Gene info: ID 6855

Gene: SYP

GENE ID: 6855

Synonyms: MRX96|MRXSYP

Description: synaptophysin

Gene type: protein-coding

Location: Xp11.23

dbXrefs: Ensembl:ENSG00000102003 MIM:313475 Vega:OTTHUMG00000034557 UniprotKB:P08247

RefSeq: NG_012532.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SULT4A1	0.986
RAB3A	0.982
SV2A	0.98
GNG3	0.978
RTN1	0.977
CLSTN3	0.977
GOT1	0.976
ENO2	0.976
ACOT7	0.974
ATP1A3	0.973

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
REST	-0.557
OR4F5	-0.533
WWTR1	-0.53
YES1	-0.524
TFPI2	-0.522
RAI14	-0.519
RNF135	-0.517
CNN2	-0.513
CLEC2B	-0.503
HEY2	-0.502

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of SYP protein"	26480858
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased degradation of SYP protein]	18487452
C120227	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of SYP mRNA"	20865013
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of SYP protein"	26480858
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of SYP protein"	26480858
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of SYP protein"	26480858
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of SYP protein"	26480858
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of SYP mRNA	12419474
C106538	abacavir	abacavir results in increased expression of SYP protein	19358275
D000082	Acetaminophen	Acetaminophen results in increased expression of SYP mRNA	29067470
D019342	Acetic Acid	Acetic Acid results in decreased expression of SYP protein	21296659
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of SYP protein]	28499986
D020106	Acrylamide	Acrylamide results in increased expression of SYP protein	15864552
C041524	aluminum sulfate	aluminum sulfate results in decreased expression of SYP mRNA	15961160
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SYP mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in decreased expression of SYP protein	11368965
C053442	annonacin	annonacin results in decreased expression of SYP protein	27569447
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of SYP protein	15255259
D001280	Atrazine	Atrazine results in increased expression of SYP mRNA	22378314
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [AGT protein results in increased degradation of SYP protein]	18487452
C006780	bisphenol A	bisphenol A results in decreased expression of SYP protein	28089772
C006780	bisphenol A	bisphenol A results in increased expression of SYP protein	22981971
C006780	bisphenol A	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SYP mRNA	25607892
C006780	bisphenol A	bisphenol A results in decreased expression of SYP mRNA	24820113\|2518105
C006780	bisphenol A	bisphenol A results in decreased expression of SYP protein	24820113
C006780	bisphenol A	bisphenol A results in increased methylation of SYP gene	28505145
C099813	bromochloroacetic acid	bromochloroacetic acid results in decreased expression of SYP protein	21296659
C038091	butylparaben	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SYP mRNA	25607892
D002220	Carbamazepine	Carbamazepine results in decreased expression of SYP mRNA	27413119
D002330	Carmustine	Carmustine results in decreased expression of SYP protein	17572393
D002330	Carmustine	Melatonin inhibits the reaction [Carmustine results in decreased expression of SYP protein]	17572393
C024714	caryophyllene	caryophyllene results in increased expression of SYP protein	27871898
C024714	caryophyllene	staurosporine aglycone inhibits the reaction [caryophyllene results in increased expression of SYP protein]	27871898
C473711	Chir 99021	"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of SYP mRNA"	20865013
D002713	Chlorine	[Ozone co-treated with Chlorine] results in increased expression of SYP mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of SYP protein	16174552
D002738	Chloroquine	"Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of SYP]"	26327526
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of SYP mRNA	26018426
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SYP gene	20938992
D019343	Citric Acid	[Citric Acid co-treated with Silver analog] results in decreased expression of SYP protein	25447321
D003042	Cocaine	Cocaine results in increased expression of SYP mRNA	16076954
D003300	Copper	[Thiosemicarbazones binds to Copper] which results in increased expression of SYP protein	20931265
C540261	cyclo-L-glycyl-L-2-allylproline	cyclo-L-glycyl-L-2-allylproline inhibits the reaction [Scopolamine Hydrobromide results in increased expression of SYP protein]	20188767
D016572	Cyclosporine	Cyclosporine results in decreased methylation of SYP promoter	27989131
C010902	decabromobiphenyl ether	decabromobiphenyl ether metabolite results in increased expression of SYP protein	19380496
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of SYP protein	25194327
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of SYP mRNA	28104350
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of SYP protein	28104350
D003907	Dexamethasone	Dexamethasone results in increased expression of SYP protein	15965953
D003993	Dibutyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of SYP mRNA	25607892
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of SYP mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SYP mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SYP mRNA	23558232
D002945	Cisplatin	trichostatin A inhibits the reaction [Cisplatin results in decreased expression of SYP mRNA]	23558232
D003633	Dichlorodiphenyl Dichloroethylene	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of SYP mRNA	25607892
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of SYP mRNA	26924002
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of SYP mRNA	26033743
D004051	Diethylhexyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of SYP mRNA	25607892
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of SYP mRNA	26924002
C038939	enzacamene	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SYP mRNA	25607892
C109476	epoxiconazole	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of SYP mRNA	25607892
D000431	Ethanol	CYP2E1 protein affects the reaction [Ethanol results in decreased expression of SYP mRNA]	28385499
D000431	Ethanol	Ethanol inhibits the reaction [pirinixic acid results in increased expression of SYP mRNA]	28385499
D000431	Ethanol	Ethanol results in decreased expression of SYP mRNA	28385499
D000431	Ethanol	Ethanol results in decreased expression of SYP protein	28385499
D000431	Ethanol	Ethanol results in decreased expression of SYP mRNA	28385499
D000431	Ethanol	Ethanol results in increased expression of SYP mRNA	20655511
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of SYP gene	16495775
C049347	fasudil	fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP mRNA]	22062134
C049347	fasudil	fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP protein]	22062134
D018120	Finasteride	Finasteride results in decreased expression of SYP mRNA	24136188
D005472	Fluorouracil	Fluorouracil results in increased expression of SYP protein	21296659
D005473	Fluoxetine	Fluoxetine results in decreased expression of SYP mRNA	20857517
D005473	Fluoxetine	Fluoxetine results in increased expression of SYP mRNA	17950272
D005485	Flutamide	Flutamide results in decreased expression of SYP mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SYP gene	20938992
D004397	Fonofos	Fonofos results in increased methylation of SYP promoter	22847954
D005947	Glucose	Glucose results in decreased expression of SYP protein	23776493
D017313	Fenretinide	Fenretinide results in decreased expression of SYP mRNA	28973697
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of SYP mRNA	17183730
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of SYP mRNA	12419474
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of SYP mRNA	27392435
C067713	lactacystin	lactacystin inhibits the reaction [AGT protein results in increased degradation of SYP protein]	18487452
D007854	Lead	Lead affects the expression of SYP mRNA	28903495
C008261	lead acetate	lead acetate results in decreased expression of SYP protein	27771255
C008261	lead acetate	BDNF protein inhibits the reaction [lead acetate results in decreased expression of SYP protein]	20375082
C008261	lead acetate	lead acetate results in decreased expression of SYP protein	17047031\|2037508
C008261	lead acetate	lead acetate results in increased expression of SYP protein	27984133
C029433	lead tetraacetate	lead tetraacetate results in decreased expression of SYP mRNA	20865013
D008044	Linuron	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of SYP mRNA	25607892
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of SYP mRNA"	24972896
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SYP protein	21161674
D008550	Melatonin	Melatonin inhibits the reaction [Carmustine results in decreased expression of SYP protein]	17572393
D008550	Melatonin	Melatonin inhibits the reaction [Methamphetamine results in decreased expression of SYP protein]	19409439
D008694	Methamphetamine	Methamphetamine results in decreased expression of SYP protein	14657756
D008694	Methamphetamine	Melatonin inhibits the reaction [Methamphetamine results in decreased expression of SYP protein]	19409439
D008694	Methamphetamine	Methamphetamine results in decreased expression of SYP protein	19409439
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SYP gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SYP protein	25809596
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SYP mRNA	27729293
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SYP mRNA	21385734
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of SYP protein	26965727
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SYP mRNA"	20188158
D008770	Methylnitrosourea	Methylnitrosourea affects the expression of SYP protein	18155124
C005238	mipafox	mipafox results in decreased expression of SYP protein	27939611
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of SYP mRNA	26924002
D037742	Nanotubes, Carbon	"Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of SYP]"	26327526
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SYP"	26327526
C031721	naphthalene	ASCL1 protein inhibits the reaction [naphthalene results in increased expression of SYP protein]	20554700
C031721	naphthalene	naphthalene results in increased expression of SYP protein	20554700
C495860	naphthol AS-E phosphate	naphthol AS-E phosphate results in decreased expression of SYP protein	25150140
D009525	Niacin	Niacin results in increased expression of SYP protein	20671245
C118580	octylmethoxycinnamate	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SYP mRNA	25607892
D010126	Ozone	[Ozone co-treated with Chlorine] results in increased expression of SYP mRNA	18636392
D010261	Paraoxon	Paraoxon results in decreased expression of SYP protein	27939611
D010269	Paraquat	Paraquat results in decreased expression of SYP protein	24521700
D010278	Parathion	Parathion results in increased methylation of SYP promoter	22847954
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of SYP protein"	26480858
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of SYP protein	21820030
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of SYP protein	19211617
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of SYP mRNA	20136073
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of SYP protein	20937303
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SYP protein	19211617
D026023	Permethrin	[Pyridostigmine Bromide co-treated with Permethrin] results in decreased expression of SYP protein	25785457
D010672	Phenytoin	Phenytoin results in decreased expression of SYP mRNA	27413119
D010672	Phenytoin	Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA]	27413119
D010830	Physostigmine	Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SYP protein]	28499986
D010862	Pilocarpine	Pilocarpine results in increased expression of SYP protein	16134595
C006253	pirinixic acid	Ethanol inhibits the reaction [pirinixic acid results in increased expression of SYP mRNA]	28385499
C006253	pirinixic acid	pirinixic acid results in increased expression of SYP mRNA	28385499
C006253	pirinixic acid	pirinixic acid results in increased expression of SYP mRNA	20813756\|2527062
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of SYP mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of SYP mRNA	27413119
C045362	prochloraz	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of SYP mRNA	25607892
C035988	procymidone	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of SYP mRNA	25607892
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of SYP mRNA	27413119
D011729	Pyridostigmine Bromide	[Pyridostigmine Bromide co-treated with Permethrin] results in decreased expression of SYP protein	25785457
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [resveratrol results in increased expression of SYP mRNA]	21161674
C059514	resveratrol	pyrrolidine dithiocarbamic acid inhibits the reaction [resveratrol results in increased expression of SYP mRNA]	21161674
C059514	resveratrol	resveratrol results in increased expression of SYP mRNA	18592012\|2116167
C059514	resveratrol	resveratrol inhibits the reaction [PPT1 gene mutant form results in decreased expression of SYP protein]	21224254
C084711	S 20098	S 20098 results in increased expression of SYP protein	22160164
D012601	Scopolamine Hydrobromide	cyclo-L-glycyl-L-2-allylproline inhibits the reaction [Scopolamine Hydrobromide results in increased expression of SYP protein]	20188767
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in increased expression of SYP protein	20188767
D012834	Silver	[Citric Acid co-treated with Silver analog] results in decreased expression of SYP protein	25447321
D012834	Silver	Silver results in decreased expression of SYP protein	25447321
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of SYP mRNA	27862939
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [caryophyllene results in increased expression of SYP protein]	27871898
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [NGF protein results in increased expression of SYP protein]	27871898
D013311	Streptozocin	Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of SYP protein]	28499986
D013311	Streptozocin	Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SYP protein]	28499986
D013311	Streptozocin	Streptozocin results in decreased expression of SYP protein	28499986
D013311	Streptozocin	Streptozocin results in increased expression of SYP mRNA	18487452
D013311	Streptozocin	telmisartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]	18487452
D013311	Streptozocin	Valsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]	18487452
D013311	Streptozocin	fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP mRNA]	22062134
D013311	Streptozocin	fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP protein]	22062134
D013311	Streptozocin	Streptozocin results in decreased expression of SYP mRNA	22062134
D013311	Streptozocin	Streptozocin results in decreased expression of SYP protein	22062134
C013690	styrene oxide	styrene oxide results in decreased expression of SYP protein	17662326
C105686	SU 5402	"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of SYP mRNA"	20865013
D013458	Sulfur Dioxide	Sulfur Dioxide affects the expression of SYP protein	25534910
D013467	Sulindac	Sulindac results in decreased expression of SYP mRNA	24136188
C084178	telmisartan	telmisartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]	18487452
C084178	telmisartan	telmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]	18487452
C084178	telmisartan	telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]	18487452
C012568	terbufos	terbufos results in increased methylation of SYP promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SYP mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SYP mRNA	19465110
D013882	Thiosemicarbazones	[Thiosemicarbazones binds to Copper] which results in increased expression of SYP protein	20931265
D013974	Thyroxine	Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA]	27413119
D024505	Tocopherols	Tocopherols results in increased expression of SYP mRNA	17654050
D014212	Tretinoin	[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of SYP protein	17085092
D014212	Tretinoin	Tretinoin results in increased expression of SYP mRNA	23903816
D014212	Tretinoin	Tretinoin results in increased expression of SYP mRNA	20865013
D014236	Trichlorfon	Trichlorfon results in decreased expression of SYP protein	27939611
C012589	trichostatin A	trichostatin A inhibits the reaction [Cisplatin results in decreased expression of SYP mRNA]	23558232
D014266	Trientine	Trientine results in increased expression of SYP protein	23541064
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of SYP mRNA	19042947
C113580	U 0126	U 0126 inhibits the reaction [AGT protein results in increased degradation of SYP protein]	18487452
D014520	Urethane	Urethane results in increased expression of SYP mRNA	28818685
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of SYP mRNA	17183730
D014635	Valproic Acid	Valproic Acid results in increased expression of SYP mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of SYP mRNA	21427059
D000068756	Valsartan	Valsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]	18487452
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]	18487452
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]	18487452
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SYP gene	25560391
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride results in increased expression of SYP mRNA	17950272
C025643	vinclozolin	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of SYP mRNA	25607892

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0015485	cholesterol binding	-	IDA	10620806
GO:0042169	SH2 domain binding	-	IEA	-
GO:0042802	identical protein binding	-	IEA	-
GO:0043621	protein self-association	-	TAS	15217342

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006897	endocytosis	-	ISS	-
GO:0016188	synaptic vesicle maturation	-	NAS	10620806
GO:0048168	regulation of neuronal synaptic plasticity	-	IBA	21873635
GO:0048169	regulation of long-term neuronal synaptic plasticity	-	ISS	-
GO:0048172	regulation of short-term neuronal synaptic plasticity	-	ISS	-
GO:0048488	synaptic vesicle endocytosis	-	IEA	-
GO:0048499	synaptic vesicle membrane organization	-	NAS	10620806
GO:0071310	cellular response to organic substance	-	IEA	-
GO:2000474	regulation of opioid receptor signaling pathway	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008021	synaptic vesicle	-	ISS	-
GO:0030054	cell junction	-	IEA	-
GO:0030285	integral component of synaptic vesicle membrane	-	NAS	1975480
GO:0031594	neuromuscular junction	-	IEA	-
GO:0042734	presynaptic membrane	-	IEA	-
GO:0043005	neuron projection	-	ISS	-
GO:0043195	terminal bouton	-	IEA	-
GO:0048786	presynaptic active zone	-	IEA	-
GO:0060076	excitatory synapse	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21426264	Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)	Fernandez-Castillo N	World J Biol Psychiatry