Gene: SYCP1

6847
CT8|HOM-TES-14|SCP-1|SCP1
synaptonemal complex protein 1
protein-coding
1p13.2
Ensembl:ENSG00000198765 MIM:602162 Vega:OTTHUMG00000012057 UniprotKB:Q15431
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.202e-1 (AD)  4.823e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs360595chr1:114930585 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR8H10.731
DEFB1210.729
LMX1A0.722
CRISP10.715
SPAG11B0.711
TMCO5A0.706
DEFB1160.704
OR6N10.699
MUC160.697
MIA20.696

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHATL-0.314
SORCS2-0.287
TMEM229A-0.253
SLC13A3-0.252
MOXD1-0.251
BGLAP-0.251
KIAA1755-0.25
LIFR-0.248
SMPD1-0.246
CRB2-0.242

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0212962-ethoxyethanol2-ethoxyethanol results in decreased expression of SYCP1 mRNA19643169
D000082AcetaminophenAcetaminophen results in increased expression of SYCP1 mRNA22230336
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SYCP1 mRNA16483693
D001151ArsenicArsenic affects the methylation of SYCP1 gene25304211
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SYCP1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SYCP1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SYCP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SYCP1 protein24552547
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SYCP1 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SYCP1 mRNA24982889
C062876cetrorelix[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of SYCP1 mRNA18160741
C062876cetrorelix[cetrorelix co-treated with testosterone enanthate] results in decreased expression of SYCP1 mRNA18160741
C014347decitabinedecitabine affects the expression of SYCP1 mRNA18240144
D017135Desogestrel[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of SYCP1 mRNA18160741
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SYCP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SYCP1 mRNA28628672
D015025ZearalenoneZearalenone results in increased expression of SYCP1 mRNA24412631
C043562flavoneflavone results in increased expression of SYCP1 protein14750173
D005419FlavonoidsFlavonoids results in increased expression of SYCP1 mRNA18035473
D004397FonofosFonofos results in increased methylation of SYCP1 promoter22847954
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SYCP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SYCP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SYCP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SYCP1 mRNA28628672
C025340manganese chloridemanganese chloride results in increased expression of SYCP1 mRNA15295902
C005219methyl cellosolvemethyl cellosolve results in decreased expression of SYCP1 mRNA19643169
C005219methyl cellosolvemethyl cellosolve results in increased expression of SYCP1 mRNA19643169
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SYCP1 mRNA26011545
D010278ParathionParathion results in increased methylation of SYCP1 promoter22847954
C006253pirinixic acidpirinixic acid results in increased expression of SYCP1 mRNA12832660
C009277sodium arsenatesodium arsenate results in decreased expression of SYCP1 mRNA23922661
C012568terbufosterbufos results in increased methylation of SYCP1 promoter22847954
C004648testosterone enanthate[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of SYCP1 mRNA18160741
C004648testosterone enanthate[cetrorelix co-treated with testosterone enanthate] results in decreased expression of SYCP1 mRNA18160741
D014635Valproic AcidValproic Acid results in increased expression of SYCP1 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in increased methylation of SYCP1 gene29154799
D019287Zinc SulfateZinc Sulfate results in increased expression of SYCP1 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000711meiotic DNA repair synthesis-IEA-  
GO:0007129synapsis-ISS-  
GO:0007130synaptonemal complex assembly-ISS15944401  
GO:0007131reciprocal meiotic recombination-ISS-  
GO:0007283spermatogenesis-TAS1464329  
GO:0032880regulation of protein localization-IEA-  
GO:0035092sperm chromatin condensation-IEA-  
GO:0051026chiasma assembly-IEA-  
GO:0051301cell division-IEA-  
GO:0051878lateral element assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000775chromosome, centromeric region-IEA-  
GO:0000795synaptonemal complex-ISS-  
GO:0000801central element-IEA-  
GO:0000802transverse filament-IEA-  
GO:0001673male germ cell nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal