Gene: AURKA

6790
AIK|ARK1|AURA|BTAK|PPP1R47|STK15|STK6|STK7
aurora kinase A
protein-coding
20q13.2
Ensembl:ENSG00000087586 MIM:603072 Vega:OTTHUMG00000032796 UniprotKB:O14965
NG_012133.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.783e-1 (AD)  8.625e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPATCH10.774
OXNAD10.756
RACGAP10.756
ZBTB90.752
ZNF1740.745
DPAGT10.744
CSTF10.739
BLMH0.735
NIF3L10.734
SMG80.734

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTRNR2L6-0.358
OR4F5-0.357
KLRB1-0.344
MTRNR2L9-0.34
P2RY14-0.32
OR4F29-0.317
NKX6-1-0.302
DCAF12L1-0.3
KLRF1-0.299
ARHGEF35-0.292

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02482PhosphonothreonineSmall MoleculeExperimentalTarget
DB05169AT9283Small Molecule-InvestigationalTarget
DB05198CYC116Small Molecule-InvestigationalTarget
DB05220AlisertibSmall MoleculeInvestigationalTarget
DB06134SNS-314Small Molecule1057249-41-8InvestigationalTarget
DB06486EnzastaurinSmall Molecule170364-57-5InvestigationalTarget
DB071864-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDESmall MoleculeExperimentalTarget
DB072668-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4',3':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-oneSmall MoleculeExperimentalTarget
DB073601-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]ureaSmall MoleculeExperimentalTarget
DB073621-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]ureaSmall MoleculeExperimentalTarget
DB07545N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDESmall MoleculeExperimentalTarget
DB07801N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamideSmall MoleculeExperimentalTarget
DB080652-(1H-pyrazol-3-yl)-1H-benzimidazoleSmall MoleculeExperimentalTarget
DB08066N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDESmall Molecule-ExperimentalTarget
DB13061MLN8054Small Molecule869363-13-3InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of AURKA mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of AURKA mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AURKA mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of AURKA mRNA"19167446
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of AURKA mRNA"19031421
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AURKA mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AURKA mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AURKA mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of AURKA mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AURKA mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AURKA mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of AURKA mRNA25088246
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AURKA mRNA"23196670
C4747224-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline results in decreased activity of AURKA protein28499611
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AURKA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AURKA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AURKA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AURKA mRNA"27188386
C5605976,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide"6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide inhibits the reaction [TPX2 protein binds to AURKA protein]"22303466
D000082AcetaminophenAcetaminophen results in decreased expression of AURKA mRNA26690555|2906747
D000082AcetaminophenAcetaminophen affects the expression of AURKA mRNA17562736
C016601afimoxifeneafimoxifene results in decreased expression of AURKA mRNA16514628
C016601afimoxifeneAURKA results in decreased susceptibility to afimoxifene21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AURKA protein20106945
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AURKA mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of AURKA mRNA"22863853
D000880AnthraquinonesAnthraquinones analog results in decreased activity of AURKA protein27473261
D001151ArsenicArsenic results in increased expression of AURKA mRNA23174854
D001151ArsenicArsenic results in increased expression of AURKA protein23174854
D001151ArsenicArsenic results in increased phosphorylation of and results in increased activity of AURKA protein23174854
D001151ArsenicE2F1 protein affects the reaction [Arsenic results in increased expression of AURKA protein]23174854
C006632arsenic trioxidearsenic trioxide results in increased expression of AURKA protein16338065
C015001arsenitearsenite results in decreased expression of AURKA mRNA18929588
D001241AspirinAspirin results in increased expression of AURKA mRNA11906190
D001280AtrazineAtrazine results in increased expression of AURKA mRNA25929836
D001374Azacitidine[Azacitidine co-treated with Thalidomide] affects the expression of AURKA mRNA18720364
D001379AzathioprineAzathioprine results in decreased expression of AURKA mRNA22623647
C547126AZM551248AZM551248 results in increased expression of AURKA mRNA22323515
C487081belinostatbelinostat results in decreased activity of AURKA protein19606018
C487081belinostatbelinostat results in decreased expression of AURKA mRNA19606018
C487081belinostatbelinostat results in decreased expression of AURKA protein19606018
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of AURKA mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AURKA mRNA21632981|2180250
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AURKA protein29126329
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AURKA mRNA19770486|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AURKA mRNA"19150397|2001819
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased expression of and results in increased phosphorylation of AURKA protein24976383
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMLN8054 inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKA protein]24976383
D004958EstradiolEstradiol results in increased expression of AURKA mRNA16474171|1651462
D004958EstradiolEstradiol results in increased expression of AURKA protein18497064
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased expression of AURKA protein]18497064
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of AURKA mRNA]25210133
D004958EstradiolEstradiol results in increased expression of AURKA mRNA25210133
C044887beta-methylcholinebeta-methylcholine affects the expression of AURKA mRNA21179406
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of AURKA mRNA27685785
C006780bisphenol Abisphenol A affects the expression of AURKA mRNA21786754
C006780bisphenol Abisphenol A inhibits the reaction [Doxorubicin results in increased expression of AURKA mRNA]26320837
C006780bisphenol Abisphenol A results in decreased expression of AURKA mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of AURKA mRNA16474171|1726806
C006780bisphenol Abisphenol A results in increased methylation of AURKA promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of AURKA mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of AURKA mRNA15003993
C584509C646 compoundC646 compound results in decreased expression of AURKA mRNA26191083
D002104CadmiumCadmium results in decreased expression of AURKA mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AURKA mRNA17582521|1918798
D019256Cadmium Chloridenickel chloride promotes the reaction [Cadmium Chloride results in decreased expression of AURKA mRNA]19187980
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AURKA mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AURKA mRNA17484886|2733941
D002251Carbon TetrachloridePLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of AURKA mRNA]16006527
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AURKA mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of AURKA mRNA26272509
D002737ChloropreneChloroprene results in increased expression of AURKA mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of AURKA mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of AURKA mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of AURKA mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of AURKA mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with ESR1 protein] results in increased expression of AURKA mRNA18310284
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of AURKA mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of AURKA mRNA19167446
D003375CoumestrolESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of AURKA mRNA]18310284
C030973cupric oxidecupric oxide results in decreased expression of AURKA mRNA22077320
D003474CurcuminCurcumin analog results in decreased expression of AURKA mRNA26409325
D016572CyclosporineCyclosporine results in decreased expression of AURKA mRNA19159671|2010694
D016572CyclosporineCyclosporine results in increased methylation of AURKA promoter27989131
D000069439DasatinibDasatinib results in decreased expression of AURKA mRNA20579391
D003630DaunorubicinDaunorubicin results in decreased expression of AURKA protein23872705
D003976DiazinonDiazinon affects the expression of AURKA mRNA22546817
D002945CisplatinAURKA protein results in decreased susceptibility to Cisplatin20890087
D002945CisplatinMYC protein promotes the reaction [AURKA protein results in decreased susceptibility to Cisplatin]20890087
D002945CisplatinCisplatin results in decreased expression of AURKA mRNA25270620
D002945CisplatinCisplatin results in increased expression of AURKA mRNA21151649
D002945CisplatinAURKA protein mutant form inhibits the reaction [JAK2 gene mutant form results in decreased susceptibility to Cisplatin]21557940
D002945CisplatinAURKA results in decreased susceptibility to Cisplatin21557940
D004026DieldrinDieldrin affects the expression of AURKA mRNA22546817
D004026DieldrinDieldrin results in increased expression of AURKA mRNA23153324
D004041Dietary FatsDietary Fats results in decreased expression of AURKA mRNA18042831
C014476diethyl maleatediethyl maleate results in decreased expression of AURKA mRNA25270620
C014476diethyl maleatediethyl maleate results in increased expression of AURKA mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AURKA mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of AURKA mRNA17854601|1850689
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of AURKA mRNA]17854601
D004052DiethylnitrosamineXRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of AURKA mRNA]18506893
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of AURKA mRNA15149470
D002117CalcitriolCalcitriol results in decreased expression of AURKA mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of AURKA mRNA21592394
D004317Doxorubicinbisphenol A inhibits the reaction [Doxorubicin results in increased expression of AURKA mRNA]26320837
D004317DoxorubicinDoxorubicin results in decreased expression of AURKA mRNA15205334
D004317DoxorubicinDoxorubicin results in increased expression of AURKA mRNA26320837
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AURKA mRNA22079256
D004967Estrogens[Estrogens co-treated with Progesterone] inhibits the reaction [Methylnitrosourea results in increased expression of AURKA mRNA]12124350
D004967EstrogensEstrogens results in increased expression of AURKA mRNA12124350
D005047EtoposideEtoposide results in decreased expression of AURKA mRNA25270620
D005419FlavonoidsFlavonoids results in decreased expression of AURKA mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of AURKA mRNA15205334|1655759
D005472FluorouracilFluorouracil results in decreased expression of AURKA mRNA19272435
D005485FlutamideFlutamide results in increased expression of AURKA mRNA24793618
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of AURKA mRNA24657277
D005557FormaldehydeFormaldehyde results in decreased expression of AURKA mRNA23649840
C070081fulvestrantfulvestrant results in decreased expression of AURKA mRNA16514628
C419708gefitinibAURKA results in decreased susceptibility to gefitinib21216229
C419708gefitinib[AURKA results in increased degradation of NFKBIA protein] which results in decreased susceptibility to gefitinib21216229
C419708gefitinib[TP53 protein results in decreased expression of AURKA protein] which results in increased susceptibility to gefitinib21216229
D019833GenisteinGenistein results in increased expression of AURKA mRNA16474171
D005947GlucoseGlucose results in increased expression of AURKA mRNA17178593
D017313FenretinideFenretinide results in decreased expression of AURKA mRNA28973697
D017313FenretinideFenretinide results in increased expression of AURKA mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of AURKA mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of AURKA mRNA25613284
C544151jinfukangjinfukang results in increased expression of AURKA mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AURKA mRNA23430699|2479639
C410337K 7174K 7174 results in decreased expression of AURKA mRNA24086573
D007840LatexLatex analog results in increased expression of AURKA mRNA24768652
C008261lead acetatelead acetate results in increased expression of AURKA mRNA20542052
C045463leflunomideleflunomide results in decreased expression of AURKA mRNA28988120
D008154LucanthoneLucanthone results in decreased expression of AURKA mRNA21148553
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of AURKA mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of AURKA mRNA24657277
C005219methyl cellosolvemethyl cellosolve results in decreased expression of AURKA mRNA19643169
D008748MethylcholanthreneMethylcholanthrene results in increased expression of AURKA mRNA20713471
C005223methyleugenolmethyleugenol results in decreased expression of AURKA mRNA26011634
C008461methyl isocyanatemethyl isocyanate affects the expression of AURKA mRNA22223508
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of AURKA mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of AURKA mRNA23649840
D008770Methylnitrosourea[Estrogens co-treated with Progesterone] inhibits the reaction [Methylnitrosourea results in increased expression of AURKA mRNA]12124350
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of AURKA mRNA12124350
C008493methylselenic acidmethylselenic acid affects the expression of AURKA mRNA14617803
C008493methylselenic acidmethylselenic acid results in decreased expression of AURKA mRNA12517777
D016685MitomycinMitomycin results in decreased expression of AURKA mRNA25270620
C518940MLN8054MLN8054 inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKA protein]24976383
C518940MLN8054MLN8054 results in decreased activity of AURKA protein21128645
C550258MLN 8237MLN 8237 results in decreased phosphorylation of and results in decreased activity of AURKA protein21291867
D009151Mustard GasMustard Gas results in decreased expression of AURKA mRNA25102026
D009151Mustard GasMustard Gas results in increased expression of AURKA mRNA26392148
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of AURKA mRNA28174063
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AURKA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AURKA mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of AURKA mRNA18978301
D009532NickelNickel results in increased expression of AURKA mRNA19031421
C022838nickel chloridenickel chloride promotes the reaction [Cadmium Chloride results in decreased expression of AURKA mRNA]19187980
C022838nickel chloridenickel chloride affects the expression of AURKA mRNA22546817
D015739Nocodazole[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased expression of and results in increased phosphorylation of AURKA protein24976383
D015739NocodazoleMLN8054 inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKA protein]24976383
C570897NSC668394NSC668394 results in decreased expression of AURKA mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of AURKA mRNA20971185
C558013NSC 689534NSC 689534 results in decreased expression of AURKA mRNA20971185
C025589ochratoxin Aochratoxin A results in increased expression of AURKA mRNA25636497
C025589ochratoxin ATRP53 gene mutant form promotes the reaction [ochratoxin A results in increased expression of AURKA mRNA]25636497
C507134ON 01910ON 01910 results in increased phosphorylation of and affects the localization of AURKA protein25580850
C030110oxaliplatinoxaliplatin results in decreased expression of AURKA mRNA17762391
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of AURKA mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of AURKA mRNA26516004
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of AURKA mRNA25658374
D017239PaclitaxelPaclitaxel results in increased expression of AURKA mRNA17374387
C500026palbociclibpalbociclib results in decreased expression of AURKA mRNA22869556
D000073878Palm OilPalm Oil results in decreased expression of AURKA mRNA18042831
D010269ParaquatParaquat affects the expression of AURKA mRNA26345256
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AURKA mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of AURKA mRNA24642059
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of AURKA mRNA26678675
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AURKA mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of AURKA mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of AURKA mRNA19482888|2040396
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AURKA mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of AURKA mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of AURKA mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of AURKA mRNA17950772|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of AURKA mRNA]17950772
D010894PiroxicamPiroxicam results in decreased expression of AURKA mRNA21858171
D010936Plant ExtractsPlant Extracts results in decreased expression of AURKA mRNA25056133
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of AURKA mRNA16474171
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in decreased expression of AURKA mRNA24583197
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AURKA mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AURKA mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of AURKA mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of AURKA mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of AURKA mRNA16888808
D011374Progesterone[Estrogens co-treated with Progesterone] inhibits the reaction [Methylnitrosourea results in increased expression of AURKA mRNA]12124350
D011374ProgesteroneProgesterone results in increased expression of AURKA mRNA12124350
D011398PromethazinePromethazine results in decreased expression of AURKA mRNA26011634
C045950propiconazolepropiconazole results in increased expression of AURKA mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of AURKA mRNA24780913
D011743PyrimidinesPyrimidines affects the splicing of AURKA mRNA25281741
D011794QuercetinQuercetin results in decreased expression of AURKA mRNA21632981
D011799QuinazolinesQuinazolines affects the splicing of AURKA mRNA25281741
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of AURKA mRNA16514628
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of AURKA mRNA19167446
C059514resveratrolresveratrol results in increased expression of AURKA mRNA19167446
D012834SilverCFL1 mRNA promotes the reaction [Silver results in increased expression of AURKA protein modified form]28499611
D012834SilverSilver results in increased expression of AURKA protein modified form28499611
D012835Silver NitrateCFL1 mRNA promotes the reaction [Silver Nitrate results in increased expression of AURKA protein modified form]28499611
D012835Silver NitrateSilver Nitrate results in increased expression of AURKA protein modified form28499611
D019821SimvastatinSimvastatin results in decreased expression of AURKA mRNA17428261
C017947sodium arsenitesodium arsenite results in decreased expression of AURKA mRNA17998272
D012999SomanSoman results in increased expression of AURKA mRNA19281266
D053260SootSoot results in increased expression of AURKA mRNA22461453|2655175
D013467SulindacSulindac results in decreased expression of AURKA mRNA11906190
C025462sulindac sulfidesulindac sulfide results in decreased expression of AURKA mRNA12734198
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased expression of AURKA protein]18497064
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of AURKA mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of AURKA mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AURKA mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AURKA mRNA21570461
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of AURKA mRNA19031421
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of AURKA mRNA25613284
D013792Thalidomide[Azacitidine co-treated with Thalidomide] affects the expression of AURKA mRNA18720364
D013853ThioacetamideThioacetamide results in increased expression of AURKA mRNA22659510|2341159
C009495titanium dioxidetitanium dioxide results in increased expression of AURKA mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AURKA mRNA28065790
D014028Tobacco Smoke PollutionNFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of AURKA mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of AURKA mRNA20133372
D024505TocopherolsTocopherols results in increased expression of AURKA mRNA17056531
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of AURKA mRNA25729387
D019772TopotecanTopotecan results in decreased expression of AURKA mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of AURKA mRNA25549359
