Gene: TARS

6897
ThrRS
threonyl-tRNA synthetase
protein-coding
5p13.3
Ensembl:ENSG00000113407 MIM:187790 Vega:OTTHUMG00000090683 UniprotKB:P26639
NC_000005.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.241e-1 (AD)  2.455e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJA10.877
PTGES30.877
PDIA60.876
CEBPG0.871
DNAJB60.868
ALG20.868
CCT40.865
TCP10.863
USPL10.862
INTS120.861

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.549
OR4F29-0.514
P2RY14-0.281
TCL1A-0.249
HES5-0.248
UPB1-0.241
SLC6A13-0.238
TTC16-0.235
REM1-0.23
NXNL1-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of TARS mRNA"26377693
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of TARS mRNA25596134
C0326681-nitropyrene1-nitropyrene results in increased expression of TARS mRNA19041380
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of TARS mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TARS mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TARS mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TARS mRNA19038236
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TARS mRNA17562736
C016601afimoxifeneafimoxifene results in decreased expression of TARS mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TARS mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of TARS protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of TARS protein26597043
D001205Ascorbic AcidAscorbic Acid results in decreased expression of TARS mRNA19197388
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TARS mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TARS mRNA22228805
D004958EstradiolEstradiol results in increased expression of TARS mRNA16514628
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of TARS mRNA26496021
C006780bisphenol Abisphenol A affects the expression of TARS mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TARS mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of TARS mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of TARS mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of TARS mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TARS gene28505145
C005066borrelidinborrelidin results in decreased activity of TARS protein6746646
C005066borrelidinTARS protein results in decreased susceptibility to borrelidin2747635|6746646|
C005066borrelidinborrelidin analog binds to and affects the folding of TARS protein26271225
C005066borrelidinborrelidin binds to and affects the folding of TARS protein26271225
C005066borrelidinborrelidin binds to and results in decreased activity of TARS protein25824639
C005066borrelidinborrelidin results in decreased activity of TARS protein25489076
C005066borrelidinborrelidin results in decreased activity of TARS protein23425968
D002065BuspironeBuspirone results in decreased expression of TARS mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TARS mRNA25596134
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of TARS mRNA25596134
C100187chloropicrinchloropicrin affects the expression of TARS mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TARS mRNA28472532
C059262cidofovircidofovir results in decreased expression of TARS mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of TARS mRNA25596134
C018021cobaltous chloridecobaltous chloride results in increased expression of TARS mRNA24612858
D003042CocaineCocaine affects the expression of TARS mRNA20187946
D003300CopperCopper results in increased expression of TARS mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of TARS mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of TARS mRNA20106945|2163298
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TARS mRNA21266533
D002945CisplatinCisplatin results in decreased expression of TARS mRNA24280081|2559613
D002945CisplatinCisplatin results in decreased expression of TARS mRNA24280081
C000944dicrotophosdicrotophos results in decreased expression of TARS mRNA28302478
C118739entinostatentinostat results in increased expression of TARS mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TARS protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TARS mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TARS mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TARS mRNA17942748
D011345FenofibrateFenofibrate results in decreased expression of TARS mRNA25596134
D005485FlutamideFlutamide results in increased expression of TARS mRNA24136188
C070081fulvestrantfulvestrant results in decreased expression of TARS mRNA16514628
D005839GentamicinsGentamicins results in increased expression of TARS mRNA22061828
D005897GlafenineGlafenine results in increased expression of TARS mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TARS mRNA20044591
D007069IfosfamideIfosfamide results in decreased expression of TARS mRNA25596134
C016517indole-3-carbinolindole-3-carbinol affects the expression of TARS mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TARS mRNA25613284
C544151jinfukangjinfukang results in decreased expression of TARS mRNA27392435
C410337K 7174K 7174 results in increased expression of TARS mRNA24086573
C008261lead acetatelead acetate results in increased expression of TARS mRNA11578147
C045463leflunomideleflunomide results in increased expression of TARS mRNA28988120
D018021Lithium ChlorideLithium Chloride results in increased expression of TARS mRNA15711924
D008627Mercuric ChlorideMercuric Chloride results in increased expression of TARS mRNA16507785
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TARS mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TARS mRNA26011545
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to TARS protein]17220478
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of TARS mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TARS mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TARS mRNA"25554681|2562005
C022838nickel chloridenickel chloride results in increased expression of TARS mRNA24612858
C018620oleoresinsoleoresins results in decreased expression of TARS mRNA20008804
D010098OxycodoneOxycodone results in decreased expression of TARS mRNA23439660
D010100OxygenOxygen deficiency results in decreased expression of TARS mRNA25596134
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TARS mRNA26272509
D010416PentachlorophenolPentachlorophenol results in decreased expression of TARS mRNA24642059
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TARS mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TARS protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of TARS mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TARS mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of TARS mRNA19270015|1948288
C006253pirinixic acidpirinixic acid results in increased expression of TARS mRNA18301758
D010936Plant ExtractsPlant Extracts results in increased expression of TARS mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of TARS mRNA11678601
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TARS mRNA16514628
D020123SirolimusSirolimus results in decreased expression of TARS mRNA11355896
C017947sodium arsenitesodium arsenite results in decreased expression of TARS protein20050688
C016104sodium bichromatesodium bichromate results in increased expression of TARS mRNA24612858
D013629TamoxifenTamoxifen affects the expression of TARS mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TARS mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TARS mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TARS mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TARS protein16548065
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TARS mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of TARS mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TARS mRNA22363418
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TARS mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TARS mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TARS mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of TARS mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TARS mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TARS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TARS mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of TARS gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TARS mRNA23179753|2627250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000049tRNA binding-IEA-  
GO:0004829threonine-tRNA ligase activity-IBA21873635  
GO:0004829threonine-tRNA ligase activity-NAS2033077  
GO:0004829threonine-tRNA ligase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0005524ATP binding-IEA-  
GO:0042803protein homodimerization activity-NAS2033077  
GO ID GO Term Qualifier Evidence PubMed
GO:0006412translation-NAS2033077  
GO:0006418tRNA aminoacylation for protein translation-IBA21873635  
GO:0006418tRNA aminoacylation for protein translation-TAS-  
GO:0006435threonyl-tRNA aminoacylation-IBA21873635  
GO:0006435threonyl-tRNA aminoacylation-NAS2033077  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-NAS2033077  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0015629actin cytoskeleton-IDA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa00970Aminoacyl-tRNA biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-379716Cytosolic tRNA aminoacylationTAS
R-HSA-379724tRNA AminoacylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
8202497Induction of cytochrome CYPIA1 and formation of toxic metabolites of benzo[a]pyrene by rat aorta: a possible role in atherogenesis. (1994 Jun 7)Thirman MJProc Natl Acad Sci U S A
837362Induction of aryl hydrocarbon hydroxylase in human pulmonary alveolar macrophages and peripheral lymphocytes by cigarette tars. (1977 Jan)McLemore TLCancer Lett