Gene: SULT2A1

6822
DHEA-ST|DHEAS|HST|ST2|ST2A1|ST2A3|STD|hSTa
sulfotransferase family 2A member 1
protein-coding
19q13.33
Ensembl:ENSG00000105398 MIM:125263 Vega:OTTHUMG00000162469 UniprotKB:Q06520
NG_016745.1
PubMed
0   ANCO-SNPs
OD|ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.650e-1 (AD)  7.212e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSD3B20.59
CYP17A10.561
CYP11B10.502
CD1B0.463
OR2M50.447
CCDC1550.441
BARHL20.436
TAS2R410.417
DMRTC20.417
FGB0.411

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDN20-0.231
SHBG-0.216
ALOX15-0.21
MED11-0.205
ZSCAN5B-0.198
SH2D6-0.193
CCL27-0.192
UBE2U-0.19
MORN5-0.188
WFDC6-0.185

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01708PrasteroneSmall Molecule53-43-0Approved|Investigational|NutraceuticalTarget
DB01812Adenosine-3'-5'-DiphosphateSmall MoleculeExperimentalTarget
DB02854AetiocholanoloneSmall Molecule53-42-9ExperimentalTarget
DB04445Mercuric iodideSmall Molecule7774-29-0ExperimentalTarget
DB00316AcetaminophenSmall Molecule103-90-2ApprovedEnzyme
DB05812AbirateroneSmall Molecule154229-19-3ApprovedEnzyme
ID Drug Name Action PubMed
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in increased expression of SULT2A1 mRNA"17070881
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SULT2A1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [[Androstenols results in decreased activity of NR1I3 protein] which results in decreased expression of SULT2A1 mRNA]"14742670
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of SULT2A1 mRNA"14742670
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SULT2A1 mRNA"15004031|1598641
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SULT2A1 protein"15986414
C0658331-hydroxymethylpyrene[SULT2A1 protein co-treated with PAPSS1 protein] results in increased activity of 1-hydroxymethylpyrene24802129
C0331461-hydroxypyreneDimethylformamide inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]14570759
C0331461-hydroxypyreneEthanol inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]14570759
C0331461-hydroxypyreneEthanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT2A1 protein]14570759
C0353141-nitropropane1-nitropropane results in increased expression of SULT2A1 mRNA17070881
C0303752,3-dichlorobiphenyl"2,3-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
C0911592,3'-dichlorobiphenyl"2,3'-dichlorobiphenyl metabolite inhibits the reaction [Dehydroepiandrosterone results in increased expression of SULT2A1 protein]"24508592
C0911592,3'-dichlorobiphenyl"2,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SULT2A1 mRNA"9566755
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of SULT2A1 mRNA"17070881
C0299072,4'-dichlorobiphenyl"2,4'-dichlorobiphenyl metabolite binds to SULT2A1 protein"24508592
C0299072,4'-dichlorobiphenyl"2,4'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SULT2A1 mRNA"21346803
C08133124-norursodeoxycholic acid24-norursodeoxycholic acid results in increased expression of SULT2A1 protein16472600
C0299052,5-dichlorobiphenyl"2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein affects the metabolism of Dehydroepiandrosterone]"17112228
C0299052,5-dichlorobiphenyl"2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
C0109252,5-dihydroxybenzoic acid"2,5-dihydroxybenzoic acid results in increased expression of SULT2A1 mRNA"16443358
C0252352,6-diaminotoluene"2,6-diaminotoluene results in increased expression of SULT2A1 mRNA"17070881
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in increased expression of SULT2A1 mRNA17070881
C0166172-nitropropane2-nitropropane results in decreased expression of SULT2A1 mRNA17070881
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in decreased expression of SULT2A1 mRNA"24610083
C0299063,3'-dichlorobiphenyl"3,3'-dichlorobiphenyl metabolite binds to SULT2A1 protein"24508592
C0299063,3'-dichlorobiphenyl"3,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
C5438473',4'-dihydroxy-4-monochlorobiphenyl"3',4'-dihydroxy-4-monochlorobiphenyl binds to SULT2A1 protein"24508592
C5438473',4'-dihydroxy-4-monochlorobiphenyl"3',4'-dihydroxy-4-monochlorobiphenyl inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
C0299043,5-dichlorobiphenyl"3,5-dichlorobiphenyl metabolite binds to SULT2A1 protein"24508592
C0299043,5-dichlorobiphenyl"3,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of SULT2A1 mRNA14610520
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of SULT2A1 mRNA14610520
C0286764-acetylaminofluorene4-acetylaminofluorene results in increased expression of SULT2A1 mRNA17070881
C0069834-chlorobiphenyl4-chlorobiphenyl metabolite binds to SULT2A1 protein24508592
C0069834-chlorobiphenyl4-chlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]24508592
C0821374-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide results in increased expression of SULT2A1 mRNA15681896
C0248364-nitrophenolSULT2A1 protein results in increased metabolism of 4-nitrophenol10623578
C0415944-nonylphenolSULT2A1 protein results in increased metabolism of 4-nonylphenol10623578
C0804174-octylphenolSULT2A1 protein results in increased metabolism of 4-octylphenol10623578
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of SULT2A1 mRNA15982314
D000082AcetaminophenAcetaminophen results in decreased expression of SULT2A1 mRNA29067470
D000082AcetaminophenAcetaminophen results in decreased expression of SULT2A1 protein29067470
D000082AcetaminophenAcetaminophen results in decreased expression of SULT2A1 mRNA26772156
D000082AcetaminophenAcetaminophen results in increased expression of SULT2A1 protein23308384
D000082Acetaminophenhyperoside inhibits the reaction [Acetaminophen results in decreased expression of SULT2A1 mRNA]26772156
D000082AcetaminophenAcetaminophen results in decreased expression of SULT2A1 mRNA15084756
C010840adenosine 3'-phosphate-5'-phosphateadenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein24059442
C010840adenosine 3'-phosphate-5'-phosphateBenzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]24059442
C010840adenosine 3'-phosphate-5'-phosphateDehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]24059442
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SULT2A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SULT2A1 mRNA22100608
D000438AlcoholsSULT2A1 protein results in increased sulfation of Alcohols23026138
C526957alisol B 23-acetatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of SULT2A1 mRNA]25655198
C103303alitretinoinalitretinoin results in decreased expression of SULT2A1 mRNA15982314
D000638AmiodaroneAmiodarone results in increased expression of SULT2A1 protein23308384
D000737Androstenols"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [[Androstenols results in decreased activity of NR1I3 protein] which results in decreased expression of SULT2A1 mRNA]"14742670
D000737Androstenols[Androstenols results in decreased activity of NR1I3 protein] which results in decreased expression of SULT2A1 mRNA14742670
C103016antalarminantalarmin results in decreased expression of SULT2A1 mRNA16014403
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in decreased expression of SULT2A1 mRNA17639512
C104416astressinastressin results in decreased expression of SULT2A1 mRNA16014403
C487081belinostatbelinostat results in decreased expression of SULT2A1 mRNA27188386
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of SULT2A1 mRNA9566755
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SULT2A1 mRNA18164116
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of SULT2A1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SULT2A1 mRNA16545412
D016227BenzoquinonesBenzoquinones analog affects the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]24059442
D016227BenzoquinonesBenzoquinones analog binds to and results in increased oxidation of SULT2A1 protein24059442
D016227BenzoquinonesBenzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]24059442
D016227BenzoquinonesBenzoquinones analog inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]24059442
D016227BenzoquinonesDehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]24059442
D004958EstradiolEstradiol results in decreased expression of SULT2A1 mRNA20106945
C095105bexarotenebexarotene results in decreased expression of SULT2A1 mRNA16648578
D001647Bile Acids and SaltsSULT2A1 protein results in increased sulfation of Bile Acids and Salts15635043|2183983
D001647Bile Acids and SaltsSULT2A1 protein results in increased sulfation of Bile Acids and Salts15986414
C004541biochanin Abiochanin A results in increased expression of SULT2A1 mRNA20391625
C004541biochanin Abiochanin A results in increased expression of SULT2A1 protein20391625
C006780bisphenol Abisphenol A results in decreased expression of SULT2A1 mRNA24214726
C006780bisphenol Abisphenol A results in increased methylation of SULT2A1 promoter24214726
C006780bisphenol ASULT2A1 protein results in increased metabolism of bisphenol A10623578
C006780bisphenol ASULT2A1 protein results in increased susceptibility to bisphenol A27491884
C006780bisphenol Abisphenol A results in decreased expression of SULT2A1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of SULT2A1 mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SULT2A1 mRNA23741332
D000068579CelecoxibCelecoxib affects the activity of SULT2A1 protein17239972
D000068579CelecoxibCelecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]15483193
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of SULT2A1 mRNA16946559
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of SULT2A1 protein16946559
D002635Chenodeoxycholic AcidSULT2A1 protein results in increased sulfation of Chenodeoxycholic Acid20102295
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of SULT2A1 mRNA16946559
D002635Chenodeoxycholic AcidNR1H4 protein promotes the reaction [Chenodeoxycholic Acid results in decreased expression of SULT2A1 mRNA]16946559
D004083CholestanolSULT2A1 protein results in increased sulfation of Cholestanol21839837
D019826Cholic AcidSULT2A1 protein results in increased sulfation of Cholic Acid20102295
D019826Cholic AcidCholic Acid results in increased expression of SULT2A1 mRNA17521389|2296165
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SULT2A1 mRNA27344345
C019304ciprofibrateciprofibrate results in increased expression of and results in increased activity of SULT2A1 protein15635043
C019304ciprofibrateciprofibrate results in increased expression of SULT2A1 mRNA15635043
D002994ClofibrateClofibrate results in decreased expression of SULT2A1 mRNA12851107
D003022ClotrimazoleClotrimazole results in decreased expression of SULT2A1 mRNA9566755
C018021cobaltous chloridecobaltous chloride results in increased expression of SULT2A1 mRNA20105288
D005576ColforsinColforsin results in decreased expression of SULT2A1 mRNA17080404|2244682
D005576ColforsinLindane promotes the reaction [Colforsin results in decreased expression of SULT2A1 mRNA]17080404
D019327Copper SulfateCopper Sulfate results in decreased expression of SULT2A1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased activity of SULT2A1 protein26198044
D016572Cyclosporine[Cyclosporine results in decreased activity of SULT2A1 protein] which results in increased abundance of Lithocholic Acid26198044
D016572CyclosporineCyclosporine results in decreased expression of SULT2A1 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of SULT2A1 protein23308384
C526360dechlorane plusdechlorane plus results in decreased expression of SULT2A1 mRNA23245762
D003671DEET[fipronil co-treated with DEET] results in increased expression of SULT2A1 mRNA27091632
D003687Dehydroepiandrosterone"2,3'-dichlorobiphenyl metabolite inhibits the reaction [Dehydroepiandrosterone results in increased expression of SULT2A1 protein]"24508592
D003687Dehydroepiandrosterone"2,3-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
D003687Dehydroepiandrosterone"2,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
D003687Dehydroepiandrosterone"2,4'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
D003687Dehydroepiandrosterone"2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein affects the metabolism of Dehydroepiandrosterone]"17112228
D003687Dehydroepiandrosterone"2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
D003687Dehydroepiandrosterone"3,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
D003687Dehydroepiandrosterone"3',4'-dihydroxy-4-monochlorobiphenyl inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
D003687Dehydroepiandrosterone"3,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]"24508592
D003687Dehydroepiandrosterone4-chlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]24508592
D003687DehydroepiandrosteroneBenzoquinones analog affects the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]24059442
D003687DehydroepiandrosteroneBenzoquinones analog inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]24059442
D003687DehydroepiandrosteroneDehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]24059442
D003687DehydroepiandrosteroneEthanol inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]14570759
D003687DehydroepiandrosteronePolychlorinated Biphenyls inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]21913674
D003687DehydroepiandrosteroneSULT2A1 protein results in increased metabolism of Dehydroepiandrosterone10623578
D003687DehydroepiandrosteroneSULT2A1 protein results in increased sulfation of Dehydroepiandrosterone10752640|1457075
D003907DexamethasoneDexamethasone results in increased expression of SULT2A1 mRNA15541768
D003907DexamethasoneDexamethasone affects the expression of SULT2A1 mRNA15102944
D003907DexamethasoneDexamethasone results in increased expression of SULT2A1 mRNA11328961|1563504
C000944dicrotophosdicrotophos results in decreased expression of SULT2A1 mRNA28302478
D004051Diethylhexyl Phthalate[Diethylhexyl Phthalate co-treated with Linuron] results in increased expression of SULT2A1 mRNA22277248
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SULT2A1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SULT2A1 mRNA28943392
D004052Diethylnitrosamine[ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of SULT2A1 mRNA22467020
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SULT2A1 mRNA22129741
D004054DiethylstilbestrolSULT2A1 protein results in increased metabolism of Diethylstilbestrol10623578
D004126DimethylformamideDimethylformamide inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]14570759
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SULT2A1 mRNA17072980
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SULT2A1 mRNA26159488
C071192entacaponeentacapone binds to SULT2A1 protein19783845
D004970EstroneSULT2A1 protein results in increased metabolism of Estrone10623578
D000431EthanolEthanol inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]14570759
D000431EthanolEthanol inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]14570759
D000431EthanolEthanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT2A1 protein]14570759
D000431EthanolEthanol results in decreased activity of SULT2A1 protein14570759
D004997Ethinyl EstradiolCelecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]15483193
D004997Ethinyl Estradiol[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol15483193
D004997Ethinyl EstradiolSULT2A1 protein affects the metabolism of [Phosphoadenosine Phosphosulfate co-treated with Ethinyl Estradiol]15483193
D004997Ethinyl EstradiolSULT2A1 protein results in increased metabolism of Ethinyl Estradiol10623578
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SULT2A1 mRNA27818225
D004997Ethinyl EstradiolSRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of SULT2A1 mRNA]27818225
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SULT2A1 mRNA15953391|1710823
C076840ethofenprox[ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of SULT2A1 mRNA22467020
C004999ferulic acidferulic acid results in increased expression of SULT2A1 mRNA16443358
C082360fipronil[fipronil co-treated with DEET] results in increased expression of SULT2A1 mRNA27091632
D005411Flame RetardantsFlame Retardants results in decreased expression of SULT2A1 mRNA22446829
D005411Flame RetardantsFlame Retardants results in decreased expression of SULT2A1 mRNA18534652
D005419FlavonoidsFlavonoids results in increased expression of SULT2A1 mRNA18035473
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of SULT2A1 mRNA17070881
C039281furanfuran results in decreased expression of SULT2A1 mRNA25539665
D005707Gallic AcidGallic Acid results in increased activity of SULT2A1 protein16443358
D005707Gallic AcidGallic Acid results in increased expression of SULT2A1 mRNA16443358
D019833GenisteinGenistein promotes the reaction [NR1H3 protein binds to SULT2A1 promoter]23352501
D019833GenisteinGenistein results in increased expression of SULT2A1 mRNA23352501
D019833GenisteinGenistein results in increased expression of SULT2A1 protein23352501
D019833GenisteinNR1H3 protein affects the reaction [Genistein results in increased expression of SULT2A1 mRNA]23352501
D019833GenisteinNR1H3 protein affects the reaction [Genistein results in increased expression of SULT2A1 protein]23352501
C412815GW 4064GW 4064 results in decreased expression of SULT2A1 mRNA16946559
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of SULT2A1 mRNA16197558
C010178heliotrineheliotrine results in decreased expression of SULT2A1 mRNA26100227
D006533HeptachlorHeptachlor results in decreased expression of SULT2A1 mRNA9566755
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of SULT2A1 mRNA18534652
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SULT2A1 mRNA20044591
D006881HydroxyacetylaminofluoreneSULT2A1 protein results in increased sulfation of Hydroxyacetylaminofluorene10752640
D002112CalcifediolCalcifediol deficiency results in decreased expression of SULT2A1 mRNA17293106
D006914HydroxysteroidsSULT2A1 protein results in increased sulfation of Hydroxysteroids15635043
D006914HydroxysteroidsSULT2A1 protein results in increased sulfation of Hydroxysteroids23026138
C021304hyperosidehyperoside inhibits the reaction [Acetaminophen results in decreased expression of SULT2A1 mRNA]26772156
C021304hyperosidehyperoside results in increased expression of SULT2A1 mRNA26772156
C011582IMOL S-140IMOL S-140 results in decreased expression of SULT2A1 mRNA22446829
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SULT2A1 mRNA22129741
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of SULT2A1 mRNA15182950
C410337K 7174K 7174 results in decreased expression of SULT2A1 mRNA24086573
C099406L 742694L 742694 affects the expression of SULT2A1 mRNA15102944
C045463leflunomideleflunomide results in increased expression of SULT2A1 mRNA28988120
D001556LindaneLindane promotes the reaction [Colforsin results in decreased expression of SULT2A1 mRNA]17080404
D001556LindaneLindane results in decreased expression of SULT2A1 mRNA17080404
D001556LindaneLindane results in decreased expression of SULT2A1 mRNA9566755
D008044Linuron[Diethylhexyl Phthalate co-treated with Linuron] results in increased expression of SULT2A1 mRNA22277248
D008095Lithocholic Acid[Cyclosporine results in decreased activity of SULT2A1 protein] which results in increased abundance of Lithocholic Acid26198044
D008095Lithocholic AcidSULT2A1 protein results in increased sulfation of Lithocholic Acid20102295|2183983
