Gene: STAT5B

6777
STAT5
signal transducer and activator of transcription 5B
protein-coding
17q21.2
Ensembl:ENSG00000173757 MIM:604260 Vega:OTTHUMG00000150724 UniprotKB:P51692
NG_007271.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.332e-1 (AD)  7.553e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCBP20.922
ADIPOR10.92
RAF10.916
CAP10.913
GOLPH30.903
RAB7A0.903
CANX0.903
RAB100.903
DDX50.898
GPBP1L10.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.848
OR4F29-0.816
OR6C74-0.151
HMHB1-0.143
SPRR2D-0.138
SPRR2A-0.125
FAM25A-0.116
UGT2B11-0.11
TCL1A-0.109
TMPRSS11B-0.106

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01254DasatinibSmall Molecule302962-49-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5859122,4-dihydroxy-N-(4-hydroxyphenyl)benzamide"2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide results in decreased phosphorylation of STAT5B protein"24144632
C0005892902-hydroxy-1-(2-((9-(4-methylcyclohexyl)-9H-pyrido(4',3'-4,5)pyrrolo(2,3-d)pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone"2-hydroxy-1-(2-((9-(4-methylcyclohexyl)-9H-pyrido(4',3'-4,5)pyrrolo(2,3-d)pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone results in decreased phosphorylation of STAT5B protein"24526162
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of STAT5B mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of STAT5B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of STAT5B gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of STAT5B mRNA19770486
C412373AG 1879[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein]21205633
C430898AGN 194204AGN 194204 results in decreased expression of STAT5B mRNA16339527
C011512alpha-naphthoflavone[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]21205633
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STAT5B mRNA16483693
D000735AndrostenedioneAndrostenedione results in increased activity of STAT5B protein28973534
C006632arsenic trioxidearsenic trioxide results in decreased expression of STAT5B protein18349030
C006632arsenic trioxidearsenic trioxide results in decreased phosphorylation of and results in decreased activity of STAT5B protein17121903
D001241AspirinAspirin results in decreased expression of STAT5B mRNA15928584
C545606AZD 1480AZD 1480 results in decreased phosphorylation of STAT5B protein21138246
C545606AZD 1480AZD 1480 results in decreased phosphorylation of STAT5B protein21138246
C030233benzo(a)pyrene-1,6-quinone"benzo(a)pyrene-1,6-quinone results in increased phosphorylation of STAT5B protein"19166869
C018003benzo(a)pyrene-3,6-quinone"benzo(a)pyrene-3,6-quinone results in increased phosphorylation of STAT5B protein"19166869
C006780bisphenol Abisphenol A affects the expression of STAT5B mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of STAT5B mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of STAT5B gene22576693
C006780bisphenol Abisphenol A affects the methylation of STAT5B promoter27334623
C006780bisphenol Abisphenol A affects the expression of STAT5B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of STAT5B gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of STAT5B mRNA17553608
C028031cadmium acetatecadmium acetate affects the expression of STAT5B mRNA16249259
D002220CarbamazepineCarbamazepine affects the expression of STAT5B mRNA24752500
D002392CatechinCatechin results in increased expression of STAT5B mRNA15465739
C018021cobaltous chloridecobaltous chloride results in decreased expression of STAT5B mRNA19320972
D003042CocaineCocaine affects the expression of STAT5B mRNA20187946
D003474CurcuminCurcumin results in decreased expression of STAT5B protein16959222
D003474CurcuminCurcumin results in increased cleavage of STAT5B protein16959222
D003520CyclophosphamideCyclophosphamide results in decreased expression of STAT5B mRNA21041162
D003907DexamethasoneDexamethasone results in increased activity of STAT5B protein14632786
D003907DexamethasoneDexamethasone results in decreased expression of STAT5B mRNA21041162
D003907Dexamethasone[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5B protein26972250
D003907Dexamethasone(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5B protein]26972250
D003907DexamethasoneDexamethasone promotes the reaction [STAT5B protein binds to SLC30A2 promoter]20133611
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased activity of STAT5B protein27589886
D004008DiclofenacDiclofenac affects the expression of STAT5B mRNA24752500
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of STAT5B mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of STAT5B mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of STAT5B mRNA21041162
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of STAT5B mRNA26924002
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of STAT5B mRNA17374397
D004147DioxinsDioxins affects the expression of STAT5B mRNA20463971
C118739entinostatentinostat results in decreased expression of STAT5B mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of STAT5B protein23301498
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of STAT5B promoter27415467
D005054EugenolEugenol results in increased expression of STAT5B mRNA17374397
D015025ZearalenoneZearalenone results in increased expression of STAT5B mRNA25455459
C039281furanfuran results in decreased expression of STAT5B mRNA24183702
C039281furanfuran results in increased methylation of STAT5B gene22079235
D006581Hexachlorobenzene[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein]21205633
D006581Hexachlorobenzene[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]21205633
D006581HexachlorobenzeneHexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein21205633
D006581Hexachlorobenzene[Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]21205633
D006581Hexachlorobenzene[tyrphostin AG 1478 results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]21205633
D006581HexachlorobenzeneHexachlorobenzene affects the expression of and affects the phosphorylation of STAT5B protein22245120
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of STAT5B protein10364193
D007213IndomethacinIndomethacin results in increased expression of STAT5B mRNA18299717
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of STAT5B mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5B protein26972250
D0150561-Methyl-3-isobutylxanthine(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5B protein]26972250
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides promotes the reaction [STAT5B protein binds to CSF2RA promoter]]25725100
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT5B protein]25725100
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of STAT5B protein]25053825
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein25053825
C561695(+)-JQ1 compoundponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein]25053825
C561695(+)-JQ1 compoundquizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein]25053825
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5B protein]26972250
D008070LipopolysaccharidesCSF2 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT5B protein]25725100
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides promotes the reaction [STAT5B protein binds to CSF2RA promoter]]25725100
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT5B protein]25725100
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [STAT5B protein binds to CSF2RA promoter]25725100
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of and affects the localization of STAT5B protein25725100
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to STAT5B promoter]20348232
D008752Methylene ChlorideMethylene Chloride results in decreased expression of STAT5B mRNA28392392
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased phosphorylation of STAT5B protein26921788
C517284monomethyl phthalatemonomethyl phthalate affects the expression of STAT5B mRNA26924002
C524250N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine"IL6 protein inhibits the reaction [N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine results in decreased phosphorylation of STAT5B protein]"18638462
C524250N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine"N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine results in decreased phosphorylation of STAT5B protein"18638462
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of STAT5B mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of STAT5B mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of STAT5B mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of STAT5B mRNA17374397
D009538NicotineNicotine results in increased expression of STAT5B mRNA18805435
D009569Nitric OxideNitric Oxide results in decreased expression of STAT5B protein16886906
D009569Nitric OxideSTAT5B protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]16886906
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5B protein]"20201035
C069741norcantharidinnorcantharidin results in decreased phosphorylation of STAT5B protein21266192
D063086OrganothiophosphatesOrganothiophosphates metabolite results in decreased phosphorylation of STAT5B protein20659491
D000073878Palm OilPalm Oil results in increased expression of STAT5B mRNA18042831
D010618Phenanthrolines[Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]21205633
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of STAT5B mRNA26272509
C008922piperinepiperine inhibits the reaction [IL2 protein results in increased phosphorylation of STAT5B protein]25655587
C014153pirimiphos methylpirimiphos methyl results in increased expression of STAT5B mRNA27845199
C545373ponatinibponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein]25053825
D011374ProgesteroneProgesterone affects the localization of STAT5B protein16175315
D011374ProgesteroneProgesterone promotes the reaction [IL2 protein results in increased phosphorylation of STAT5B protein]21768398
D011374ProgesteroneProgesterone results in increased expression of STAT5B protein16175315
D011374ProgesteroneSTAT5B protein affects the abundance of Progesterone15471942
C045950propiconazolepropiconazole results in decreased expression of STAT5B mRNA19363144|2127805
D011441PropylthiouracilPropylthiouracil results in decreased expression of STAT5B mRNA24780913
C544967quizartinib(+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of STAT5B protein]25053825
C544967quizartinibquizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein]25053825
C544967quizartinibquizartinib results in decreased phosphorylation of STAT5B protein25053825
C059514resveratrolresveratrol affects the localization of STAT5B protein26911335
C059514resveratrolresveratrol promotes the reaction [sorafenib results in decreased phosphorylation of STAT5B protein]26911335
C059514resveratrolresveratrol results in decreased activity of and results in decreased phosphorylation of STAT5B protein26911335
C410958sauchinonesauchinone inhibits the reaction [IFNG protein results in increased phosphorylation of STAT5B protein]21167929
C410958sauchinonesauchinone inhibits the reaction [IL1B protein results in increased phosphorylation of STAT5B protein]21167929
C017947sodium arsenitesodium arsenite results in decreased phosphorylation of STAT5B protein26921788
C471405sorafenibresveratrol promotes the reaction [sorafenib results in decreased phosphorylation of STAT5B protein]26911335
D014284TriiodothyronineTriiodothyronine results in increased expression of STAT5B mRNA15953391
C061133tamibarotenetamibarotene results in decreased expression of STAT5B mRNA15498508
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of STAT5B mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of STAT5B protein19490989
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STAT5B mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STAT5B mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STAT5B mRNA11752688|2121527
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of STAT5B mRNA25613284
C479163tofacitinibtofacitinib inhibits the reaction [IL15 protein results in increased phosphorylation of STAT5B protein]21155605
C479163tofacitinibtofacitinib results in decreased phosphorylation of STAT5B protein22705984|2624487
C479163tofacitinibtofacitinib inhibits the reaction [IL2 protein results in increased phosphorylation of STAT5B protein]21155605
C479163tofacitinibtofacitinib inhibits the reaction [PRL protein results in increased phosphorylation of STAT5B protein]27708194
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5B protein"28329851
D014051Toluene 2,4-Diisocyanate"TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5B protein]"28329851
D014212TretinoinTretinoin results in decreased expression of STAT5B mRNA15498508
C032910triadimefontriadimefon results in decreased expression of STAT5B mRNA19363144
D014241TrichloroethyleneTrichloroethylene results in decreased expression of STAT5B mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of STAT5B mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of STAT5B mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of STAT5B mRNA28973697
C101044tyrphostin AG 1478[tyrphostin AG 1478 results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]21205633
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of STAT5B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of STAT5B mRNA23179753|2438349
D014638VanadatesVanadates results in decreased expression of STAT5B mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of STAT5B mRNA22570695
D014810Vitamin EVitamin E results in increased expression of STAT5B mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of STAT5B mRNA26272509
C519885WP1066WP1066 results in decreased phosphorylation of STAT5B protein18056455|1824554

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003682chromatin binding-ISS-  
GO:0003700DNA-binding transcription factor activity-TAS8631883  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005515protein binding-IPI9989503  15611091  16729043  21106534  
GO:0035259glucocorticoid receptor binding-IPI12552091  
GO:0046983protein dimerization activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000255allantoin metabolic process-ISS-  
GO:0001553luteinization-IEA-  
GO:0001779natural killer cell differentiation-IEA-  
GO:0006101citrate metabolic process-ISS-  
GO:00061032-oxoglutarate metabolic process-ISS-  
GO:0006105succinate metabolic process-ISS-  
GO:0006107oxaloacetate metabolic process-ISS-  
GO:0006357regulation of transcription by RNA polymerase II-TAS8631883  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006549isoleucine metabolic process-ISS-  
GO:0006573valine metabolic process-ISS-  
GO:0006600creatine metabolic process-ISS-  
GO:0006631fatty acid metabolic process-ISS-  
GO:0007259JAK-STAT cascade-TAS8631883  
GO:0007565female pregnancy-IEA-  
GO:0007595lactation-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0019218regulation of steroid metabolic process-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0019530taurine metabolic process-ISS-  
GO:0019915lipid storage-IEA-  
GO:0030856regulation of epithelial cell differentiation-IEA-  
GO:0032355response to estradiol-IDA12552091  
GO:0032819positive regulation of natural killer cell proliferation-IEA-  
GO:0032825positive regulation of natural killer cell differentiation-IEA-  
GO:0032870cellular response to hormone stimulus-IDA12552091  
GO:0033077T cell differentiation in thymus-IEA-  
GO:0035723interleukin-15-mediated signaling pathway-TAS-  
GO:0038110interleukin-2-mediated signaling pathway-TAS-  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0040014regulation of multicellular organism growth-ISS-  
GO:0040018positive regulation of multicellular organism growth-IEA-  
GO:0042104positive regulation of activated T cell proliferation-IEA-  
GO:0042448progesterone metabolic process-IEA-  
GO:0043029T cell homeostasis-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045086positive regulation of interleukin-2 biosynthetic process-IEA-  
GO:0045579positive regulation of B cell differentiation-IEA-  
GO:0045588positive regulation of gamma-delta T cell differentiation-IEA-  
GO:0045647negative regulation of erythrocyte differentiation-IEA-  
GO:0045648positive regulation of erythrocyte differentiation-IDA20702587  
GO:0045931positive regulation of mitotic cell cycle-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0045954positive regulation of natural killer cell mediated cytotoxicity-IEA-  
GO:0046449creatinine metabolic process-ISS-  
GO:0046543development of secondary female sexual characteristics-IEA-  
GO:0046544development of secondary male sexual characteristics-IEA-  
GO:0048541Peyer's patch development-IEA-  
GO:0050729positive regulation of inflammatory response-IEA-  
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-IDA12552091  
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-TAS-  
GO:0070670response to interleukin-4-IEA-  
GO:0071363cellular response to growth factor stimulus-ISS-  
GO:0071364cellular response to epidermal growth factor stimulus-ISS-  
GO:0097531mast cell migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04062Chemokine signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-1170546Prolactin receptor signalingIEA
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1266695Interleukin-7 signalingIEA
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-1839117Signaling by cytosolic FGFR1 fusion mutantsTAS
R-HSA-1839124FGFR1 mutant receptor activationTAS
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-2586552Signaling by LeptinIEA
R-HSA-2586552Signaling by LeptinTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-451927Interleukin-2 family signalingIEA
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingIEA
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-8854691Interleukin-20 family signalingTAS
R-HSA-8983432Interleukin-15 signalingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9020558Interleukin-2 signalingTAS
R-HSA-9020558Interleukin-2 signalingIEA
R-HSA-9020958Interleukin-21 signalingTAS
R-HSA-982772Growth hormone receptor signalingIEA
R-HSA-982772Growth hormone receptor signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25104439Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. (2014 Aug)Slattery MLBreast Cancer Res Treat
22121102JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)Slattery MLMol Carcinog
21752895Variants in STAT5B associate with serum TC and LDL-C levels. (2011 Sep)Kornfeld JWJ Clin Endocrinol Metab
25137041Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features. (2014)Pastuszak-Lewandoska DPLoS One