Gene: STX1A

6804
HPC-1|P35-1|STX1|SYN1A
syntaxin 1A
protein-coding
7q11.23
Ensembl:ENSG00000106089 MIM:186590 Vega:OTTHUMG00000137422 UniprotKB:Q16623
NG_013360.1
PubMed
0   ANCO-SNPs
CD|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.846e-1 (AD)  4.785e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LINGO10.956
ADAM110.955
EXTL10.954
MPPED10.949
SYNGR30.947
SCAMP50.946
SPRN0.946
SYNGR10.946
STX1B0.943
DIRAS10.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WWTR1-0.575
C1orf87-0.557
TFPI2-0.55
REST-0.545
CLEC2B-0.544
RBPMS-0.541
ARHGEF5-0.541
OR4F5-0.527
YES1-0.516
NEDD4-0.516

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of STX1A mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of STX1A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of STX1A mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STX1A mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of STX1A protein16483693
D003913DextroamphetamineDextroamphetamine affects the expression of STX1A protein11368965
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of STX1A mRNA24449571
D001151ArsenicArsenic affects the methylation of STX1A gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of STX1A mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of STX1A mRNA25929836
C024986barium chloridebarium chloride affects the localization of STX1A protein29320738
C024986barium chloridePropofol inhibits the reaction [barium chloride affects the localization of STX1A protein]29320738
C024986barium chlorideSTX1A protein modified form inhibits the reaction [Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]]29320738
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STX1A mRNA22228805
D004958EstradiolEstradiol affects the expression of STX1A mRNA22574217
D004958EstradiolEstradiol results in increased expression of STX1A mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of STX1A mRNA15223131
C006780bisphenol Abisphenol A results in decreased methylation of STX1A promoter27312807
C006780bisphenol Abisphenol A results in increased expression of STX1A mRNA25181051
C096324botulinum toxin type Cbotulinum toxin type C results in increased cleavage of and results in increased degradation of STX1A protein26615023
C096324botulinum toxin type Cbotulinum toxin type C results in increased cleavage of STX1A protein17666428
C584509C646 compoundC646 compound results in decreased expression of STX1A mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of STX1A mRNA16239168
D003024ClozapineClozapine results in increased expression of STX1A mRNA15860345
D019327Copper SulfateCopper Sulfate results in increased expression of STX1A mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of STX1A mRNA20106945|2556210
C089595cylindrospermopsincylindrospermopsin results in increased expression of STX1A mRNA24921660
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of STX1A mRNA28104350
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of STX1A protein28104350
D003976DiazinonDiazinon results in increased methylation of STX1A gene22964155
D002945CisplatinCisplatin results in decreased expression of STX1A mRNA27392435
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of STX1A mRNA17005392
D000431EthanolEthanol results in increased expression of STX1A mRNA19167417
D000431EthanolEthanol results in decreased expression of STX1A mRNA20655511
D005045EtomidateEtomidate affects the localization of STX1A protein29320738
D005419FlavonoidsFlavonoids results in increased expression of STX1A mRNA18035473
C039281furanfuran results in increased methylation of STX1A gene22079235
D006220HaloperidolHaloperidol results in increased expression of STX1A mRNA15860345
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of STX1A protein21179406
C492448ICG 001ICG 001 results in decreased expression of STX1A mRNA26191083
C544151jinfukangjinfukang results in increased expression of STX1A mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of STX1A mRNA23430699
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of STX1A mRNA25119042
C008261lead acetatelead acetate results in decreased expression of STX1A mRNA27984133
C008261lead acetatelead acetate results in increased expression of STX1A mRNA11578147
C008261lead acetatelead acetate results in increased expression of STX1A protein11578147
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine affects the methylation of STX1A promoter"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of STX1A mRNA"26251327
C008493methylselenic acidmethylselenic acid affects the expression of STX1A mRNA14617803
D010269ParaquatParaquat results in decreased expression of STX1A protein24521700
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of STX1A mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of STX1A mRNA25119042
D010634PhenobarbitalPhenobarbital affects the expression of STX1A mRNA19159669
D017035Pravastatin[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of STX1A protein26875785
D000069583PregabalinSTX1A affects the susceptibility to Pregabalin24269977
D015742PropofolPropofol affects the localization of STX1A protein29320738
D015742PropofolPropofol affects the localization of STX1A protein29320738
D015742PropofolPropofol inhibits the reaction [barium chloride affects the localization of STX1A protein]29320738
D015742PropofolSNAP25 protein affects the reaction [Propofol affects the localization of STX1A protein]29320738
D015742PropofolSTX1A protein modified form inhibits the reaction [Propofol affects the localization of STX1A protein]29320738
D015742PropofolSTX1A protein modified form inhibits the reaction [Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]]29320738
D011794QuercetinQuercetin results in increased expression of STX1A mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of STX1A mRNA15849065
D012822Silicon DioxideSilicon Dioxide results in increased expression of STX1A mRNA25351596
C080703SK&F 83959SK&F 83959 results in increased expression of STX1A protein25852303
D013501Surface-Active AgentsSurface-Active Agents results in increased expression of STX1A mRNA22467014
C061133tamibarotenetamibarotene results in decreased expression of STX1A mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STX1A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STX1A mRNA19465110
D024505TocopherolsTocopherols results in increased expression of STX1A mRNA17654050
D014212TretinoinTretinoin results in decreased expression of STX1A mRNA15498508
D014212TretinoinTretinoin results in increased expression of STX1A mRNA16604517
C012589trichostatin Atrichostatin A results in increased expression of STX1A mRNA23558232
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of STX1A mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of STX1A mRNA19140230

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IBA21873635  
GO:0005484SNAP receptor activity-IBA21873635  
GO:0005515protein binding-IPI10321247  10481273  12730201  15459722  19748891  26359495  
GO:0019855calcium channel inhibitor activity-IEA-  
GO:0019869chloride channel inhibitor activity-IDA18570918  
GO:0019900kinase binding-IPI12730201  
GO:0019904protein domain specific binding-IEA-  
GO:0030674protein binding, bridging-IEA-  
GO:0032028myosin head/neck binding-IEA-  
GO:0043008ATP-dependent protein binding-IEA-  
GO:0044325ion channel binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0047485protein N-terminus binding-IEA-  
GO:0048306calcium-dependent protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001956positive regulation of neurotransmitter secretion-IEA-  
GO:0006886intracellular protein transport-IBA21873635  
GO:0006887exocytosis-IBA21873635  
GO:0006906vesicle fusion-IBA21873635  
GO:0009629response to gravity-IEA-  
GO:0010701positive regulation of norepinephrine secretion-ISS-  
GO:0010807regulation of synaptic vesicle priming-IEA-  
GO:0016081synaptic vesicle docking-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0031629synaptic vesicle fusion to presynaptic active zone membrane-IBA21873635  
GO:0032940secretion by cell-IDA12130530  
GO:0033605positive regulation of catecholamine secretion-ISS-  
GO:0035493SNARE complex assembly-IEA-  
GO:0045956positive regulation of calcium ion-dependent exocytosis-ISS-  
GO:0048278vesicle docking-IBA21873635  
GO:0050796regulation of insulin secretion-TAS15537656  
GO:0072657protein localization to membrane-IEA-  
GO:2000463positive regulation of excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA12730201  17543282  24885604  
GO:0005886plasma membrane-TAS10099709  
GO:0008021synaptic vesicle-IBA21873635  
GO:0008076voltage-gated potassium channel complexcolocalizes_withISS-  
GO:0012505endomembrane system-IBA21873635  
GO:0014069postsynaptic density-IEA-  
GO:0016021integral component of membrane-IBA21873635  
GO:0030054cell junction-IEA-  
GO:0030141secretory granule-IEA-  
GO:0030424axon-IEA-  
GO:0030672synaptic vesicle membrane-IEA-  
GO:0031201SNARE complex-IBA21873635  
GO:0031201SNARE complex-IDA12730201  19546860  
GO:0031201SNARE complex-TAS10099709  
GO:0031965nuclear membrane-IEA-  
GO:0042641actomyosin-IEA-  
GO:0042734presynaptic membrane-IBA21873635  
GO:0043005neuron projection-IDA12115694  
GO:0048787presynaptic active zone membrane-IBA21873635  
GO:0048787presynaptic active zone membrane-IEA-  
GO:0070032synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex-IEA-  
GO:0070033synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex-IEA-  
GO:0070044synaptobrevin 2-SNAP-25-syntaxin-1a complex-IEA-  
KEGG ID KEGG Term
hsa04130SNARE interactions in vesicular transport
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1430728MetabolismIEA
R-HSA-163685Integration of energy metabolismIEA
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-168799Neurotoxicity of clostridium toxinsTAS
R-HSA-181429Serotonin Neurotransmitter Release CycleTAS
R-HSA-181430Norepinephrine Neurotransmitter Release CycleTAS
R-HSA-210500Glutamate Neurotransmitter Release CycleTAS
R-HSA-212676Dopamine Neurotransmitter Release CycleTAS
R-HSA-264642Acetylcholine Neurotransmitter Release CycleTAS
R-HSA-264876Insulin processingIEA
R-HSA-2980736Peptide hormone metabolismIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-422356Regulation of insulin secretionIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449836Other interleukin signalingTAS
R-HSA-5250971Toxicity of botulinum toxin type C (BoNT/C)TAS
R-HSA-5339562Uptake and actions of bacterial toxinsTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5682910LGI-ADAM interactionsTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesIEA
R-HSA-888590GABA synthesis, release, reuptake and degradationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15846778Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. (2005 May 15)Worst TJJ Neurosci Res
21426264Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)Fernandez-Castillo NWorld J Biol Psychiatry