Gene: SULT1E1

6783
EST|EST-1|ST1E1|STE
sulfotransferase family 1E member 1
protein-coding
4q13.3
Ensembl:ENSG00000109193 MIM:600043 Vega:OTTHUMG00000129403 UniprotKB:P49888
NC_000004.12
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.652e-1 (AD)  2.155e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSDMA0.837
MROH50.782
DPPA40.78
FER1L60.749
C2orf830.747
RNF170.741
GADL10.736
COL15A10.727
AADACL20.718
KLRF10.714

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.487
HHATL-0.462
TM7SF2-0.457
DBP-0.455
HDAC11-0.451
C1orf53-0.447
FUT9-0.442
KLHL26-0.43
PLA2G6-0.427
C9orf24-0.426

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01176CyclizineSmall Molecule82-92-8ApprovedTarget
DB01812Adenosine-3'-5'-DiphosphateSmall MoleculeExperimentalTarget
DB029023'-Phosphate-Adenosine-5'-Phosphate SulfateSmall MoleculeExperimentalTarget
DB033463,5,3',5'-Tetrachloro-Biphenyl-4,4'-DiolSmall MoleculeExperimentalTarget
DB00316AcetaminophenSmall Molecule103-90-2ApprovedEnzyme
ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of SULT1E1 protein22527513
C42256513beta-methyl 19-nor-steroid13beta-methyl 19-nor-steroid inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA]22414680
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of SULT1E1 mRNA"22496397
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SULT1E1 mRNA"22496397|2269881
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SULT1E1 mRNA]"22496397
C0658331-hydroxymethylpyrene[SULT1E1 protein co-treated with PAPSS1 protein] results in increased activity of 1-hydroxymethylpyrene24802129
C0658331-hydroxymethylpyreneSULT1E1 protein results in increased activity of 1-hydroxymethylpyrene24802129
C0658331-hydroxymethylpyreneSULT1E1 protein results in increased activity of 1-hydroxymethylpyrene24802129
C0331461-hydroxypyrene1-hydroxypyrene results in decreased activity of SULT1E1 protein14570759
C0331461-hydroxypyreneacetonitrile promotes the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]14570759
C0331461-hydroxypyreneEthanol inhibits the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]14570759
C0331461-hydroxypyreneEthanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1E1 protein]14570759
C0331461-hydroxypyreneSULT1E1 protein results in increased sulfation of 1-hydroxypyrene14570759|1691411
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SULT1E1 protein results in increased metabolism of Estradiol]"18161906
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether metabolite co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein"23959441
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether metabolite results in decreased activity of SULT1E1 protein"23959441
C4172072,2',4,6,6'-pentachlorobiphenyl"2,2',4,6,6'-pentachlorobiphenyl results in decreased activity of SULT1E1 protein"21357386
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of SULT1E1 mRNA"23756648
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of SULT1E1 protein"23756648
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl results in decreased activity of SULT1E1 protein"21357386
C0158022,6-dichloro-4-nitrophenol"[2,6-dichloro-4-nitrophenol co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol"15483196
C0013902-hydroxyestradiol2-hydroxyestradiol affects the sulfation of SULT1E1 protein11358677
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in decreased activity of SULT1E1 protein"24610083
C0415253,3',4,5'-tetrahydroxystilbene"[3,3',4,5'-tetrahydroxystilbene results in decreased activity of SULT1E1 protein] which results in increased abundance of Estradiol"24610083
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in increased expression of SULT1E1 mRNA"24610083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SULT1E1 mRNA"25433332
C0213383-hydroxybenzo(a)pyrenePolychlorinated Biphenyls metabolite inhibits the reaction [SULT1E1 protein results in increased sulfation of 3-hydroxybenzo(a)pyrene]15929889
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in increased expression of SULT1E1 mRNA15135645
C0248364-nitrophenolSULT1E1 protein results in increased sulfation of 4-nitrophenol8185618
C0415944-nonylphenol4-nonylphenol inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA]22414680
C5014744-OH-2',3,3',4',5'-pentachlorobiphenyl"4-OH-2',3,3',4',5'-pentachlorobiphenyl results in decreased activity of SULT1E1 protein"17239972
C5213345-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of SULT1E1 mRNA20932894
D000082AcetaminophenAcetaminophen affects the expression of SULT1E1 mRNA17562736
D000082AcetaminophenAcetaminophen affects the expression of SULT1E1 mRNA18246545
D000082AcetaminophenAcetaminophen results in decreased expression of SULT1E1 protein16538041
C032159acetonitrileacetonitrile promotes the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]14570759
C010840adenosine 3'-phosphate-5'-phosphate"[2,2',4,4'-tetrabromodiphenyl ether metabolite co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein"23959441
C010840adenosine 3'-phosphate-5'-phosphate[Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein23959441
C010840adenosine 3'-phosphate-5'-phosphateEstradiol inhibits the reaction [[tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]23959441
