Gene: STAT6

6778
D12S1644|IL-4-STAT|STAT6B|STAT6C
signal transducer and activator of transcription 6
protein-coding
12q13.3
Ensembl:ENSG00000166888 MIM:601512 Vega:OTTHUMG00000171194 UniprotKB:P42226
NG_021272.1
PubMed
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.656e-1 (AD)  1.908e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GGA20.871
ZDHHC70.847
MAP3K30.847
PPT20.843
ATXN2L0.843
TMEM1090.841
TSPAN140.84
GTPBP20.835
LMBR1L0.834
SEC24C0.832

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.55
OR4F29-0.528
PDE11A-0.378
SOX3-0.345
HMX2-0.324
LHX5-0.321
C5orf38-0.321
FOXB1-0.319
HCRT-0.314
OTP-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of STAT6 mRNA"20453058
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of STAT6 protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of STAT6 mRNA12419474
C5843684'-methoxy licoflavanone4'-methoxy licoflavanone results in decreased phosphorylation of and results in decreased activity of STAT6 protein23850732
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in decreased activity of STAT6 protein"22561122
D000082AcetaminophenAcetaminophen results in decreased expression of STAT6 mRNA21420995|2906747
C010395acetylsalicylic acid lysinateacetylsalicylic acid lysinate affects the reaction [IL4 results in increased activity of STAT6 protein]19767084
C010395acetylsalicylic acid lysinateacetylsalicylic acid lysinate inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein]19767084
D000393Air PollutantsAir Pollutants analog results in decreased expression of STAT6 mRNA21757418
C000154alpinumisoflavonealpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT6 protein23850732
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STAT6 mRNA16483693
D001241AspirinAspirin inhibits the reaction [IL4 results in increased activity of STAT6 protein]19767084
D001241AspirinAspirin inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein]19767084
D001280AtrazineAtrazine results in increased expression of STAT6 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STAT6 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the phosphorylation of STAT6 protein12459556
C006780bisphenol Abisphenol A results in increased expression of STAT6 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of STAT6 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of STAT6 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of STAT6 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of STAT6 gene28505145
D001761BleomycinSTAT6 gene mutant form results in decreased susceptibility to Bleomycin15322207
D001761BleomycinSTAT6 protein affects the reaction [Bleomycin results in increased expression of RETNLA mRNA]15322207
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of STAT6 mRNA12419474
C584509C646 compoundC646 compound results in increased expression of STAT6 mRNA26191083
D002122Calcium ChlorideCalcium Chloride results in decreased expression of STAT6 protein25824407
D002220CarbamazepineCarbamazepine affects the expression of STAT6 mRNA24752500
D002392CatechinCatechin results in increased expression of STAT6 mRNA15465739
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of STAT6 mRNA23650126
D003033Coal TarCoal Tar inhibits the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein]23348739
C018021cobaltous chloridecobaltous chloride results in decreased expression of STAT6 mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in increased expression of STAT6 mRNA19549813
C038459curdlancurdlan results in increased expression of STAT6 mRNA23543010
C052570cyfluthrincyfluthrin results in decreased expression of STAT6 protein12755381
C107676deguelindeguelin metabolite results in increased phosphorylation of STAT6 protein19139008
C107676deguelindeguelin results in increased phosphorylation of STAT6 protein19139008
D013759DronabinolDronabinol results in increased phosphorylation of STAT6 protein16434616|1704100
D013759DronabinolIL4 protein mutant form inhibits the reaction [Dronabinol results in increased phosphorylation of STAT6 protein]17041005
D013759DronabinolSTAT6 affects the reaction [Dronabinol results in increased expression of CNR1 mRNA]17041005
D013759DronabinolSTAT6 affects the reaction [Dronabinol results in increased expression of GATA3 mRNA]16434616
D013759DronabinolSTAT6 affects the reaction [Dronabinol results in increased expression of OPRM1 mRNA]16434616
D016190CarboplatinSTAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2]21765211
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of STAT6 mRNA27392435
D002945CisplatinCisplatin results in decreased phosphorylation of STAT6 protein21765211
D002945CisplatinCisplatin results in decreased phosphorylation of STAT6 protein21765211
D002945CisplatinCisplatin results in increased expression of STAT6 mRNA21151649
D004008DiclofenacDiclofenac affects the expression of STAT6 mRNA24752500
D004041Dietary FatsDietary Fats results in increased expression of STAT6 mRNA23409006
D002117Calcitriol[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein] affects the phosphorylation of STAT6 protein26091108
D002117Calcitriol[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with IL4 protein] affects the phosphorylation of STAT6 protein26091108
D002117Calcitriol"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"26091108
D002117Calcitriol"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon co-treated with IL4 protein] affects the phosphorylation of STAT6 protein"26091108
D002117Calcitriol[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL4 protein] affects the phosphorylation of STAT6 protein26091108
D002117Calcitriol"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL4 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"26091108
C042080diisodecyl phthalatediisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]27871981
C042080diisodecyl phthalateMelatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]]27871981
D004229Dithiothreitol"Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]"26699812
D004229Dithiothreitol"Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]"26699812
D004229Dithiothreitol"Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]"26699812
D004229DithiothreitolDithiothreitol inhibits the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]26699812
D004229DithiothreitolDithiothreitol inhibits the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]26699812
D004229Dithiothreitol"Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]"26699812
C076946donepezildonepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]]26114860
C118739entinostatentinostat results in increased expression of STAT6 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum results in decreased expression of STAT6 mRNA"27351882
D015025ZearalenoneZearalenone results in increased expression of STAT6 mRNA25455459
C077139fidarestatfidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein]21203431
C077139fidarestatfidarestat results in decreased phosphorylation of STAT6 protein21203431
C077139fidarestatfidarestat inhibits the reaction [Plant Extracts results in increased phosphorylation of STAT6 protein]21203431
D005419FlavonoidsFlavonoids results in increased expression of STAT6 mRNA15465739
D016650Fluorescein-5-isothiocyanatediisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]27871981
D016650Fluorescein-5-isothiocyanateFluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein27871981
D016650Fluorescein-5-isothiocyanateMelatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]]27871981
D005485FlutamideFlutamide results in decreased expression of STAT6 mRNA24793618
C004312glycidolglycidol results in increased expression of STAT6 mRNA24915197
C054591hachimijioganhachimijiogan results in increased phosphorylation of STAT6 protein12022442
D006632HistamineHistamine results in increased expression of STAT6 protein12755381
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of STAT6 protein12755381
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of and results in increased activity of STAT6 protein18441283
D006861Hydrogen PeroxidePTPN6 protein inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of STAT6 protein]18441283
C492448ICG 001ICG 001 results in increased expression of STAT6 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of STAT6 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of STAT6 mRNA27392435
C544151jinfukangjinfukang results in increased expression of STAT6 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of STAT6 mRNA24796395
D020910KetorolacKetorolac inhibits the reaction [IL4 results in increased activity of STAT6 protein]19767084
D020910KetorolacKetorolac inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein]19767084
D007854LeadLead results in decreased expression of STAT6 mRNA19921347
C045463leflunomide"leflunomide inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of STAT6 protein]"26699812
C045463leflunomideleflunomide inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]26699812
C045463leflunomideleflunomide results in decreased phosphorylation of STAT6 protein26699812
D008043Linseed OilLinseed Oil results in increased expression of STAT6 mRNA23409006
D008070Lipopolysaccharides[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein] affects the phosphorylation of STAT6 protein26091108
D008070Lipopolysaccharides[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with IL4 protein] affects the phosphorylation of STAT6 protein26091108
D008070Lipopolysaccharides"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"26091108
D008070Lipopolysaccharides"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon co-treated with IL4 protein] affects the phosphorylation of STAT6 protein"26091108
D008070Lipopolysaccharides[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL4 protein] affects the phosphorylation of STAT6 protein26091108
D008070Lipopolysaccharides"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL4 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"26091108
D018021Lithium ChlorideLithium Chloride results in increased expression of STAT6 mRNA23527032
D008550MelatoninMelatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]]27871981
D008627Mercuric ChlorideMercuric Chloride results in increased phosphorylation of STAT6 protein19604304
D008694MethamphetamineMethamphetamine results in decreased expression of STAT6 mRNA15644446
D008727MethotrexateMethotrexate results in decreased expression of STAT6 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of STAT6 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]26114860
D0156551-Methyl-4-phenylpyridiniumdonepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]]26114860
D008775MethylprednisoloneMethylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]11997017
D008775MethylprednisoloneMethylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein]11997017
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of STAT6 mRNA22108045
D009020MorphineSTAT6 gene SNP affects the susceptibility to Morphine16103897
D037742Nanotubes, Carbon"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"26091108
D037742Nanotubes, Carbon"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon co-treated with IL4 protein] affects the phosphorylation of STAT6 protein"26091108
D037742Nanotubes, Carbon"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL4 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"26091108
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased phosphorylation of STAT6 protein"27106021
D009538NicotineNicotine results in increased expression of STAT6 mRNA18805435
C030110oxaliplatinSTAT6 results in increased susceptibility to oxaliplatin21765211
C030110oxaliplatinoxaliplatin results in decreased phosphorylation of STAT6 protein21765211
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of STAT6 mRNA26272509
C016030pantogabpantogab results in decreased expression of STAT6 mRNA17379144
D052638Particulate MatterParticulate Matter results in increased expression of STAT6 mRNA22134058
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of STAT6 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of STAT6 mRNA18445702|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of STAT6 mRNA]20059764
D010936Plant ExtractsPlant Extracts results in increased expression of STAT6 mRNA15465739
D010936Plant Extractsfidarestat inhibits the reaction [Plant Extracts results in increased phosphorylation of STAT6 protein]21203431
D010936Plant ExtractsPlant Extracts results in increased phosphorylation of STAT6 protein21203431
D011092Polyethylene Glycols"Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]"26699812
D011092Polyethylene Glycols"Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]"26699812
D011092Polyethylene GlycolsDithiothreitol inhibits the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]26699812
D011092Polyethylene GlycolsPolyethylene Glycols results in increased oxidation of STAT6 protein26699812
C063471polyethylene glycol-superoxide dismutase"Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]"26699812
C063471polyethylene glycol-superoxide dismutaseDithiothreitol inhibits the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]26699812
C063471polyethylene glycol-superoxide dismutase"polyethylene glycol-superoxide dismutase affects the reaction [STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TNF mRNA]]"26699812
C063471polyethylene glycol-superoxide dismutasepolyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein26699812
D059808PolyphenolsPolyphenols results in increased expression of STAT6 mRNA15465739
D011441PropylthiouracilPropylthiouracil results in decreased expression of STAT6 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of STAT6 mRNA27029645
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of STAT6 mRNA25800948
C059514resveratrolresveratrol results in decreased expression of STAT6 protein modified form22254182
D017632Asbestos, Serpentine"Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]"26699812
D017632Asbestos, Serpentine"Asbestos, Serpentine promotes the reaction [STAT6 protein binds to KDM6B promoter]"26699812
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased oxidation of and results in increased phosphorylation of STAT6 protein"26699812
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased oxidation of STAT6 protein"26699812
D017632Asbestos, Serpentine"Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]"26699812
D017632Asbestos, Serpentine"Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]"26699812
D017632Asbestos, Serpentine"Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]"26699812
D017632Asbestos, Serpentine"Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]"26699812
D017632Asbestos, Serpentine"leflunomide inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of STAT6 protein]"26699812
D017632Asbestos, Serpentine"polyethylene glycol-superoxide dismutase affects the reaction [STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TNF mRNA]]"26699812
D017632Asbestos, Serpentine"SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]"26699812
D017632Asbestos, Serpentine"STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of CHIL3 mRNA]"26699812
D017632Asbestos, Serpentine"STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of CHIL3 protein]"26699812
D017632Asbestos, Serpentine"STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of KDM6B mRNA]"26699812
D017632Asbestos, Serpentine"STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of RETNLA mRNA]"26699812
D017632Asbestos, Serpentine"STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TGFB1 protein]"26699812
D017632Asbestos, Serpentine"STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TNF mRNA]"26699812
D017632Asbestos, Serpentine"STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TNF protein]"26699812
D019821SimvastatinSimvastatin affects the expression of STAT6 protein17507688
D012980Sodium SalicylateSodium Salicylate affects the reaction [IL4 results in increased activity of STAT6 protein]19767084
D012980Sodium SalicylateSodium Salicylate inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein]19767084
D013458Sulfur DioxideSulfur Dioxide promotes the reaction [OVAL protein results in increased expression of STAT6 mRNA]29288730
D013458Sulfur DioxideSulfur Dioxide results in increased expression of STAT6 mRNA29288730
D013578SynephrineSynephrine inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]25111027
D013629TamoxifenTamoxifen results in increased expression of STAT6 mRNA19031437
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STAT6 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STAT6 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of STAT6 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STAT6 mRNA24058054
D013755Tetradecanoylphorbol Acetate[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein] affects the phosphorylation of STAT6 protein26091108
D013755Tetradecanoylphorbol Acetate[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with IL4 protein] affects the phosphorylation of STAT6 protein26091108
D013755Tetradecanoylphorbol Acetate"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"26091108
D013755Tetradecanoylphorbol Acetate"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon co-treated with IL4 protein] affects the phosphorylation of STAT6 protein"26091108
D013755Tetradecanoylphorbol Acetate[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL4 protein] affects the phosphorylation of STAT6 protein26091108
D013755Tetradecanoylphorbol Acetate"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL4 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"26091108
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of STAT6 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of STAT6 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of STAT6 mRNA28065790
C479163tofacitinibtofacitinib inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]21383241
D014212TretinoinTretinoin results in increased expression of STAT6 mRNA17118196
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of STAT6 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of STAT6 mRNA23558232
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of STAT6 mRNA20219652
D014520UrethaneUrethane results in decreased expression of STAT6 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of STAT6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of STAT6 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of STAT6 mRNA23179753|2438349
C025643vinclozolinvinclozolin results in increased expression of STAT6 mRNA22570695
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STAT6 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of STAT6 mRNA26272509
D015032ZincZinc deficiency results in increased expression of STAT6 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA8810328  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA8810328  
GO:0003700DNA-binding transcription factor activity-TAS10747856  
GO:0005515protein binding-IPI8816495  9392697  9651359  22000020  23461825  
GO:0019903protein phosphatase binding-IPI17210636  
GO:0042802identical protein binding-IPI22000020  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0002296T-helper 1 cell lineage commitment-IEA-  
GO:0002829negative regulation of type 2 immune response-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS8810328  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007165signal transduction-TAS10747856  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032481positive regulation of type I interferon production-TAS-  
GO:0033598mammary gland epithelial cell proliferation-IEA-  
GO:0035771interleukin-4-mediated signaling pathway-IMP17210636  
GO:0042127regulation of cell proliferation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA8810328  
GO:0048295positive regulation of isotype switching to IgE isotypes-IEA-  
GO:0060443mammary gland morphogenesis-IEA-  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:1902170cellular response to reactive nitrogen species-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0031965nuclear membrane-IDA-  
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-1834941STING mediated induction of host immune responsesTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-3249367STAT6-mediated induction of chemokinesTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25104439Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. (2014 Aug)Slattery MLBreast Cancer Res Treat
22121102JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)Slattery MLMol Carcinog
26219600The indirect NMDAR antagonist acamprosate induces postischemic neurologic recovery associated with sustained neuroprotection and neuroregeneration. (2015 Dec)Doeppner TRJ Cereb Blood Flow Metab
27557561Simvastatin up-regulates adenosine deaminase and suppresses osteopontin expression in COPD patients through an IL-13-dependent mechanism. (2016 Aug 24)Maneechotesuwan KRespir Res
21930963Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation. (2011 Nov 1)Singh SPJ Immunol