Gene: TACR1

6869
NK1R|NKIR|SPR|TAC1R
tachykinin receptor 1
protein-coding
2p12
Ensembl:ENSG00000115353 MIM:162323 Vega:OTTHUMG00000129973 UniprotKB:P25103
NG_029522.1
PubMed
0   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.620e-1 (AD)  9.282e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GAD20.866
GAD10.846
SLC32A10.841
ZNF385D0.833
BTBD110.828
MYOZ30.828
VWC20.814
LHX60.811
NRIP30.809
TAC10.809

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGIF1-0.535
NFATC1-0.516
ROM1-0.514
HEBP2-0.513
AGTRAP-0.513
OTOS-0.508
PLIN2-0.505
FCGRT-0.498
ITPRIP-0.497
ATOH8-0.496

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00673AprepitantSmall Molecule170729-80-3Approved|InvestigationalTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
DB04894VapreotideSmall Molecule103222-11-3Approved|InvestigationalTarget
DB05072AV608Small Molecule-InvestigationalTarget
DB05418GW 597599Small Molecule-InvestigationalTarget
DB05421CP-122721Small MoleculeInvestigationalTarget
DB05466R673Small Molecule-InvestigationalTarget
DB05790SR 140333Small Molecule-InvestigationalTarget
DB06634CasopitantSmall Molecule414910-27-3InvestigationalTarget
DB09048NetupitantSmall Molecule290297-26-6Approved|InvestigationalTarget
DB11949VestipitantSmall Molecule334476-46-9InvestigationalTarget
DB12436VofopitantSmall Molecule168266-90-8InvestigationalTarget
ID Drug Name Action PubMed
C0407561,2-naphthoquinone"[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA"19399481
C0407561,2-naphthoquinone"Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA]"19399481
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TACR1 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TACR1 mRNA"19114083
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of TACR1 mRNA25088246
C0807553-(2-methoxybenzylamino)-2-phenylpiperidine3-(2-methoxybenzylamino)-2-phenylpiperidine inhibits the reaction [TAC1 protein results in increased expression of TACR1 mRNA]18441096
C0807553-(2-methoxybenzylamino)-2-phenylpiperidine3-(2-methoxybenzylamino)-2-phenylpiperidine binds to and results in decreased activity of TACR1 protein11458534|1844109
C1037883-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine"3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine binds to and results in decreased activity of TACR1 protein"18407414
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of TACR1 mRNA"19627578
C0716937,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one"7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one binds to and results in decreased activity of TACR1 protein"17056641
C0716937,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one"7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one binds to and results in decreased activity of TACR1 protein"16125318|1798863
C0716937,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one"7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one results in decreased activity of TACR1 protein"17056641|2444871
D000143AcidsAcids affects the localization of TACR1 protein16091555
D000143Acidscapsazepine inhibits the reaction [Acids affects the localization of TACR1 protein]16091555
D000143AcidsFamotidine inhibits the reaction [Acids affects the localization of TACR1 protein]16091555
D000143AcidsOmeprazole inhibits the reaction [Acids affects the localization of TACR1 protein]16091555
D000143AcidsTRPV1 protein affects the reaction [Acids affects the localization of TACR1 protein]16091555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TACR1 gene27153756
D000602Amino Acids, Peptides, and Proteins"Amino Acids, Peptides, and Proteins binds to and results in decreased activity of TACR1 protein"21233199
D000602Amino Acids, Peptides, and Proteins"[[GR 159897 binds to and results in decreased activity of TACR2 protein] co-treated with [Amino Acids, Peptides, and Proteins binds to and results in decreased activity of TACR1 protein]] results in decreased susceptibility to Paclitaxel"21233199
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TACR1 mRNA16483693
D003913DextroamphetamineTACR1 protein affects the susceptibility to Dextroamphetamine11897087
C036380amyrinamyrin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein]18210232
C114556aprepitantaprepitant binds to and results in decreased activity of TACR1 protein20623144|2071875
C114556aprepitantaprepitant binds to and results in increased activity of TACR1 protein18930726
C114556aprepitantaprepitant inhibits the reaction [TAC1 protein results in increased expression of TACR1 mRNA]18441096
C114556aprepitantaprepitant binds to and results in decreased activity of TACR1 protein17389531|1844109
C114556aprepitantaprepitant results in decreased activity of TACR1 protein18719071
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of TACR1 mRNA15894712
C015001arsenitearsenite results in decreased expression of TACR1 mRNA15894712
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of TACR1 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TACR1 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TACR1 mRNA21839799
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TACR1 mRNA22374506
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of TACR1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of TACR1 mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of TACR1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of TACR1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TACR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TACR1 gene28505145
D002104CadmiumCadmium results in increased expression of TACR1 mRNA21694771
D002118CalciumTACR1 protein affects the reaction [TAC1 protein alternative form results in increased abundance of Calcium]7513838
D002211CapsaicinCapsaicin results in decreased expression of TACR1 mRNA18441096
D002211CapsaicinCapsaicin results in decreased expression of TACR1 protein18441096
D002211CapsaicinCapsaicin results in increased expression of TACR1 protein21294877
D002211CapsaicinTACR1 results in increased susceptibility to Capsaicin10360863|1116697
D002211CapsaicinCapsaicin affects the expression of TACR1 mRNA13680092
D002211CapsaicinCapsaicin affects the reaction [Vehicle Emissions affects the expression of TACR1 mRNA]13680092
D002211Capsaicin"Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA]"19399481
D002211CapsaicinCapsaicin promotes the reaction [Vehicle Emissions results in increased expression of TACR1 protein]13680092
C071423capsazepinecapsazepine inhibits the reaction [Acids affects the localization of TACR1 protein]16091555
C531951casopitantcasopitant binds to and results in decreased activity of TACR1 protein21229983
C531951casopitantcasopitant inhibits the reaction [vofopitant binds to TACR1 protein]21229983
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of TACR1 mRNA]17988634
C066892CP 96345CP 96345 inhibits the reaction [TAC1 protein affects the localization of TACR1 protein]7524481
D003520Cyclophosphamideamyrin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein]18210232
D003520CyclophosphamideCyclophosphamide results in increased expression of TACR1 protein18210232
D003520CyclophosphamideTACR1 gene mutant form results in decreased susceptibility to Cyclophosphamide10854767
D003520CyclophosphamideCyclophosphamide results in increased expression of TACR1 protein23666265
D003520CyclophosphamideGR 82334 inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein]23666265
D003520CyclophosphamideSuramin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein]23666265
D016264Dextran SulfateTACR1 protein affects the susceptibility to Dextran Sulfate20889569
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of TACR1 mRNA15620428
D004280DobutamineDobutamine promotes the reaction [TAC1 protein binds to and results in increased activity of TACR1 protein]8994422
D004394DydrogesteroneDydrogesterone results in decreased expression of TACR1 protein16389545
C010452estradiol-17 beta-benzoateestradiol-17 beta-benzoate results in increased expression of TACR1 mRNA19627578
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TACR1 mRNA29097150
D015738FamotidineFamotidine inhibits the reaction [Acids affects the localization of TACR1 protein]16091555
C078949FK 888FK 888 binds to and results in decreased activity of TACR1 protein9308027
C069837fullerene C60fullerene C60 results in decreased expression of TACR1 mRNA19167457
C039281furanfuran results in decreased expression of TACR1 mRNA25539665
D019833GenisteinGenistein inhibits the reaction [CALCA protein results in increased expression of TACR1 mRNA]16777450
D019833GenisteinGenistein inhibits the reaction [CALCA protein results in increased expression of TACR1 protein]16777450
D005839GentamicinsGentamicins results in decreased expression of TACR1 mRNA22061828
