Gene info: ID 688

Gene: KLF5

GENE ID: 688

Synonyms: BTEB2|CKLF|IKLF

Description: Kruppel like factor 5

Gene type: protein-coding

Location: 13q22.1

dbXrefs: Ensembl:ENSG00000102554 MIM:602903 Vega:OTTHUMG00000017074 UniprotKB:Q13887

RefSeq: NC_000013.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.024e-1 (AD) 5.735e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MYO3A	0.762
LAMC2	0.76
GPR1	0.758
MYB	0.751
PRLR	0.743
KL	0.738
OTOF	0.738
TMPRSS6	0.732
TNFRSF8	0.719
ZBED2	0.717

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HPSE2	-0.341
NXPH3	-0.335
ALDH1A1	-0.334
ASCL1	-0.319
NTNG2	-0.311
HHATL	-0.307
TPPP3	-0.3
NEU4	-0.291
LHPP	-0.281
CDKN2C	-0.279

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of KLF5 mRNA"	21354444
C477819	15-deoxyprostaglandin J2	15-deoxyprostaglandin J2 inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA]	25874449
C477819	15-deoxyprostaglandin J2	15-deoxyprostaglandin J2 inhibits the reaction [AGT protein results in increased expression of KLF5 protein]	25874449
C477819	15-deoxyprostaglandin J2	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxyprostaglandin J2 inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA]]"	25874449
C477819	15-deoxyprostaglandin J2	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxyprostaglandin J2 inhibits the reaction [AGT protein results in increased expression of KLF5 protein]]"	25874449
C477819	15-deoxyprostaglandin J2	2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxyprostaglandin J2 inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA]]	25874449
C477819	15-deoxyprostaglandin J2	2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxyprostaglandin J2 inhibits the reaction [AGT protein results in increased expression of KLF5 protein]]	25874449
C477819	15-deoxyprostaglandin J2	PPARG mutant form inhibits the reaction [15-deoxyprostaglandin J2 inhibits the reaction [AGT protein results in increased expression of KLF5 protein]]	25874449
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF5 mRNA	28329830
C051246	1-methylanthracene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF5 mRNA]	28329830
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of KLF5 mRNA"	23829299
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CXCL8 protein co-treated with CCL5 protein] results in increased expression of KLF5 protein]	21297082
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of KLF5 protein]	21297082
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased phosphorylation of KLF5 protein]	25874449
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxyprostaglandin J2 inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA]]"	25874449
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxyprostaglandin J2 inhibits the reaction [AGT protein results in increased expression of KLF5 protein]]"	25874449
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA]]"	25874449
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 protein]]"	25874449
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of KLF5 mRNA"	23829299
C107946	2,7-dihydroxynaphthalene	"2,7-dihydroxynaphthalene results in decreased expression of KLF5 mRNA"	28940058
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxyprostaglandin J2 inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA]]	25874449
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxyprostaglandin J2 inhibits the reaction [AGT protein results in increased expression of KLF5 protein]]	25874449
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA]]	25874449
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 protein]]	25874449
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of KLF5 mRNA"	19936915
D000082	Acetaminophen	Acetaminophen affects the expression of KLF5 mRNA	25458485
D000082	Acetaminophen	Acetaminophen results in increased expression of KLF5 mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen results in decreased expression of KLF5 mRNA	17585979
D020106	Acrylamide	Acrylamide results in decreased expression of KLF5 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of KLF5 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of KLF5 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of KLF5 mRNA	23630614
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of KLF5 mRNA	16483693
D016718	Arachidonic Acid	Arachidonic Acid results in increased expression of KLF5 mRNA	16704987
C006632	arsenic trioxide	arsenic trioxide results in increased expression of KLF5 mRNA	15761015\|2045855
C006632	arsenic trioxide	KLF5 protein results in decreased susceptibility to arsenic trioxide	20707922
C015001	arsenite	arsenite results in increased expression of KLF5 mRNA	15868481
D001379	Azathioprine	Azathioprine results in increased expression of KLF5 mRNA	22623647
C006680	baicalein	baicalein results in decreased expression of KLF5 mRNA	24560969
C487081	belinostat	belinostat results in increased expression of KLF5 mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of KLF5 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KLF5 mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the reaction [AHR protein binds to KLF5 promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of KLF5 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KLF5 mRNA	20713471
