Gene info: ID 6833

Gene: ABCC8

GENE ID: 6833

Synonyms: ABC36|HHF1|HI|HRINS|MRP8|PHHI|SUR|SUR1|SUR1delta2|TNDM2

Description: ATP binding cassette subfamily C member 8

Gene type: protein-coding

Location: 11p15.1

dbXrefs: Ensembl:ENSG00000006071 MIM:600509 Vega:OTTHUMG00000166316 UniprotKB:Q09428

RefSeq: NG_008867.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : 6.437e-1 (AD) 1.250e-2 (ND) (Frontal_Cortex)

Pascal p-value : 4.136e-1 (AD) 1.360e-3 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4148646	chr11:17393643 (GRCh38.p7)	C>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PKD1	0.934
SLC26A10	0.922
CORO6	0.921
SRRM3	0.917
ZFR2	0.911
IFT172	0.911
CHRD	0.909
L3MBTL1	0.909
GGT7	0.908
TMEM145	0.907

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YES1	-0.461
RAI14	-0.46
SGMS2	-0.443
OR4F5	-0.443
ZNF114	-0.441
HEY2	-0.438
RAB13	-0.435
CNN2	-0.425
WWTR1	-0.423
SNHG18	-0.415

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00171	ATP	Small Molecule	56-65-5	Investigational\|Nutraceutical	Target
DB00222	Glimepiride	Small Molecule	93479-97-1	Approved	Target
DB00672	Chlorpropamide	Small Molecule	94-20-2	Approved\|Investigational	Target
DB00731	Nateglinide	Small Molecule	105816-04-4	Approved\|Investigational	Target
DB00912	Repaglinide	Small Molecule	135062-02-1	Approved\|Investigational	Target
DB01067	Glipizide	Small Molecule	29094-61-9	Approved\|Investigational	Target
DB01120	Gliclazide	Small Molecule	21187-98-4	Approved	Target
DB01124	Tolbutamide	Small Molecule	64-77-7	Approved\|Investigational	Target
DB01251	Gliquidone	Small Molecule	33342-05-1	Approved\|Investigational	Target
DB01252	Mitiglinide	Small Molecule	145375-43-5	Approved\|Investigational	Target
DB01382	Glycodiazine	Small Molecule	339-44-6	Approved\|Investigational	Target
DB00839	Tolazamide	Small Molecule	1156-19-0	Approved\|Investigational	Target
DB01016	Glyburide	Small Molecule	10238-21-8	Approved	Target

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ABCC8 mRNA"	21346803
C570534	7-chloro-3-(1-hydroxy-2-propyl)amino-4H-1,2,4-benzothiadiazine 1,1-dioxide	"7-chloro-3-(1-hydroxy-2-propyl)amino-4H-1,2,4-benzothiadiazine 1,1-dioxide analog affects the activity of [ABCC8 protein binds to KCNJ11 protein]"	22077416
D000082	Acetaminophen	Acetaminophen results in decreased expression of ABCC8 mRNA	15976192
D000109	Acetylcholine	ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]]	15894309
D000255	Adenosine Triphosphate	Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]	19095654
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ABCC8 mRNA	16483693
D001280	Atrazine	Atrazine results in decreased expression of ABCC8 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to ABCC8 promoter]	19654925
C035982	beryllium fluoride	beryllium fluoride results in decreased activity of ABCC8 protein	18025464
C035982	beryllium fluoride	beryllium fluoride results in decreased activity of ABCC8 protein	17561960
D004958	Estradiol	ABCC8 protein affects the susceptibility to Estradiol	19095654
D004958	Estradiol	Estradiol binds to and affects the activity of ABCC8 protein	19095654
D004958	Estradiol	ABCC8 protein mutant form results in decreased susceptibility to Estradiol	19095654
D004958	Estradiol	ABCC8 protein mutant form results in increased susceptibility to Estradiol	19095654
D004958	Estradiol	ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP3 protein]	19095654
D004958	Estradiol	ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP8 protein]	19095654
D004958	Estradiol	ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP9 protein]	19095654
D004958	Estradiol	ABCC8 protein results in increased susceptibility to Estradiol	19095654
D004958	Estradiol	Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]	19095654
D004958	Estradiol	Estradiol binds to ABCC8 protein mutant form	19095654
D004958	Estradiol	Estradiol binds to and affects the activity of ABCC8 protein	19095654
D004958	Estradiol	Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]	19095654
D004958	Estradiol	Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein mutant form]	19095654
C006780	bisphenol A	bisphenol A affects the expression of ABCC8 mRNA	23328667
C006780	bisphenol A	bisphenol A results in decreased expression of ABCC8 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ABCC8 gene	28505145
C032036	bromobenzene	bromobenzene results in decreased expression of ABCC8 mRNA	15976192
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ABCC8 mRNA	25993096
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ABCC8 mRNA	15976192
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ABCC8 protein	17544377
D002747	Chlorpropamide	[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide	22209866
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ABCC8 mRNA]	27941970
D003981	Diazoxide	Diazoxide results in increased activity of ABCC8 protein	28842488
D003981	Diazoxide	Diazoxide results in increased activity of ABCC8 protein	21428460
D002945	Cisplatin	ABCC8 mRNA affects the susceptibility to Cisplatin	18610736
D004026	Dieldrin	Dieldrin results in increased expression of ABCC8 mRNA	23041725
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of ABCC8 mRNA	21658437
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of ABCC8 mRNA	15976192
D004970	Estrone	ABCC8 protein results in increased susceptibility to Estrone	19095654
D005419	Flavonoids	Flavonoids results in increased expression of ABCC8 mRNA	18035473
C039281	furan	furan results in decreased expression of ABCC8 mRNA	25539665\|2619464
D005907	Gliclazide	[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to Gliclazide	22209866
C057619	glimepiride	[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to glimepiride	22209866
D005905	Glyburide	ABCC8 protein results in increased susceptibility to Glyburide	19095654
D005905	Glyburide	Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]	19095654
D005905	Glyburide	Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]	19095654
D005905	Glyburide	Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein mutant form]	19095654
D005905	Glyburide	Glyburide binds to ABCC8 protein	19095654
D005905	Glyburide	Glyburide binds to ABCC8 protein mutant form	19095654
D005905	Glyburide	resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein]	17138562
D005905	Glyburide	Glyburide binds to and results in decreased activity of ABCC8 protein	15652236
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABCC8 mRNA	25613284
D015122	Mercaptopurine	Mercaptopurine results in decreased expression of ABCC8 mRNA	23358152
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ABCC8 mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of ABCC8 promoter"	26251327
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of ABCC8 mRNA	16000145
D015735	Mifepristone	Mifepristone results in decreased expression of ABCC8 mRNA	17584828
C087255	mitiglinide	[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to mitiglinide	22209866
D016627	Oxidopamine	Oxidopamine results in increased expression of ABCC8 mRNA	15857625
D016627	Oxidopamine	Oxidopamine results in increased expression of ABCC8 protein	15857625
D010634	Phenobarbital	Phenobarbital results in decreased expression of ABCC8 mRNA	19162173
D010852	Picrotoxin	Picrotoxin results in decreased expression of ABCC8 mRNA	18021373
D010852	Picrotoxin	Picrotoxin results in increased expression of ABCC8 mRNA	18021373
D010852	Picrotoxin	Picrotoxin results in increased expression of ABCC8 protein	18021373
D010936	Plant Extracts	Plant Extracts results in decreased expression of ABCC8 mRNA	23557933
D028321	Plant Preparations	Plant Preparations results in decreased expression of ABCC8 mRNA	18047722
D011188	Potassium	ABCC8 protein results in increased transport of Potassium	10022826
D011188	Potassium	ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]]	15894309
C059514	resveratrol	ABCC8 protein results in increased susceptibility to resveratrol	19095654
C059514	resveratrol	resveratrol binds to ABCC8 protein	17138562
C059514	resveratrol	resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein]	17138562
C059514	resveratrol	resveratrol affects the activity of ABCC8 protein	19095654
C013672	riddelliine	riddelliine results in decreased expression of ABCC8 mRNA	18047722\|1804772
D012413	Rubidium	[KCNJ11 protein binds to ABCC8 protein] which results in increased export of Rubidium	28842488
D012413	Rubidium	[KCNJ8 protein binds to ABCC8 protein] which results in increased export of Rubidium	28842488
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of ABCC8 mRNA	25895662
D012834	Silver	Silver results in decreased expression of ABCC8 mRNA	27131904
D020123	Sirolimus	Sirolimus results in decreased expression of ABCC8 mRNA	21865292
C017947	sodium arsenite	sodium arsenite affects the methylation of ABCC8 gene	28589171
C016104	sodium bichromate	sodium bichromate results in decreased expression of ABCC8 mRNA	25993096
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of ABCC8 mRNA	27862939
D053260	Soot	Soot results in increased expression of ABCC8 mRNA	26551751
D016593	Terfenadine	Terfenadine results in decreased activity of [KCNJ11 protein binds to ABCC8 protein]	10928959
C501413	tesaglitazar	tesaglitazar results in increased expression of ABCC8 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ABCC8 mRNA]	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ABCC8 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ABCC8 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABCC8 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in decreased expression of ABCC8 mRNA	15976192\|2341159
C009495	titanium dioxide	titanium dioxide results in decreased expression of ABCC8 mRNA	23557971
D014044	Tolbutamide	ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein]	9568693
D014044	Tolbutamide	[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide	22209866
D014044	Tolbutamide	Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein]	18025464
D014044	Tolbutamide	Tolbutamide binds to and results in decreased activity of ABCC8 protein	15652236
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of ABCC8 mRNA	26898711
C057693	troglitazone	troglitazone results in decreased expression of ABCC8 mRNA	21515302
D014501	Uranium	Uranium affects the expression of ABCC8 mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of ABCC8 mRNA	15672453
C406224	valdecoxib	valdecoxib results in decreased expression of ABCC8 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in increased methylation of ABCC8 gene	29154799

