Gene: STXBP1

6812
MUNC18-1|NSEC1|P67|RBSEC1|UNC18
syntaxin binding protein 1
protein-coding
9q34.11
Ensembl:ENSG00000136854 MIM:602926 Vega:OTTHUMG00000020713 UniprotKB:P61764
NG_016623.1
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.227e-1 (AD)  6.572e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SV2A0.984
ENO20.98
DNM10.979
RTN10.979
RAB3A0.978
SCAMP50.977
MADD0.976
ATP1A30.976
SULT4A10.974
ATCAY0.973

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.581
OR4F29-0.546
TFPI2-0.492
REST-0.472
HEY2-0.465
RAI14-0.464
MYL3-0.463
WWTR1-0.457
YES1-0.456
CSAG1-0.451

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of STXBP1 mRNA19643169
C0179063-dinitrobenzene3-dinitrobenzene results in increased oxidation of STXBP1 protein25716674
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STXBP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STXBP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STXBP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STXBP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of STXBP1 mRNA21420995|2223033
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of STXBP1 mRNA25607892
C014949acetylhydrazineacetylhydrazine results in decreased expression of STXBP1 mRNA15282401
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of STXBP1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STXBP1 mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of STXBP1 mRNA25607892
D001241AspirinAspirin affects the expression of STXBP1 mRNA12800193
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of STXBP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STXBP1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STXBP1 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of STXBP1 mRNA21185374
D001622BetaineBetaine results in decreased expression of STXBP1 mRNA26391144
C006780bisphenol Abisphenol A results in increased expression of STXBP1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of STXBP1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of STXBP1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of STXBP1 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of STXBP1 mRNA25607892
C013418bromfenacoumbromfenacoum results in increased expression of STXBP1 protein28903499
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of STXBP1 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of STXBP1 mRNA25607892
D020148Butyric AcidButyric Acid results in increased expression of STXBP1 mRNA12800193
D003024ClozapineClozapine affects the expression of STXBP1 mRNA12437575
C018021cobaltous chloridecobaltous chloride results in increased expression of STXBP1 mRNA17553155
D003042CocaineCocaine affects the expression of STXBP1 mRNA20187946
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of STXBP1 mRNA23640034
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STXBP1 mRNA25607892
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of STXBP1 mRNA21266533
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STXBP1 mRNA25607892
D004026DieldrinDieldrin results in decreased expression of STXBP1 mRNA28385952
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STXBP1 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of STXBP1 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of STXBP1 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STXBP1 mRNA25607892
D000431EthanolEthanol results in increased expression of STXBP1 mRNA20655511
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STXBP1 mRNA17942748
D005473FluoxetineFluoxetine results in increased expression of STXBP1 mRNA21852994
D005557FormaldehydeFormaldehyde results in decreased expression of STXBP1 mRNA12679049
C039281furanfuran results in increased expression of STXBP1 mRNA25539665
D019833GenisteinGenistein results in increased expression of STXBP1 mRNA20884965
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of STXBP1 mRNA21782745
D005839GentamicinsGentamicins results in decreased expression of STXBP1 mRNA22061828
D003932HeroinHeroin results in decreased expression of STXBP1 mRNA16710320
D007854LeadLead affects the expression of STXBP1 mRNA28903495
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STXBP1 mRNA25607892
D008627Mercuric ChlorideMercuric Chloride affects the expression of STXBP1 mRNA20353558
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of STXBP1 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of STXBP1 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased methylation of STXBP1 gene23303685
C005219methyl cellosolvemethyl cellosolve results in increased expression of STXBP1 mRNA19643169|2106145
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of STXBP1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STXBP1 mRNA"27188386
C025256nonylphenolnonylphenol results in decreased expression of STXBP1 mRNA22982499
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of STXBP1 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of STXBP1 mRNA25607892
D009966OrphenadrineOrphenadrine affects the expression of STXBP1 mRNA23665939
D010100OxygenOxygen deficiency results in decreased expression of STXBP1 protein25937538
D010126OzoneOzone results in decreased expression of STXBP1 mRNA16330353
D010416PentachlorophenolPentachlorophenol results in increased expression of STXBP1 mRNA23892564
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STXBP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of STXBP1 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of STXBP1 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of STXBP1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of STXBP1 mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in increased expression of STXBP1 protein23718831
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STXBP1 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STXBP1 mRNA25607892
D011441PropylthiouracilPropylthiouracil results in decreased expression of STXBP1 mRNA24780913
D012524SarinSarin results in increased expression of STXBP1 protein25842371
D012834SilverSilver results in decreased expression of STXBP1 mRNA27131904
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STXBP1 mRNA17942748
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of STXBP1 protein20109541
D013853ThioacetamideThioacetamide results in increased expression of STXBP1 mRNA23411599
D024505TocopherolsTocopherols results in increased expression of STXBP1 mRNA17654050
C012589trichostatin Atrichostatin A affects the expression of STXBP1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of STXBP1 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of STXBP1 mRNA23558232
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of STXBP1 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of STXBP1 mRNA22083351|2493525
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STXBP1 mRNA25607892
C025643vinclozolinvinclozolin affects the expression of STXBP1 mRNA19015723
C111237vorinostatvorinostat results in decreased expression of STXBP1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-ISS-  
GO:0003723RNA binding-HDA22658674  
GO:0005515protein binding-IPI25416956  25910212  
GO:0017075syntaxin-1 binding-IPI12730201  19748891  
GO:0017075syntaxin-1 binding-ISS-  
GO:0019901protein kinase binding-IEA-  
GO:0019904protein domain specific binding-IEA-  
GO:0019905syntaxin binding-IPI12773094  
GO:0042802identical protein binding-ISS-  
GO:0043274phospholipase binding-IEA-  
GO:0047485protein N-terminus binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-IMP12773094  
GO:0003006developmental process involved in reproduction-IEA-  
GO:0006904vesicle docking involved in exocytosis-ISS-  
GO:0007269neurotransmitter secretion-IEA-  
GO:0007274neuromuscular synaptic transmission-IEA-  
GO:0007412axon target recognition-ISS-  
GO:0010807regulation of synaptic vesicle priming-ISS-  
GO:0015031protein transport-IEA-  
GO:0016188synaptic vesicle maturation-ISS-  
GO:0031333negative regulation of protein complex assembly-IEA-  
GO:0031630regulation of synaptic vesicle fusion to presynaptic active zone membrane-TAS15217342  
GO:0032229negative regulation of synaptic transmission, GABAergic-ISS-  
GO:0032355response to estradiol-IEA-  
GO:0035542regulation of SNARE complex assembly-TAS15217342  
GO:0043306positive regulation of mast cell degranulation-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0045956positive regulation of calcium ion-dependent exocytosis-IEA-  
GO:0050821protein stabilization-IEA-  
GO:0060292long term synaptic depression-IEA-  
GO:0070527platelet aggregation-IMP12773094  
GO:0071346cellular response to interferon-gamma-IEA-  
GO:0072659protein localization to plasma membrane-IDA17543282  
GO:0099525presynaptic dense core vesicle exocytosis-IEA-  
GO:0106022positive regulation of vesicle docking-IEA-  
GO:1903296positive regulation of glutamate secretion, neurotransmission-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-ISS-  
GO:0005739mitochondrion-ISS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-IDA12773094  
GO:0005886plasma membranecolocalizes_withISS-  
GO:0030424axon-IEA-  
GO:0031091platelet alpha granule-IDA12773094  
GO:0032991protein-containing complex-ISS-  
GO:0043209myelin sheath-IEA-  
GO:0045335phagocytic vesicle-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0048787presynaptic active zone membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  
GO:0098794postsynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-1430728MetabolismIEA
R-HSA-163685Integration of energy metabolismIEA
R-HSA-181429Serotonin Neurotransmitter Release CycleTAS
R-HSA-181430Norepinephrine Neurotransmitter Release CycleTAS
R-HSA-210500Glutamate Neurotransmitter Release CycleTAS
R-HSA-212676Dopamine Neurotransmitter Release CycleTAS
R-HSA-264642Acetylcholine Neurotransmitter Release CycleTAS
R-HSA-422356Regulation of insulin secretionIEA
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesIEA
R-HSA-888590GABA synthesis, release, reuptake and degradationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21426264Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)Fernandez-Castillo NWorld J Biol Psychiatry