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of KLF5 mRNA	21839799
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLF5 mRNA"	19150397
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of KLF5 mRNA	20876846
D004958	Estradiol	Estradiol results in decreased expression of KLF5 mRNA	20876846
D004958	Estradiol	Estradiol results in decreased expression of KLF5 mRNA	19167446
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of KLF5 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of KLF5 mRNA	20678512\|2768578
C006780	bisphenol A	bisphenol A affects the methylation of KLF5 promoter	27334623
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of KLF5 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of KLF5 mRNA	25181051
C032688	boric acid	boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of KLF5 mRNA]	28285642
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of KLF5 mRNA	26472689
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of KLF5 mRNA	22110744
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of KLF5 mRNA	24763279
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of KLF5 mRNA	26272509
D002737	Chloroprene	Chloroprene results in increased expression of KLF5 mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF5 mRNA	20938992
C018021	cobaltous chloride	cobaltous chloride results in increased expression of KLF5 mRNA	24386269
D003042	Cocaine	Cocaine affects the expression of KLF5 mRNA	20187946
D003300	Copper	Copper results in increased expression of KLF5 mRNA	19747488
D019327	Copper Sulfate	Copper Sulfate results in increased expression of KLF5 mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in increased expression of KLF5 mRNA	18579281
C041246	cucurbitacin B	cucurbitacin B results in increased expression of KLF5	24316209
C038106	cucurbitacin I	cucurbitacin I results in increased expression of KLF5	24316209
C015763	cumene	[cumene co-treated with KRAS gene mutant form] results in increased expression of KLF5 mRNA	18648096
D003471	Cuprizone	Cuprizone results in decreased expression of KLF5 mRNA	26577399
D003520	Cyclophosphamide	KLF5 protein affects the susceptibility to Cyclophosphamide	16217747
D016572	Cyclosporine	Cyclosporine results in decreased expression of KLF5 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of KLF5 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of KLF5 mRNA	21865292
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of KLF5 mRNA	23640034
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of KLF5 mRNA	23914054
C014347	decitabine	[decitabine co-treated with trichostatin A] results in increased expression of KLF5 mRNA	20678512
D003907	Dexamethasone	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA	25559859
D003907	Dexamethasone	boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of KLF5 mRNA]	28285642
D003907	Dexamethasone	[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of KLF5 mRNA	28285642
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF5 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of KLF5 mRNA	21041162
D003907	Dexamethasone	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF5 mRNA]	16054899
D003907	Dexamethasone	silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA]	25559859
D003907	Dexamethasone	sodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of KLF5 mRNA]	28285642
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF5 mRNA]	16054899
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of KLF5 mRNA	21266533
D004041	Dietary Fats	Dietary Fats results in increased expression of KLF5 mRNA	18042831
D002117	Calcitriol	Calcitriol results in increased expression of KLF5 mRNA	21592394\|2648566
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of KLF5 mRNA	21592394
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of KLF5 mRNA	18095165
D004317	Doxorubicin	Doxorubicin results in increased expression of KLF5 mRNA	28940058
D004317	Doxorubicin	KLF5 protein affects the susceptibility to Doxorubicin	16217747
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of KLF5 mRNA"	23811387
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of KLF5 mRNA	17942748
D005419	Flavonoids	Flavonoids results in decreased expression of KLF5 mRNA	18035473
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF5 mRNA	28329830
C007738	fluoranthene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF5 mRNA]	28329830
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of KLF5 mRNA]	15016801
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF5 mRNA	20938992
C039281	furan	furan results in increased expression of KLF5 mRNA	27387713
C039281	furan	furan results in increased methylation of KLF5 gene	22079235
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of KLF5 mRNA	24763279
D017313	Fenretinide	Fenretinide results in increased expression of KLF5 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of KLF5 mRNA	20044591
D015056	1-Methyl-3-isobutylxanthine	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA	25559859
D015056	1-Methyl-3-isobutylxanthine	boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of KLF5 mRNA]	28285642
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of KLF5 mRNA	28285642
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF5 mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF5 mRNA]	16054899
