Gene: STK4

6789
KRS2|MST1|YSK3
serine/threonine kinase 4
protein-coding
20q13.12
Ensembl:ENSG00000101109 MIM:604965 Vega:OTTHUMG00000033059 UniprotKB:Q13043
NG_032172.1
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.305e-1 (AD)  3.426e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIP120.896
ZC3H140.893
CNOT10.892
EXOC20.878
CBL0.877
ZNF3180.87
ANKRD170.868
DHX150.866
DNAJC130.866
UBXN2B0.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.553
OR4F29-0.542
SLC22A6-0.318
PON1-0.308
NXNL1-0.306
PLA2G5-0.305
S100A1-0.295
REN-0.29
HPDL-0.286
HES5-0.266

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of STK4 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of STK4 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STK4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STK4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of STK4 mRNA22230336|2776149
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of STK4 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of STK4 mRNA19770486
D019386AlendronateAlendronate results in increased cleavage of STK4 protein14502240
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of STK4 mRNA24449571
C025657arsenic acidarsenic acid results in increased phosphorylation of STK4 protein26763397
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of STK4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STK4 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of STK4 mRNA"19150397|2001819
C044887beta-methylcholinebeta-methylcholine affects the expression of STK4 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of STK4 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of STK4 protein22174045
D000069286BortezomibBortezomib results in increased activity of and results in increased localization of STK4 protein16778179
D000069286Bortezomibleptomycin B promotes the reaction [Bortezomib results in increased activity of STK4 protein]16778179
D000069286BortezomibSTK4 mutant form inhibits the reaction [Bortezomib results in increased activity of CASP3 protein]16778179
D000069286BortezomibSTK4 protein results in increased susceptibility to Bortezomib16778179
D000069286BortezomibSTK4 results in increased susceptibility to Bortezomib16778179
D002737ChloropreneChloroprene results in increased expression of STK4 mRNA23125180
D060729Coal AshCoal Ash results in increased expression of STK4 mRNA19000753
D019327Copper SulfateCopper Sulfate results in increased expression of STK4 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of STK4 mRNA19167446
D003520CyclophosphamideCyclophosphamide results in decreased expression of STK4 mRNA21041162
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of STK4 mRNA23640034
D003703DemecolcineDemecolcine results in increased expression of STK4 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of STK4 mRNA21041162
D016264Dextran Sulfate[RASSF1 gene mutant form results in increased susceptibility to Dextran Sulfate] which results in decreased activity of STK4 protein24146755
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of STK4 mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of STK4 mRNA26924002
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of STK4 mRNA21041162
C024629dimethyl phthalatedimethyl phthalate results in increased expression of STK4 mRNA26924002
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STK4 mRNA22079256
D005472FluorouracilSTK4 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
D006918HydroxyureaHydroxyurea results in increased cleavage of STK4 protein29228353
D006918HydroxyureaTRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of STK4 protein]29228353
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of STK4 mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of STK4 mRNA18927307
C051890irinotecanirinotecan metabolite results in decreased expression of STK4 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of STK4 mRNA15956246
C051890irinotecanSTK4 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
C038753leptomycin Bleptomycin B promotes the reaction [Bortezomib results in increased activity of STK4 protein]16778179
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of STK4 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STK4 mRNA"27188386
C517284monomethyl phthalatemonomethyl phthalate affects the expression of STK4 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of STK4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of STK4 mRNA"25554681
D009532NickelNickel results in increased expression of STK4 mRNA24768652|2558310
D010795Phthalic AcidsPhthalic Acids results in decreased expression of STK4 mRNA21061450
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STK4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of STK4 mRNA22079256
C017947sodium arsenitesodium arsenite affects the methylation of STK4 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of STK4 mRNA21340527
D053260SootSoot results in decreased expression of STK4 mRNA26551751
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of STK4 mRNA"26680231
D013605T-2 ToxinT-2 Toxin results in decreased expression of STK4 mRNA26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STK4 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STK4 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of STK4 mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of STK4 mRNA17656681
D019772TopotecanTopotecan results in increased expression of STK4 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of STK4 mRNA23228038
C012589trichostatin Atrichostatin A affects the expression of STK4 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of STK4 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of STK4 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of STK4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of STK4 mRNA23179753|2800136
D014750VincristineVincristine results in increased expression of STK4 mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of STK4 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA8566796  
GO:0004672protein kinase activity-IGI19962960  
GO:0004674protein serine/threonine kinase activity-EXP9545236  11278283  15109305  15688006  16930133  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA8566796  11805089  16751106  18328708  18986304  19525978  
21212262  21512132  
GO:0005515protein binding-IPI14729613  15109305  16892067  16930133  17932490  18986304  
19525978  20562859  20920251  21199877  21212262  21512132  
21516123  21730291  22863277  23386615  23455922  24255178  
24366813  28087714  28169360  
GO:0005524ATP binding-IDA8566796  
GO:0008134transcription factor binding-IPI16751106  
GO:0042802identical protein binding-IPI8702870  20562859  23386615  
GO:0042803protein homodimerization activity-IDA11805089  
GO:0043539protein serine/threonine kinase activator activity-TAS20412773  
GO:0046983protein dimerization activity-IDA8702870  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IDA11805089  
GO:0001569branching involved in blood vessel morphogenesis-IEA-  
GO:0001841neural tube formation-IEA-  
GO:0001934positive regulation of protein phosphorylation-IDA19962960  
GO:0003157endocardium development-IEA-  
GO:0006468protein phosphorylation-IDA8566796  11805089  
GO:0006915apoptotic process-IDA21212262  
GO:0007165signal transduction-TAS7665586  8816758  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0007417central nervous system development-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0018105peptidyl-serine phosphorylation-IDA16751106  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0030216keratinocyte differentiation-IEA-  
GO:0032092positive regulation of protein binding-IDA22292086  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IDA19962960  
GO:0035329hippo signaling-IBA21873635  
GO:0035329hippo signaling-IDA20412773  
GO:0035329hippo signaling-TAS19484742  
GO:0035556intracellular signal transduction-IDA8566796  
GO:0043065positive regulation of apoptotic process-IDA15109305  
GO:0045600positive regulation of fat cell differentiation-IEA-  
GO:0046621negative regulation of organ growth-IEA-  
GO:0046777protein autophosphorylation-IDA11805089  
GO:0050821protein stabilization-IDA19962960  
GO:0060215primitive hemopoiesis-IEA-  
GO:0060706cell differentiation involved in embryonic placenta development-IEA-  
GO:0060800regulation of cell differentiation involved in embryonic placenta development-IEA-  
GO:0071902positive regulation of protein serine/threonine kinase activity-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP20412773  
GO:0097284hepatocyte apoptotic process-IEA-  
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptors-IEA-  
GO:1905461positive regulation of vascular associated smooth muscle cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA17932490  21512132  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA17932490  19525978  21512132  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016604nuclear body-IDA-  
GO:0032991protein-containing complex-IDA19962960  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa05200Pathways in cancer
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-2028269Signaling by HippoTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal