Gene info: ID 6850

Gene: SYK

GENE ID: 6850

Synonyms: p72-Syk

Description: spleen associated tyrosine kinase

Gene type: protein-coding

Location: 9q22.2

dbXrefs: Ensembl:ENSG00000165025 MIM:600085 Vega:OTTHUMG00000020200 UniprotKB:P43405

RefSeq: NG_017046.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.999e-1 (AD) 8.281e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2042984	chr9:90810813 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NCKAP1L	0.959
TBXAS1	0.959
APBB1IP	0.953
IRF8	0.951
PTPRC	0.945
DOCK2	0.943
CD37	0.941
BTK	0.94
IL18	0.939
ADAM28	0.933

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP2C2	-0.447
MAGIX	-0.443
KCNIP3	-0.424
ASPDH	-0.418
KREMEN2	-0.41
CHRNA4	-0.406
ZSCAN1	-0.405
WNT7A	-0.403
HAGHL	-0.397
HAS1	-0.395

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02010	Staurosporine	Small Molecule	62996-74-1	Experimental	Target
DB06834	N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide	Small Molecule		Experimental	Target
DB07159	6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one	Small Molecule		Experimental	Target
DB07194	2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide	Small Molecule		Experimental	Target
DB08361	2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide	Small Molecule		Experimental	Target
DB08846	Ellagic Acid	Small Molecule	476-66-4	Investigational	Target

ID	Drug Name	Action	PubMed
C569670	1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one	"1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one results in decreased activity of SYK protein"	21981714
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of SYK mRNA"	21346803
C041525	3,3',4,5'-tetrahydroxystilbene	"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [arsenic trioxide results in increased phosphorylation of SYK protein]"	19925860
C041525	3,3',4,5'-tetrahydroxystilbene	"[3,3',4,5'-tetrahydroxystilbene results in decreased activity of SYK protein] which results in decreased abundance of phosphatidylinositol 3,4,5-triphosphate"	12606772
C041525	3,3',4,5'-tetrahydroxystilbene	"3,3',4,5'-tetrahydroxystilbene results in decreased activity of SYK protein"	12444159\|1617801
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl affects the expression of SYK mRNA"	20638727
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of SYK mRNA	25064622
D000082	Acetaminophen	Acetaminophen affects the expression of SYK mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of SYK gene	27153756
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of SYK mRNA"	23195993
D000638	Amiodarone	Amiodarone affects the expression of SYK mRNA	25064622
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SYK mRNA	16483693
D000941	Antigens	Antigens results in increased phosphorylation of and results in increased activity of SYK protein	21958720
D000941	Antigens	Quinoxalines analog inhibits the reaction [Antigens results in increased phosphorylation of and results in increased activity of SYK protein]	21958720
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SYK mRNA	24449571
D047310	Apigenin	Apigenin results in decreased activity of SYK protein	19814731
C006632	arsenic trioxide	"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [arsenic trioxide results in increased phosphorylation of SYK protein]"	19925860
C006632	arsenic trioxide	arsenic trioxide results in increased expression of SYK mRNA	20458559
C006632	arsenic trioxide	arsenic trioxide results in increased phosphorylation of SYK protein	19925860
C015001	arsenite	arsenite results in decreased expression of SYK mRNA	18191166
C012768	benzanthrone	benzanthrone results in increased phosphorylation of SYK protein	28495615
C012768	benzanthrone	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [benzanthrone results in increased phosphorylation of SYK protein]	28495615
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in increased expression of SYK mRNA	26314263
D047071	beta-Glucans	beta-Glucans results in increased phosphorylation of SYK protein	17572156
C004541	biochanin A	biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of SYK protein]	22387535
C006780	bisphenol A	bisphenol A results in decreased expression of SYK mRNA	25912373
C006780	bisphenol A	bisphenol A results in decreased expression of SYK mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of SYK mRNA	26314263
C117446	cangrelor	[cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased phosphorylation of SYK protein	12606772
D002746	Chlorpromazine	Chlorpromazine affects the expression of SYK mRNA	25064622
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SYK mRNA	26314263
D003300	Copper	Copper inhibits the reaction [APP protein modified form results in increased phosphorylation of SYK protein]	27122238
D003314	Corn Oil	Corn Oil results in increased expression of SYK mRNA	23409006
D003471	Cuprizone	Cuprizone results in increased expression of SYK mRNA	27523638
C038459	curdlan	curdlan results in decreased expression of SYK protein	24821724
D016572	Cyclosporine	Cyclosporine affects the expression of SYK mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in decreased expression of SYK mRNA	20106945
C014347	decitabine	decitabine affects the expression of SYK mRNA	17145863
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of SYK mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of SYK mRNA	27392435
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of SYK mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in increased expression of SYK mRNA	23409006
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of SYK mRNA	26924002
C034638	dinitrophenyl-bovine serum albumin	dinitrophenyl-bovine serum albumin results in increased expression of SYK protein	7730640
D004365	Drugs, Chinese Herbal	"[Drugs, Chinese Herbal co-treated with niuhuang] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SYK protein]"	23256447
D004365	Drugs, Chinese Herbal	"[Drugs, Chinese Herbal co-treated with niuhuang] results in decreased activity of SYK protein"	23256447
C118739	entinostat	entinostat results in increased expression of SYK mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
D000431	Ethanol	Ethanol results in decreased expression of SYK mRNA	17920746
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of SYK mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SYK mRNA	17557909
C507035	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [benzanthrone results in increased phosphorylation of SYK protein]	28495615
D005419	Flavonoids	Flavonoids results in increased expression of SYK mRNA	18035473
D019833	Genistein	Genistein inhibits the reaction [CXCL8 protein results in increased phosphorylation of SYK protein]	22387535
D017313	Fenretinide	Fenretinide results in decreased expression of SYK mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased phosphorylation of SYK protein	17656488
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SYK mRNA	25613284
D007545	Isoproterenol	Isoproterenol results in increased expression of SYK mRNA	20003209
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of SYK mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SYK mRNA	22802445\|2479639
D008043	Linseed Oil	Linseed Oil results in increased expression of SYK mRNA	23409006
D008070	Lipopolysaccharides	"[Drugs, Chinese Herbal co-treated with niuhuang] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SYK protein]"	23256447
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased activity of and results in increased phosphorylation of SYK protein	23735482
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased activity of SYK protein	24486434
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SYK mRNA	10975854
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of SYK protein	23256447
D008070	Lipopolysaccharides	Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased phosphorylation of SYK protein]	23735482
D017997	Leukotriene C4	SYK protein promotes the reaction [Peptidoglycan results in increased metabolism of Leukotriene C4]	17030235
D017997	Leukotriene C4	SYK protein promotes the reaction [Zymosan results in increased metabolism of Leukotriene C4]	17030235
D008627	Mercuric Chloride	Mercuric Chloride promotes the reaction [CD22 protein results in increased phosphorylation of SYK protein]	17656488
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of SYK mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SYK mRNA	23649840
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of SYK mRNA	26924002
C510788	N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine	"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in decreased activity of SYK protein"	16339999\|2548728
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of SYK mRNA	19812364
D009532	Nickel	Nickel results in decreased expression of SYK mRNA	23195993
D009532	Nickel	Nickel results in increased expression of SYK mRNA	25583101
C028007	nickel monoxide	nickel monoxide results in increased expression of SYK mRNA	19167457
D005996	Nitroglycerin	Nitroglycerin results in increased expression of SYK mRNA	12102619
C570000	niuhuang	"[Drugs, Chinese Herbal co-treated with niuhuang] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SYK protein]"	23256447
C570000	niuhuang	"[Drugs, Chinese Herbal co-treated with niuhuang] results in decreased activity of SYK protein"	23256447
C025589	ochratoxin A	ochratoxin A metabolite results in increased expression of SYK mRNA	26314263
C025589	ochratoxin A	ochratoxin A results in increased expression of SYK mRNA	26314263
C507134	ON 01910	ON 01910 results in increased phosphorylation of SYK protein	25472472
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of SYK mRNA	26272509
D010269	Paraquat	Paraquat affects the expression of SYK mRNA	25064622
D010457	Peptidoglycan	SYK protein promotes the reaction [Peptidoglycan results in increased metabolism of Leukotriene C4]	17030235
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of SYK mRNA	16221955
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SYK mRNA	26272509
C060974	phosphatidylinositol 3,4,5-triphosphate	"[3,3',4,5'-tetrahydroxystilbene results in decreased activity of SYK protein] which results in decreased abundance of phosphatidylinositol 3,4,5-triphosphate"	12606772
C006253	pirinixic acid	pirinixic acid results in decreased expression of SYK mRNA	17426115
D010936	Plant Extracts	Plant Extracts results in decreased phosphorylation of SYK protein	24832111
D010936	Plant Extracts	Plant Extracts results in increased expression of SYK mRNA	23557933
D011794	Quercetin	Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased phosphorylation of SYK protein]	23735482
D011794	Quercetin	Quercetin results in decreased activity of SYK protein	19814731
D011810	Quinoxalines	Quinoxalines analog inhibits the reaction [Antigens results in increased phosphorylation of and results in increased activity of SYK protein]	21958720
C059514	resveratrol	resveratrol inhibits the reaction [COL1A1 protein promotes the reaction [PTPN11 protein binds to SYK protein]]	26482867
C059514	resveratrol	resveratrol inhibits the reaction [COL1A1 protein results in increased phosphorylation of SYK protein]	26482867
C059514	resveratrol	resveratrol results in decreased phosphorylation of SYK protein	24832111
C059514	resveratrol	resveratrol results in decreased phosphorylation of and results in decreased activity of SYK protein	23514766
C059514	resveratrol	resveratrol results in decreased phosphorylation of and results in decreased activity of SYK protein	23514766
C410733	scriptaid	scriptaid affects the expression of SYK mRNA	18813790
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of SYK mRNA	19073995
C080613	spiraeoside	spiraeoside results in decreased phosphorylation of SYK protein	15613018
D013752	Tetracycline	Tetracycline affects the expression of SYK mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SYK mRNA	25613284
D013853	Thioacetamide	Thioacetamide affects the expression of SYK mRNA	25064622
D014212	Tretinoin	Tretinoin results in decreased expression of SYK mRNA	23724009
D014212	Tretinoin	Tretinoin results in decreased expression of SYK mRNA	20488242
C011559	tributyltin	tributyltin results in increased expression of SYK mRNA	26314263
D014635	Valproic Acid	Valproic Acid affects the expression of SYK mRNA	25064622
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYK mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of SYK mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SYK mRNA	23179753\|2352703
D015034	Zinc Oxide	[Zinc Oxide analog co-treated with OVAL protein] results in increased phosphorylation of SYK protein	25127755
D015054	Zymosan	SYK protein promotes the reaction [Zymosan results in increased metabolism of Leukotriene C4]	17030235
D015054	Zymosan	[CLEC7A protein binds to Zymosan] which results in increased expression of SYK protein modified form	15845454
D015054	Zymosan	SYK gene mutant form inhibits the reaction [Zymosan results in increased expression of IL10 protein]	15845454
D015054	Zymosan	SYK gene mutant form inhibits the reaction [Zymosan results in increased expression of IL2 protein]	15845454
D015054	Zymosan	SYK protein promotes the reaction [Zymosan results in increased activity of MAPK1 protein]	17458858
D015054	Zymosan	SYK protein promotes the reaction [Zymosan results in increased activity of MAPK3 protein]	17458858

