Gene info: ID 6898

Gene: TAT

GENE ID: 6898

Synonyms: -

Description: tyrosine aminotransferase

Gene type: protein-coding

Location: 16q22.2

dbXrefs: Ensembl:ENSG00000198650 MIM:613018 Vega:OTTHUMG00000137590 UniprotKB:P17735

RefSeq: NG_008235.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 30

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.852e-1 (AD) 2.905e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
IFNA13	0.491
DCST1	0.465
GIPR	0.455
MAP4K5	0.45
TMEM165	0.447
HSD17B3	0.441
CYP1A2	0.439
DCST2	0.435
C9orf43	0.435
METTL25	0.433

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
IQCJ	-0.22
CXorf49B	-0.218
BTBD8	-0.198
METTL24	-0.191
LCE3E	-0.19
AVPR2	-0.184
TMPPE	-0.183
ASB12	-0.183
NDNF	-0.174
PRLHR	-0.173

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00114	Pyridoxal Phosphate	Small Molecule	54-47-7	Approved\|Investigational\|Nutraceutical	Target
DB00120	L-Phenylalanine	Small Molecule	63-91-2	Approved\|Investigational\|Nutraceutical	Target
DB00135	L-Tyrosine	Small Molecule	60-18-4	Approved\|Investigational\|Nutraceutical	Target
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C038806	1,4-dihydropyridine	"1,4-dihydropyridine analog inhibits the reaction [Dexamethasone results in increased activity of TAT protein]"	15698539
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TAT mRNA"	25614096
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TAT mRNA"	21346803
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of TAT mRNA	15890375
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TAT mRNA"	19692669
C503101	(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid	"(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased activity of TAT protein]"	15784656
C503101	(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid	"(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased expression of TAT mRNA]"	15784656
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of TAT mRNA"	18648102
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TAT mRNA	15890375
C001969	acephate	acephate results in increased activity of TAT protein	19118596\|2277807
C001969	acephate	diphenyldiselenide inhibits the reaction [acephate results in increased activity of TAT protein]	22778074
D000082	Acetaminophen	Acetaminophen results in decreased expression of TAT mRNA	25704631\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of TAT mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of TAT mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TAT mRNA]	17585979
D000082	Acetaminophen	Acetaminophen affects the expression of TAT mRNA	17366322
D019342	Acetic Acid	Acetic Acid results in decreased expression of TAT protein	21296659
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of TAT protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TAT mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of TAT gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TAT mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TAT mRNA	15890375
D000450	Aldosterone	Aldosterone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA]	22465009\|2246500
D009762	o-Aminoazotoluene	o-Aminoazotoluene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	16267830
D009762	o-Aminoazotoluene	o-Aminoazotoluene inhibits the reaction [Glucocorticoids results in increased expression of TAT mRNA]	11443928\|1288263
D009762	o-Aminoazotoluene	o-Aminoazotoluene inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]	16267830
D000625	Aminooxyacetic Acid	Aminooxyacetic Acid results in decreased activity of TAT protein	8000450
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TAT mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TAT mRNA	20458559
C015001	arsenite	arsenite promotes the reaction [NR3C1 protein results in increased expression of TAT mRNA]	15310238
C015001	arsenite	arsenite results in increased expression of TAT mRNA	15310238
D001285	Atropine	[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein]	7761789
D001374	Azacitidine	Azacitidine results in increased expression of TAT mRNA	27590069
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of TAT mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TAT mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of TAT mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TAT mRNA	19770486\|2171566
C020711	beryllium sulfate	beryllium sulfate inhibits the reaction [Hydrocortisone results in increased expression of TAT protein]	6120038
D004958	Estradiol	Estradiol results in decreased expression of TAT mRNA	20106945
C006780	bisphenol A	bisphenol A affects the expression of TAT mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of TAT mRNA	26364221
C006780	bisphenol A	bisphenol A results in decreased expression of TAT mRNA	26196221
C006780	bisphenol A	bisphenol A affects the methylation of TAT promoter	27415467
C006780	bisphenol A	bisphenol A results in decreased expression of TAT mRNA	25181051
D001966	Bromine	Bromine results in increased expression of TAT mRNA	21391292
C099813	bromochloroacetic acid	bromochloroacetic acid results in decreased expression of TAT protein	21296659
D002104	Cadmium	Cadmium affects the reaction [Dexamethasone results in increased activity of TAT protein]	8975639
D002104	Cadmium	Cadmium results in decreased activity of TAT protein	8975639
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of TAT mRNA	22110744
D000001	Calcimycin	Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]	9398635
D000001	Calcimycin	Sphingosine inhibits the reaction [Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D002737	Chloroprene	Chloroprene results in increased expression of TAT mRNA	23125180
D002922	Ciguatoxins	Ciguatoxins affects the expression of TAT mRNA	18353800
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of TAT mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of TAT mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TAT mRNA]	17585979
D003078	Colchicine	Colchicine results in decreased expression of TAT mRNA	15744361
D003078	Colchicine	pyrazolanthrone inhibits the reaction [Colchicine results in decreased expression of TAT mRNA]	15744361
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TAT mRNA	19789285
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TAT mRNA	19789285
D003314	Corn Oil	Corn Oil affects the expression of TAT mRNA	16360708
D003345	Corticosterone	Corticosterone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA]	22465009\|2246500
D003345	Corticosterone	[Mirex co-treated with Corticosterone] results in increased activity of TAT protein	2893471
D003520	Cyclophosphamide	Cyclophosphamide affects the expression of TAT mRNA	18246545
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of TAT mRNA	18246545
D016572	Cyclosporine	Cyclosporine results in decreased expression of TAT mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of TAT mRNA	25562108\|2798913
C017160	cypermethrin	cypermethrin inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]	26647222
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	28483492
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Dexamethasone results in increased activity of TAT protein]	9398635
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	20599767
