Gene: BTD

686
-
biotinidase
protein-coding
3p25.1
Ensembl:ENSG00000169814 MIM:609019 Vega:OTTHUMG00000129861 UniprotKB:P43251
NG_008019.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.140e-1 (AD)  6.096e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCSTN0.783
RFC10.751
APH1B0.745
GALC0.739
RPA10.722
CNNM30.722
PIGO0.721
LMBRD10.72
PCCB0.716
SLC35A50.715

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.503
OR4F29-0.458
OR7C2-0.221
OR6C74-0.218
OR4F16-0.217
HMHB1-0.215
KISS1-0.206
MTRNR2L6-0.198
OIT3-0.195
MAFA-0.193

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of BTD mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BTD mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BTD mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of BTD mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of BTD protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of BTD mRNA19770486
D004958EstradiolEstradiol results in decreased expression of BTD mRNA21984479
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BTD mRNA28628672
C006780bisphenol Abisphenol A affects the expression of BTD mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BTD mRNA28628672
C006780bisphenol Abisphenol A affects the expression of BTD mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of BTD mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of BTD mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BTD mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BTD mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased activity of BTD protein12867299
C074702chromium hexavalent ionchromium hexavalent ion affects the localization of BTD protein24858232
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of BTD mRNA21641978
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of BTD protein21641978
C074702chromium hexavalent iontrichostatin A inhibits the reaction [chromium hexavalent ion results in decreased expression of BTD protein]21641978
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of BTD mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of BTD mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of BTD mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of BTD mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of BTD mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased methylation of BTD promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of BTD mRNA23914054
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BTD mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BTD mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of BTD mRNA27392435
D002945CisplatinCisplatin results in increased expression of BTD mRNA27392435
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of BTD mRNA20064776
C024565ethylene dichlorideethylene dichloride results in increased expression of BTD mRNA28189721
D005485FlutamideFlutamide results in decreased expression of BTD mRNA24793618
C039281furanfuran results in increased methylation of BTD gene22079235
D017313FenretinideFenretinide results in decreased expression of BTD mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BTD mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BTD mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of BTD mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BTD mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BTD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BTD mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of BTD mRNA27392435
C544151jinfukangjinfukang results in increased expression of BTD mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of BTD mRNA22904298
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BTD mRNA"20188158
C500085muraglitazarmuraglitazar results in increased expression of BTD mRNA21515302
D009532NickelNickel results in decreased expression of BTD mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of BTD mRNA22110744
D010433PentylenetetrazolePentylenetetrazole affects the expression of BTD mRNA21503142
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of BTD mRNA21984479
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of BTD mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BTD mRNA21984479
D011374ProgesteroneProgesterone results in decreased expression of BTD mRNA19693291
D011374ProgesteroneProgesterone results in decreased expression of BTD mRNA19690047
D015474IsotretinoinIsotretinoin results in decreased expression of BTD mRNA20436886
C017947sodium arsenitesodium arsenite results in increased methylation of BTD gene24118411
C501413tesaglitazartesaglitazar results in increased expression of BTD mRNA21515302
D013739TestosteroneTestosterone results in decreased expression of BTD mRNA19693291
C004648testosterone enanthatetestosterone enanthate affects the expression of BTD mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BTD mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BTD mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of BTD mRNA23411599
C012589trichostatin Atrichostatin A inhibits the reaction [chromium hexavalent ion results in decreased expression of BTD protein]21641978
C012589trichostatin Atrichostatin A results in increased expression of BTD protein21641978
D014635Valproic AcidValproic Acid affects the expression of BTD mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of BTD mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds-IBA21873635  
GO:0047708biotinidase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006768biotin metabolic process-IBA21873635  
GO:0006768biotin metabolic process-TAS-  
GO:0007417central nervous system development-TAS7550325  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005759mitochondrial matrix-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00780Biotin metabolism
hsa01100Metabolic pathways
hsa04977Vitamin digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-196780Biotin transport and metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-3296482Defects in vitamin and cofactor metabolismTAS
R-HSA-3323169Defects in biotin (Btn) metabolismTAS
R-HSA-3371598Defective BTD causes biotidinase deficiencyTAS
R-HSA-5668914Diseases of metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15881092[Functional condition of bone tissue in smoking and non-smoking patients with chronic obstructive pulmonary disease]. (2005)-Ter Arkh