Gene: TAP1

6890
ABC17|ABCB2|APT1|D6S114E|PSF-1|PSF1|RING4|TAP1*0102N|TAP1N
transporter 1, ATP binding cassette subfamily B member
protein-coding
6p21.32
Ensembl:ENSG00000168394 MIM:170260 Vega:OTTHUMG00000031067 UniprotKB:Q03518
NG_011759.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24154161chr6:32820421TAP1Gene body1.406e-4Alcohol use disorders26763658
cg02181920chr6:32820029TAP11.500e-8Smoking27651444
cg10666909chr6:32820249TAP16.900e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYD880.899
APOL60.897
PLSCR10.892
GBP10.89
IRF70.889
DTX3L0.888
NLRC50.882
IL18BP0.88
PSMB80.876
HELZ20.875

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.456
ABCC12-0.448
MARCH4-0.432
NEUROD6-0.428
PPEF1-0.418
ADRA1D-0.416
CASC15-0.41
CALHM1-0.41
MYADML2-0.407
LHX6-0.404

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01259LapatinibSmall Molecule231277-92-2Approved|InvestigationalTransporter
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of TAP1 mRNA"26377693
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TAP1 mRNA"21346803
C0194992-nitrofluorene2-nitrofluorene results in increased expression of TAP1 mRNA14600272
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TAP1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TAP1 mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TAP1 mRNA14600272
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TAP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TAP1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TAP1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TAP1 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TAP1 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TAP1 mRNA14600272|2181346
C027955aflatoxin G1aflatoxin G1 results in decreased expression of TAP1 mRNA20381597
C027955aflatoxin G1aflatoxin G1 results in decreased expression of TAP1 protein20381597
C430898AGN 194204AGN 194204 results in decreased expression of TAP1 mRNA16339527
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TAP1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TAP1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of TAP1 mRNA19128835
C015001arsenitearsenite results in decreased expression of TAP1 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of TAP1 mRNA]18929588
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TAP1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TAP1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TAP1 mRNA20106945|2163298
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TAP1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TAP1 mRNA19770486|2373587
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TAP1 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TAP1 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of TAP1 mRNA21185374
C006780bisphenol Abisphenol A results in increased expression of TAP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TAP1 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of TAP1 mRNA18958704
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TAP1 mRNA14729362|1500399
C584509C646 compoundC646 compound results in increased expression of TAP1 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TAP1 mRNA25993096
D002166CamptothecinCamptothecin results in increased expression of TAP1 mRNA17374387
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TAP1 mRNA17484886
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TAP1 mRNA]18038451
D002725ChloroformChloroform results in increased expression of TAP1 mRNA21813463
D002737ChloropreneChloroprene results in decreased expression of TAP1 mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TAP1 mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TAP1 mRNA27858113
D003471CuprizoneCuprizone results in increased expression of TAP1 mRNA26577399
D003520CyclophosphamideCyclophosphamide results in increased expression of TAP1 mRNA21527772
D016572CyclosporineCyclosporine results in increased expression of TAP1 mRNA20106945|2214713
D003609DactinomycinDactinomycin results in increased expression of TAP1 mRNA21527772
D003630DaunorubicinDaunorubicin results in increased expression of TAP1 mRNA17374387
C014347decitabinedecitabine affects the expression of TAP1 mRNA23300844
D003703DemecolcineDemecolcine results in increased expression of TAP1 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in decreased expression of TAP1 mRNA15766417
C007262deoxynivalenoldeoxynivalenol results in decreased expression of TAP1 protein15766417
D016264Dextran SulfateDextran Sulfate results in increased expression of TAP1 mRNA23894361
D002945CisplatinCisplatin affects the expression of TAP1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TAP1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TAP1 mRNA19561079|2073748
D002945CisplatinCisplatin results in increased expression of TAP1 mRNA24280081
D004006DichlorvosDichlorvos results in increased expression of TAP1 mRNA21813463
C121718dicyclanildicyclanil results in decreased expression of TAP1 mRNA15664270
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of TAP1 mRNA27405655
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of TAP1 mRNA28085963
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of TAP1 mRNA21318169
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TAP1 mRNA21813463
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of TAP1 mRNA20886546
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TAP1 mRNA14600272
D004317DoxorubicinDoxorubicin results in increased expression of TAP1 mRNA22712078
C118739entinostatentinostat results in increased expression of TAP1 mRNA27188386
C007630estradiol 17 beta-cypionateestradiol 17 beta-cypionate results in increased expression of TAP1 mRNA22497863
D000431EthanolEthanol results in decreased expression of TAP1 mRNA15353170
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TAP1 mRNA23649840
D005047EtoposideEtoposide results in increased expression of TAP1 mRNA17374387|2152777
D005419FlavonoidsFlavonoids results in increased expression of TAP1 mRNA18035473
D005472FluorouracilFluorouracil results in increased expression of TAP1 mRNA17982676|2073748
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of TAP1 mRNA]17982676
D005557FormaldehydeFormaldehyde results in increased expression of TAP1 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of TAP1 mRNA22061828
D006220HaloperidolHaloperidol results in decreased expression of TAP1 mRNA16452686
D017313FenretinideFenretinide results in increased expression of TAP1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TAP1 mRNA20044591
D006918HydroxyureaHydroxyurea results in increased expression of TAP1 mRNA27208086
C492448ICG 001ICG 001 results in increased expression of TAP1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TAP1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TAP1 mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TAP1 mRNA21641980
D008628MercuryMercury results in decreased expression of TAP1 mRNA22688007
D008701MethapyrileneMethapyrilene results in increased expression of TAP1 mRNA21813463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TAP1 mRNA21527772|2364984
D008942MitoxantroneTAP1 protein affects the susceptibility to Mitoxantrone17523305
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of TAP1 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TAP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TAP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TAP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TAP1 mRNA"25554681
D009532NickelNickel results in increased expression of TAP1 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of TAP1 mRNA22714537
D015376NimustineTAP1 protein affects the susceptibility to Nimustine17523305
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of TAP1 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of TAP1 mRNA19716841
D010081OxazoloneOxazolone results in increased expression of TAP1 mRNA21893156
D010100OxygenOxygen deficiency results in increased expression of TAP1 mRNA24205000
D017239PaclitaxelPaclitaxel results in increased expression of TAP1 mRNA20737486
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TAP1 mRNA26705709
D010416PentachlorophenolPentachlorophenol results in increased expression of TAP1 mRNA23892564
C011272perfosfamideTAP1 protein affects the susceptibility to perfosfamide18473730
D026023PermethrinPermethrin results in decreased expression of TAP1 mRNA25073980
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of TAP1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of TAP1 mRNA20813756
D011223PraziquantelPraziquantel results in increased expression of TAP1 mRNA21813463
D011374ProgesteroneProgesterone results in decreased expression of TAP1 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in increased expression of TAP1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TAP1 mRNA27029645
D011794QuercetinQuercetin results in increased expression of TAP1 mRNA21632981
C059514resveratrolresveratrol results in increased expression of TAP1 protein25505154
D012643SeleniumSelenium results in increased expression of TAP1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of TAP1 mRNA25351596
D012834SilverSilver results in increased expression of TAP1 mRNA28959546
D012834SilverSilver results in decreased expression of TAP1 mRNA27131904
C016104sodium bichromatesodium bichromate results in decreased expression of TAP1 mRNA22155349
D012999SomanSoman results in increased expression of TAP1 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TAP1 mRNA21641980
C061133tamibarotenetamibarotene results in increased expression of TAP1 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of TAP1 mRNA20937368
D013629TamoxifenTamoxifen results in decreased expression of TAP1 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TAP1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TAP1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TAP1 mRNA22363418
D014118Toxins, Biological"Toxins, Biological affects the expression of TAP1 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of TAP1 mRNA15498508|1721838
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TAP1 mRNA21893156
D014635Valproic AcidValproic Acid affects the expression of TAP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TAP1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of TAP1 mRNA21318169
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TAP1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TAP1 mRNA22570695
D014750VincristineVincristine results in increased expression of TAP1 mRNA23649840
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TAP1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of TAP1 mRNA27188386
D015032ZincZinc deficiency results in increased expression of TAP1 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12213826  15793001  16828748  17055437  18802093  19165146  
19201886  19297616  22810586  26789246  
GO:0005524ATP binding-IDA7673167  11133832  
GO:0005524ATP binding-IMP15793001  
GO:0015433peptide antigen-transporting ATPase activity-IEA-  
GO:0023029MHC class Ib protein binding-IPI10605026  
GO:0042288MHC class I protein binding-IEA-  
GO:0042605peptide antigen binding-NAS11133832  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IBA21873635  
GO:0042803protein homodimerization activity-ISS-  
GO:0043531ADP binding-IDA11532960  
GO:0046978TAP1 binding-ISS-  
GO:0046979TAP2 binding-IPI1538751  11133832  15518576  
GO:1904680peptide transmembrane transporter activitycontributes_toIGI7673167  
GO:1904680peptide transmembrane transporter activity-IMP17418234  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0002474antigen processing and presentation of peptide antigen via MHC class I-TAS-  
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-TAS-  
GO:0006952defense response-IEA-  
GO:0015031protein transport-IEA-  
GO:0015833peptide transport-IMP11133832  17418234  
GO:0016032viral process-IEA-  
GO:0019885antigen processing and presentation of endogenous peptide antigen via MHC class I-IMP11133832  
GO:0046967cytosol to ER transport-IMP7538543  
GO:0055085transmembrane transport-IBA21873635  
GO:0055085transmembrane transport-IEA-  
GO:1990668vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005815microtubule organizing center-IDA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-IDA8955196  
GO:0030176integral component of endoplasmic reticulum membrane-IDA7673167  11133832  15577206  
GO:0030670phagocytic vesicle membrane-TAS-  
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane-TAS-  
GO:0042825TAP complex-IDA11133832  15518576  
KEGG ID KEGG Term
hsa02010ABC transporters
hsa04145Phagosome
hsa04612Antigen processing and presentation
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1236974ER-Phagosome pathwayTAS
R-HSA-1236974ER-Phagosome pathwayIEA
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1236975Antigen processing-Cross presentationIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationIEA
R-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHCTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17917315Association study between hypertension and A/G polymorphism at codon 637 of the transporter associated with antigen processing 1 gene. (2007 Aug)Shen CHypertens Res