D015056	1-Methyl-3-isobutylxanthine	silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA]	25559859
D015056	1-Methyl-3-isobutylxanthine	sodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of KLF5 mRNA]	28285642
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF5 mRNA]	16054899
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of KLF5 protein	17337753
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of KLF5 mRNA	26752646
C011890	kojic acid	kojic acid results in increased expression of KLF5 mRNA	16595896
C045463	leflunomide	leflunomide results in increased expression of KLF5 mRNA	28988120
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of KLF5 mRNA	26667767
C025340	manganese chloride	manganese chloride results in decreased expression of KLF5 mRNA	17467022
C042720	mercuric bromide	mercuric bromide results in increased expression of KLF5 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
D008694	Methamphetamine	Methamphetamine results in increased expression of KLF5 mRNA	19564919
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF5 mRNA	20938992
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of KLF5 mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of KLF5 mRNA	28001369
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of KLF5 mRNA"	25554681
D009285	Naphthoquinones	Naphthoquinones results in increased expression of KLF5 mRNA	23811387
C022838	nickel chloride	nickel chloride affects the expression of KLF5 mRNA	22110744
C028007	nickel monoxide	nickel monoxide results in decreased expression of KLF5 mRNA	19167457
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of KLF5 mRNA	17616710
C507134	ON 01910	ON 01910 results in increased expression of KLF5 mRNA	22351695
D010126	Ozone	pyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLF5 mRNA]	17460151
D000073878	Palm Oil	Palm Oil results in increased expression of KLF5 mRNA	18042831
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of KLF5 mRNA	26272509
D052638	Particulate Matter	Particulate Matter results in increased expression of KLF5 mRNA	21703343
C410127	PCB 180	PCB 180 results in decreased expression of KLF5 mRNA	23829299
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased activity of KLF5 protein	27589886
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of KLF5 mRNA	25868421
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of KLF5 mRNA	17097637
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of KLF5 mRNA	26272509
D010705	Phosgene	Phosgene affects the expression of KLF5 mRNA	16300373
C060836	pioglitazone	pioglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA]	25874449
C060836	pioglitazone	pioglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 protein]	25874449
D010936	Plant Extracts	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of KLF5 protein]	21297082
D010936	Plant Extracts	KLF5 protein affects the reaction [Plant Extracts results in increased expression of ILK protein]	21297082
D010936	Plant Extracts	Plant Extracts results in increased expression of KLF5 mRNA	21297082
D010936	Plant Extracts	Plant Extracts results in increased expression of KLF5 protein	21297082
D010938	Plant Oils	Plant Oils results in increased expression of KLF5 mRNA	23370395
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of KLF5 mRNA	20876846
D011374	Progesterone	Progesterone results in increased expression of KLF5 mRNA	18037150\|1807036
D011441	Propylthiouracil	Propylthiouracil affects the expression of KLF5 mRNA	24780913
C010313	pseudocumene	pseudocumene results in decreased expression of KLF5 protein	17337753
C043680	ptaquiloside	ptaquiloside results in decreased expression of KLF5 mRNA	23274088
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLF5 mRNA]	17460151
D011794	Quercetin	Quercetin results in increased expression of KLF5 mRNA	21632981
C059514	resveratrol	[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of KLF5 mRNA	26667767
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of KLF5 mRNA	21127053
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF5 mRNA	16054899
C089730	rosiglitazone	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF5 mRNA]	16054899
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF5 mRNA]	16054899
C089730	rosiglitazone	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA]]"	25874449
C089730	rosiglitazone	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 protein]]"	25874449
C089730	rosiglitazone	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA]]	25874449
C089730	rosiglitazone	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 protein]]	25874449
C089730	rosiglitazone	PPARG mutant form inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 protein]]	25874449
C089730	rosiglitazone	rosiglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA]	25874449
C089730	rosiglitazone	rosiglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 protein]	25874449
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of KLF5 mRNA"	16678137
C093642	SB 203580	SB 203580 inhibits the reaction [TGFB1 protein results in decreased expression of KLF5 mRNA]	21712382
C093642	SB 203580	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF5 mRNA]	28329830
C534628	SCH 23390	SCH 23390 results in decreased expression of KLF5 mRNA	19564919
D012715	Sesame Oil	Sesame Oil results in decreased expression of KLF5 mRNA	29191790
D012834	Silver	Silver results in increased expression of KLF5 mRNA	26014281
C440975	silybin	silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA]	25559859
D020123	Sirolimus	Sirolimus results in increased expression of KLF5 mRNA	21865292
D012906	Smoke	Smoke results in decreased expression of KLF5 mRNA	21095227
C009277	sodium arsenate	sodium arsenate results in increased expression of KLF5 mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in increased expression of KLF5 mRNA	12760830
C016104	sodium bichromate	sodium bichromate affects the expression of KLF5 mRNA	22110744
C538809	sodium pentaborate	sodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of KLF5 mRNA]	28285642
D012999	Soman	Soman results in increased expression of KLF5 mRNA	19281266
D013467	Sulindac	Sulindac results in increased expression of KLF5 mRNA	11906190
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of KLF5 mRNA"	18579281
D016559	Tacrolimus	Tacrolimus results in increased expression of KLF5 mRNA	21865292
C061133	tamibarotene	tamibarotene inhibits the reaction [KLF5 protein binds to PDGFA promoter]	16224062
C061133	tamibarotene	tamibarotene inhibits the reaction [KLF5 protein binds to [RARA protein binds to RXRA protein]]	16224062
C061133	tamibarotene	tamibarotene inhibits the reaction [[KLF5 protein binds to [RARA protein binds to RXRA protein]] which binds to PDGFA promoter]	16224062
C061133	tamibarotene	tamibarotene inhibits the reaction [KLF5 results in increased expression of PDGFA mRNA]	16224062
C061133	tamibarotene	tamibarotene inhibits the reaction [[RARA co-treated with RXRA] promotes the reaction [KLF5 results in increased expression of PDGFA mRNA]]	16224062
C061133	tamibarotene	tamibarotene results in decreased expression of KLF5 mRNA	16224062
C061133	tamibarotene	tamibarotene results in decreased activity of KLF5	16224062
C061133	tamibarotene	tamibarotene results in decreased expression of KLF5 mRNA	16224062
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of KLF5 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of KLF5 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of KLF5 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of KLF5 mRNA	12377990\|2315218
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of KLF5 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF5 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KLF5 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of KLF5 mRNA	18691609\|2405805
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of KLF5 mRNA	20558275
C009495	titanium dioxide	titanium dioxide results in decreased expression of KLF5 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of KLF5 mRNA	28065790
D019772	Topotecan	Topotecan results in decreased expression of KLF5 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of KLF5 mRNA	21934132
D014212	Tretinoin	Tretinoin results in decreased expression of KLF5 mRNA	16224062
C034613	triacsin C	triacsin C results in increased expression of KLF5 mRNA	16704987
C012589	trichostatin A	[decitabine co-treated with trichostatin A] results in increased expression of KLF5 mRNA	20678512
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of KLF5 mRNA	20678512\|2493525
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KLF5 mRNA"	26179874
C022884	undecane	undecane results in decreased expression of KLF5 protein	17337753
D014520	Urethane	Urethane results in increased expression of KLF5 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of KLF5 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in decreased expression of KLF5 mRNA	19136453
D014635	Valproic Acid	Valproic Acid results in increased expression of KLF5 mRNA	21427059
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of KLF5 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of KLF5 mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of KLF5 mRNA	23034163\|2355583
D015034	Zinc Oxide	Zinc Oxide analog results in increased expression of KLF5 mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	16595680
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	16595680
GO:0005515	protein binding	-	IPI	17320083
GO:0008134	transcription factor binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0001525	angiogenesis	-	IEA	-
GO:0006357	regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0006366	transcription by RNA polymerase II	-	TAS	8479902
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0030033	microvillus assembly	-	IEA	-
GO:0032534	regulation of microvillus assembly	-	IEA	-
GO:0035914	skeletal muscle cell differentiation	-	IEA	-
GO:0045600	positive regulation of fat cell differentiation	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	16595680
GO:0060576	intestinal epithelial cell development	-	IEA	-
GO:0071407	cellular response to organic cyclic compound	-	IEA	-
GO:0099156	cell-cell signaling via exosome	-	IDA	28408180
GO:1901653	cellular response to peptide	-	IEA	-
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	-	IDA	28408180
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	IDA	-
GO:0005794	Golgi apparatus	-	IDA	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
12707992	[Cardiovascular research in the era of genome medicine and EBM]. (2003 Mar)	Nagai R	Rinsho Byori