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D003671	DEET	DEET results in decreased expression of TAT mRNA	27091632
D003907	Dexamethasone	Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	28483492
D003907	Dexamethasone	Dexamethasone results in increased expression of TAT mRNA	19022236\|2848349
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	19022236
D003907	Dexamethasone	Dexamethasone results in increased expression of TAT mRNA	16267830\|2922274
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	29222744
D003907	Dexamethasone	o-Aminoazotoluene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	16267830
D003907	Dexamethasone	Ketoconazole inhibits the reaction [Dexamethasone results in increased activity of TAT protein]	15755314
D003907	Dexamethasone	"N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide inhibits the reaction [Dexamethasone results in increased activity of TAT protein]"	15755314
D003907	Dexamethasone	"1,4-dihydropyridine analog inhibits the reaction [Dexamethasone results in increased activity of TAT protein]"	15698539
D003907	Dexamethasone	Cadmium affects the reaction [Dexamethasone results in increased activity of TAT protein]	8975639
D003907	Dexamethasone	Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]	9398635
D003907	Dexamethasone	Dactinomycin inhibits the reaction [Dexamethasone results in increased activity of TAT protein]	9398635
D003907	Dexamethasone	Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	20599767
D003907	Dexamethasone	Dactinomycin inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D003907	Dexamethasone	Dexamethasone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA]	22465009\|2246500
D003907	Dexamethasone	Dexamethasone results in increased activity of TAT protein	15698539\|1630746
D003907	Dexamethasone	Dexamethasone results in increased expression of TAT mRNA	16267830\|2059976
D003907	Dexamethasone	Dexamethasone results in increased expression of TAT protein	2882798
D003907	Dexamethasone	Mercury inhibits the reaction [Dexamethasone results in increased activity of TAT protein]	16307467
D003907	Dexamethasone	Methyldimethylaminoazobenzene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	16267830
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased activity of TAT protein]	15698539
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	20599767\|9566755
D003907	Dexamethasone	Sphingosine inhibits the reaction [Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D003907	Dexamethasone	Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D003907	Dexamethasone	Sphingosine inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D003907	Dexamethasone	Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]	9398635
D003907	Dexamethasone	Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]	9398635
D003907	Dexamethasone	Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased expression of TAT mRNA]	9398635
D003975	Diazepam	[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein]	7761789
D002945	Cisplatin	Cisplatin results in decreased expression of TAT mRNA	18246545
D004006	Dichlorvos	[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein]	7761789
D004006	Dichlorvos	Dichlorvos results in increased expression of TAT protein	7761789
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TAT mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]	16267830
D004052	Diethylnitrosamine	Diethylnitrosamine inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]	16267830
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of TAT mRNA	15890375
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of TAT mRNA	15890375
C061132	diphenyldiselenide	diphenyldiselenide inhibits the reaction [acephate results in increased activity of TAT protein]	22778074
D004221	Disulfiram	[Ethanol co-treated with Disulfiram] results in increased activity of TAT protein	9591243
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of TAT mRNA	20064776
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased methylation of TAT promoter	27415467
D000431	Ethanol	[Ethanol co-treated with Disulfiram] results in increased activity of TAT protein	9591243
D000431	Ethanol	Ethanol results in increased expression of TAT mRNA	15353170
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TAT mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TAT mRNA	17108234
D005472	Fluorouracil	Fluorouracil results in decreased expression of TAT protein	21296659
C039281	furan	furan results in decreased expression of TAT mRNA	26194646
C039281	furan	furan results in increased methylation of TAT gene	22079235
D005938	Glucocorticoids	Glucocorticoids results in increased expression of TAT mRNA	11443928\|1288263
D005938	Glucocorticoids	o-Aminoazotoluene inhibits the reaction [Glucocorticoids results in increased expression of TAT mRNA]	11443928\|1288263
D005938	Glucocorticoids	Glucocorticoids results in increased expression of TAT mRNA	12882633
D005938	Glucocorticoids	Methyldimethylaminoazobenzene inhibits the reaction [Glucocorticoids results in increased expression of TAT mRNA]	12882633
D006854	Hydrocortisone	Diethylnitrosamine inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]	16267830
D006854	Hydrocortisone	Hydrocortisone results in increased activity of TAT protein	16267830
D006854	Hydrocortisone	o-Aminoazotoluene inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]	16267830
D006854	Hydrocortisone	beryllium sulfate inhibits the reaction [Hydrocortisone results in increased expression of TAT protein]	6120038
D006854	Hydrocortisone	cypermethrin inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]	26647222
D006854	Hydrocortisone	Diethylnitrosamine inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]	16267830
D006854	Hydrocortisone	Hydrocortisone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA]	22465009\|2246500
D006854	Hydrocortisone	Hydrocortisone results in increased activity of TAT protein	16267830
D006854	Hydrocortisone	Hydrocortisone results in increased expression of TAT mRNA	26647222
D006854	Hydrocortisone	Methoxychlor inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]	26647222
D006854	Hydrocortisone	Methyldimethylaminoazobenzene inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]	16267830
D006854	Hydrocortisone	Mifepristone inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]	26647222
D006854	Hydrocortisone	"N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]"	26647222
D006854	Hydrocortisone	"o,p'-DDT inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]"	26647222
D003900	Desoxycorticosterone	Desoxycorticosterone promotes the reaction [EP300 protein binds to TAT promoter]	22465009
D003900	Desoxycorticosterone	Desoxycorticosterone promotes the reaction [NR3C1 protein binds to TAT promoter]	22465009
D007654	Ketoconazole	Ketoconazole results in decreased expression of TAT mRNA	16608920\|2500029
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Dexamethasone results in increased activity of TAT protein]	15755314
C008261	lead acetate	lead acetate results in decreased expression of TAT mRNA	22609695\|2527062
C008261	lead acetate	lead acetate results in decreased expression of TAT mRNA	11578147
C045463	leflunomide	leflunomide results in increased expression of TAT mRNA	28988120