D008095Lithocholic AcidLithocholic Acid results in increased expression of SULT2A1 mRNA12370413
D008095Lithocholic Acid[NR1I2 protein co-treated with RXRA protein] promotes the reaction [Lithocholic Acid results in increased expression of SULT2A1 mRNA]12370413
D008694MethamphetamineMethamphetamine results in increased expression of SULT2A1 mRNA23026138
D008694MethamphetamineMethamphetamine results in increased expression of SULT2A1 protein23026138
D008727MethotrexateMethotrexate results in decreased expression of SULT2A1 mRNA24449571
D008727MethotrexateMethotrexate results in increased expression of SULT2A1 mRNA17400583
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of SULT2A1 mRNA9566755
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SULT2A1 mRNA23179753
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of SULT2A1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SULT2A1 mRNA"25620056
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SULT2A1 mRNA27344345
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SULT2A1 mRNA25655198
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SULT2A1 protein28549656
D0150581-Naphthylisothiocyanatealisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of SULT2A1 mRNA]25655198
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of SULT2A1 mRNA19716841
D010100OxygenOxygen deficiency results in decreased expression of SULT2A1 mRNA19695866
D017239PaclitaxelPaclitaxel analog results in increased expression of SULT2A1 mRNA15585946
D017239PaclitaxelPaclitaxel results in increased expression of SULT2A1 mRNA15585946
D010278ParathionParathion results in increased activity of SULT2A1 protein15351727
D010278ParathionParathion results in increased expression of SULT2A1 mRNA15351727
D010278ParathionParathion results in increased expression of SULT2A1 protein15351727
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SULT2A1 mRNA17097637
D010634Phenobarbital[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of SULT2A1 mRNA14742670
D010634PhenobarbitalPhenobarbital results in increased expression of SULT2A1 mRNA15986414|2081699
D010634PhenobarbitalPhenobarbital results in increased expression of SULT2A1 protein15986414
D010634PhenobarbitalPhenobarbital results in decreased expression of SULT2A1 mRNA11328961|1916217
D010672PhenytoinPhenytoin results in decreased expression of SULT2A1 mRNA9566755
D010724Phosphoadenosine PhosphosulfateCelecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]15483193
D010724Phosphoadenosine Phosphosulfate[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol15483193
D010724Phosphoadenosine PhosphosulfateSULT2A1 protein affects the metabolism of [Phosphoadenosine Phosphosulfate co-treated with Ethinyl Estradiol]15483193
C006253pirinixic acidpirinixic acid results in increased expression of and results in increased activity of SULT2A1 protein15635043
C006253pirinixic acidpirinixic acid results in decreased expression of SULT2A1 mRNA19162173
D010936Plant Extracts[Plant Extracts results in increased activity of NR1I2 protein] which results in increased expression of SULT2A1 mRNA14742670
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the metabolism of SULT2A1 protein21913674
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]21913674
D011078Polychlorinated BiphenylsSULT2A1 protein affects the metabolism of Polychlorinated Biphenyls metabolite17112228
D011078Polychlorinated BiphenylsSULT2A1 protein results in increased sulfation of Polychlorinated Biphenyls21913674
C019536potassium bromatepotassium bromate results in increased expression of SULT2A1 mRNA23588252
D017035PravastatinPravastatin results in decreased expression of SULT2A1 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of SULT2A1 mRNA27225895
D011285Pregnenolone Carbonitrile[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of SULT2A1 mRNA12370413
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]12370413
D011285Pregnenolone Carbonitrile[Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA12370413|1237041
D011285Pregnenolone Carbonitrile[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of SULT2A1 mRNA12370413|1474267
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SULT2A1 mRNA15541768|2741311
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]12370413
D011285Pregnenolone Carbonitrile[Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA12370413|1237041
D011285Pregnenolone Carbonitrile[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of SULT2A1 mRNA12370413
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of SULT2A1 mRNA26100227
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in decreased expression of SULT2A1 mRNA17639512
D011794QuercetinQuercetin results in decreased expression of SULT2A1 mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of SULT2A1 mRNA21632981
D015474IsotretinoinIsotretinoin results in increased expression of SULT2A1 mRNA15982314
D012293RifampinRifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]12370413
D012293Rifampin[Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA12370413|1237041
D012293RifampinRifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]12370413
D012293Rifampin[Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA12370413|1237041
C488333Ro 65-7199Ro 65-7199 affects the expression of SULT2A1 mRNA14610520
C009238senkirkinesenkirkine results in decreased expression of SULT2A1 mRNA26100227
C017947sodium arsenitesodium arsenite results in decreased expression of SULT2A1 mRNA17451858
C075117squalestatin 1squalestatin 1 results in increased expression of SULT2A1 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of SULT2A1 mRNA27225895
C525422SRT1720SRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of SULT2A1 mRNA]27818225
D014284TriiodothyronineTriiodothyronine results in increased expression of SULT2A1 mRNA15953391
D013629TamoxifenTamoxifen results in increased expression of SULT2A1 protein19812351
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SULT2A1 mRNA26988606
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SULT2A1 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SULT2A1 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SULT2A1 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SULT2A1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SULT2A1 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SULT2A1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SULT2A1 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SULT2A1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SULT2A1 mRNA16054898|1817854
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SULT2A1 mRNA28943392
D013963Thyroid HormonesSULT2A1 protein affects the metabolism of Thyroid Hormones15004031
C423915TO-901317TO-901317 results in increased expression of SULT2A1 mRNA17256725
C066340tolcaponetolcapone binds to SULT2A1 protein19783845
C495469trans-3-(4'-hydroxyphenyl)-2-propenoic acidtrans-3-(4'-hydroxyphenyl)-2-propenoic acid results in increased activity of SULT2A1 protein16443358
C495469trans-3-(4'-hydroxyphenyl)-2-propenoic acidtrans-3-(4'-hydroxyphenyl)-2-propenoic acid results in increased expression of SULT2A1 mRNA16443358
D014212TretinoinTretinoin metabolite results in decreased expression of SULT2A1 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of SULT2A1 mRNA15982314
C072782tri-(2-chloroisopropyl)phosphatetri-(2-chloroisopropyl)phosphate results in decreased expression of SULT2A1 mRNA22446829
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of SULT2A1 mRNA22446829
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SULT2A1 mRNA"22446829|2617987
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in decreased expression of SULT2A1 mRNA22446829
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in decreased expression of SULT2A1 mRNA22446829
D014520UrethaneUrethane results in decreased expression of SULT2A1 mRNA28818685
D014580Ursodeoxycholic AcidSULT2A1 protein results in increased sulfation of Ursodeoxycholic Acid20102295
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of SULT2A1 protein16472600
D014810Vitamin EVitamin E results in decreased expression of SULT2A1 mRNA28923436

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004062aryl sulfotransferase activity-TAS-  
GO:0004304estrone sulfotransferase activity-TAS-  
GO:0005515protein binding-IPI21988832  25416956  
GO:0008146sulfotransferase activity-IDA19548878  20056724  
GO:0008146sulfotransferase activity-TAS-  
GO:0047704bile-salt sulfotransferase activity-IDA1588921  
GO:0050294steroid sulfotransferase activity-IDA23207770  
GO:0050294steroid sulfotransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006068ethanol catabolic process-IDA23207770  
GO:0008202steroid metabolic process-IDA1588921  23207770  
GO:0016042lipid catabolic process-IEA-  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0030573bile acid catabolic process-IEA-  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-IDA23207770  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-TAS-  
GO:0051923sulfation-IDA19548878  20056724  23207770  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156584Cytosolic sulfonation of small moleculesTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25802089Genetic variation, expression and ontogeny of sulfotransferase SULT2A1 in humans. (2015 Aug)Ekstrom LPharmacogenomics J
23197595Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)O'Shaughnessy PJMol Hum Reprod
22946908Sulfation of buprenorphine, pentazocine, and naloxone by human cytosolic sulfotransferases. (2012 Jun 1)Kurogi KDrug Metab Lett