Gene: SYN1

6853
SYN1a|SYN1b|SYNI
synapsin I
protein-coding
Xp11.3-p11.23
Ensembl:ENSG00000008056 MIM:313440 Vega:OTTHUMG00000021454 UniprotKB:P17600
NG_008437.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNM10.975
GPI0.961
SSBP30.959
SCAMP50.957
EEF1A20.957
CLIP30.957
PRKAR1B0.957
STX1B0.955
GSK3A0.954
FAIM20.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.653
OR4F29-0.62
TFPI2-0.444
REST-0.431
RAI14-0.429
SH2D1A-0.411
ARHGEF5-0.397
MBNL3-0.397
WWTR1-0.392
SNHG18-0.387

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02930Adenosine 5'-[gamma-thio]triphosphateSmall Molecule35094-46-3ExperimentalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SYN1 mRNA"19114083
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SYN1 mRNA"15215175
D000082AcetaminophenAcetaminophen results in decreased expression of SYN1 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of SYN1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SYN1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SYN1 mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 mRNA]28153600
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SYN1 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased phosphorylation of SYN1 protein"20224926
C041524aluminum sulfatealuminum sulfate results in decreased expression of SYN1 mRNA15961160
D0157614-AminopyridineSYN1 protein affects the susceptibility to 4-Aminopyridine22759588
D0157614-AminopyridineSYN1 results in increased susceptibility to 4-Aminopyridine28132918
D0157614-Aminopyridine4-Aminopyridine results in increased expression of SYN1 protein modified form28132918
D0157614-Aminopyridineciproxifan inhibits the reaction [4-Aminopyridine results in increased expression of SYN1 protein modified form]28132918
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SYN1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SYN1 mRNA24449571
C006780bisphenol Abisphenol A results in decreased expression of SYN1 protein23490186|2352374
C006780bisphenol Abisphenol A results in decreased expression of SYN1 mRNA25181051
C006780bisphenol Abisphenol A results in decreased phosphorylation of SYN1 protein20399245
C013418bromfenacoumbromfenacoum results in decreased expression of SYN1 protein28903499
D0200011-Butanol1-Butanol inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]18004999
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of SYN1 mRNA15878706
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SYN1 mRNA19840844
D002220CarbamazepineCarbamazepine results in decreased expression of SYN1 mRNA27413119
C024714caryophyllenecaryophyllene results in increased expression of SYN1 protein27871898
C024714caryophyllenestaurosporine aglycone inhibits the reaction [caryophyllene results in increased expression of SYN1 protein]27871898
C115705ciproxifanciproxifan inhibits the reaction [4-Aminopyridine results in increased expression of SYN1 protein modified form]28132918
D019343Citric Acid[Citric Acid co-treated with Silver analog] results in decreased expression of SYN1 protein25447321
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SYN1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of SYN1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SYN1 mRNA]17585979
D003042CocaineSYN1 protein affects the reaction [Cocaine results in increased secretion of Dopamine]16554471
D003042CocaineCocaine affects the expression of SYN1 mRNA20187946
D003042CocaineCocaine results in increased expression of SYN1 protein19629758
D003042CocaineILK mutant form inhibits the reaction [Cocaine results in increased expression of SYN1 protein]19629758
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SYN1 mRNA23640034
D003907DexamethasoneDexamethasone results in decreased expression of SYN1 mRNA29111458
C000944dicrotophosdicrotophos results in increased expression of SYN1 mRNA28302478
D004298DopamineSYN1 protein affects the reaction [Cocaine results in increased secretion of Dopamine]16554471
D000431EthanolEthanol results in decreased expression of SYN1 mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SYN1 mRNA17108234
C540355fenamidonefenamidone results in decreased expression of SYN1 mRNA27029645
D005473FluoxetineFluoxetine results in increased expression of SYN1 mRNA16887358
C069837fullerene C60fullerene C60 results in decreased expression of SYN1 mRNA19167457
D019833GenisteinGenistein results in increased expression of SYN1 mRNA21782745
D005978GlutathioneGlutathione inhibits the reaction [Particulate Matter results in decreased expression of SYN1 mRNA]28153600
C055957hispidulinSYN1 protein affects the susceptibility to hispidulin22759588
D017313FenretinideFenretinide results in decreased expression of SYN1 mRNA28973697
C503753Indolinone AIndolinone A results in increased expression of SYN1 mRNA15712243
D015759IonomycinSYN1 protein affects the susceptibility to Ionomycin22759588
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SYN1 mRNA24796395
C063302KN 62KN 62 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]18004999
D007854LeadLead affects the expression of SYN1 mRNA28903495
D007854LeadLead results in decreased phosphorylation of SYN1 protein22345308
C008261lead acetatelead acetate results in increased expression of SYN1 mRNA24260418
C008261lead acetatelead acetate results in decreased expression of SYN1 protein17047031
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SYN1 mRNA21641980
D008345ManganeseManganese results in increased phosphorylation of SYN1 protein20224926
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SYN1 mRNA28001369
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SYN1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SYN1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SYN1 mRNA19840844
D008874MidazolamMidazolam results in decreased expression of SYN1 protein21920406
C005238mipafoxmipafox results in decreased expression of SYN1 protein27939611
D009118MuscimolMuscimol results in decreased expression of SYN1 protein21920406
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SYN1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of SYN1 mRNA19167457
D009569Nitric OxideNitric Oxide deficiency results in increased expression of SYN1 mRNA15878706
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of SYN1 mRNA27935865
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SYN1 mRNA19840844
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of SYN1 mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SYN1 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SYN1 mRNA]"21673326
D010261ParaoxonParaoxon results in decreased expression of SYN1 protein27939611
D010269ParaquatParaquat results in decreased expression of SYN1 protein24521700
D052638Particulate MatterAcetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 mRNA]28153600
D052638Particulate MatterGlutathione inhibits the reaction [Particulate Matter results in decreased expression of SYN1 mRNA]28153600
D052638Particulate MatterParticulate Matter results in decreased expression of SYN1 mRNA25816123|2815360
C015421pentachloroanisolepentachloroanisole results in increased expression of SYN1 mRNA25463847
D010416PentachlorophenolPentachlorophenol results in increased expression of SYN1 mRNA25463847
D010416PentachlorophenolPentachlorophenol results in increased expression of SYN1 mRNA19082768
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SYN1 protein20937303
D010634PhenobarbitalPhenobarbital affects the expression of SYN1 mRNA19136022
D010672PhenytoinPhenytoin results in decreased expression of SYN1 mRNA27413119
D010672PhenytoinThyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA]27413119
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of SYN1 mRNA27935865
C006253pirinixic acidNCF1 protein inhibits the reaction [pirinixic acid results in decreased expression of SYN1 mRNA]17950772
C006253pirinixic acidpirinixic acid affects the expression of SYN1 mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of SYN1 mRNA17950772
D010936Plant ExtractsPlant Extracts results in decreased expression of SYN1 mRNA23557933
D011189Potassium Chloride1-Butanol inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]18004999
D011189Potassium ChlorideCAMK2D protein affects the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]18004999
D011189Potassium ChlorideKN 62 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]18004999
D011189Potassium ChloridePLD2 protein affects the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]18004999
D011189Potassium ChloridePotassium Chloride results in increased expression of SYN1 mRNA18004999
D011189Potassium ChloridePotassium Chloride results in increased expression of SYN1 protein18004999
D011189Potassium ChlorideU 0126 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]18004999
D011189Potassium ChlorideU 0126 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 protein]18004999
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SYN1 mRNA27413119
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SYN1 mRNA22698814
D011441PropylthiouracilPropylthiouracil results in decreased expression of SYN1 mRNA27413119
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of SYN1 mRNA21427059
D012834SilverSilver results in increased expression of SYN1 mRNA27131904
D012834Silver[Citric Acid co-treated with Silver analog] results in decreased expression of SYN1 protein25447321
D012834SilverSilver results in decreased expression of SYN1 protein25447321
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [caryophyllene results in increased expression of SYN1 protein]27871898
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [NGF protein results in increased expression of SYN1 protein]27871898
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SYN1 mRNA21641980
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SYN1 mRNA19840844
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of SYN1 protein"25852303
D013974ThyroxineThyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA]27413119
D024505TocopherolsTocopherols results in increased expression of SYN1 mRNA17654050
D014236TrichlorfonTrichlorfon results in decreased expression of SYN1 protein27939611
C113580U 0126U 0126 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]18004999
C113580U 0126U 0126 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 protein]18004999
D014635Valproic AcidValproic Acid results in increased methylation of SYN1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SYN1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SYN1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SYN1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005215transporter activity-TAS2110562  
GO:0005515protein binding-IPI22163275  
GO:0005524ATP binding-TAS15217342  
GO:0019901protein kinase binding-ISS-  
GO:0048306calcium-dependent protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007268chemical synaptic transmission-TAS2110562  
GO:0007269neurotransmitter secretion-IBA21873635  
GO:0007269neurotransmitter secretion-IEA-  
GO:0046928regulation of neurotransmitter secretion-TAS21563316  
GO:0097091synaptic vesicle clustering-IEA-  
GO:2000300regulation of synaptic vesicle exocytosis-NAS10099709  
GO ID GO Term Qualifier Evidence PubMed
GO:0000795synaptonemal complex-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-IEA-  
GO:0005856cytoskeleton-IDA24327345  
GO:0008021synaptic vesicle-TAS16141272  
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0030424axon-IEA-  
GO:0030425dendrite-IEA-  
GO:0030672synaptic vesicle membrane-IBA21873635  
GO:0043209myelin sheath-IEA-  
GO:0048786presynaptic active zone-IEA-  
GO:0098993anchored component of synaptic vesicle membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181429Serotonin Neurotransmitter Release CycleTAS
R-HSA-212676Dopamine Neurotransmitter Release CycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29744169Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents. (2016 Dec)Heikkinen AMClin Exp Dent Res