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001784	phosphotyrosine residue binding	-	IMP	12051764
GO:0001784	phosphotyrosine residue binding	-	IPI	12051764 20624904
GO:0004672	protein kinase activity	-	IDA	18818202
GO:0004672	protein kinase activity	-	NAS	12885943
GO:0004674	protein serine/threonine kinase activity	-	IDA	23071339
GO:0004713	protein tyrosine kinase activity	-	EXP	8629002 8657103 10648173 17993265 18818202 22041900
GO:0004713	protein tyrosine kinase activity	-	NAS	28386764
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IDA	8163536
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	TAS	-
GO:0005178	integrin binding	-	IPI	12885943
GO:0005515	protein binding	-	IPI	7761456 8621719 8627166 8647200 8657103 8798676 8810294 9280292 9698567 11940607 15536084 15556646 16273093 18273061 19843936 20133729 20585042 20713593 21044950 21516116 22019427 22624718 23001182 23299888 24525236 24728074 25416956 25605870 25814554
GO:0005524	ATP binding	-	IEA	-
GO:0019901	protein kinase binding	-	IEA	-
GO:0019902	phosphatase binding	-	IEA	-
GO:0035325	Toll-like receptor binding	-	IEA	-
GO:0042169	SH2 domain binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001525	angiogenesis	-	IEA	-
GO:0001945	lymph vessel development	-	ISS	-
GO:0002092	positive regulation of receptor internalization	-	IEA	-
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	-
GO:0002250	adaptive immune response	-	IBA	21873635
GO:0002250	adaptive immune response	-	ISS	-
GO:0002281	macrophage activation involved in immune response	-	IBA	21873635
GO:0002281	macrophage activation involved in immune response	-	ISS	-
GO:0002283	neutrophil activation involved in immune response	-	IBA	21873635
GO:0002283	neutrophil activation involved in immune response	-	ISS	-
GO:0002366	leukocyte activation involved in immune response	-	ISS	-
GO:0002554	serotonin secretion by platelet	-	ISS	-
GO:0006468	protein phosphorylation	-	IDA	17681949
GO:0006468	protein phosphorylation	-	ISS	-
GO:0006606	protein import into nucleus	-	IMP	23071339
GO:0007159	leukocyte cell-cell adhesion	-	IDA	12885943
GO:0007229	integrin-mediated signaling pathway	-	ISS	-
GO:0007229	integrin-mediated signaling pathway	-	NAS	12885943
GO:0007257	activation of JUN kinase activity	-	IEA	-
GO:0008283	cell proliferation	-	TAS	10963601
GO:0009887	animal organ morphogenesis	-	TAS	7477352
GO:0010543	regulation of platelet activation	-	ISS	-
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	-	IMP	19151749
GO:0016032	viral process	-	IEA	-
GO:0018105	peptidyl-serine phosphorylation	-	IEA	-
GO:0019370	leukotriene biosynthetic process	-	IEA	-
GO:0030168	platelet activation	-	TAS	-
GO:0030593	neutrophil chemotaxis	-	IDA	12885943
GO:0031623	receptor internalization	-	ISS	-
GO:0032481	positive regulation of type I interferon production	-	IEA	-
GO:0032753	positive regulation of interleukin-4 production	-	ISS	-
GO:0032928	regulation of superoxide anion generation	-	ISS	-
GO:0033630	positive regulation of cell adhesion mediated by integrin	-	IBA	21873635
GO:0033630	positive regulation of cell adhesion mediated by integrin	-	ISS	-
GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	-	IEA	-
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	-
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	-
GO:0038110	interleukin-2-mediated signaling pathway	-	TAS	-
GO:0038156	interleukin-3-mediated signaling pathway	-	ISS	-
GO:0042742	defense response to bacterium	-	ISS	-
GO:0043306	positive regulation of mast cell degranulation	-	IBA	21873635
GO:0043313	regulation of neutrophil degranulation	-	ISS	-
GO:0043366	beta selection	-	IEA	-
GO:0045087	innate immune response	-	ISS	-
GO:0045401	positive regulation of interleukin-3 biosynthetic process	-	IEA	-
GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process	-	IEA	-
GO:0045579	positive regulation of B cell differentiation	-	IBA	21873635
GO:0045579	positive regulation of B cell differentiation	-	IMP	18369315
GO:0045588	positive regulation of gamma-delta T cell differentiation	-	IEA	-
GO:0045780	positive regulation of bone resorption	-	ISS	-
GO:0046638	positive regulation of alpha-beta T cell differentiation	-	IEA	-
GO:0046641	positive regulation of alpha-beta T cell proliferation	-	IBA	21873635
GO:0048514	blood vessel morphogenesis	-	ISS	-
GO:0050715	positive regulation of cytokine secretion	-	IEA	-
GO:0050764	regulation of phagocytosis	-	ISS	-
GO:0050850	positive regulation of calcium-mediated signaling	-	IEA	-
GO:0050853	B cell receptor signaling pathway	-	IBA	21873635
GO:0050853	B cell receptor signaling pathway	-	ISS	-
GO:0051090	regulation of DNA-binding transcription factor activity	-	IMP	23071339
GO:0070372	regulation of ERK1 and ERK2 cascade	-	ISS	-
GO:0071226	cellular response to molecule of fungal origin	-	ISS	-
GO:0071404	cellular response to low-density lipoprotein particle stimulus	-	ISS	-
GO:0090237	regulation of arachidonic acid secretion	-	ISS	-
GO:0090330	regulation of platelet aggregation	-	IBA	21873635
GO:0090330	regulation of platelet aggregation	-	ISS	-
GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	23071339
GO:0005737	cytoplasm	-	IDA	23071339
GO:0005829	cytosol	-	IC	8163536
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0019815	B cell receptor complex	-	IEA	-
GO:0032009	early phagosome	-	ISS	-
GO:0032991	protein-containing complex	-	IDA	23071339
GO:0042101	T cell receptor complex	-	IDA	8176201