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005267	potassium channel activity	CONTRIBUTES_TO	IBA	21873635
GO:0005267	potassium channel activity	-	IMP	24814349 25720052
GO:0005524	ATP binding	-	IEA	-
GO:0008281	sulfonylurea receptor activity	-	IEA	-
GO:0015272	ATP-activated inward rectifier potassium channel activity	-	TAS	-
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	-	IBA	21873635
GO:0044325	ion channel binding	-	IPI	20610380

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006813	potassium ion transport	-	IBA	21873635
GO:0006813	potassium ion transport	-	TAS	7502040
GO:0007165	signal transduction	-	IEA	-
GO:0042493	response to drug	-	IBA	21873635
GO:0050796	regulation of insulin secretion	-	TAS	-
GO:0055085	transmembrane transport	-	IBA	21873635
GO:0071805	potassium ion transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0008282	inward rectifying potassium channel	-	IBA	21873635
GO:0008282	inward rectifying potassium channel	-	IDA	20610380
GO:0016020	membrane	-	IBA	21873635
GO:0042383	sarcolemma	-	IBA	21873635

KEGG ID	KEGG Term
hsa02010	ABC transporters
hsa04930	Type II diabetes mellitus

Reactome ID	Reactome Term	Evidence
R-HSA-112316	Neuronal System	TAS
R-HSA-1296025	ATP sensitive Potassium channels	TAS
R-HSA-1296065	Inwardly rectifying K+ channels	TAS
R-HSA-1296071	Potassium Channels	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-163685	Integration of energy metabolism	TAS
R-HSA-1643685	Disease	TAS
R-HSA-422356	Regulation of insulin secretion	TAS
R-HSA-5619084	ABC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-5683177	Defective ABCC8 can cause hypoglycemias and hyperglycemias	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal