Gene: SULT1A3

6818
HAST|HAST3|M-PST|ST1A3|ST1A3/ST1A4|ST1A5|STM|TL-PST
sulfotransferase family 1A member 3
protein-coding
16p11.2
Ensembl:ENSG00000261052 MIM:600641 Vega:OTTHUMG00000048083 UniprotKB:P0DMM9
NC_000016.10
PubMed
0   ANCO-SNPs
OD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCNA20.726
DNASE1L20.725
FGFR40.704
KLK140.689
CNTD20.682
ZGLP10.678
BNIPL0.674
TLR90.672
GSDMB0.669
SLFNL10.643

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH1L1-AS2-0.388
PRSS27-0.341
HPDL-0.339
CTSO-0.326
CACNG1-0.323
TMEM220-0.32
STARD6-0.306
ACBD7-0.305
HSF2BP-0.291
TXNRD3-0.288

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00316AcetaminophenSmall Molecule103-90-2ApprovedEnzyme
ID Drug Name Action PubMed
C0331461-hydroxypyrene1-hydroxypyrene results in decreased activity of SULT1A3 protein14570759
C0331461-hydroxypyreneDimethylformamide inhibits the reaction [SULT1A3 protein results in increased sulfation of 1-hydroxypyrene]14570759
C0331461-hydroxypyreneEthanol inhibits the reaction [SULT1A3 protein results in increased sulfation of 1-hydroxypyrene]14570759
C0331461-hydroxypyreneEthanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1A3 protein]14570759
C0331461-hydroxypyreneSULT1A3 protein results in increased metabolism of 1-hydroxypyrene24140465
C0331461-hydroxypyreneSULT1A3 protein results in increased sulfation of 1-hydroxypyrene14570759
C0293501-naphtholSULT1A3 protein results in increased sulfation of 1-naphthol15684482
C0158022,6-dichloro-4-nitrophenol"[2,6-dichloro-4-nitrophenol co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiol"15483196
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]"11425650|1553151
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol results in decreased activity of SULT1A3 protein"10692228
C0158022,6-dichloro-4-nitrophenol"[2,6-dichloro-4-nitrophenol results in decreased activity of SULT1A3 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"10692228
C0775842-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine"SULT1A3 protein results in increased sulfation of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine"11181495
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"SULT1A3 protein promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APRT gene] which affects the susceptibility to 8-azaadenine]"10692228
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2,6-dichloro-4-nitrophenol results in decreased activity of SULT1A3 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"10692228
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"SULT1A3 protein results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"10692228
C0013902-hydroxyestradiol2-hydroxyestradiol affects the sulfation of SULT1A3 protein11358677
C0306293,3'-diiodothyronine"3,3'-diiodothyronine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]"15531517
C0248364-nitrophenolSULT1A3 protein results in increased metabolism of 4-nitrophenol10623578
C0248364-nitrophenolSULT1A3 protein results in increased sulfation of 4-nitrophenol9566748
C0415944-nonylphenolSULT1A3 protein results in increased metabolism of 4-nonylphenol10623578
C0804174-octylphenolSULT1A3 protein results in increased metabolism of 4-octylphenol10623578
C0267855-hydroxyindoleSULT1A3 protein results in increased sulfation of 5-hydroxyindole11181495
C0123656-hydroxymelatoninSULT1A3 protein results in increased sulfation of 6-hydroxymelatonin11181495
C0066548-azaadenine"SULT1A3 protein promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APRT gene] which affects the susceptibility to 8-azaadenine]"10692228
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SULT1A3 gene27153756
D0150812-NaphthylamineSULT1A3 protein results in increased sulfation of 2-Naphthylamine17433394
D000638AmiodaroneAmiodarone results in increased expression of SULT1A3 mRNA19774075
D001205Ascorbic AcidAscorbic Acid results in decreased expression of SULT1A3 mRNA21144891
C076588benzo(a)pyrene-7,8-dione"SULT1A3 protein results in increased metabolism of benzo(a)pyrene-7,8-dione"22782890
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SULT1A3 mRNA16545412
D001564Benzo(a)pyreneSULT1A3 protein results in increased sulfation of Benzo(a)pyrene11181495
D019905Benzyl AlcoholSULT1A3 protein results in increased sulfation of Benzyl Alcohol26663444
D004958EstradiolEstradiol affects the sulfation of SULT1A3 protein11358677
D004958EstradiolSULT1A3 protein results in increased sulfation of Estradiol11181495
C044887beta-methylcholinebeta-methylcholine affects the expression of SULT1A3 mRNA21179406
C040048caffeic acidSULT1A3 protein results in increased sulfation of caffeic acid17433394
C034221catecholSULT1A3 protein results in increased sulfation of catechol17433394
D007464ClioquinolClioquinol inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]21820498
D007464ClioquinolSULT1A3 protein results in increased sulfation of Clioquinol21820498
C004742daidzeindaidzein inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]15531517
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SULT1A3 mRNA28412506
D004054DiethylstilbestrolSULT1A3 protein results in increased metabolism of Diethylstilbestrol10623578
D004295DihydroxyphenylalanineManganese promotes the reaction [SULT1A3 protein results in increased sulfation of Dihydroxyphenylalanine]12424257
D004295DihydroxyphenylalanineSULT1A3 protein results in increased sulfation of Dihydroxyphenylalanine12424257
D004126DimethylformamideDimethylformamide inhibits the reaction [SULT1A3 protein results in increased sulfation of 1-hydroxypyrene]14570759
D004298Dopamine"2,6-dichloro-4-nitrophenol inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]"11425650|1553151
D004298Dopamine"3,3'-diiodothyronine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]"15531517
D004298DopamineClioquinol inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]21820498
D004298Dopaminedaidzein inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]15531517
D004298DopamineEthanol inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]14570759
D004298DopamineGenistein inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]15531517
D004298DopamineMefenamic Acid inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]11181495
D004298DopamineSodium Chloride inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]11425650|1553151
D004298DopamineSULT1A3 protein results in increased metabolism of Dopamine10623578
D004298DopamineSULT1A3 protein results in increased sulfation of Dopamine11181495|1457075
D004298DopamineThyroxine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]15531517
D004298DopamineTriiodothyronine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]15531517
D004298Dopamine"Triiodothyronine, Reverse inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]"15531517
D004837EpinephrineSULT1A3 protein results in increased sulfation of Epinephrine11181495
D004970EstroneEstrone affects the sulfation of SULT1A3 protein11358677
D004970Estrone[Estrone co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiol15483196
D004970EstroneSULT1A3 protein results in increased metabolism of Estrone10623578
D000431EthanolEthanol inhibits the reaction [SULT1A3 protein results in increased sulfation of 1-hydroxypyrene]14570759
D000431EthanolEthanol inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]14570759
D000431EthanolEthanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1A3 protein]14570759
D000431EthanolEthanol results in decreased activity of SULT1A3 protein14570759
D004997Ethinyl Estradiol"[2,6-dichloro-4-nitrophenol co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiol"15483196
D004997Ethinyl Estradiol[Estrone co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiol15483196
D004997Ethinyl Estradiol[Quercetin co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiol15483196
D004997Ethinyl EstradiolSULT1A3 protein results in increased sulfation of Ethinyl Estradiol15483196
D019833GenisteinGenistein inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]15531517
C071834glycidamideglycidamide results in increased expression of SULT1A3 mRNA17822822
C001326harmolSULT1A3 protein results in increased sulfation of harmol11181495
D012701SerotoninSULT1A3 protein results in increased sulfation of Serotonin11181495
D006917HydroxytryptopholSULT1A3 protein results in increased sulfation of Hydroxytryptophol11181495
D008345ManganeseManganese promotes the reaction [SULT1A3 protein results in increased sulfation of Dihydroxyphenylalanine]12424257
D008528Mefenamic AcidMefenamic Acid inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]11181495
D008914MinoxidilSULT1A3 protein results in increased sulfation of Minoxidil11181495
C005273naringeninSULT1A3 protein results in increased sulfation of naringenin11181495
C014593N-hydroxy-4-aminobiphenylSULT1A3 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl17433394
C007350nitrofenSULT1A3 protein results in increased activity of nitrofen14754874
D009638NorepinephrineSULT1A3 protein results in increased sulfation of Norepinephrine11181495
D009647NormetanephrineSULT1A3 protein results in increased sulfation of Normetanephrine11181495
D010646PhentolamineSULT1A3 protein results in increased sulfation of Phentolamine11181495
D010724Phosphoadenosine PhosphosulfateSULT1A3 protein results in increased sulfation of Phosphoadenosine Phosphosulfate11425650
C016063pinocembrinSULT1A3 protein results in increased sulfation of pinocembrin11181495
D011794Quercetin[Quercetin co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiol15483196
C059514resveratrolSULT1A3 protein results in increased sulfation of resveratrol16418064
C009237senecioninesenecionine results in increased expression of SULT1A3 mRNA26100227
D012965Sodium ChlorideSodium Chloride inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]11425650|1553151
D014284TriiodothyronineTriiodothyronine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]15531517
D013974ThyroxineThyroxine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]15531517
D014212TretinoinTretinoin results in decreased expression of SULT1A3 mRNA17045167
D014285Triiodothyronine, Reverse"Triiodothyronine, Reverse inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]"15531517
C057693troglitazoneSULT1A3 protein results in increased sulfation of troglitazone11181495
D014439TyramineSULT1A3 protein results in increased sulfation of Tyramine11181495
D014635Valproic AcidValproic Acid results in increased methylation of SULT1A3 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004062aryl sulfotransferase activity-IMP9855620  
GO:0004062aryl sulfotransferase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0008146sulfotransferase activity-IDA20056724  
GO:0043199sulfate binding-IDA10543947  
GO:0047685amine sulfotransferase activity-IDA23207770  
GO ID GO Term Qualifier Evidence PubMed
GO:0006068ethanol catabolic process-IDA23207770  
GO:0006805xenobiotic metabolic process-IDA20056724  
GO:0007212dopamine receptor signaling pathway-IDA24136195  
GO:0008202steroid metabolic process-IEA-  
GO:0009812flavonoid metabolic process-IDA20056724  
GO:0036498IRE1-mediated unfolded protein response-TAS-  
GO:0042420dopamine catabolic process-IDA23207770  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-IDA23207770  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-TAS-  
GO:0051923sulfation-IDA20056724  23207770  
GO:0070371ERK1 and ERK2 cascade-IDA24136195  
GO:0097720calcineurin-mediated signaling-IDA24136195  
GO:0098989NMDA selective glutamate receptor signaling pathway-IDA24136195  
GO:1901215negative regulation of neuron death-IMP24136195  
GO:1903351cellular response to dopamine-IMP24136195  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00920Sulfur metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156584Cytosolic sulfonation of small moleculesTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-381038XBP1(S) activates chaperone genesTAS
R-HSA-381070IRE1alpha activates chaperonesTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22946908Sulfation of buprenorphine, pentazocine, and naloxone by human cytosolic sulfotransferases. (2012 Jun 1)Kurogi KDrug Metab Lett