Gene info: ID 685

Gene: BTC

GENE ID: 685

Synonyms: -

Description: betacellulin

Gene type: protein-coding

Location: 4q13.3

dbXrefs: Ensembl:ENSG00000174808 MIM:600345 Vega:OTTHUMG00000130107 UniprotKB:P35070

RefSeq: NC_000004.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.211e-1 (AD) 1.001e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HERC6	0.808
KCNT2	0.776
VPS13A	0.768
RASAL2	0.767
IFIT1	0.764
ABCA5	0.763
EXOC6	0.761
SLC16A14	0.758
CYP4X1	0.757
HDX	0.757

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
S100A1	-0.465
LRAT	-0.428
MDFI	-0.412
PLA2G5	-0.408
BCL7C	-0.405
RBP1	-0.402
ROM1	-0.395
RAB13	-0.379
MYL3	-0.375
GNA12	-0.37

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of BTC mRNA	19933214
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BTC protein results in increased expression of CCND1 protein]	19105244
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of BTC mRNA"	18648102
C041594	4-nonylphenol	ADAM10 protein affects the reaction [[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein]	28703301
C041594	4-nonylphenol	[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein	28703301
C041594	4-nonylphenol	[RHBDF2 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein	28703301
D000082	Acetaminophen	Acetaminophen results in decreased expression of BTC mRNA	26690555
D000082	Acetaminophen	Acetaminophen results in increased expression of BTC mRNA	29174983
D000082	Acetaminophen	Acetaminophen results in increased secretion of BTC protein	29174983
D000082	Acetaminophen	MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of BTC mRNA]	18700144
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of BTC mRNA	23630614
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of BTC mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of BTC gene	25304211
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of BTC mRNA	19770486\|2222880
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of BTC mRNA	26496021
C006780	bisphenol A	bisphenol A affects the expression of BTC mRNA	21786754
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of BTC mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of BTC mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of BTC gene	28505145
D002104	Cadmium	Cadmium results in decreased expression of BTC mRNA	24376830
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of BTC promoter	22457795
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of BTC mRNA	17484886
D002857	Chromium	LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of BTC mRNA]	16940432
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of BTC mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of BTC mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of BTC mRNA	19770486
D003609	Dactinomycin	Dactinomycin inhibits the reaction [BTC protein results in increased expression of ID1 mRNA]	18325989
D003609	Dactinomycin	Dactinomycin inhibits the reaction [BTC protein results in increased expression of ID3 mRNA]	18325989
D003609	Dactinomycin	Dactinomycin inhibits the reaction [BTC protein results in increased expression of ID4 mRNA]	18325989
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of BTC mRNA	28104404
D002945	Cisplatin	Cisplatin results in decreased expression of BTC mRNA	27392435
D004041	Dietary Fats	Dietary Fats results in increased expression of BTC mRNA	25016146
D006064	Gonadotropins, Equine	"[Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of BTC mRNA"	15831568
D006118	Griseofulvin	Griseofulvin results in increased expression of BTC protein	19267999
D006063	Chorionic Gonadotropin	"[Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of BTC mRNA"	15831568
D017313	Fenretinide	Fenretinide results in decreased expression of BTC mRNA	28973697
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BTC mRNA	25613284
D048628	Ketolides	Ketolides analog results in increased expression of BTC mRNA	24967691
D009525	Niacin	LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of BTC mRNA]	16940432
D009532	Nickel	Nickel results in decreased expression of BTC mRNA	24768652\|2558310
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of BTC mRNA	23892564
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of BTC mRNA	23608068
C045950	propiconazole	propiconazole results in increased expression of BTC mRNA	21278054
D011524	Protoporphyrins	Protoporphyrins results in increased expression of BTC protein	19267999
D012172	Retinaldehyde	Retinaldehyde results in decreased expression of BTC mRNA	16470170
D012834	Silver	Silver results in increased expression of BTC mRNA	27131904
D020123	Sirolimus	Sirolimus inhibits the reaction [BTC protein affects the localization of CDKN1A protein]	19105244
D020123	Sirolimus	Sirolimus inhibits the reaction [BTC protein affects the localization of CDKN1B protein]	19105244
D020123	Sirolimus	Sirolimus inhibits the reaction [BTC protein results in increased expression of CCND1 protein]	19105244
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BTC mRNA	19933214
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BTC mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of BTC mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in increased expression of BTC mRNA	23557971
D014212	Tretinoin	Tretinoin results in decreased expression of BTC mRNA	16470170
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of BTC gene	27618143
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of BTC mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BTC mRNA"	26179874
C113580	U 0126	U 0126 inhibits the reaction [BTC protein results in increased expression of CCND1 protein]	19105244
D014635	Valproic Acid	Valproic Acid affects the expression of BTC mRNA	17963808

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005154	epidermal growth factor receptor binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	19740107 25416956 25910212 26871637
GO:0008083	growth factor activity	-	IBA	21873635
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0007173	epidermal growth factor receptor signaling pathway	-	IBA	21873635
GO:0008284	positive regulation of cell proliferation	-	IBA	21873635
GO:0008284	positive regulation of cell proliferation	-	TAS	8144591
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0035810	positive regulation of urine volume	-	IEA	-
GO:0038128	ERBB2 signaling pathway	-	TAS	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0045597	positive regulation of cell differentiation	-	IEA	-
GO:0045840	positive regulation of mitotic nuclear division	-	IEA	-
GO:0046854	phosphatidylinositol phosphorylation	-	IEA	-
GO:0048146	positive regulation of fibroblast proliferation	-	IEA	-
GO:0051781	positive regulation of cell division	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	TAS	-
GO:2000145	regulation of cell motility	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005622	intracellular	-	IEA	-
GO:0005886	plasma membrane	-	IEA	-
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04012	ErbB signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1227986	Signaling by ERBB2	TAS
R-HSA-1227986	Signaling by ERBB2	IEA
R-HSA-1236394	Signaling by ERBB4	TAS
R-HSA-1236394	Signaling by ERBB4	IEA
R-HSA-1250196	SHC1 events in ERBB2 signaling	IEA
R-HSA-1250196	SHC1 events in ERBB2 signaling	TAS
R-HSA-1250342	PI3K events in ERBB4 signaling	TAS
R-HSA-1250347	SHC1 events in ERBB4 signaling	TAS
R-HSA-1251985	Nuclear signaling by ERBB4	IEA
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-1963640	GRB2 events in ERBB2 signaling	TAS
R-HSA-1963642	PI3K events in ERBB2 signaling	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6785631	ERBB2 Regulates Cell Motility	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-8847993	ERBB2 Activates PTK6 Signaling	TAS
R-HSA-8848021	Signaling by PTK6	TAS
R-HSA-8863795	Downregulation of ERBB2 signaling	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16393673	Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. (2006 Feb)	de Boer WI	Am J Clin Pathol
24077614	Substrate selectivity of high-activity mutants of human butyrylcholinesterase. (2013 Nov 21)	Hou S	Org Biomol Chem
20060817	Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine. (2010 Sep 6)	Yang W	Chem Biol Interact
25217982	Essential role of polymorphism of Gab1, EGFR, and EGF for the susceptibility of biliary tract cancer. (2014 Dec)	Meng LQ	Tumour Biol