affects the expression of STAT5A mRNA20864626
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT5A mRNA]24056979
D008752Methylene ChlorideMethylene Chloride results in decreased expression of STAT5A mRNA28392392
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of STAT5A mRNA"26251327
D008774MethylphenidateMethylphenidate results in decreased expression of STAT5A mRNA22470460
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [IL7 protein results in increased phosphorylation of STAT5A protein]26518055
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased phosphorylation of STAT5A protein26518055|2692178
D009173Mycophenolic Acid[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of STAT5A protein15604220
C524250N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine"IL6 protein inhibits the reaction [N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine results in decreased phosphorylation of STAT5A protein]"18638462
C524250N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine"N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine results in decreased phosphorylation of STAT5A protein"18638462
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of STAT5A mRNA"29244179
D009525NiacinNiacin results in decreased activity of STAT5A protein15746188
D009532NickelNickel results in increased expression of STAT5A mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of STAT5A mRNA16780908
D009569Nitric OxideNitric Oxide results in decreased expression of STAT5A protein16886906
D009569Nitric OxideSTAT5A protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]16886906
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5A protein]"20201035
C025256nonylphenolnonylphenol results in decreased phosphorylation of STAT5A protein15242752
C069741norcantharidinnorcantharidin results in decreased phosphorylation of STAT5A protein21266192
D063086OrganothiophosphatesOrganothiophosphates metabolite results in decreased phosphorylation of STAT5A protein20659491
C406545pegvisomantpegvisomant inhibits the reaction [GH1 protein results in increased phosphorylation of STAT5A protein]18388193
C539933pevonedistatpevonedistat affects the expression of STAT5A mRNA24634471
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of STAT5A mRNA26272509
C008922piperinepiperine inhibits the reaction [IL2 protein results in increased phosphorylation of STAT5A protein]25655587
C006253pirinixic acidpirinixic acid results in increased expression of STAT5A mRNA18301758
C545373ponatinibponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5A protein]25053825
C545373ponatinibponatinib results in decreased phosphorylation of STAT5A protein22875613
D011374ProgesteroneProgesterone affects the localization of STAT5A protein16175315
D011374ProgesteroneProgesterone promotes the reaction [IL2 protein results in increased phosphorylation of STAT5A protein]21768398
D011374ProgesteroneProgesterone results in increased expression of STAT5A protein16175315
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of STAT5A protein17884938
D011374ProgesteroneSTAT5A protein affects the abundance of Progesterone15471942
D011441PropylthiouracilPropylthiouracil results in decreased expression of STAT5A mRNA24780913
D015237DinoprostDinoprost results in increased expression of STAT5A mRNA21654155
C544967quizartinib(+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of STAT5A protein]25053825
C544967quizartinibquizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5A protein]25053825
C544967quizartinibquizartinib results in decreased phosphorylation of STAT5A protein25053825
C059514resveratrolresveratrol affects the localization of STAT5A protein26911335
C059514resveratrolresveratrol promotes the reaction [sorafenib results in decreased phosphorylation of STAT5A protein]26911335
C059514resveratrolresveratrol results in decreased activity of and results in decreased phosphorylation of STAT5A protein26911335
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in decreased expression of STAT5A mRNA21127053
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of STAT5A mRNA"16678137
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of STAT5A mRNA21427059
C410958sauchinonesauchinone inhibits the reaction [IFNG protein results in increased phosphorylation of STAT5A protein]21167929
C410958sauchinonesauchinone inhibits the reaction [IL1B protein results in increased phosphorylation of STAT5A protein]21167929
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of STAT5A mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of STAT5A mRNA25351596
D012822Silicon DioxideAHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of STAT5A mRNA]22273745
D012822Silicon Dioxide[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of STAT5A mRNA22273745
D019821SimvastatinSimvastatin affects the expression of STAT5A protein17507688
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of STAT5A mRNA25879800
C017947sodium arsenitesodium arsenite results in decreased phosphorylation of STAT5A protein26518055|2692178
D012999SomanSoman results in increased expression of STAT5A mRNA19281266
C471405sorafenibresveratrol promotes the reaction [sorafenib results in decreased phosphorylation of STAT5A protein]26911335
C471405sorafenibsorafenib results in decreased activity of STAT5A protein17595328
C471405sorafenibsorafenib results in decreased phosphorylation of STAT5A protein23036488
D014284TriiodothyronineTriiodothyronine results in increased expression of STAT5A mRNA25172293
D013629TamoxifenTamoxifen results in increased expression of STAT5A mRNA25123088
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of STAT5A mRNA21592394
D013739Testosterone[Testosterone results in increased activity of RAF1 protein] which results in increased activity of STAT5A protein20372086
D013739TestosteroneTestosterone results in increased expression of STAT5A mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of STAT5A mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of STAT5A protein19490989
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STAT5A mRNA24058054
D013755Tetradecanoylphorbol AcetateCYBA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT5A protein]20523355
D013755Tetradecanoylphorbol Acetatediphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT5A protein]20523355
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of STAT5A protein20523355
C009495titanium dioxidetitanium dioxide results in increased expression of STAT5A mRNA27760801
C479163tofacitinibtofacitinib inhibits the reaction [IL15 protein results in increased phosphorylation of STAT5A protein]21155605
C479163tofacitinibtofacitinib results in decreased phosphorylation of STAT5A protein22705984|2624487
C479163tofacitinibtofacitinib inhibits the reaction [IL2 protein results in increased phosphorylation of STAT5A protein]21155605
C479163tofacitinibtofacitinib inhibits the reaction [PRL protein results in increased phosphorylation of STAT5A protein]27708194
D014050TolueneToluene results in increased expression of STAT5A mRNA21601613
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5A protein"28329851
D014051Toluene 2,4-Diisocyanate"TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5A protein]"28329851
D014118Toxins, Biological"Toxins, Biological affects the expression of STAT5A mRNA"19682533
C012589trichostatin Atrichostatin A inhibits the reaction [STAT5A gene mutant form results in increased expression of CISH mRNA]25769527
C057693troglitazonetroglitazone results in increased expression of STAT5A mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of STAT5A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of STAT5A mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of STAT5A gene28853863|2915479
D014635Valproic AcidValproic Acid results in increased expression of STAT5A mRNA21427059
D014638VanadatesVanadates results in decreased expression of STAT5A mRNA22714537
D014801Vitamin AVitamin A affects the phosphorylation of and affects the localization of STAT5A protein15963505
D014810Vitamin EVitamin E results in increased expression of STAT5A mRNA19244175
C088658zoledronic acidzoledronic acid results in increased expression of STAT5A mRNA24714768
C067172zopolrestatzopolrestat results in decreased phosphorylation of and results in decreased activity of STAT5A protein15746188

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS7719937  8631883  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005515protein binding-IPI12237455  15304355  15611091  16819511  20075866  24658140  
25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000255allantoin metabolic process-ISS-  
GO:0001938positive regulation of endothelial cell proliferation-IMP20489169  
GO:0006101citrate metabolic process-ISS-  
GO:00061032-oxoglutarate metabolic process-ISS-  
GO:0006105succinate metabolic process-ISS-  
GO:0006107oxaloacetate metabolic process-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS8631883  
GO:0006549isoleucine metabolic process-ISS-  
GO:0006573valine metabolic process-ISS-  
GO:0006600creatine metabolic process-ISS-  
GO:0006631fatty acid metabolic process-ISS-  
GO:0007259JAK-STAT cascade-TAS7719937  
GO:0007595lactation-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0019530taurine metabolic process-ISS-  
GO:0035723interleukin-15-mediated signaling pathway-TAS-  
GO:0038110interleukin-2-mediated signaling pathway-TAS-  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0040014regulation of multicellular organism growth-ISS-  
GO:0043536positive regulation of blood vessel endothelial cell migration-IMP20489169  
GO:0046449creatinine metabolic process-ISS-  
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-1170546Prolactin receptor signalingIEA
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1236394Signaling by ERBB4TAS
R-HSA-1251985Nuclear signaling by ERBB4TAS
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1266695Interleukin-7 signalingIEA
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-1839117Signaling by cytosolic FGFR1 fusion mutantsTAS
R-HSA-1839124FGFR1 mutant receptor activationTAS
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-2586552Signaling by LeptinIEA
R-HSA-2586552Signaling by LeptinTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-451927Interleukin-2 family signalingIEA
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingIEA
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-8854691Interleukin-20 family signalingTAS
R-HSA-8983432Interleukin-15 signalingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9020558Interleukin-2 signalingTAS
R-HSA-9020558Interleukin-2 signalingIEA
R-HSA-9020958Interleukin-21 signalingTAS
R-HSA-982772Growth hormone receptor signalingIEA
R-HSA-982772Growth hormone receptor signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25104439Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. (2014 Aug)Slattery MLBreast Cancer Res Treat
22121102JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)Slattery MLMol Carcinog
21752895Variants in STAT5B associate with serum TC and LDL-C levels. (2011 Sep)Kornfeld JWJ Clin Endocrinol Metab
25137041Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features. (2014)Pastuszak-Lewandoska DPLoS One