C092990GR 159897"[[GR 159897 binds to and results in decreased activity of TACR2 protein] co-treated with [Amino Acids, Peptides, and Proteins binds to and results in decreased activity of TACR1 protein]] results in decreased susceptibility to Paclitaxel"21233199
C068032GR 73632GR 73632 results in increased expression of TACR1 protein18809416
C068032GR 73632GR 73632 binds to and results in increased activity of TACR1 protein18809416|2122998
C079014GR 82334GR 82334 inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein]23666265
C079014GR 82334GR 82334 binds to and results in decreased activity of TACR1 protein16125318|9308027
C079014GR 82334GR 82334 results in decreased activity of TACR1 protein7957606
D006851Hydrochloric AcidTACR1 affects the susceptibility to Hydrochloric Acid12212954
D006851Hydrochloric AcidTACR1 protein affects the susceptibility to Hydrochloric Acid11730984
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"TACR1 protein affects the susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"14660035
C076851L 703606L 703606 binds to and results in decreased activity of TACR1 protein18364471
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TACR1 mRNA"22384199
C440499lipopolysaccharide, Escherichia coli O111 B4"SC 514 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TACR1 mRNA]"22384199
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TACR1 protein21570423
C102280LY 306740LY 306740 binds to and results in decreased activity of TACR1 protein11458534
D008345ManganeseManganese results in decreased expression of TACR1 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of TACR1 mRNA17175027
C518176maropitantmaropitant binds to and results in decreased activity of TACR1 protein19000276
D008464MecamylamineMecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]26524655
D008464MecamylamineMecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]26524655
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of TACR1 protein"28790194
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]26524655
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]26524655
D009020MorphineMorphine results in decreased expression of TACR1 protein19428329
D009020MorphineMorphine results in increased expression of TACR1 protein15964684|1712373
D009020Morphine[SR 140333 binds to and results in decreased activity of TACR1 protein] which results in increased susceptibility to Morphine14511336
D009020Morphinesubstance P-saporin inhibits the reaction [Morphine results in increased expression of TACR1 protein]17123731
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [CALCA protein results in increased expression of TACR1 mRNA]16777450
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [CALCA protein results in increased expression of TACR1 protein]16777450
C005274naringinnaringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TACR1 protein]24085318
D009538NicotineMecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]26524655
D009538NicotineMecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]26524655
D009538Nicotinemethyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]26524655
D009538Nicotinemethyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]26524655
D009538NicotineNicotine results in decreased expression of TACR1 mRNA27329243
D009538NicotineNicotine results in decreased expression of TACR1 protein27329243
D009538NicotineNicotine results in increased expression of TACR1 mRNA26524655
D009538NicotineNicotine results in increased expression of TACR1 protein26524655
D009599NitroprussideTACR1 protein results in increased susceptibility to Nitroprusside16982039
C502587(N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide)"(N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide) binds to TACR1 protein"15925360
D009853OmeprazoleOmeprazole inhibits the reaction [Acids affects the localization of TACR1 protein]16091555
C029341oxophenylarsineoxophenylarsine inhibits the reaction [TAC1 protein affects the localization of TACR1 protein]7524481
D010100OxygenTACR1 protein results in increased susceptibility to Oxygen11463606
D010126OzoneOzone results in increased expression of TACR1 mRNA16777450
D017239Paclitaxel"[[GR 159897 binds to and results in decreased activity of TACR2 protein] co-treated with [Amino Acids, Peptides, and Proteins binds to and results in decreased activity of TACR1 protein]] results in decreased susceptibility to Paclitaxel"21233199
C008846phenyl biguanideTACR1 protein results in increased susceptibility to phenyl biguanide16982039
D010656PhenylephrineTACR1 protein results in increased susceptibility to Phenylephrine16982039
D059808PolyphenolsPolyphenols results in decreased expression of TACR1 mRNA16293270
C400708R116301R116301 analog binds to TACR1 protein15698775
C103198S 18523S 18523 binds to TACR1 protein8880065
C103198S 18523S 18523 binds to and results in decreased activity of TACR1 protein8880065
C477523SC 514"SC 514 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TACR1 mRNA]"22384199
C054724senktidesenktide binds to and results in increased activity of TACR1 protein11245602
C017947sodium arsenitesodium arsenite results in increased activity of TACR1 protein17056641
D012966Sodium CyanideTACR1 protein results in increased susceptibility to Sodium Cyanide16982039
C042867spantidespantide binds to and results in decreased activity of TACR1 protein17961222
C085215SR 140333SR 140333 binds to and results in decreased activity of TACR1 protein11245602|9179376
C085215SR 140333[SR 140333 binds to and results in decreased activity of TACR1 protein] which results in increased susceptibility to Morphine14511336
C085215SR 140333SR 140333 binds to and results in decreased activity of TACR1 protein14511336|1458580
C526005SR140333BSR140333B binds to and results in decreased activity of TACR1 protein16788306
C105686SU 5402SU 5402 inhibits the reaction [FGF2 protein results in increased expression of TACR1 mRNA alternative form]16154193
C105686SU 5402SU 5402 inhibits the reaction [TNF protein results in increased expression of TACR1 mRNA alternative form]16154193
C105686SU 5402SU 5402 results in decreased expression of TACR1 mRNA alternative form16154193
C468274substance P-saporinsubstance P-saporin inhibits the reaction [Morphine results in increased expression of TACR1 protein]17123731
C062618substance P, Sar(9)-Met(O2)(11)-"substance P, Sar(9)-Met(O2)(11)- binds to and results in increased activity of TACR1 protein"16125318
D013395SucroseSucrose inhibits the reaction [TAC1 protein affects the localization of TACR1 protein]7524481
D013498SuraminSuramin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein]23666265
D013654TaurineTaurine results in decreased expression of TACR1 mRNA16579726
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of TACR1 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TACR1 mRNA21570461
D014028Tobacco Smoke Pollutionnaringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TACR1 protein]24085318
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TACR1 protein24085318
D014302Trinitrobenzenesulfonic AcidTACR1 gene mutant form inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A2 mRNA]20889569
D014302Trinitrobenzenesulfonic AcidTACR1 gene mutant form inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 protein]20889569
D014302Trinitrobenzenesulfonic AcidTACR1 gene mutant form inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGFB1 protein]20889569
D014302Trinitrobenzenesulfonic AcidTACR1 gene mutant form inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VIM mRNA]20889569
D014302Trinitrobenzenesulfonic AcidTACR1 protein affects the susceptibility to Trinitrobenzenesulfonic Acid20889569
D014635Valproic AcidValproic Acid results in decreased expression of TACR1 mRNA12807426
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TACR1 gene25560391
D001335Vehicle Emissions"[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA"19399481
D001335Vehicle EmissionsCapsaicin affects the reaction [Vehicle Emissions affects the expression of TACR1 mRNA]13680092
D001335Vehicle Emissions"Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA]"19399481
D001335Vehicle EmissionsCapsaicin promotes the reaction [Vehicle Emissions results in increased expression of TACR1 protein]13680092
D001335Vehicle EmissionsVehicle Emissions affects the expression of TACR1 mRNA13680092
D001335Vehicle EmissionsVehicle Emissions results in increased expression of TACR1 mRNA15916011
D001335Vehicle EmissionsVehicle Emissions results in increased expression of TACR1 protein13680092|1591601
C534550vestipitantvestipitant binds to and results in decreased activity of TACR1 protein21229983
C103207vofopitantcasopitant inhibits the reaction [vofopitant binds to TACR1 protein]21229983
C103207vofopitantvofopitant binds to TACR1 protein21229983
C017967W 7W 7 inhibits the reaction [CALCA protein results in increased expression of TACR1 mRNA]16777450
C017967W 7W 7 inhibits the reaction [CALCA protein results in increased expression of TACR1 protein]16777450
C086111WIN 51708WIN 51708 binds to and results in decreased activity of TACR1 protein12435818
C086111WIN 51708WIN 51708 binds to and results in decreased activity of TACR1 protein15381058
C086110WIN 62577WIN 62577 binds to and results in decreased activity of TACR1 protein12435818
D015054ZymosanZymosan affects the localization of TACR1 protein17257769

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004995tachykinin receptor activity-TAS8985172  
GO:0005515protein binding-IPI12716968  17986524  23597562  
GO:0016496substance P receptor activity-IBA21873635  
GO:0016496substance P receptor activity-IMP12716968  
GO ID GO Term Qualifier Evidence PubMed
GO:0002118aggressive behavior-IEA-  
GO:0002526acute inflammatory response-IEA-  
GO:0002687positive regulation of leukocyte migration-IEA-  
GO:0003051angiotensin-mediated drinking behavior-IEA-  
GO:0006954inflammatory response-TAS10854844  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-TAS1657150  
GO:0007204positive regulation of cytosolic calcium ion concentration-IDA12716968  
GO:0007217tachykinin receptor signaling pathway-IDA17986524  
GO:0007217tachykinin receptor signaling pathway-IMP12716968  
GO:0007616long-term memory-IEA-  
GO:0008306associative learning-IEA-  
GO:0009408response to heat-IEA-  
GO:0009582detection of abiotic stimulus-TAS9537323  
GO:0010193response to ozone-IEA-  
GO:0010634positive regulation of epithelial cell migration-IEA-  
GO:0010996response to auditory stimulus-IEA-  
GO:0014910regulation of smooth muscle cell migration-IEA-  
GO:0019233sensory perception of pain-IEA-  
GO:0032224positive regulation of synaptic transmission, cholinergic-IEA-  
GO:0032230positive regulation of synaptic transmission, GABAergic-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0032570response to progesterone-IEA-  
GO:0035094response to nicotine-IEA-  
GO:0035106operant conditioning-IEA-  
GO:0035815positive regulation of renal sodium excretion-IEA-  
GO:0042713sperm ejaculation-IEA-  
GO:0042755eating behavior-IEA-  
GO:0043117positive regulation of vascular permeability-IEA-  
GO:0043278response to morphine-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0045760positive regulation of action potential-IEA-  
GO:0045777positive regulation of blood pressure-IEA-  
GO:0045778positive regulation of ossification-IEA-  
GO:0045907positive regulation of vasoconstriction-IEA-  
GO:0046878positive regulation of saliva secretion-IEA-  
GO:0046887positive regulation of hormone secretion-IEA-  
GO:0048266behavioral response to pain-IEA-  
GO:0048660regulation of smooth muscle cell proliferation-IEA-  
GO:0050671positive regulation of lymphocyte proliferation-IEA-  
GO:0050679positive regulation of epithelial cell proliferation-IEA-  
GO:0051496positive regulation of stress fiber assembly-IEA-  
GO:0051602response to electrical stimulus-IEA-  
GO:0060083smooth muscle contraction involved in micturition-IEA-  
GO:0070474positive regulation of uterine smooth muscle contraction-IEA-  
GO:1902093positive regulation of flagellated sperm motility-IMP17437961  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IDA17986524  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS1657150  
GO:0009986cell surface-IEA-  
GO:0030425dendrite-IEA-  
GO:0036126sperm flagellum-IDA17437961  
GO:0044297cell body-IEA-  
GO:0061827sperm head-IDA17437961  
GO:0097225sperm midpiece-IDA17437961  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380095Tachykinin receptors bind tachykininsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20021265Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (2010)Goecke TWActa Obstet Gynecol Scand
23078527TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence. (2013 Jan)Blaine SAlcohol Clin Exp Res
24817687Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome. (2014 Jun)Sharp SIAm J Med Genet B Neuropsychiatr Genet
23488934Blockade of ethanol-induced behavioral sensitization by sodium butyrate: descriptive analysis of gene regulations in the striatum. (2013 Jul)Legastelois RAlcohol Clin Exp Res
19204064NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD. (2010 Jan)Yan TCJ Psychopharmacol
23419547Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats. (2013 Apr 15)Schank JRBiol Psychiatry