C010840adenosine 3'-phosphate-5'-phosphate[tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein23959441
C010840adenosine 3'-phosphate-5'-phosphatetetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]23959441
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SULT1E1 gene27153756
C518327aloe emodinaloe emodin results in decreased activity of SULT1E1 protein27633141
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of SULT1E1 protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SULT1E1 protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SULT1E1 mRNA16483693
D047310ApigeninApigenin inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA]22414680
C076588benzo(a)pyrene-7,8-dione"SULT1E1 protein results in increased metabolism of benzo(a)pyrene-7,8-dione"22782890
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of SULT1E1 mRNA22258563
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SULT1E1 mRNA19770486|2373587
D004958Estradiol"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SULT1E1 protein results in increased metabolism of Estradiol]"18161906
D004958Estradiol"[3,3',4,5'-tetrahydroxystilbene results in decreased activity of SULT1E1 protein] which results in increased abundance of Estradiol"24610083
D004958EstradiolEstradiol affects the sulfation of SULT1E1 protein11358677
D004958Estradiol[Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein23959441
D004958EstradiolEstradiol inhibits the reaction [[tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]23959441
D004958EstradiolEstradiol results in decreased activity of SULT1E1 protein16914110
D004958EstradiolFlame Retardants inhibits the reaction [SULT1E1 protein results in increased metabolism of Estradiol]18161906
D004958Estradiol[resveratrol analog results in decreased activity of SULT1E1 protein] which results in increased abundance of Estradiol24610083
D004958Estradiol[resveratrol results in decreased activity of SULT1E1 protein] which results in increased abundance of Estradiol24610083
D004958EstradiolSULT1E1 protein affects the susceptibility to Estradiol16914110
D004958EstradiolSULT1E1 protein results in increased metabolism of Estradiol18161906
D004958EstradiolSULT1E1 protein results in increased sulfation of Estradiol19646966|2395944
D004958Estradioltetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]23959441
D004958EstradiolEstradiol results in decreased expression of SULT1E1 mRNA23144751
D004958EstradiolEstradiol results in decreased expression of SULT1E1 mRNA23209616
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased expression of SULT1E1 mRNA]23209616
D004958EstradiolSULT1E1 protein results in increased metabolism of Estradiol11301044
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of SULT1E1 mRNA]21251947
C004541biochanin Abiochanin A results in increased expression of SULT1E1 mRNA20391625
C004541biochanin Abiochanin A results in increased expression of SULT1E1 protein20391625
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of SULT1E1 mRNA26894911
C006780bisphenol Abisphenol A inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA]22414680
C006780bisphenol Abisphenol A results in decreased expression of SULT1E1 mRNA22576693
C006780bisphenol Abisphenol A results in decreased expression of SULT1E1 protein18634814
C006780bisphenol Abisphenol A results in increased methylation of SULT1E1 gene22576693
C006780bisphenol ASULT1E1 protein results in decreased susceptibility to bisphenol A27491884
C006780bisphenol ASULT1E1 protein results in increased sulfation of bisphenol A11425650
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of SULT1E1 mRNA"23756648
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of SULT1E1 protein"23756648
C006780bisphenol A[bisphenol A co-treated with Dietary Fats] results in decreased expression of SULT1E1 protein24472609
C006780bisphenol Abisphenol A results in decreased expression of SULT1E1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SULT1E1 mRNA12075121
C006780bisphenol Abisphenol A results in increased expression of SULT1E1 protein24472609
D001966BromineBromine results in decreased expression of SULT1E1 mRNA18790026
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of SULT1E1 mRNA25922074
C038091butylparabenbutylparaben results in decreased expression of SULT1E1 mRNA26888303
C038091butylparabenbutylparaben results in decreased expression of SULT1E1 protein26888303
C028031cadmium acetatecadmium acetate affects the expression of SULT1E1 mRNA16249259
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of SULT1E1 mRNA27174168
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of SULT1E1 mRNA23650126
C043561chrysinSULT1E1 protein results in increased sulfation of and results in decreased activity of chrysin17293380
D002994Clofibrate[Clofibrate co-treated with PPARA protein mutant form] results in increased expression of SULT1E1 mRNA22496397
D002994ClofibrateClofibrate results in decreased expression of SULT1E1 mRNA25270620
D002994ClofibrateClofibrate results in decreased expression of SULT1E1 protein16470657
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SULT1E1 mRNA17602206
D005576ColforsinColforsin results in decreased expression of SULT1E1 mRNA22446829
C030123coumarincoumarin results in decreased expression of SULT1E1 mRNA18480146