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TAT mRNA"	18930950
D008628	Mercury	Mercury inhibits the reaction [Dexamethasone results in increased activity of TAT protein]	16307467
D008628	Mercury	Mercury results in increased activity of TAT protein	16307467
D008701	Methapyrilene	Methapyrilene results in increased expression of TAT mRNA	15890375\|2248451
D008731	Methoxychlor	Methoxychlor inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]	26647222
D008749	Methyldimethylaminoazobenzene	Methyldimethylaminoazobenzene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	16267830
D008749	Methyldimethylaminoazobenzene	Methyldimethylaminoazobenzene inhibits the reaction [Glucocorticoids results in increased expression of TAT mRNA]	12882633
D008749	Methyldimethylaminoazobenzene	Methyldimethylaminoazobenzene inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]	16267830
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TAT mRNA	26011545
D008825	Miconazole	Miconazole results in decreased expression of TAT mRNA	16608920
D008825	Miconazole	Miconazole results in increased expression of TAT mRNA	22262564
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	19022236
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	29222744
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased activity of TAT protein]	15698539
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]	20599767\|9566755
D015735	Mifepristone	Mifepristone inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]	26647222
D008917	Mirex	[Mirex co-treated with Corticosterone] results in increased activity of TAT protein	2893471
C500085	muraglitazar	muraglitazar results in increased expression of TAT mRNA	21515302
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TAT mRNA"	25554681
C070021	N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide	"N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide inhibits the reaction [Dexamethasone results in increased activity of TAT protein]"	15755314
C070021	N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide	"N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]"	26647222
D009532	Nickel	Nickel results in increased expression of TAT mRNA	24084258
C012655	nimesulide	nimesulide results in decreased expression of TAT mRNA	24136188
D009768	Obidoxime Chloride	[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein]	7761789
C016340	o,p'-DDT	"o,p'-DDT inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]"	26647222
D009930	Organic Chemicals	Organic Chemicals results in increased expression of TAT mRNA	20526952
D010126	Ozone	Ozone results in increased expression of TAT mRNA	25838073
C016030	pantogab	pantogab results in increased expression of TAT mRNA	17379144
D010269	Paraquat	Paraquat results in decreased expression of TAT mRNA	26196221
D010278	Parathion	Parathion results in decreased expression of TAT mRNA	26196221
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of TAT mRNA	27153767
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of TAT mRNA	27153767
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TAT mRNA	25868421
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TAT mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TAT mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of TAT mRNA	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of TAT mRNA	19162173
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in decreased expression of TAT mRNA	15890375
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TAT mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of TAT mRNA	18445702
C006253	pirinixic acid	pirinixic acid results in increased expression of TAT mRNA	15890375\|1716443
D011239	Prednisolone	"(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased activity of TAT protein]"	15784656
D011239	Prednisolone	"(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased expression of TAT mRNA]"	15784656
D011239	Prednisolone	Prednisolone results in increased activity of TAT protein	15784656
D011239	Prednisolone	Prednisolone results in increased expression of TAT mRNA	15784656
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of TAT mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of TAT mRNA	19162173
D011374	Progesterone	Progesterone results in increased expression of TAT mRNA	20631399\|2301239
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Colchicine results in decreased expression of TAT mRNA]	15744361
C066198	SDZ 51641	SDZ 51641 results in increased expression of TAT mRNA	19234235
C110822	SDZ CPI 975	SDZ CPI 975 results in increased expression of TAT mRNA	19234235
C094089	SDZ FOX 988	SDZ FOX 988 results in increased expression of TAT mRNA	19234235
C009277	sodium arsenate	sodium arsenate results in decreased expression of TAT mRNA	23922661
C016104	sodium bichromate	sodium bichromate affects the expression of TAT mRNA	22110744
C016104	sodium bichromate	sodium bichromate results in decreased expression of TAT mRNA	25993096
D053260	Soot	Soot results in increased expression of TAT mRNA	26551751
D013110	Sphingosine	Sphingosine inhibits the reaction [Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D013110	Sphingosine	Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D013110	Sphingosine	Sphingosine inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D013629	Tamoxifen	Tamoxifen affects the expression of TAT mRNA	20937368
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TAT mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TAT mRNA	20106945
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TAT mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased activity of TAT protein	1672475
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TAT mRNA	17949056\|1977048
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TAT mRNA	16267337
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TAT mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TAT mRNA	18465118\|1969266
D013752	Tetracycline	Tetracycline results in decreased expression of TAT mRNA	24489787
D013755	Tetradecanoylphorbol Acetate	Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]	9398635
D014212	Tretinoin	Tretinoin results in increased expression of TAT mRNA	18230668
C001899	triptolide	triptolide results in decreased expression of TAT mRNA	23639586
C001899	triptolide	triptolide results in increased expression of TAT mRNA	23639586
C057693	troglitazone	troglitazone results in increased expression of TAT mRNA	21515302
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TAT mRNA"	18930950
C044609	Ultroser G	Ultroser G results in increased expression of TAT protein	2882798
D014520	Urethane	Urethane affects the expression of TAT mRNA	28818685
D014580	Ursodeoxycholic Acid	Dactinomycin inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D014580	Ursodeoxycholic Acid	Sphingosine inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]	9398635
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]	9398635
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased expression of TAT mRNA]	9398635
C406224	valdecoxib	valdecoxib results in decreased expression of TAT mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in increased expression of TAT mRNA	25084468\|2915479
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of TAT mRNA"	20526952

