Gene: STIM1

6786
D11S4896E|GOK|IMD10|STRMK|TAM|TAM1
stromal interaction molecule 1
protein-coding
11p15.4
Ensembl:ENSG00000167323 MIM:605921 Vega:OTTHUMG00000133360 UniprotKB:Q13586
NG_016277.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.747e-1 (AD)  4.440e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IP6K10.952
TM9SF40.95
ATG9A0.946
VPS26B0.943
PDK20.941
NUDCD30.94
USP220.939
LRRC140.939
PPP2R5D0.938
LASP10.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.66
OR4F29-0.6
TFPI2-0.435
RAI14-0.382
SH2D1A-0.371
C9orf135-0.369
C9orf153-0.368
SGMS2-0.368
CTNNA3-0.363
KLRB1-0.354

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of STIM1 mRNA"21346803
C5837162,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide"2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide inhibits the reaction [Ethanol results in increased expression of STIM1 protein]"26033013
C5387582-aminoethyl diphenylborinate2-aminoethyl diphenylborinate inhibits the reaction [Ethanol results in increased expression of STIM1 protein]26033013
D000082AcetaminophenAcetaminophen results in increased expression of STIM1 mRNA29067470
D001280AtrazineAtrazine results in decreased expression of STIM1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STIM1 mRNA27863410
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STIM1 protein27863410
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STIM1 mRNA27863410
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STIM1 protein27863410
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STIM1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of STIM1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of STIM1 mRNA28628672
C584509C646 compoundC646 compound results in decreased expression of STIM1 mRNA26191083
D002110CaffeineCaffeine results in increased expression of STIM1 mRNA20864626
D002118CalciumSTIM1 protein affects the abundance of Calcium18439569
D002118CalciumSTIM1 protein results in increased uptake of Calcium24990931
D002118Calcium[Calcium affects the activity of and affects the localization of STIM1 protein] which affects the activity of ORAI1 protein23212906
D002118CalciumSTIM1 protein promotes the reaction [Taurodeoxycholic Acid results in increased abundance of Calcium]18342630
D002118CalciumCalcium affects the activity of and affects the localization of STIM1 protein23212906
D002118CalciumCalcium affects the reaction [STIM1 protein binds to ORAI1 protein]23212906
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of STIM1 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of STIM1 mRNA16934159
C113861corosolic acidcorosolic acid inhibits the reaction [Ethanol results in increased expression of STIM1 protein]26033013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STIM1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of STIM1 mRNA28628672
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of STIM1 mRNA"25908611
D004041Dietary FatsDietary Fats results in decreased expression of STIM1 mRNA25016146
D000431EthanolEthanol results in increased expression of STIM1 mRNA22119170
D000431EthanolEthanol results in increased expression of STIM1 protein22119170
D000431EthanolSTIM1 affects the susceptibility to Ethanol22119170
D000431Ethanol"2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide inhibits the reaction [Ethanol results in increased expression of STIM1 protein]"26033013
D000431Ethanol2-aminoethyl diphenylborinate inhibits the reaction [Ethanol results in increased expression of STIM1 protein]26033013
D000431Ethanolcorosolic acid inhibits the reaction [Ethanol results in increased expression of STIM1 protein]26033013
D000431EthanolEthanol results in increased expression of STIM1 mRNA26033013
D000431EthanolEthanol results in increased expression of STIM1 protein26033013
D000431EthanolLanthanoid Series Elements inhibits the reaction [Ethanol results in increased expression of STIM1 protein]26033013
D000431EthanolSTIM1 protein affects the reaction [Ethanol results in increased cleavage of CASP3 protein]26033013
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STIM1 mRNA17555576
D005230Fatty Acids, Nonesterified"Fatty Acids, Nonesterified promotes the reaction [STIM1 protein binds to ORAI1 protein]"23527285
D005947GlucoseGlucose results in increased expression of STIM1 mRNA27234048
D005947GlucoseGlucose results in increased expression of STIM1 protein27234048
D005947GlucoseSTIM1 protein affects the reaction [Glucose results in decreased expression of BCL2 protein]27234048
D005947GlucoseSTIM1 protein affects the reaction [Glucose results in increased cleavage of CASP3 protein]27234048
D005947GlucoseSTIM1 protein affects the reaction [Glucose results in increased expression of BAX protein]27234048
C492448ICG 001ICG 001 results in decreased expression of STIM1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STIM1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of STIM1 mRNA28628672
D015759Ionomycin[Thapsigargin co-treated with Ionomycin] promotes the reaction [STIM1 protein binds to ATP2A3 protein]18439569
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of STIM1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STIM1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of STIM1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of STIM1 mRNA23086925
D007649KetamineKetamine results in increased expression of STIM1 mRNA20080153
D028581Lanthanoid Series ElementsLanthanoid Series Elements inhibits the reaction [Ethanol results in increased expression of STIM1 protein]26033013
D007854LeadLead affects the expression of STIM1 mRNA28903495
D007854Lead[ORAI1 protein binds to STIM1 protein] which results in increased transport of and affects the susceptibility to Lead19429662
D007854LeadSTIM1 mutant form inhibits the reaction [TRPC1 protein results in increased import of Lead]24953315
D008095Lithocholic AcidLithocholic Acid affects the localization of STIM1 protein18342630
D008694MethamphetamineMethamphetamine results in increased expression of STIM1 mRNA26307267
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of STIM1 mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of STIM1 mRNA20864626
D0156551-Methyl-4-phenylpyridinium[1-Methyl-4-phenylpyridinium co-treated with STIM1 mutant form] results in increased expression of HOMER1 mRNA24358303
D0156551-Methyl-4-phenylpyridinium[1-Methyl-4-phenylpyridinium co-treated with STIM1 mutant form] results in increased expression of HOMER1 protein24358303
D0156551-Methyl-4-phenylpyridiniumSTIM1 mutant form inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]24358303
D0156551-Methyl-4-phenylpyridiniumSTIM1 mutant form inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]24358303
D0156551-Methyl-4-phenylpyridiniumSTIM1 mutant form inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAD protein]24358303
D0156551-Methyl-4-phenylpyridiniumSTIM1 mutant form inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]24358303
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of STIM1 mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of STIM1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of STIM1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of STIM1 mRNA19167457
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of STIM1 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of STIM1 mRNA24780913
D012402RotenoneRotenone results in decreased expression of STIM1 mRNA23186747
D012969Sodium FluorideSodium Fluoride results in increased expression of STIM1 protein28918527
D013629TamoxifenTamoxifen affects the expression of STIM1 mRNA17555576
D013657Taurodeoxycholic AcidSTIM1 protein promotes the reaction [Taurodeoxycholic Acid results in increased abundance of Calcium]18342630
D013657Taurodeoxycholic AcidTaurodeoxycholic Acid affects the localization of STIM1 protein18342630
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STIM1 mRNA16962184|2157046
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of STIM1 mRNA25613284
D019284Thapsigargin[Thapsigargin co-treated with Ionomycin] promotes the reaction [STIM1 protein binds to ATP2A3 protein]18439569
D019284ThapsigarginThapsigargin affects the localization of STIM1 protein18342630
D014212TretinoinTretinoin results in increased expression of STIM1 protein17090780
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of STIM1 mRNA17982090
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of STIM1 mRNA"26179874
C073339usnic acidusnic acid results in increased expression of STIM1 protein25870318
C073339usnic acidusnic acid results in increased expression of STIM1 protein25870318
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of STIM1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI25384971  
GO:0005246calcium channel regulator activity-IBA21873635  
GO:0005246calcium channel regulator activity-IDA25326555  26322679  
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IDA16005298  
GO:0005515protein binding-IPI11463338  17905723  18484746  19249086  19632184  19706554  
19897728  20418871  21408196  21427704  21876174  21941299  
22451904  22464749  22586105  24954132  24996186  25996873  
26322679  27185316  28219928  
GO:0042802identical protein binding-IPI17517596  19249086  20418871  21427704  22451904  24996186  
GO:0051010microtubule plus-end binding-IDA19632184  
GO ID GO Term Qualifier Evidence PubMed
GO:0002115store-operated calcium entry-IBA21873635  
GO:0002115store-operated calcium entry-IDA28219928  
GO:0005513detection of calcium ion-IDA16005298  
GO:0006874cellular calcium ion homeostasis-IBA21873635  
GO:0032237activation of store-operated calcium channel activity-IBA21873635  
GO:0032237activation of store-operated calcium channel activity-IDA16005298  26322679  28219928  
GO:0045766positive regulation of angiogenesis-IMP26694763  
GO:0051924regulation of calcium ion transport-IDA16005298  
GO:0070166enamel mineralization-IMP24621671  
GO:1903779regulation of cardiac conduction-TAS-  
GO:2001256regulation of store-operated calcium entry-IMP23332920  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA27185316  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005874microtubule-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA27185316  
GO:0005887integral component of plasma membrane-IDA16208375  28219928  
GO:0030176integral component of endoplasmic reticulum membrane-IDA16208375  22586105  
GO:0032541cortical endoplasmic reticulum-IDA22586105  
GO:0032541cortical endoplasmic reticulum-TAS26322679  
GO:0033017sarcoplasmic reticulum membrane-IDA25326555  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-139853Elevation of cytosolic Ca2+ levelsIEA
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-397014Muscle contractionIEA
R-HSA-397014Muscle contractionTAS
R-HSA-418346Platelet homeostasisIEA
R-HSA-418360Platelet calcium homeostasisIEA
R-HSA-5576891Cardiac conductionIEA
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisIEA
R-HSA-5578775Ion homeostasisTAS
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersIEA
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25623308[Polarization of neutrophils from patients with asthma, chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease overlap syndrome]. (2014 Dec 30)Deng FZhonghua Yi Xue Za Zhi
26075746Mechanisms of Cigarette Smoke Effects on Human Airway Smooth Muscle. (2015)Wylam MEPLoS One
26113109Cigarette Smoke and Estrogen Signaling in Human Airway Smooth Muscle. (2015)Sathish VCell Physiol Biochem