Gene: STC1

6781
STC
stanniocalcin 1
protein-coding
8p21.2
Ensembl:ENSG00000159167 MIM:601185 Vega:OTTHUMG00000097853 UniprotKB:P52823
NG_029711.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.571e-2 (AD)  5.842e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAMTS90.872
TREM10.848
GABRE0.846
PDLIM10.833
ANGPT20.83
MPZL20.816
CD930.81
SRPX20.799
PLAUR0.799
CASP40.794

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.534
NEUROD6-0.526
MARCH4-0.521
DLX1-0.508
KIT-0.5
CPLX3-0.499
EDN3-0.496
CRH-0.491
ST6GAL2-0.489
TMEM179-0.488

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5171131,1-bis(4-hydroxyphenyl)cyclohexane"1,1-bis(4-hydroxyphenyl)cyclohexane results in increased expression of STC1 mRNA"28591870
C42256513beta-methyl 19-nor-steroid13beta-methyl 19-nor-steroid inhibits the reaction [Progesterone results in increased expression of STC1 mRNA]16452456
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate affects the expression of STC1 mRNA"19527780
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of STC1 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of STC1 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of STC1 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of STC1 mRNA"23196670
C0020104-(2-aminoethyl)benzenesulfonylfluoride4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of STC1 mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of STC1 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STC1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STC1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STC1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of STC1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of STC1 mRNA29067470
D000393Air PollutantsAir Pollutants analog results in increased expression of STC1 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STC1 mRNA16483693
C018453ammonium hexachloroplatinateammonium hexachloroplatinate affects the expression of STC1 mRNA19527780
C006632arsenic trioxidearsenic trioxide results in decreased expression of STC1 mRNA25258189
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of STC1 mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of STC1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of STC1 mRNA27614199
D004958Estradiol4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of STC1 mRNA18191855|2871154
D004958EstradiolEstradiol results in increased expression of STC1 protein18191855
D004958EstradiolN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
D004958Estradiolpepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of STC1 mRNA17404688
D004958EstradiolU 0126 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
C031463beta-glycerophosphoric acidbeta-glycerophosphoric acid results in decreased expression of STC1 mRNA17438129
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of STC1 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of STC1 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of STC1 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of STC1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STC1 mRNA20147733
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of STC1 mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of STC1 mRNA18804290
D002220CarbamazepineCarbamazepine affects the expression of STC1 mRNA25979313
D002330CarmustineSTC1 mRNA affects the susceptibility to Carmustine16365179
C100187chloropicrinchloropicrin results in increased expression of STC1 mRNA26352163
C018021cobaltous chloridecobaltous chloride results in increased expression of STC1 mRNA24386269
D003375CoumestrolCoumestrol results in decreased expression of STC1 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of STC1 mRNA20106945
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of STC1 mRNA16963248
D000069439DasatinibDasatinib results in decreased expression of STC1 mRNA20579391
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of STC1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of STC1 mRNA21266533|2174549
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of STC1 mRNA27392435
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of STC1 mRNA27614199
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of STC1 mRNA25031359
D004317DoxorubicinDoxorubicin results in decreased expression of STC1 mRNA28940058
C118739entinostatentinostat results in increased expression of STC1 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STC1 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of STC1 mRNA23550701
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of STC1 mRNA23649840
C082360fipronilfipronil results in increased expression of STC1 mRNA27091632
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of STC1 mRNA28329830
D005473FluoxetineFluoxetine results in increased expression of STC1 mRNA17033635
D005557FormaldehydeFormaldehyde results in decreased expression of STC1 mRNA23649840
D017245FoscarnetFoscarnet results in increased expression of STC1 mRNA17438129
C039281furanfuran results in decreased expression of STC1 mRNA25539665
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of STC1 mRNA16963248
D019833GenisteinGenistein results in decreased expression of STC1 mRNA26865667
D019833GenisteinGenistein results in increased expression of STC1 mRNA12075121
C004312glycidolglycidol results in decreased expression of STC1 mRNA24915197
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of STC1 mRNA16963248
C010974glyphosateglyphosate results in increased expression of STC1 mRNA28711546
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of STC1 mRNA16206274
D017313FenretinideFenretinide results in increased expression of STC1 mRNA28973697
D007213IndomethacinIndomethacin results in decreased expression of STC1 mRNA17401462
D007545IsoproterenolIsoproterenol results in increased expression of STC1 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of STC1 mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of STC1 mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of STC1 mRNA25119042
C031895lead chromatelead chromate results in increased expression of STC1 mRNA23584427
C018091maduramicinmaduramicin results in decreased expression of STC1 mRNA29128925
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of STC1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of STC1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of STC1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of STC1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of STC1 mRNA24810058
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of STC1 mRNA16809437
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of STC1 mRNA"25102311
D009532NickelNickel results in increased expression of STC1 mRNA24768652
C022838nickel chloridenickel chloride results in increased expression of STC1 mRNA21455298
C029938nickel sulfatenickel sulfate results in increased expression of STC1 mRNA17382205
C025589ochratoxin Aochratoxin A results in increased expression of STC1 mRNA22124623
C030110oxaliplatinoxaliplatin results in decreased expression of STC1 mRNA17762391
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of STC1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of STC1 mRNA24236059|2651600
D017239PaclitaxelSTC1 protein affects the susceptibility to Paclitaxel16217747
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STC1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of STC1 mRNA26272509
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of STC1 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of STC1 mRNA25119042
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of STC1 mRNA26705709
C031375pepstatinpepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of STC1 mRNA27614199
D010656PhenylephrinePhenylephrine affects the expression of STC1 mRNA18158353
D010795Phthalic AcidsPhthalic Acids results in increased expression of STC1 mRNA15728792
C006253pirinixic acidpirinixic acid results in increased expression of STC1 mRNA12832660
D011374Progesterone4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA20660070
D011374ProgesteroneN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
D011374Progesteronepepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of STC1 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of STC1 mRNA17404688|2066007
D011374ProgesteroneU 0126 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
D011374Progesterone13beta-methyl 19-nor-steroid inhibits the reaction [Progesterone results in increased expression of STC1 mRNA]16452456
D011374ProgesteroneCSH1 protein promotes the reaction [Progesterone results in increased expression of STC1 mRNA]16452456
D011374ProgesteroneGH1 protein promotes the reaction [Progesterone results in increased expression of STC1 mRNA]16452456
D011374ProgesteroneProgesterone results in increased expression of STC118448839
D011374ProgesteroneProgesterone results in increased expression of STC1 mRNA16452456
D011374ProgesteroneProgesterone results in increased expression of STC1 mRNA21770760
D011374ProgesteroneProgesterone results in decreased expression of STC117510236
D011441PropylthiouracilPropylthiouracil results in decreased expression of STC1 mRNA24780913
D011794QuercetinQuercetin results in increased expression of STC1 mRNA19729006
D017382Reactive Oxygen SpeciesSTC1 affects the reaction [sorafenib results in increased abundance of Reactive Oxygen Species]25370841
C089730rosiglitazonerosiglitazone results in decreased expression of STC1 mRNA25572481
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of STC1 mRNA25895662
C471405sorafenibsorafenib results in decreased expression of STC1 mRNA25370841
C471405sorafenibsorafenib results in decreased expression of STC1 mRNA25370841
C471405sorafenibSTC1 affects the reaction [sorafenib results in increased abundance of Reactive Oxygen Species]25370841
C047246temozolomideSTC1 mRNA affects the susceptibility to temozolomide16365179
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of STC1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STC1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STC1 mRNA22808131
D013849ThimerosalThimerosal results in decreased expression of STC1 mRNA27188386
D019772TopotecanSTC1 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of STC1 mRNA25729387
C011559tributyltintributyltin results in decreased expression of STC1 mRNA27614199
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STC1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of STC1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride affects the expression of STC1 mRNA19527780
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of STC1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of STC1 mRNA25572481
C057693troglitazonetroglitazone results in increased expression of STC1 mRNA19140230
C113580U 0126U 0126 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]20660070
C113580U 0126U 0126 results in decreased expression of STC1 mRNA20660070
D014527Uric AcidSTC1 gene SNP affects the abundance of Uric Acid23263486
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STC1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of STC1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of STC1 mRNA24383497|2493525
D014638VanadatesVanadates results in increased expression of STC1 mRNA22714537
C066075vanadium pentoxidevanadium pentoxide results in increased expression of STC1 mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of STC1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of STC1 mRNA20566332
D014810Vitamin EVitamin E results in decreased expression of STC1 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of STC1 mRNA27188386
C111237vorinostatvorinostat results in increased expression of STC1 mRNA26272509
C088658zoledronic acidzoledronic acid results in increased expression of STC1 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005179hormone activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-IEA-  
GO:0001886endothelial cell morphogenesis-IDA14500721  
GO:0003421growth plate cartilage axis specification-IDA16377640  
GO:0006874cellular calcium ion homeostasis-IDA8700837  12663264  
GO:0007566embryo implantation-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010596negative regulation of endothelial cell migration-IDA14500721  
GO:0030336negative regulation of cell migration-IDA17032941  
GO:0033280response to vitamin D-IEA-  
GO:0035988chondrocyte proliferation-IDA16377640  
GO:0044070regulation of anion transport-IDA16377640  
GO:0046697decidualization-IEA-  
GO:0051926negative regulation of calcium ion transport-IDA8700837  
GO:0060348bone development-IDA16377640  
GO:0071320cellular response to cAMP-IEA-  
GO:0071385cellular response to glucocorticoid stimulus-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:0086004regulation of cardiac muscle cell contraction-IDA12663264  
GO:0090280positive regulation of calcium ion import-IDA17032941  
GO:1903403negative regulation of renal phosphate excretion-IDA8700837  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005634nucleus-IDA12663264  
GO:0005737cytoplasm-IDA12663264  
GO:0016324apical plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27603899Stanniocalcin-1 Hormone in Nonpreeclamptic and Preeclamptic Pregnancy: Clinical, Life-Style, and Genetic Modulators. (2016 Dec)Juhanson PJ Clin Endocrinol Metab