Gene info: ID 6857

Gene: SYT1

GENE ID: 6857

Synonyms: P65|SVP65|SYT

Description: synaptotagmin 1

Gene type: protein-coding

Location: 12q21.2

dbXrefs: Ensembl:ENSG00000067715 MIM:185605 Vega:OTTHUMG00000134326 UniprotKB:P21579

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.037e-1 (AD) 4.992e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SNAP91	0.987
SH3GL2	0.983
NELL2	0.981
RTN1	0.979
NSF	0.979
NAPB	0.979
NEFL	0.977
GABRA1	0.977
SULT4A1	0.977
RBFOX1	0.976

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSAG1	-0.521
ARHGEF5	-0.52
TFPI2	-0.517
CNN2	-0.509
RNF135	-0.509
RUNX3	-0.506
HEY2	-0.5
WWTR1	-0.5
REST	-0.499
RHOD	-0.495

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SYT1 mRNA"	22698814\|2890350
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of SYT1 mRNA"	20453058
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of SYT1 mRNA"	20206263
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of SYT1 mRNA	25458485
D000082	Acetaminophen	Acetaminophen results in decreased expression of SYT1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of SYT1 mRNA	17562736
D020106	Acrylamide	Acrylamide binds to and affects the metabolism of SYT1 protein	17698512
D020106	Acrylamide	Acrylamide results in decreased expression of SYT1 mRNA	28959563
C016601	afimoxifene	afimoxifene inhibits the reaction [Estrogens results in decreased expression of SYT1 mRNA]	21233418
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of SYT1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of SYT1 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SYT1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of SYT1 mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SYT1 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of SYT1 protein	16483693
C015001	arsenite	arsenite results in decreased expression of SYT1 mRNA	23974009
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of SYT1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SYT1 mRNA	19770486\|2373587
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SYT1 mRNA	21964900
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SYT1 protein	21467743
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SYT1 mRNA	21839799
D004958	Estradiol	EGF protein promotes the reaction [Estradiol results in decreased expression of SYT1 mRNA]	24758408
D004958	Estradiol	Estradiol results in decreased expression of SYT1 mRNA	20106945\|2475840
C006780	bisphenol A	bisphenol A results in decreased methylation of SYT1 promoter	27312807
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in decreased expression of SYT1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of SYT1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of SYT1 gene	28505145
C013418	bromfenacoum	bromfenacoum results in increased expression of SYT1 protein	28903499
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of SYT1 mRNA	15336504
D002118	Calcium	Calcium binds to SYT1 protein	16262243
D003042	Cocaine	Cocaine affects the expression of SYT1 mRNA	20187946
D003300	Copper	Copper affects the secretion of [FGF1 protein binds to SYT1 protein binds to S100A13 protein]	16262243
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of SYT1 mRNA	20971185
D003300	Copper	Copper binds to and affects the folding of SYT1 protein	16262243
D003300	Copper	Copper deficiency results in increased expression of SYT1 mRNA	26033743
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SYT1 mRNA	19020976
D003471	Cuprizone	Cuprizone results in decreased expression of SYT1 mRNA	26577399
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of SYT1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SYT1 mRNA	21603599\|2739243
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of SYT1 mRNA	26924002
D002117	Calcitriol	Calcitriol results in increased expression of SYT1 mRNA	16002434
D004967	Estrogens	afimoxifene inhibits the reaction [Estrogens results in decreased expression of SYT1 mRNA]	21233418
D004967	Estrogens	Estrogens results in decreased expression of SYT1 mRNA	21233418
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of SYT1 mRNA	28189721
C540355	fenamidone	fenamidone results in decreased expression of SYT1 mRNA	27029645
D005947	Glucose	Glucose results in increased expression of SYT1 protein	23776493
D003932	Heroin	Heroin results in decreased expression of SYT1 mRNA	16710320
D017313	Fenretinide	Fenretinide results in increased expression of SYT1 mRNA	28973697
D002112	Calcifediol	Calcifediol deficiency results in decreased expression of SYT1 mRNA	17293106
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of SYT1 mRNA"	26377693
C051890	irinotecan	irinotecan analog results in decreased expression of SYT1 mRNA	18927307
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of SYT1 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of SYT1 mRNA	27392435
C008261	lead acetate	lead acetate results in decreased expression of SYT1 protein	27984133
D008727	Methotrexate	Methotrexate results in increased expression of SYT1 mRNA	24449571
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SYT1 protein	25809596
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of SYT1 mRNA	26558463
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SYT1 mRNA"	20188158
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of SYT1 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SYT1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SYT1 mRNA"	25620056
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of SYT1 mRNA	20971185
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of SYT1 mRNA]"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SYT1 mRNA"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SYT1 mRNA]"	21673326
D010269	Paraquat	Paraquat results in increased expression of SYT1 mRNA	25314302
D010269	Paraquat	Paraquat results in decreased expression of SYT1 protein	24521700
D052638	Particulate Matter	Particulate Matter results in decreased expression of SYT1 mRNA	22178795
D010433	Pentylenetetrazole	Pentylenetetrazole affects the expression of SYT1 mRNA	21503142
D010634	Phenobarbital	Phenobarbital affects the expression of SYT1 mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in decreased expression of SYT1 mRNA	20813756\|2381119
C043680	ptaquiloside	[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of SYT1 mRNA	23274088
C043680	ptaquiloside	ptaquiloside results in decreased expression of SYT1 mRNA	23274088
D012524	Sarin	Sarin results in increased expression of SYT1 mRNA	19522546
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of SYT1 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of SYT1 mRNA	23806026
D020123	Sirolimus	Sirolimus inhibits the reaction [TP73 protein results in increased expression of SYT1 mRNA]	21245298
D012906	Smoke	Smoke results in increased expression of SYT1 mRNA	21095227
C017947	sodium arsenite	sodium arsenite affects the methylation of SYT1 gene	28589171
C017947	sodium arsenite	sodium arsenite results in increased expression of SYT1 mRNA	22714537
D018038	Sodium Selenite	[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of SYT1 mRNA	23274088
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of SYT1 mRNA	23274088
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in decreased expression of SYT1 mRNA	26496021
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of SYT1 protein"	25852303
D014212	Tretinoin	Tretinoin results in decreased expression of SYT1 mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of SYT1 mRNA	16604517
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYT1 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of SYT1 mRNA	24935251\|2627250
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of SYT1 mRNA	19042947
D014635	Valproic Acid	Valproic Acid affects the expression of SYT1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SYT1 mRNA	23179753\|2718838
C111237	vorinostat	vorinostat results in increased expression of SYT1 mRNA	20060208
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of SYT1 mRNA	27215404
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of SYT1 mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000149	SNARE binding	-	ISS	-
GO:0001786	phosphatidylserine binding	-	IEA	-
GO:0005509	calcium ion binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	11438518 16525042 19234194 19284995 20098747
GO:0005516	calmodulin binding	-	IEA	-
GO:0005544	calcium-dependent phospholipid binding	-	IBA	21873635
GO:0005544	calcium-dependent phospholipid binding	-	ISS	-
GO:0005544	calcium-dependent phospholipid binding	-	TAS	12526776
GO:0005545	1-phosphatidylinositol binding	-	TAS	11438518
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	-	IBA	21873635
GO:0008022	protein C-terminus binding	-	IEA	-
GO:0017075	syntaxin-1 binding	-	ISS	-
GO:0017075	syntaxin-1 binding	-	TAS	11438518
GO:0019905	syntaxin binding	-	IBA	21873635
GO:0030276	clathrin binding	-	IBA	21873635
GO:0030348	syntaxin-3 binding	-	IEA	-
GO:0042802	identical protein binding	-	IEA	-
GO:0046982	protein heterodimerization activity	-	IEA	-
GO:0048306	calcium-dependent protein binding	-	IEA	-
GO:0050750	low-density lipoprotein particle receptor binding	-	IDA	15082773

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005513	detection of calcium ion	-	TAS	11438518
GO:0006906	vesicle fusion	-	IBA	21873635
GO:0007268	chemical synaptic transmission	-	TAS	1840599
GO:0007269	neurotransmitter secretion	-	TAS	11438518
GO:0007420	brain development	-	IEA	-
GO:0014047	glutamate secretion	-	TAS	-
GO:0014059	regulation of dopamine secretion	-	IEA	-
GO:0016079	synaptic vesicle exocytosis	-	IBA	21873635
GO:0017157	regulation of exocytosis	-	TAS	11438518
GO:0017158	regulation of calcium ion-dependent exocytosis	-	IBA	21873635
GO:0031340	positive regulation of vesicle fusion	-	IEA	-
GO:0045956	positive regulation of calcium ion-dependent exocytosis	-	IEA	-
GO:0048278	vesicle docking	-	IEA	-
GO:0048488	synaptic vesicle endocytosis	-	IBA	21873635
GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	-	IBA	21873635
GO:0050806	positive regulation of synaptic transmission	-	ISS	-
GO:0051260	protein homooligomerization	-	TAS	11438518
GO:0051291	protein heterooligomerization	-	IEA	-
GO:0051966	regulation of synaptic transmission, glutamatergic	-	ISS	-
GO:0061024	membrane organization	-	TAS	-
GO:0071277	cellular response to calcium ion	-	ISS	-
GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	-	ISS	-
GO:1903305	regulation of regulated secretory pathway	-	ISS	-
GO:1903861	positive regulation of dendrite extension	-	IDA	23999003

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	24327345
GO:0005794	Golgi apparatus	-	IEA	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0008021	synaptic vesicle	-	TAS	11438518
GO:0030054	cell junction	-	IEA	-
GO:0030285	integral component of synaptic vesicle membrane	-	IEA	-
GO:0030424	axon	-	IEA	-
GO:0030665	clathrin-coated vesicle membrane	-	TAS	-
GO:0030672	synaptic vesicle membrane	-	IBA	21873635
GO:0030672	synaptic vesicle membrane	-	TAS	-
GO:0031045	dense core granule	-	IEA	-
GO:0031201	SNARE complex	-	IEA	-
GO:0042584	chromaffin granule membrane	-	IEA	-
GO:0042734	presynaptic membrane	-	IEA	-
GO:0043005	neuron projection	-	ISS	-
GO:0044306	neuron projection terminus	-	IEA	-
GO:0060076	excitatory synapse	-	IEA	-
GO:0060201	clathrin-sculpted acetylcholine transport vesicle membrane	-	TAS	-
GO:0060203	clathrin-sculpted glutamate transport vesicle membrane	-	TAS	-
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	-	TAS	-
GO:0070083	clathrin-sculpted monoamine transport vesicle membrane	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-112310	Neurotransmitter release cycle	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-112316	Neuronal System	IEA
R-HSA-1643685	Disease	TAS
R-HSA-168799	Neurotoxicity of clostridium toxins	TAS
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	TAS
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-210500	Glutamate Neurotransmitter Release Cycle	TAS
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	TAS
R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle	TAS
R-HSA-5250958	Toxicity of botulinum toxin type B (BoNT/B)	TAS
R-HSA-5250989	Toxicity of botulinum toxin type G (BoNT/G)	TAS
R-HSA-5339562	Uptake and actions of bacterial toxins	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-6794361	Neurexins and neuroligins	IEA
R-HSA-6794362	Protein-protein interactions at synapses	IEA
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	TAS
R-HSA-8856828	Clathrin-mediated endocytosis	TAS
R-HSA-888590	GABA synthesis, release, reuptake and degradation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27207918	Association of Superoxide Dismutase 2 (SOD2) Genotype with Gray Matter Volume Shrinkage in Chronic Alcohol Users: Replication and Further Evaluation of an Addiction Gene Panel. (2016 Sep)	Gitik M	Int J Neuropsychopharmacol
21426264	Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)	Fernandez-Castillo N	World J Biol Psychiatry