C012589trichostatin Atrichostatin A affects the expression of AURKA mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of AURKA mRNA19606018
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of AURKA mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AURKA mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of AURKA mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of AURKA mRNA22083351|2317975
D014635Valproic AcidValproic Acid results in decreased expression of AURKA mRNA21427059
D014750VincristineAURKA gene SNP results in increased susceptibility to Vincristine20864405
D014750VincristineVincristine results in increased expression of AURKA mRNA17374387
C029297vinylidene chloridevinylidene chloride results in increased expression of AURKA mRNA26682919
C484810VX680VX680 results in decreased phosphorylation of AURKA protein18765535
C484810VX680VX680 results in decreased activity of AURKA protein21128645
D015032ZincZinc deficiency results in increased expression of AURKA mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA14580337  19801554  21600873  
GO:0004674protein serine/threonine kinase activity-EXP13678582  18566290  21807936  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004712protein serine/threonine/tyrosine kinase activity-TAS19774610  
GO:0005515protein binding-IPI12244051  14580337  15987997  17726514  17939994  18361916  
18521620  18615013  18662907  18663142  19111882  19357306  
19801554  20360068  20460379  20596670  20643351  21242313  
21821029  22014574  22110403  22305495  22306998  22340593  
23520446  23792191  24857377  24996188  25175806  25986610  
27728805  27837025  
GO:0005524ATP binding-IEA-  
GO:0019901protein kinase binding-IPI18615013  
GO:0031625ubiquitin protein ligase binding-IEA-  
GO:0035174histone serine kinase activity-IBA21873635  
GO:0046982protein heterodimerization activity-IPI20460379  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0000278mitotic cell cycle-TAS9153231  
GO:0006468protein phosphorylation-IDA21600873  21820309  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0007051spindle organization-IMP21820309  
GO:0007052mitotic spindle organization-IBA21873635  
GO:0007057spindle assembly involved in female meiosis I-IEA-  
GO:0007100mitotic centrosome separation-IEA-  
GO:0009611response to wounding-IDA19435814  
GO:0009948anterior/posterior axis specification-IEA-  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0010972negative regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0031145anaphase-promoting complex-dependent catabolic process-TAS-  
GO:0031647regulation of protein stability-IMP15987997  
GO:0032091negative regulation of protein binding-IDA21820309  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IEA-  
GO:0032465regulation of cytokinesis-IBA21873635  
GO:0035404histone-serine phosphorylation-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045840positive regulation of mitotic nuclear division-TAS19774610  
GO:0046605regulation of centrosome cycle-TAS19774610  
GO:0046777protein autophosphorylation-TAS19774610  
GO:0051301cell division-IEA-  
GO:0051642centrosome localization-IEA-  
GO:0071539protein localization to centrosome-IEA-  
GO:0097421liver regeneration-IDA19435814  
GO:1900195positive regulation of oocyte maturation-IEA-  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:1990138neuron projection extension-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000780condensed nuclear chromosome, centromeric region-IBA21873635  
GO:0005634nucleus-IDA20531406  
GO:0005654nucleoplasm-TAS-  
GO:0005813centrosome-IDA17726514  21399614  21600873  25657325  
GO:0005813centrosome-TAS19774610  
GO:0005814centriole-IEA-  
GO:0005819spindle-TAS19774610  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005876spindle microtubule-IBA21873635  
GO:0005876spindle microtubulecolocalizes_withIDA19801554  
GO:0005929cilium-IEA-  
GO:0015630microtubule cytoskeleton-IDA19801554  
GO:0030496midbody-TAS19774610  
GO:0031616spindle pole centrosome-IBA21873635  
GO:0031616spindle pole centrosome-IDA19801554  
GO:0032133chromosome passenger complex-IBA21873635  
GO:0042585germinal vesicle-IEA-  
GO:0043203axon hillock-IEA-  
GO:0045120pronucleus-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA20531406  
GO:0051233spindle midzone-IBA21873635  
GO:0072687meiotic spindle-IEA-  
GO:0097431mitotic spindle pole-IDA25657325  
KEGG ID KEGG Term
hsa04114Oocyte meiosis
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1TAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-2990846SUMOylationIEA
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsIEA
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-4615885SUMOylation of DNA replication proteinsIEA
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-597592Post-translational protein modificationIEA
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8854050FBXL7 down-regulates AURKA during mitotic entry and in early mitosisTAS
R-HSA-8854518AURKA Activation by TPX2TAS
R-HSA-8854521Interaction between PHLDA1 and AURKATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28949095Differential protein-coding gene and long noncoding RNA expression in smoking-related lung squamous cell carcinoma. (2017 Nov)Li SThorac Cancer
28968711Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients. (2017 Oct 26)Couto PPCarcinogenesis