Gene: SULT1A2

6799
HAST4|P-PST|ST1A2|STP2|TSPST2
sulfotransferase family 1A member 2
protein-coding
16p11.2
Ensembl:ENSG00000197165 MIM:601292 Vega:OTTHUMG00000048082 UniprotKB:P50226
NG_032570.1
PubMed
0   ANCO-SNPs
OD|ND
2   
4.417e-1 (AD)  9.185e-1 (ND)   (Frontal_Cortex)
2.667e-1 (AD)  7.667e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C20orf2030.512
VTN0.485
TDRP0.476
AMT0.461
CORO60.46
COL7A10.455
TTC21A0.449
ACBD40.448
IL11RA0.448
ALS2CL0.446

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUC3A-0.274
CEACAM21-0.246
USP17L8-0.239
HAS2-0.235
ELF5-0.225
CRYBG3-0.221
PLEKHN1-0.219
ZNF114-0.218
HOXA3-0.217
DUOXA2-0.214

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0331461-hydroxypyreneSULT1A2 protein results in increased metabolism of 1-hydroxypyrene24140465
C5022392-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct"[SULT1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct"26940682
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[SULT1A1 protein co-treated with SULT1A2 protein] results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"22006426
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"SULT1A2 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"21900212|2200642
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"SULT1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"26940682
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[SULT1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct"26940682
C0178212-amino-3-methyl-9H-pyrido(2,3-b)indole"SULT1A2 protein results in increased activity of 2-amino-3-methyl-9H-pyrido(2,3-b)indole"14729582
C1172203-nitrobenzanthrone[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]20545351
C1172203-nitrobenzanthroneSULT1A2 protein results in increased activity of 3-nitrobenzanthrone15805261
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
C0080465-hydroxymethylfurfural[SULT1A1 protein co-treated with SULT1A2 protein] results in increased susceptibility to 5-hydroxymethylfurfural22006426
C0080465-hydroxymethylfurfuralSULT1A2 protein results in increased activity of 5-hydroxymethylfurfural22006426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SULT1A2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SULT1A2 mRNA18246545
D000082AcetaminophenAcetaminophen results in increased expression of SULT1A2 mRNA18246545
D000105Acetyl Coenzyme A[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]20545351
D0150812-NaphthylamineSULT1A2 protein results in increased sulfation of 2-Naphthylamine17433394
C006632arsenic trioxidearsenic trioxide results in increased expression of SULT1A2 mRNA22521957
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SULT1A2 mRNA"19150397
D019905Benzyl AlcoholSULT1A2 protein results in increased sulfation of Benzyl Alcohol26663444
C040048caffeic acidSULT1A2 protein results in increased sulfation of caffeic acid17433394
C034221catecholSULT1A2 protein results in increased sulfation of catechol17433394
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SULT1A2 mRNA26272509
D002734Chlorophyll"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of SULT1A2 mRNA]"22079312
D019327Copper SulfateCopper Sulfate results in decreased expression of SULT1A2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SULT1A2 mRNA20106945|2556210
D003671DEET[fipronil co-treated with DEET] results in increased expression of SULT1A2 mRNA27091632
D003907DexamethasoneDexamethasone affects the expression of SULT1A2 mRNA15102944
C041517dibenzo(a,l)pyrene"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of SULT1A2 mRNA]"22079312
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of SULT1A2 mRNA"22079312
D002945CisplatinSULT1A2 protein affects the susceptibility to Cisplatin16217747
C118739entinostatentinostat results in increased expression of SULT1A2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
C082360fipronil[fipronil co-treated with DEET] results in increased expression of SULT1A2 mRNA27091632
C099406L 742694L 742694 affects the expression of SULT1A2 mRNA15102944
C042720mercuric bromidemercuric bromide results in increased expression of SULT1A2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SULT1A2 mRNA23649840
C014593N-hydroxy-4-aminobiphenylSULT1A2 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl17433394
D010098OxycodoneOxycodone results in decreased expression of SULT1A2 mRNA23439660
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SULT1A2 mRNA26272509
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SULT1A2 mRNA18692542
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SULT1A2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SULT1A2 mRNA26272509
D010724Phosphoadenosine Phosphosulfate[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]20545351
D059808PolyphenolsPolyphenols results in decreased expression of SULT1A2 mRNA16293270
D011794QuercetinQuercetin results in decreased expression of SULT1A2 mRNA21632981
C059514resveratrolSULT1A2 protein results in increased sulfation of resveratrol16418064
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SULT1A2 mRNA20106945|2163298
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SULT1A2 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of SULT1A2 mRNA23179753|2800136

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004062aryl sulfotransferase activity-IDA20417180  23207770  
GO:0004062aryl sulfotransferase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0008146sulfotransferase activity-TAS-  
GO:0047894flavonol 3-sulfotransferase activity-IDA20056724  
GO ID GO Term Qualifier Evidence PubMed
GO:0006068ethanol catabolic process-IDA23207770  
GO:0006584catecholamine metabolic process-IEA-  
GO:0006805xenobiotic metabolic process-IDA20417180  
GO:0008202steroid metabolic process-IEA-  
GO:0009309amine biosynthetic process-TAS9119390  
GO:0018958phenol-containing compound metabolic process-IDA20417180  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-IDA23207770  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-TAS-  
GO:0051923sulfation-IDA20056724  23207770  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00920Sulfur metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156584Cytosolic sulfonation of small moleculesTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22946908Sulfation of buprenorphine, pentazocine, and naloxone by human cytosolic sulfotransferases. (2012 Jun 1)Kurogi KDrug Metab Lett
16926176Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps. (2007 Feb)Goode ELCarcinogenesis