Gene: STK11

6794
LKB1|PJS|hLKB1
serine/threonine kinase 11
protein-coding
19p13.3
Ensembl:ENSG00000118046 MIM:602216 Vega:OTTHUMG00000180118 UniprotKB:Q15831
NG_007460.2
PubMed
0   ANCO-SNPs
ND
15   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.513e-1 (AD)  5.738e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24145685chr19:1227852STK113'UTR2.327e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGAP30.925
ZNF4440.923
NELFB0.918
DVL10.917
LRRC4B0.915
GNA110.914
FBXW50.913
B4GALNT40.912
EPN10.908
MAP2K20.907

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.757
OR4F29-0.709
KCNJ15-0.28
C9orf153-0.269
TFPI2-0.265
CNTF-0.256
CTNNA3-0.256
IL18RAP-0.255
PPBP-0.253
CSRP3-0.252

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5696701-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one"STK11 gene mutant form results in increased susceptibility to 1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one"23136191
C0251603-aminobenzamide3-aminobenzamide inhibits the reaction [resveratrol results in increased phosphorylation of STK11 protein]19620254
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal binds to STK11 protein19289642
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased activity of STK11 protein19289642
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of STK11 protein19289642
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified form19289642
C0275764-hydroxy-2-nonenalresveratrol inhibits the reaction [4-hydroxy-2-nonenal binds to STK11 protein]19289642
C0275764-hydroxy-2-nonenalresveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased activity of STK11 protein]19289642
C0275764-hydroxy-2-nonenalresveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified form]19289642
C5248145-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [STK11 mutant form results in decreased expression of CDKN1A protein]24793789
C5248145-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [STK11 mutant form results in increased expression of CDK4 protein]24793789
C5248145-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [STK11 mutant form results in increased expression of MYC protein]24793789
C5248145-(4-ethylbenzylidene)-2-thioxothiazolidin-4-onebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [STK11 mutant form results in increased expression of MYC protein]]24793789
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of STK11 protein]"22062806
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of STK11 protein"18482975
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"STK11 protein promotes the reaction [[6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased activity of SIRT1 protein] which results in increased phosphorylation of PRKAA2 protein]"18482975
C099958acanthoic acidacanthoic acid inhibits the reaction [Ethanol results in decreased phosphorylation of STK11 protein]28964808
D000082AcetaminophenAcetaminophen affects the expression of STK11 mRNA17562736
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]27688165
D016718Arachidonic AcidSTK11 protein affects the reaction [resveratrol results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]]19620254
D001151ArsenicArsenic affects the methylation of STK11 gene25304211
D001151ArsenicArsenic results in decreased localization of STK11 protein20439172
D001151ArsenicArsenic results in decreased phosphorylation of and results in decreased activity of STK11 protein20439172
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [STK11 mutant form results in increased expression of MYC protein]]24793789
C516541BI D1870BI D1870 results in decreased phosphorylation of STK11 protein21488662
D001688Biological ProductsBiological Products results in increased phosphorylation of STK11 protein23266269
C006780bisphenol Abisphenol A affects the expression of STK11 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of STK11 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of STK11 mRNA25181051|2753935
C017092bromopyruvatebromopyruvate results in decreased expression of STK11 protein modified form24307199
C584509C646 compoundC646 compound results in decreased expression of STK11 mRNA26191083
D002104CadmiumCadmium results in increased phosphorylation of STK11 protein21767558
D002104CadmiumCAT protein inhibits the reaction [Cadmium results in increased phosphorylation of STK11 protein]21767558
D002104CadmiumSOD1 protein inhibits the reaction [Cadmium results in increased phosphorylation of STK11 protein]21767558
D002104CadmiumSOD2 protein inhibits the reaction [Cadmium results in increased phosphorylation of STK11 protein]21767558
D002104CadmiumSTK11 mutant form inhibits the reaction [Cadmium results in decreased phosphorylation of MTOR protein]21767558
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STK11 gene20938992
C113861corosolic acidcorosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]26513295
C113861corosolic acidcorosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]26513295
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of STK11 mRNA23914054
D003840Deoxycholic AcidDeoxycholic Acid results in increased phosphorylation of STK11 protein27743861
D003847DeoxyglucoseDeoxyglucose results in decreased phosphorylation of STK11 protein23041229
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of STK11 mRNA17361019
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of STK11 mRNA27392435
D002945CisplatinCisplatin promotes the reaction [ADRM1 protein binds to UCHL5 protein binds to STK11 protein alternative form]21191146
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein alternative form21191146
D002945Cisplatinlactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein]21191146
D002945CisplatinSTK11 protein promotes the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased expression of MAP1LC3B protein]21191146
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased phosphorylation of STK11 protein"27916511
D000431Ethanolacanthoic acid inhibits the reaction [Ethanol results in decreased phosphorylation of STK11 protein]28964808
D000431EthanolEthanol results in decreased expression of STK11 protein27688165
D000431EthanolEthanol results in decreased expression of STK11 protein modified form27688165
D000431EthanolEthanol results in decreased phosphorylation of STK11 protein28964808
D000431Ethanolthymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein]27688165
D000431Ethanolthymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein modified form]27688165
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STK11 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of STK11 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STK11 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased phosphorylation of STK11 protein27090119
D011345FenofibrateFenofibrate results in increased expression of and results in increased phosphorylation of STK11 protein25545733
D005485FlutamideFlutamide results in decreased expression of STK11 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STK11 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of STK11 mRNA19167457
C045345gastrodingastrodin results in increased phosphorylation of STK11 protein26634892
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased phosphorylation of STK11 protein]19332549
C102521GGTI 298GGTI 298 results in increased phosphorylation of STK11 protein19332549
C049864ginsenoside Reginsenoside Re results in increased phosphorylation of STK11 protein21971952
C026474ginsenoside Rg2"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of STK11 protein]"22062806
C026474ginsenoside Rg2ginsenoside Rg2 results in increased phosphorylation of STK11 protein22062806
D005947GlucoseGlucose results in increased acetylation of and results in decreased activity of STK11 protein19765649
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased acetylation of and results in decreased activity of STK11 protein]19765649
D006152Cyclic GMPSTK11 protein promotes the reaction [Histamine results in increased abundance of Cyclic GMP]21145922
D006632HistamineHistamine results in increased phosphorylation of STK11 protein21145922
D006632HistamineSTK11 protein promotes the reaction [Histamine results in increased abundance of Cyclic GMP]21145922
D006632HistamineSTK11 protein promotes the reaction [Histamine results in increased phosphorylation of NOS2 protein]21145922
C492448ICG 001ICG 001 results in decreased expression of STK11 mRNA26191083
D007501IronSTK11 protein affects the reaction [resveratrol results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]]19620254
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of STK11 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [STK11 mutant form results in decreased expression of CDKN1A protein]24793789
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [STK11 mutant form results in increased expression of CDK4 protein]24793789
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [STK11 mutant form results in increased expression of MYC protein]24793789
C561695(+)-JQ1 compoundSTK11 gene mutant form inhibits the reaction [KRAS gene mutant form results in increased susceptibility to (+)-JQ1 compound]24045185
C561695(+)-JQ1 compoundSTK11 gene mutant form inhibits the reaction [[KRAS gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in increased activity of CASP3 protein]24045185
C561695(+)-JQ1 compoundSTK11 gene mutant form inhibits the reaction [[KRAS gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in increased cleavage of PARP1 protein]24045185
C561695(+)-JQ1 compoundSTK11 protein results in increased susceptibility to (+)-JQ1 compound24045185
C561695(+)-JQ1 compound[STK11 protein results in increased susceptibility to (+)-JQ1 compound] which results in decreased expression of MYC protein24045185
C561695(+)-JQ1 compound[STK11 protein results in increased susceptibility to (+)-JQ1 compound] which results in increased activity of CASP3 protein24045185
C561695(+)-JQ1 compound[STK11 protein results in increased susceptibility to (+)-JQ1 compound] which results in increased cleavage of PARP1 protein24045185
C561695(+)-JQ1 compoundSTK11 gene mutant form affects the reaction [[KRAS gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in decreased expression of MYC protein]24045185
C561695(+)-JQ1 compoundSTK11 gene mutant form affects the reaction [[KRAS gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in increased expression of BRD4 protein]24045185
C067713lactacystinlactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein]21191146
D008070LipopolysaccharidesLipopolysaccharides results in decreased phosphorylation of STK11 protein24465016
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of STK11 protein]24465016
C016371lonidaminelonidamine results in increased phosphorylation of STK11 protein23041229
C412811maslinic acidmaslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]26513295
C412811maslinic acidmaslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]26513295
D008466MechlorethamineMechlorethamine results in increased expression of STK11 mRNA17107856
D008687MetforminMetformin results in increased phosphorylation of STK11 protein19236843
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STK11 gene20938992
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in increased phosphorylation of STK11 protein]19332549
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased phosphorylation of STK11 protein27702592
D0150581-NaphthylisothiocyanateU 0126 inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of STK11 protein]27702592
C047330N-methylisoindigotinN-methylisoindigotin results in decreased phosphorylation of STK11 protein26887594
D009963Orotic AcidOrotic Acid inhibits the reaction [STK11 protein results in decreased phosphorylation of RPS6KB1 protein]22863860
D009963Orotic AcidOrotic Acid inhibits the reaction [STK11 protein results in increased phosphorylation of RPTOR protein]22863860
D010936Plant ExtractsPlant Extracts results in increased phosphorylation of STK11 protein27916511
C107773pterostilbenepterostilbene results in increased phosphorylation of STK11 protein26443543
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of STK11 protein]24465016
D011794QuercetinQuercetin results in increased phosphorylation of STK11 protein24465016
C059514resveratrol3-aminobenzamide inhibits the reaction [resveratrol results in increased phosphorylation of STK11 protein]19620254
C059514resveratrolresveratrol results in decreased acetylation of STK11 protein25849131
C059514resveratrolresveratrol results in increased expression of STK11 protein modified form23680031
C059514resveratrolresveratrol results in increased phosphorylation of STK11 protein18482975|1962025
C059514resveratrolSTK11 protein affects the reaction [resveratrol results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]]19620254
C059514resveratrolSTK11 protein affects the susceptibility to resveratrol19620254
C059514resveratrolSTK11 protein promotes the reaction [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of PRKAA2 protein]18482975
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased acetylation of and results in decreased activity of STK11 protein]19765649
C059514resveratrolSTK11 protein promotes the reaction [resveratrol results in increased phosphorylation of ACACA protein]17438283
C059514resveratrolSTK11 protein promotes the reaction [resveratrol results in increased phosphorylation of PRKAA1 protein]17438283
C059514resveratrolSTK11 protein promotes the reaction [resveratrol results in increased phosphorylation of PRKAA2 protein]17438283
C059514resveratrolresveratrol inhibits the reaction [4-hydroxy-2-nonenal binds to STK11 protein]19289642
C059514resveratrolresveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased activity of STK11 protein]19289642
C059514resveratrolresveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified form]19289642
C059514resveratrolresveratrol results in decreased acetylation of STK11 protein25849131
C059514resveratrolresveratrol results in increased expression of STK11 protein modified form19289642
C089730rosiglitazonerosiglitazone results in increased phosphorylation of STK11 protein21373642
C089730rosiglitazoneSIRT6 affects the reaction [rosiglitazone results in increased phosphorylation of STK11 protein]21373642
C046245rubimaillinrubimaillin results in increased phosphorylation of STK11 protein23466342
C410958sauchinonesauchinone results in increased phosphorylation of STK11 protein27871897
D012643SeleniumSelenium results in increased expression of STK11 mRNA19244175
D019821SimvastatinCAMKK2 mutant form inhibits the reaction [Simvastatin results in increased activity of STK11 protein]19332549
D019821SimvastatinCAMKK2 mutant form inhibits the reaction [Simvastatin results in increased phosphorylation of STK11 protein]19332549
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased phosphorylation of STK11 protein]19332549
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in increased phosphorylation of STK11 protein]19332549
D019821SimvastatinRAC1 mutant form inhibits the reaction [Simvastatin results in increased phosphorylation of STK11 protein]19332549
D019821SimvastatinSimvastatin results in increased activity of STK11 protein19332549
D019821SimvastatinSimvastatin results in increased phosphorylation of STK11 protein19332549
D019821SimvastatinSTO 609 inhibits the reaction [Simvastatin results in increased phosphorylation of STK11 protein]19332549
D019821SimvastatinSimvastatin results in increased phosphorylation of STK11 protein19332549
C458525STO 609STO 609 inhibits the reaction [Simvastatin results in increased phosphorylation of STK11 protein]19332549
C458525STO 609STK11 protein affects the susceptibility to STO 60921145922
D013629TamoxifenTamoxifen affects the expression of STK11 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STK11 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STK11 mRNA17942748
D013755Tetradecanoylphorbol Acetatecorosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]26513295
D013755Tetradecanoylphorbol Acetatecorosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]26513295
D013755Tetradecanoylphorbol Acetatemaslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]26513295
D013755Tetradecanoylphorbol Acetatemaslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]26513295
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein26513295
C003466thymoquinonethymoquinone inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]27688165
C003466thymoquinonethymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein]27688165
C003466thymoquinonethymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein modified form]27688165
C012589trichostatin Atrichostatin A results in increased expression of STK11 mRNA15901671
C113580U 0126U 0126 inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of STK11 protein]27702592
D014635Valproic AcidValproic Acid results in increased methylation of STK11 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of STK11 mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA12805220  
GO:0002039p53 binding-IDA11430832  
GO:0004674protein serine/threonine kinase activity-IDA11430832  12805220  19892943  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI12595760  12753905  12805220  14676191  15733851  17216128  
19513107  19892943  20562859  22575644  22939624  24362629  
25036637  25241761  25329316  25852190  26479318  
GO:0005524ATP binding-IDA12805220  
GO:0030275LRR domain binding-IEA-  
GO:0030295protein kinase activator activity-IDA19892943  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-ISS-  
GO:0001894tissue homeostasis-IEA-  
GO:0001944vasculature development-ISS-  
GO:0006468protein phosphorylation-IDA12805220  25329316  
GO:0006914autophagy-IEA-  
GO:0006974cellular response to DNA damage stimulus-IMP25329316  
GO:0007050cell cycle arrest-IDA12805220  17216128  
GO:0007050cell cycle arrest-TAS-  
GO:0007283spermatogenesis-IEA-  
GO:0007409axonogenesis-IEA-  
GO:0008285negative regulation of cell proliferation-IMP17216128  25329316  
GO:0010212response to ionizing radiation-ISS-  
GO:0010508positive regulation of autophagy-IMP23878245  
GO:0030010establishment of cell polarity-ISS-  
GO:0030111regulation of Wnt signaling pathway-IEA-  
GO:0030308negative regulation of cell growth-ISS-  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IMP18311138  
GO:0032147activation of protein kinase activity-IEA-  
GO:0036399TCR signalosome assembly-IEA-  
GO:0042593glucose homeostasis-ISS-  
GO:0043276anoikis-IMP19622832  
GO:0045059positive thymic T cell selection-IEA-  
GO:0046777protein autophosphorylation-IDA11430832  
GO:0048814regulation of dendrite morphogenesis-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0050772positive regulation of axonogenesis-IEA-  
GO:0050852T cell receptor signaling pathway-IEA-  
GO:0051055negative regulation of lipid biosynthetic process-IEA-  
GO:0051645Golgi localization-IEA-  
GO:0051896regulation of protein kinase B signaling-IEA-  
GO:0060070canonical Wnt signaling pathway-IEA-  
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development-IEA-  
GO:0071493cellular response to UV-B-IDA25329316  
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator-IDA11430832  
GO:0097484dendrite extension-IEA-  
GO:1900182positive regulation of protein localization to nucleus-IEA-  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:1904262negative regulation of TORC1 signaling-IMP23878245  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12805220  18854309  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA11430832  12805220  17216128  18854309  
GO:0005739mitochondrion-IDA11430832  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-ISS-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-ISS-  
GO:0036398TCR signalosome-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04150mTOR signaling pathway
hsa04920Adipocytokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-162582Signal TransductionTAS
R-HSA-163680AMPK inhibits chREBP transcriptional activation activityIEA
R-HSA-163685Integration of energy metabolismIEA
R-HSA-165159mTOR signallingTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-380972Energy dependent regulation of mTOR by LKB1-AMPKTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25234657Tongue carcinoma infrequently harbor common actionable genetic alterations. (2014 Sep 19)Tan DSBMC Cancer
16888680[Familial pancreatic cancer]. (2006)Zalatnai AMagy Onkol
28911955Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients. (2017 Dec)Gimbrone NTJ Thorac Oncol
27565922Hot spot mutations in Finnish non-small cell lung cancers. (2016 Sep)Maki-Nevala SLung Cancer
28914263Coexistent genetic alterations involving ALK, RET, ROS1 or MET in 15 cases of lung adenocarcinoma. (2018 Feb)Tang ZMod Pathol
11561603Familial pancreatic cancer. (2001 Jul-Aug)Klein APCancer J
28145643Analysis of Fifty Hotspot Mutations of Lung Squamous Cell Carcinoma in Never-smokers. (2017 Mar)Lee HYJ Korean Med Sci
17711506LKB1 gene mutations in Japanese lung cancer patients. (2007 Nov)Onozato RCancer Sci
16162302Treatment of familial pancreatic cancer and its precursors. (2005 Oct)Hruban RHCurr Treat Options Gastroenterol
27467949PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations. (2016 May)Scheel AHOncoimmunology
25695224Somatic STK11 and concomitant STK11/KRAS mutational frequency in stage IV lung adenocarcinoma adrenal metastases. (2015 Mar)Gleeson FCJ Thorac Oncol
22768234Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status. (2012)An SJPLoS One
25278450Genome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome. (2014 Dec 1)Karlsson AClin Cancer Res
24077454CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer. (2013 Nov)Tam KWJ Thorac Oncol
26599269Mutation Profiling of Lung Cancers with Long-Term Response to Gefitinib Therapy. (2015)Gautschi OOncol Res Treat