D003671DEET[fipronil co-treated with DEET] results in decreased expression of SULT1E1 mRNA27091632
D003687DehydroepiandrosteroneSULT1E1 protein results in increased sulfation of Dehydroepiandrosterone8185618
D003907DexamethasoneDexamethasone results in decreased expression of SULT1E1 mRNA11328961
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SULT1E1 mRNA15901914
D004028DienestrolDienestrol results in decreased activity of SULT1E1 protein16914110
D004041Dietary FatsDietary Fats results in decreased expression of SULT1E1 mRNA23756648|2501614
D004041Dietary Fats"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of SULT1E1 mRNA"23756648
D004041Dietary Fats"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of SULT1E1 protein"23756648
D004041Dietary Fats[bisphenol A co-treated with Dietary Fats] results in decreased expression of SULT1E1 protein24472609
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SULT1E1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SULT1E1 mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of SULT1E1 mRNA"23756648
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of SULT1E1 protein"23756648
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT1E1 mRNA17917374
D004052Diethylnitrosamine[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA16158176
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SULT1E1 mRNA14656948
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SULT1E1 mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SULT1E1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SULT1E1 mRNA19638242
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA18253720
D004054DiethylstilbestrolDiethylstilbestrol results in decreased activity of SULT1E1 protein16914110
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SULT1E1 mRNA17072980
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SULT1E1 mRNA26159488
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of SULT1E1 mRNA20064776
D004964EstriolEstriol results in decreased activity of SULT1E1 protein16914110
D004970EstroneEstrone affects the sulfation of SULT1E1 protein11358677
D004970Estrone[Estrone co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol15483196
D004970EstroneEstrone results in decreased activity of SULT1E1 protein16914110
D004970EstroneSULT1E1 protein results in increased sulfation of Estrone8185618
C017296estrone sulfate[[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 protein] which results in increased abundance of estrone sulfate25922074
D000431EthanolEthanol inhibits the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]14570759
D000431EthanolEthanol inhibits the reaction [SULT1E1 protein results in increased sulfation of Ethinyl Estradiol]14570759
D000431EthanolEthanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1E1 protein]14570759
D000431EthanolEthanol results in decreased activity of SULT1E1 protein14570759
D000431EthanolEthanol results in increased expression of SULT1E1 mRNA15353170
D004997Ethinyl Estradiol"[2,6-dichloro-4-nitrophenol co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol"15483196
D004997Ethinyl Estradiol[Estrone co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol15483196
D004997Ethinyl EstradiolEthanol inhibits the reaction [SULT1E1 protein results in increased sulfation of Ethinyl Estradiol]14570759
D004997Ethinyl EstradiolEthinyl Estradiol affects the sulfation of SULT1E1 protein11358677
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased activity of SULT1E1 protein16914110
D004997Ethinyl Estradiol[Quercetin co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol15483196
D004997Ethinyl EstradiolSULT1E1 protein results in increased sulfation of Ethinyl Estradiol14570759|1548319
D015025ZearalenoneZearalenone results in decreased activity of SULT1E1 protein16914110
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA18253720
C082360fipronil[fipronil co-treated with DEET] results in decreased expression of SULT1E1 mRNA27091632
C082360fipronilfipronil results in decreased expression of SULT1E1 mRNA27091632
D005411Flame RetardantsFlame Retardants inhibits the reaction [SULT1E1 protein results in increased metabolism of Estradiol]18161906
D005411Flame RetardantsFlame Retardants results in decreased expression of SULT1E1 mRNA22446829
D0150732-Acetylaminofluorene[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA16158176
D0150732-Acetylaminofluorene[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SULT1E1 mRNA14656948
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased expression of SULT1E1 mRNA]23209616
C039281furanfuran results in decreased expression of SULT1E1 mRNA25539665
D019833GenisteinGenistein results in decreased activity of SULT1E1 protein16914110
D019833GenisteinGenistein results in decreased expression of SULT1E1 mRNA18634814
D019833GenisteinGenistein results in decreased expression of SULT1E1 protein18634814
D019833GenisteinGenistein results in increased expression of SULT1E1 mRNA24967385
D005897GlafenineGlafenine results in decreased expression of SULT1E1 mRNA24136188
C010178heliotrineheliotrine results in decreased expression of SULT1E1 mRNA26100227
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of SULT1E1 mRNA15159207
D006589HexestrolHexestrol results in decreased activity of SULT1E1 protein16914110
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [NFE2L2 protein binds to SULT1E1 promoter]25922074
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SULT1E1 mRNA25922074
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SULT1E1 protein25922074
D007052IbuprofenIbuprofen results in decreased activity of SULT1E1 protein17073578
C011582IMOL S-140IMOL S-140 results in decreased expression of SULT1E1 mRNA22446829
C016517indole-3-carbinolindole-3-carbinol affects the expression of SULT1E1 mRNA21396975
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT1E1 mRNA17917374
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA18544905
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SULT1E1 mRNA"20371263
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SULT1E1 mRNA"26220752
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SULT1E1 mRNA27339419
D008469Meclofenamic AcidMeclofenamic Acid results in decreased activity of SULT1E1 protein17073578
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SULT1E1 mRNA29191790
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA]22414680
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in increased expression of SULT1E1 protein]22414680
C487056N-AcetylcysteinamideN-Acetylcysteinamide inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 mRNA]25922074
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SULT1E1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SULT1E1 mRNA"25620056
D009532NickelNickel results in decreased expression of SULT1E1 mRNA24768652|2558310
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of SULT1E1 protein19716841
C016340o,p'-DDT"o,p'-DDT results in decreased expression of SULT1E1 mRNA"23209616
D009966OrphenadrineOrphenadrine affects the expression of SULT1E1 mRNA23665939
D010100OxygenN-Acetylcysteinamide inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 mRNA]25922074
D010100OxygenNFE2L2 protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 mRNA]25922074
D010100OxygenNFE2L2 protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 protein]25922074
D010100Oxygen[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 mRNA25922074
D010100Oxygen[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 protein25922074
D010100Oxygen[[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 protein] which results in increased abundance of estrone sulfate25922074
D010100OxygenSULT1E1 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of IGFBP4 mRNA]25922074
D010100OxygenSULT1E1 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SULF2 mRNA]25922074
D010100OxygenSULT1E1 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Oxygen]25922074
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SULT1E1 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SULT1E1 mRNA20118188
D010634PhenobarbitalPhenobarbital results in decreased expression of SULT1E1 mRNA19084549|2225856
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SULT1E1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of SULT1E1 mRNA19482888|2309116
D010634PhenobarbitalPhenobarbital results in increased expression of SULT1E1 mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SULT1E1 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SULT1E1 mRNA19710929
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the metabolism of SULT1E1 protein21913674
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls metabolite inhibits the reaction [SULT1E1 protein results in increased sulfation of 3-hydroxybenzo(a)pyrene]15929889
D017035PravastatinPravastatin results in decreased expression of SULT1E1 mRNA27225895
D011285Pregnenolone Carbonitrile[Pregnenolone Carbonitrile co-treated with NR1I2 protein mutant form] results in increased expression of SULT1E1 mRNA22496397
D011374Progesterone13beta-methyl 19-nor-steroid inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA]22414680
D011374Progesterone4-nonylphenol inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA]22414680
D011374ProgesteroneApigenin inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA]22414680
D011374Progesteronebisphenol A inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA]22414680
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA]22414680
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in increased expression of SULT1E1 protein]22414680
D011374ProgesteroneProgesterone results in increased expression of SULT1E1 mRNA22414680
D011374ProgesteroneProgesterone results in increased expression of SULT1E1 protein22414680
C045950propiconazolepropiconazole results in increased expression of SULT1E1 mRNA21278054
C015586propiverinepropiverine binds to SULT1E1 protein29273565
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of SULT1E1 mRNA26100227
D011794Quercetin[Quercetin co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol15483196
D011794QuercetinSULT1E1 protein results in increased sulfation of and results in decreased activity of Quercetin17293380
C059514resveratrolresveratrol analog results in decreased activity of SULT1E1 protein24610083
C059514resveratrol[resveratrol analog results in decreased activity of SULT1E1 protein] which results in increased abundance of Estradiol24610083
C059514resveratrolresveratrol results in decreased activity of SULT1E1 protein24610083
C059514resveratrol[resveratrol results in decreased activity of SULT1E1 protein] which results in increased abundance of Estradiol24610083
C059514resveratrolresveratrol results in increased expression of SULT1E1 mRNA17287390|2461008
C059514resveratrolresveratrol results in increased expression of SULT1E1 protein17287390|1863481
C059514resveratrolSULT1E1 protein results in increased sulfation of and results in decreased activity of resveratrol17293380
C059514resveratrolSULT1E1 protein results in increased sulfation of resveratrol16418064
D012293Rifampin[NR1I2 protein co-treated with Rifampin] results in decreased expression of SULT1E1 mRNA21764778
D012293RifampinRifampin inhibits the reaction [HNF4A protein binds to SULT1E1 enhancer]21764778
D012293Rifampin[Rifampin results in increased activity of NR1I2 protein] inhibits the reaction [HNF4A protein binds to SULT1E1 enhancer]21764778
C037663ropivacaineSULT1E1 protein results in increased sulfation of ropivacaine metabolite10460806
D012402RotenoneRotenone results in decreased expression of SULT1E1 mRNA27979718
C009237senecioninesenecionine results in decreased expression of SULT1E1 mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of SULT1E1 mRNA26100227
D012715Sesame OilSesame Oil results in increased expression of SULT1E1 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SULT1E1 mRNA23806026|2589566
D012906SmokeSmoke results in decreased expression of SULT1E1 mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of SULT1E1 mRNA28595984
D053260SootSoot results in increased expression of SULT1E1 mRNA22461453
C075117squalestatin 1squalestatin 1 results in increased expression of SULT1E1 mRNA27225895
D013467SulindacSulindac results in decreased activity of SULT1E1 protein17073578
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SULT1E1 mRNA"20371263
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of SULT1E1 mRNA]21079772
C020806tetrabromobisphenol AEstradiol inhibits the reaction [[tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]23959441
C020806tetrabromobisphenol A[tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein23959441
C020806tetrabromobisphenol Atetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]23959441
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased activity of SULT1E1 protein23959441
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SULT1E1 mRNA26988606
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SULT1E1 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SULT1E1 mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SULT1E1 mRNA28922406
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of SULT1E1 mRNA"23756648
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of SULT1E1 protein"23756648
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SULT1E1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SULT1E1 mRNA19770486|2471369
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SULT1E1 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SULT1E1 mRNA18796159
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SULT1E1 mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of SULT1E1 mRNA16337175|2341159
C072782tri-(2-chloroisopropyl)phosphatetri-(2-chloroisopropyl)phosphate results in decreased expression of SULT1E1 mRNA22446829
C032910triadimefontriadimefon results in decreased expression of SULT1E1 mRNA26705709
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SULT1E1 mRNA"22446829
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in decreased expression of SULT1E1 mRNA22446829
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in decreased expression of SULT1E1 mRNA22446829
D014520UrethaneUrethane results in decreased expression of SULT1E1 mRNA28818685
D014810Vitamin EVitamin E results in increased expression of SULT1E1 mRNA28923436

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004062aryl sulfotransferase activity-TAS-  
GO:0004304estrone sulfotransferase activity-TAS-  
GO:0005496steroid binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0008146sulfotransferase activity-IDA19548878  
GO:0047894flavonol 3-sulfotransferase activity-IDA20056724  
GO:0050294steroid sulfotransferase activity-IDA11884392  23207770  
GO:0050294steroid sulfotransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006068ethanol catabolic process-IDA23207770  
GO:0006711estrogen catabolic process-IDA23207770  
GO:0008202steroid metabolic process-TAS8185618  
GO:0008210estrogen metabolic process-IDA11884392  
GO:0045600positive regulation of fat cell differentiation-IMP24567372  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-IDA23207770  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-TAS-  
GO:0051923sulfation-IDA19548878  20056724  23207770  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
hsa00140Steroid hormone biosynthesis
hsa00920Sulfur metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156584Cytosolic sulfonation of small moleculesTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23197595Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)O'Shaughnessy PJMol Hum Reprod
26422515Identification of Clinical and Genetic Parameters Associated with Hidradenitis Suppurativa in Inflammatory Bowel Disease. (2016 Jan)Janse ICInflamm Bowel Dis