Gene: TACR3

6870
HH11|NK-3R|NK3|NK3R|NKR|TAC3R|TAC3RL
tachykinin receptor 3
protein-coding
4q24
Ensembl:ENSG00000169836 MIM:162332 Vega:OTTHUMG00000131124 UniprotKB:P29371
NG_023344.1
PubMed
0   ANCO-SNPs
CD|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.170e-1 (AD)  3.422e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NHLH20.619
HMSD0.582
RCAN30.576
FAM221A0.56
C2orf880.56
ZNF7080.554
PRCD0.548
C1QL40.543
LRRC630.541
CRNDE0.539

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCA4-0.327
TNNT2-0.319
AZU1-0.31
SSC5D-0.297
PRELP-0.286
COL5A3-0.286
MGLL-0.281
TMEM200B-0.278
RGS5-0.276
PDGFRB-0.276

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04872OsanetantSmall Molecule160492-56-8InvestigationalTarget
DB06429TalnetantSmall Molecule174636-32-9InvestigationalTarget
ID Drug Name Action PubMed
C5306981-(2-(2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl)ethyl)spiro(benzo(c)thiophene-1(3H),4'-piperidine)-2-oxide"1-(2-(2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl)ethyl)spiro(benzo(c)thiophene-1(3H),4'-piperidine)-2-oxide binds to and results in decreased activity of TACR3 protein"21185367
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of TACR3 mRNA"19627578
D000082AcetaminophenAcetaminophen results in increased expression of TACR3 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TACR3 gene27153756
D000438AlcoholsTACR3 SNP results in increased susceptibility to Alcohols18422838
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TACR3 mRNA16483693
D000068180AripiprazoleAripiprazole results in decreased expression of TACR3 mRNA17868501
D000068180AripiprazoleAripiprazole results in increased expression of TACR3 mRNA17868501
C015001arsenitearsenite results in increased methylation of TACR3 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of TACR3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TACR3 mRNA27195522
C006780bisphenol Abisphenol A results in decreased expression of TACR3 mRNA25181051
D002211CapsaicinTACR3 protein affects the susceptibility to Capsaicin18207255
D004390ChlorpyrifosChlorpyrifos results in increased expression of TACR3 mRNA20682304
D003042CocaineTACR3 SNP results in increased susceptibility to Cocaine18422838
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of TACR3 mRNA16963248
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TACR3 mRNA15620428
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of TACR3 mRNA28871463
C010452estradiol-17 beta-benzoateestradiol-17 beta-benzoate results in decreased expression of TACR3 mRNA19627578
D005419FlavonoidsFlavonoids results in increased expression of TACR3 mRNA18035473
D005492Folic AcidFolic Acid results in increased expression of TACR3 mRNA25006883
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of TACR3 mRNA16963248
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of TACR3 mRNA21782745
D019833GenisteinGenistein results in decreased expression of TACR3 mRNA21782745
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of TACR3 mRNA16963248
D006851Hydrochloric AcidTACR3 affects the susceptibility to Hydrochloric Acid12212954
D006851Hydrochloric AcidTACR3 protein affects the susceptibility to Hydrochloric Acid11730984
C082359imidaclopridimidacloprid results in increased expression of TACR3 mRNA27782041
C008261lead acetatelead acetate results in decreased expression of TACR3 mRNA22641619
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TACR3 mRNA"22384199
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of TACR3 mRNA21782745
D008731MethoxychlorMethoxychlor results in decreased expression of TACR3 mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TACR3 mRNA21385734
C502587(N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide)"(N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide) binds to TACR3 protein"15925360
D010795Phthalic AcidsPhthalic Acids results in decreased expression of TACR3 mRNA21061450
C005556propionaldehydepropionaldehyde results in decreased expression of TACR3 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of TACR3 mRNA24780913
C089730rosiglitazonerosiglitazone results in increased expression of TACR3 mRNA23166672
C109112SB 222200SB 222200 binds to and results in decreased activity of TACR3 protein18930726
C109112SB 222200SB 222200 binds to and results in decreased activity of TACR3 protein19500601
C106716SB 223412SB 223412 binds to and results in decreased activity of TACR3 protein21185367
C106716SB 223412SB 223412 binds to and results in decreased activity of TACR3 protein18930726
C054724senktidesenktide binds to and results in increased activity of TACR3 protein18930726
C017947sodium arsenitesodium arsenite affects the methylation of TACR3 gene28589171
C091554SR 142801SR 142801 binds to and results in decreased activity of TACR3 protein18207255
C091554SR 142801SR 142801 binds to and results in decreased activity of TACR3 protein18930726
C091554SR 142801SR 142801 binds to and results in decreased activity of TACR3 protein15190231|1700493
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TACR3 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of TACR3 mRNA25423262

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004995tachykinin receptor activity-IEA-  
GO:0005515protein binding-IPI12716968  23597562  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007217tachykinin receptor signaling pathway-TAS8990205  
GO:0007568aging-IEA-  
GO:0010460positive regulation of heart rate-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0042053regulation of dopamine metabolic process-IEA-  
GO:0042220response to cocaine-IEA-  
GO:0042538hyperosmotic salinity response-IEA-  
GO:0043278response to morphine-IEA-  
GO:0045777positive regulation of blood pressure-IEA-  
GO:0060259regulation of feeding behavior-IEA-  
GO:0070474positive regulation of uterine smooth muscle contraction-IEA-  
GO:1902093positive regulation of flagellated sperm motility-IMP17437961  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS1374246  
GO:0032590dendrite membrane-IEA-  
GO:0032809neuronal cell body membrane-IEA-  
GO:0097225sperm midpiece-IDA17437961  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380095Tachykinin receptors bind tachykininsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18422838The tachykinin receptor 3 is associated with alcohol and cocaine dependence. (2008 Jun)Foroud TAlcohol Clin Exp Res