Gene info: ID 683

Gene: BST1

GENE ID: 683

Synonyms: CD157

Description: bone marrow stromal cell antigen 1

Gene type: protein-coding

Location: 4p15.32

dbXrefs: Ensembl:ENSG00000109743 MIM:600387 Vega:OTTHUMG00000097739 UniprotKB:Q10588

RefSeq: NC_000004.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.282e-1 (AD) 8.487e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SEPT10	0.712
SLC35D2	0.702
TANC1	0.688
FAM114A1	0.685
WIPF1	0.677
CNN2	0.675
VRK2	0.672
STON1	0.671
HEY2	0.669
S100A4	0.667

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CDH22	-0.543
FAM57B	-0.521
SLC30A3	-0.521
SLC45A4	-0.518
ABCG4	-0.514
MPPED1	-0.513
GNG13	-0.512
SCRT1	-0.511
ANKRD34A	-0.511
FAM163B	-0.511

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02483	Etheno-Nad	Small Molecule		Experimental	Target
DB02701	Nicotinamide	Small Molecule	98-92-0	Approved\|Investigational	Target
DB02930	Adenosine 5'-[gamma-thio]triphosphate	Small Molecule	35094-46-3	Experimental	Target
DB03227	Nicotinamide Mononucleotide	Small Molecule		Experimental	Target
DB03732	Etheno-Nadp	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in increased expression of BST1 mRNA"	20406850
D000082	Acetaminophen	Acetaminophen results in decreased expression of BST1 mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of BST1 mRNA	17562736
D020106	Acrylamide	Acrylamide results in increased expression of BST1 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of BST1 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of BST1 mRNA	22100608
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of BST1 mRNA	16483693
D001151	Arsenic	Arsenic results in decreased expression of BST1 mRNA	19654921
C039726	artesunate	BST1 mRNA results in increased susceptibility to artesunate	20144594
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of BST1 mRNA	26377693
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of BST1 mRNA"	20382639
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of BST1 mRNA	26496021
C006780	bisphenol A	bisphenol A affects the methylation of BST1 promoter	27334623
C006780	bisphenol A	bisphenol A affects the expression of BST1 mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of BST1 mRNA	26496021
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BST1 mRNA	28628672
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of BST1 mRNA	15336504
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of BST1 mRNA	21968025
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of BST1 mRNA	28472532
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of BST1 mRNA	19320972
D003042	Cocaine	Cocaine affects the expression of BST1 mRNA	20187946
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of BST1 mRNA	15467011
C423222	cotylenin A	cotylenin A results in increased expression of BST1 mRNA	16129123
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BST1 mRNA	28628672
D003976	Diazinon	Diazinon results in decreased expression of BST1 mRNA	21968025
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of BST1 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of BST1 mRNA	27392435
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of BST1 mRNA"	27840820
D000431	Ethanol	Ethanol results in decreased expression of BST1 mRNA	15353170
C039281	furan	furan results in increased expression of BST1 mRNA	27387713
D005839	Gentamicins	Gentamicins results in increased expression of BST1 mRNA	22061828
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BST1 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BST1 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BST1 mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of BST1 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of BST1 mRNA	27392435
D008713	Methimazole	Methimazole results in increased expression of BST1 mRNA	22504374
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BST1 mRNA	23519560
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of BST1 mRNA	28001369
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of BST1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of BST1 mRNA"	25554681
D010269	Paraquat	Paraquat results in increased expression of BST1 mRNA	18198484
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of BST1 mRNA	23602845
C006253	pirinixic acid	pirinixic acid results in decreased expression of BST1 mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of BST1 mRNA	20813756
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of BST1 mRNA	22714537
D011441	Propylthiouracil	Propylthiouracil results in increased expression of BST1 mRNA	22504374
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of BST1 mRNA	23221170
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of BST1 mRNA	21602193
D012999	Soman	Soman results in increased expression of BST1 mRNA	19281266
D053260	Soot	Soot results in increased expression of BST1 mRNA	26551751
C016766	sulforafan	sulforafan results in increased expression of BST1 mRNA	26833863
D013739	Testosterone	Testosterone results in increased expression of BST1 mRNA	15788153
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BST1 mRNA	17101203
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BST1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BST1 gene]	20819909
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BST1 mRNA	20819909
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BST1 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BST1 mRNA	23519560
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BST1 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of BST1 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of BST1 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of BST1 mRNA	15289447
D014118	Toxins, Biological	"Toxins, Biological affects the expression of BST1 mRNA"	19682533
C057693	troglitazone	troglitazone results in decreased expression of BST1 mRNA	19140230
D014640	Vancomycin	Vancomycin results in decreased expression of BST1 mRNA	18930951

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003953	NAD+ nucleosidase activity	-	EXP	11866528
GO:0003953	NAD+ nucleosidase activity	-	IBA	21873635
GO:0016740	transferase activity	-	IEA	-
GO:0016849	phosphorus-oxygen lyase activity	-	IBA	21873635
GO:0050135	NAD(P)+ nucleosidase activity	-	IEA	-
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	-	IEA	-
GO:0061811	ADP-ribosyl cyclase activity	-	IDA	7805847 11866528
GO:0061812	cyclic ADP-ribose hydrolase	-	IDA	7805847 11866528

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001952	regulation of cell-matrix adhesion	-	IDA	15328157
GO:0002691	regulation of cellular extravasation	-	TAS	23576305
GO:0006959	humoral immune response	-	IC	8202488
GO:0007165	signal transduction	-	TAS	23576305
GO:0008284	positive regulation of cell proliferation	-	IDA	8202488
GO:0019674	NAD metabolic process	-	TAS	-
GO:0030890	positive regulation of B cell proliferation	-	IBA	21873635
GO:0032956	regulation of actin cytoskeleton organization	-	IDA	15328157
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0050727	regulation of inflammatory response	-	IDA	15328157
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	-	IDA	8941363
GO:0050848	regulation of calcium-mediated signaling	-	IMP	15328157
GO:0050848	regulation of calcium-mediated signaling	-	TAS	23576305
GO:0090022	regulation of neutrophil chemotaxis	-	IDA	15328157
GO:0090322	regulation of superoxide metabolic process	-	TAS	23576305
GO:2001044	regulation of integrin-mediated signaling pathway	-	TAS	23576305

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001931	uropod	-	IDA	15328157
GO:0005576	extracellular region	-	TAS	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0008305	integrin complex	colocalizes_with	IDA	15328157
GO:0019898	extrinsic component of membrane	-	IDA	8202488
GO:0031225	anchored component of membrane	-	IEA	-
GO:0035579	specific granule membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa00760	Nicotinate and nicotinamide metabolism
hsa01100	Metabolic pathways
hsa04020	Calcium signaling pathway
hsa04970	Salivary secretion
hsa04972	Pancreatic secretion

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-196807	Nicotinate metabolism	TAS
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	TAS
R-HSA-196854	Metabolism of vitamins and cofactors	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23026536	Lack of association between BST1 polymorphisms and sporadic Parkinson's disease in a Japanese population. (2012 Dec 15)	Miyake Y	J Neurol Sci