KEGG ID	KEGG Term
hsa04380	Osteoclast differentiation
hsa04650	Natural killer cell mediated cytotoxicity
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-109582	Hemostasis	IEA
R-HSA-114604	GPVI-mediated activation cascade	TAS
R-HSA-114604	GPVI-mediated activation cascade	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	IEA
R-HSA-2029481	FCGR activation	TAS
R-HSA-2029481	FCGR activation	IEA
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	TAS
R-HSA-2029485	Role of phospholipids in phagocytosis	TAS
R-HSA-2172127	DAP12 interactions	TAS
R-HSA-2424491	DAP12 signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	IEA
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	TAS
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	IEA
R-HSA-2871796	FCERI mediated MAPK activation	TAS
R-HSA-2871809	FCERI mediated Ca+2 mobilization	IEA
R-HSA-2871809	FCERI mediated Ca+2 mobilization	TAS
R-HSA-354192	Integrin alphaIIb beta3 signaling	TAS
R-HSA-449147	Signaling by Interleukins	IEA
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-451927	Interleukin-2 family signaling	TAS
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	IEA
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	IEA
R-HSA-5621480	Dectin-2 family	TAS
R-HSA-5621480	Dectin-2 family	IEA
R-HSA-5621481	C-type lectin receptors (CLRs)	IEA
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	IEA
R-HSA-76009	Platelet Aggregation (Plug Formation)	TAS
R-HSA-9006921	Integrin signaling	TAS
R-HSA-9020558	Interleukin-2 signaling	TAS
R-HSA-912631	Regulation of signaling by CBL	IEA
R-HSA-912631	Regulation of signaling by CBL	TAS
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	TAS
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29286114	Cigarette smoke-induced EGFR activation promotes epithelial mesenchymal migration of human retinal pigment epithelial cells through regulation of the FAK-mediated Syk/Src pathway. (2018 Mar)	Park GB	Mol Med Rep
25921550	Associations between polymorphisms in the SYK promoter and susceptibility to sporadic colorectal cancer in a Southern Han Chinese population - a short report. (2015 Apr)	Peng H	Cell Oncol (Dordr)
29197760	Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors. (2018 Feb)	Callahan CL	Environ Res