Gene: TAF11

6882
MGC:15243|PRO2134|TAF2I|TAFII28
TATA-box binding protein associated factor 11
protein-coding
6p21.31
Ensembl:ENSG00000064995 MIM:600772 Vega:OTTHUMG00000014556 UniprotKB:Q15544
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
5.030e-1 (AD)  6.830e-2 (ND)   (Frontal_Cortex)
8.653e-1 (AD)  9.313e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2273006chr6:34883357 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF2B10.938
GLT8D10.928
XPNPEP10.925
MRPL320.92
USF10.919
PA2G40.919
CDC1230.916
PSMD130.915
DAP30.914
GNL30.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.734
OR4F29-0.689
MTRNR2L6-0.284
MTRNR2L9-0.277
MTRNR2L10-0.245
ZBTB20-0.242
EVC2-0.205
KCNK5-0.205
NKAIN3-0.205
TTLL10-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TAF11 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of TAF11 mRNA21420995
C041512benzo(b)fluorene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of TAF11 mRNA22120849
D053119Benzophenanthridines[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of TAF11 mRNA22120849
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TAF11 mRNA22228805
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TAF11 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of TAF11 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of TAF11 mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of TAF11 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of TAF11 mRNA19789285
D019327Copper SulfateCopper Sulfate results in decreased expression of TAF11 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TAF11 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TAF11 mRNA28628672
C012301domoic aciddomoic acid results in decreased expression of TAF11 mRNA18936300
D005557FormaldehydeFormaldehyde results in decreased expression of TAF11 mRNA20655997
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TAF11 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TAF11 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TAF11 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TAF11 mRNA28628672
C410337K 7174K 7174 results in decreased expression of TAF11 mRNA24086573
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TAF11 mRNA23458150
C022838nickel chloridenickel chloride results in decreased expression of TAF11 mRNA17312168
C031181phenanthrenephenanthrene results in decreased expression of TAF11 mRNA19457238
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TAF11 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of TAF11 mRNA23557933
C045362prochlorazprochloraz results in increased expression of TAF11 mRNA21470553
C447880retene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of TAF11 mRNA22120849
D012999SomanSoman results in decreased expression of TAF11 mRNA19281266
D012999SomanSoman results in increased expression of TAF11 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TAF11 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TAF11 mRNA25613284
D014635Valproic AcidValproic Acid results in increased expression of TAF11 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of TAF11 mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of TAF11 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IBA21873635  
GO:0003713transcription coactivator activity-IDA8670810  
GO:0005515protein binding-IPI7729427  9045704  9695952  25416956  
GO:0008134transcription factor binding-IBA21873635  
GO:0042809vitamin D receptor binding-IPI10744685  
GO:0046966thyroid hormone receptor binding-IPI10744685  
GO:0046982protein heterodimerization activity-IEA-  
GO:0047485protein N-terminus binding-IPI7729427  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006366transcription by RNA polymerase II-IC7729427  
GO:0006366transcription by RNA polymerase II-TAS-  
GO:0006367transcription initiation from RNA polymerase II promoter-IC7729427  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0042795snRNA transcription by RNA polymerase II-TAS-  
GO:0043923positive regulation by host of viral transcription-IDA9108034  
GO:0051123RNA polymerase II transcriptional preinitiation complex assembly-IBA21873635  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005669transcription factor TFIID complex-IBA21873635  
GO:0005669transcription factor TFIID complex-IDA7729427  8670810  14580349  
GO:0005794Golgi apparatus-IDA-  
KEGG ID KEGG Term
hsa03022Basal transcription factors
Reactome ID Reactome Term Evidence
R-HSA-162587HIV Life CycleIEA
R-HSA-162599Late Phase of HIV Life CycleIEA
R-HSA-162906HIV InfectionIEA
R-HSA-1643685DiseaseIEA
R-HSA-167161HIV Transcription InitiationIEA
R-HSA-167162RNA Polymerase II HIV Promoter EscapeIEA
R-HSA-167172Transcription of the HIV genomeIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5663205Infectious diseaseIEA
R-HSA-674695RNA Polymerase II Pre-transcription EventsTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-6807505RNA polymerase II transcribes snRNA genesTAS
R-HSA-6807505RNA polymerase II transcribes snRNA genesIEA
R-HSA-73776RNA Polymerase II Promoter EscapeTAS
R-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-75953RNA Polymerase II Transcription InitiationTAS
R-HSA-76042RNA Polymerase II Transcription Initiation And Promoter ClearanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal