Gene info: ID 6885

Gene: MAP3K7

GENE ID: 6885

Synonyms: CSCF|FMD2|MEKK7|TAK1|TGF1a

Description: mitogen-activated protein kinase kinase kinase 7

Gene type: protein-coding

Location: 6q15

dbXrefs: Ensembl:ENSG00000135341 MIM:602614 Vega:OTTHUMG00000015217 UniprotKB:O43318

RefSeq: NG_011966.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.796e-2 (AD) 7.769e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZNF207	0.94
ZRANB2	0.933
RPS6KB1	0.932
STT3B	0.931
API5	0.93
TRMT1L	0.93
GOPC	0.93
VPS37A	0.93
MAP4K3	0.929
KPNA3	0.929

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.63
OR4F29	-0.589
MTRNR2L10	-0.303
MTRNR2L9	-0.292
MTRNR2L6	-0.289
TTLL10	-0.277
KLRB1	-0.273
RSPO1	-0.26
PTGDR2	-0.26
RNF223	-0.242

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MAP3K7 protein"	21705713
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of MAP3K7 mRNA"	21346803
C003898	2-anisidine	2-anisidine results in decreased expression of MAP3K7 mRNA	28089782
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP3K7 mRNA"	27188386
C403563	5-7-oxo-zeaenol	5-7-oxo-zeaenol inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAP3K7 protein]	22171160
C403563	5-7-oxo-zeaenol	5-7-oxo-zeaenol inhibits the reaction [Quercetin results in increased phosphorylation of MAP3K7 protein]	22711909
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP3K7 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of MAP3K7 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of MAP3K7 gene	27153756
C011860	alpha-chaconine	"alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP3K7 protein]"	25913072
C088115	anacardic acid	anacardic acid results in decreased activity of MAP3K7 protein	18349320
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of MAP3K7 mRNA	25339124
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of MAP3K7 mRNA	24449571
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAP3K7 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MAP3K7 mRNA	20127859
C006780	bisphenol A	bisphenol A affects the expression of MAP3K7 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of MAP3K7 mRNA	16029874
C006780	bisphenol A	bisphenol A results in decreased expression of MAP3K7 mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of MAP3K7 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of MAP3K7 mRNA	25181051\|2717856
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of MAP3K7 mRNA	15336504
D002104	Cadmium	Cadmium results in increased expression of MAP3K7 mRNA	24084258
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MAP3K7 mRNA	18974090
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of MAP3K7 mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of MAP3K7 promoter	22457795
D002166	Camptothecin	MAP3K7 mRNA results in decreased susceptibility to Camptothecin	25269479
D002211	Capsaicin	5-7-oxo-zeaenol inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAP3K7 protein]	22171160
D002211	Capsaicin	Capsaicin results in increased phosphorylation of and results in increased activity of MAP3K7 protein	22171160
D002211	Capsaicin	capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAP3K7 protein]	22171160
C071423	capsazepine	capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAP3K7 protein]	22171160
D002220	Carbamazepine	Carbamazepine affects the expression of MAP3K7 mRNA	24752500
C054133	casticin	casticin results in increased expression of MAP3K7 mRNA	27862857
D016572	Cyclosporine	Cyclosporine results in increased phosphorylation of MAP3K7 protein	23958496
D003609	Dactinomycin	Dactinomycin results in decreased expression of MAP3K7 mRNA	16001973
D003703	Demecolcine	Demecolcine results in decreased expression of MAP3K7 mRNA	23649840
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of MAP3K7 mRNA	21266533
D004008	Diclofenac	Diclofenac affects the expression of MAP3K7 mRNA	24752500
D004041	Dietary Fats	Dietary Fats results in decreased expression of MAP3K7 mRNA	25016146
C049347	fasudil	fasudil results in decreased expression of MAP3K7 protein	22465603
C020748	ferrous sulfate	ferrous sulfate affects the localization of MAP3K7 protein	17172471
C020748	ferrous sulfate	ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]	17172471
C020748	ferrous sulfate	ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]	17172471
C020748	ferrous sulfate	ferrous sulfate results in increased activity of MAP3K7 protein	17172471
C020748	ferrous sulfate	Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]	17172471
C020748	ferrous sulfate	Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]	17172471
C020748	ferrous sulfate	MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]	17172471
C020748	ferrous sulfate	MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]	17172471
C020748	ferrous sulfate	MAP3K7 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]	17172471
D005372	Filipin	Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]	17172471
D005372	Filipin	Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]	17172471
D005372	Filipin	Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]	17172471
D005372	Filipin	Filipin inhibits the reaction [Iron results in increased activity of MAP3K7 protein]	17172471
D005557	Formaldehyde	Formaldehyde results in decreased expression of MAP3K7 mRNA	23649840
C103280	goniothalamin	goniothalamin results in decreased activity of MAP3K7 protein	23845509
D006854	Hydrocortisone	Hydrocortisone results in decreased expression of MAP3K7 mRNA	21267416
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of MAP3K7 mRNA	19376150
D007501	Iron	Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]	17172471
D007501	Iron	Filipin inhibits the reaction [Iron results in increased activity of MAP3K7 protein]	17172471
D007501	Iron	Iron affects the localization of MAP3K7 protein	17172471
D007501	Iron	Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]	17172471
D007501	Iron	Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]	17172471
D007501	Iron	Iron results in increased activity of MAP3K7 protein	17172471
D007501	Iron	MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]	17172471
D007501	Iron	MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]	17172471
D007501	Iron	MAP3K7 protein affects the reaction [Iron results in increased secretion of TNF protein]	17172471
C410337	K 7174	K 7174 results in increased expression of MAP3K7 mRNA	24086573
D048628	Ketolides	Ketolides analog results in decreased expression of MAP3K7 mRNA	24967691
C570295	labdanolic acid methyl ester	"labdanolic acid methyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP3K7 protein]"	22036724
C440499	lipopolysaccharide, Escherichia coli O111 B4	"alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP3K7 protein]"	25913072
C440499	lipopolysaccharide, Escherichia coli O111 B4	"labdanolic acid methyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP3K7 protein]"	22036724
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP3K7 protein"	22036724\|2591307
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MAP3K7 mRNA	12057914
C025340	manganese chloride	manganese chloride results in increased methylation of MAP3K7 gene	27913844
D008694	Methamphetamine	Methamphetamine results in increased expression of MAP3K7 mRNA	19564919
D008727	Methotrexate	Methotrexate results in decreased expression of MAP3K7 mRNA	25339124
D008727	Methotrexate	Methotrexate results in increased phosphorylation of MAP3K7 protein	19100307
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of MAP3K7 mRNA	23103053
D009151	Mustard Gas	Mustard Gas results in increased expression of MAP3K7 mRNA	18955075
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MAP3K7 mRNA"	25620056
C022838	nickel chloride	nickel chloride affects the expression of MAP3K7 mRNA	22546817
D010076	Oxazepam	Oxazepam results in increased expression of MAP3K7 mRNA	12727805
D010269	Paraquat	Paraquat results in increased expression of MAP3K7 mRNA	21371552
C008776	pelargonic acid	pelargonic acid results in decreased expression of MAP3K7 mRNA	11379042
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP3K7 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of MAP3K7 mRNA	26272509
D010695	Phlorhizin	Phlorhizin results in decreased expression of MAP3K7 mRNA	22538082
C006253	pirinixic acid	pirinixic acid results in decreased expression of MAP3K7 mRNA	12727805
C006253	pirinixic acid	pirinixic acid results in increased expression of MAP3K7 mRNA	12727805
D010936	Plant Extracts	Plant Extracts results in increased expression of MAP3K7 mRNA	23557933
D011794	Quercetin	5-7-oxo-zeaenol inhibits the reaction [Quercetin results in increased phosphorylation of MAP3K7 protein]	22711909
D011794	Quercetin	Quercetin results in increased phosphorylation of MAP3K7 protein	22711909
D017382	Reactive Oxygen Species	MAP3K7 protein affects the abundance of Reactive Oxygen Species	20855879
D017382	Reactive Oxygen Species	MAP3K7 protein results in decreased abundance of Reactive Oxygen Species	20959492
D017382	Reactive Oxygen Species	[MAP3K7 protein results in increased expression of NFE2L2 protein] which results in decreased abundance of Reactive Oxygen Species	20855879
C041376	rosmarinic acid	rosmarinic acid results in decreased phosphorylation of MAP3K7 protein	28789951
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of MAP3K7 mRNA	21427059
D012643	Selenium	Selenium results in decreased expression of MAP3K7 mRNA	19244175
D019821	Simvastatin	Simvastatin results in decreased activity of [MAP3K7 protein co-treated with TAB1 protein]	17277159
C017947	sodium arsenite	sodium arsenite results in increased expression of MAP3K7 protein	21925251
C016104	sodium bichromate	sodium bichromate results in increased expression of MAP3K7 mRNA	22155349
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of MAP3K7 mRNA	27862939
D018038	Sodium Selenite	Sodium Selenite results in increased expression of MAP3K7 mRNA	18175754
D013431	Sulfates	Sulfates affects the methylation of MAP3K7 promoter	25395096
D016559	Tacrolimus	Tacrolimus results in increased phosphorylation of MAP3K7 protein	23958496
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MAP3K7 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MAP3K7 mRNA	19770486
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in decreased expression of MAP3K7 mRNA"	11379042
C012589	trichostatin A	trichostatin A affects the expression of MAP3K7 mRNA	28542535
D014415	Tunicamycin	Tunicamycin results in increased expression of MAP3K7 mRNA	17127020
D014635	Valproic Acid	Valproic Acid affects the expression of MAP3K7 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of MAP3K7 gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of MAP3K7 mRNA	21427059
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of MAP3K7 gene	25560391
D014750	Vincristine	Vincristine results in decreased expression of MAP3K7 mRNA	23649840

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	IEA	-
GO:0004672	protein kinase activity	-	IDA	10094049
GO:0004674	protein serine/threonine kinase activity	-	EXP	10702308 11460167 20538596
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0004709	MAP kinase kinase kinase activity	-	EXP	11460167
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004709	MAP kinase kinase kinase activity	-	IDA	11460167
GO:0005515	protein binding	-	IPI	10094049 11460167 12496252 15075345 15764709 16840345 16845370 17079228 17110930 17158449 17449468 17709393 18286207 18591963 18758450 19820695 21512573 21903422 22081109 22158122 22904686 25241761 26334375 27426733
GO:0005524	ATP binding	-	IEA	-
GO:0030971	receptor tyrosine kinase binding	-	IPI	18762249
GO:0042802	identical protein binding	-	IPI	27426733
GO:0097110	scaffold protein binding	-	IDA	23776175

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000186	activation of MAPKK activity	-	IBA	21873635
GO:0000186	activation of MAPKK activity	-	IDA	8663074 9079627
GO:0000187	activation of MAPK activity	-	IDA	9079627
GO:0000187	activation of MAPK activity	-	TAS	-
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	-
GO:0002726	positive regulation of T cell cytokine production	-	IMP	15125833
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	-	TAS	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007179	transforming growth factor beta receptor signaling pathway	-	TAS	9466656
GO:0007223	Wnt signaling pathway, calcium modulating pathway	-	TAS	-
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	TAS	-
GO:0007250	activation of NF-kappaB-inducing kinase activity	-	IMP	10094049 15125833
GO:0007252	I-kappaB phosphorylation	-	IDA	11460167
GO:0007254	JNK cascade	-	IDA	9079627
GO:0007254	JNK cascade	-	TAS	-
GO:0016032	viral process	-	IEA	-
GO:0016239	positive regulation of macroautophagy	-	ISS	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0032743	positive regulation of interleukin-2 production	-	IMP	15125833
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IMP	14982987
GO:0043276	anoikis	-	ISS	-
GO:0043507	positive regulation of JUN kinase activity	-	IDA	11460167
GO:0043507	positive regulation of JUN kinase activity	-	IMP	10094049
GO:0043966	histone H3 acetylation	-	IDA	18838386
GO:0050852	T cell receptor signaling pathway	-	NAS	15125833
GO:0050852	T cell receptor signaling pathway	-	TAS	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	TAS	-
GO:0051403	stress-activated MAPK cascade	-	IDA	9079627
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	-	TAS	-
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	-	IDA	18838386
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IEA	-
GO:0008385	IkappaB kinase complex	colocalizes_with	IPI	10094049
GO:0010008	endosome membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04310	Wnt signaling pathway
hsa04380	Osteoclast differentiation
hsa04520	Adherens junction
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04660	T cell receptor signaling pathway
hsa05140	Leishmaniasis
hsa05145	Toxoplasmosis

Reactome ID	Reactome Term	Evidence
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	IEA
R-HSA-1169091	Activation of NF-kappaB in B cells	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168638	NOD1/2 Signaling Pathway	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-4086398	Ca2+ pathway	TAS
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	TAS
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	TAS
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-75893	TNF signaling	TAS
R-HSA-9014325	TICAM1,TRAF6-dependent induction of TAK1 complex	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23027623	MAP kinase genes and colon and rectal cancer. (2012 Dec)	Slattery ML	Carcinogenesis
22199996	Tumor necrosis factor-related genes and colon and rectal cancer. (2011)	Slattery ML	Int J Mol Epidemiol Genet