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	-	IDA	7999802
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	-	NAS	1973834
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	25910212
GO:0016597	amino acid binding	-	IEA	-
GO:0030170	pyridoxal phosphate binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006103	2-oxoglutarate metabolic process	-	IDA	7999802
GO:0006536	glutamate metabolic process	-	IDA	7999802
GO:0006559	L-phenylalanine catabolic process	-	IEA	-
GO:0006559	L-phenylalanine catabolic process	-	TAS	-
GO:0006572	tyrosine catabolic process	-	IDA	7999802
GO:0006979	response to oxidative stress	-	IEA	-
GO:0009058	biosynthetic process	-	IEA	-
GO:0046689	response to mercury ion	-	IEA	-
GO:0051384	response to glucocorticoid	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005575	cellular_component	-	ND	-
GO:0005739	mitochondrion	-	IEA	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis
hsa00270	Cysteine and methionine metabolism
hsa00350	Tyrosine metabolism
hsa00360	Phenylalanine metabolism
hsa00400	Phenylalanine, tyrosine and tryptophan biosynthesis
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-6788656	Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	TAS
R-HSA-71182	Phenylalanine and tyrosine catabolism	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
1772997	Increased plasminogen activator inhibitor antigen levels in diabetic patients with stable angina. (1991 Feb)	Davi G	Blood Coagul Fibrinolysis
8075305	Prothrombin fragment F1 + 2: correlations with cardiovascular risk factors. (1994 Jun)	Rugman FP	Blood Coagul Fibrinolysis
17478053	Glial-restricted precursors: patterns of expression of opioid receptors and relationship to human immunodeficiency virus-1 Tat and morphine susceptibility in vitro. (2007 Jun 8)	Buch SK	Neuroscience
21900165	HIV-1 coinfection and morphine coexposure severely dysregulate hepatitis C virus-induced hepatic proinflammatory cytokine release and free radical production: increased pathogenesis coincides with uncoordinated host defenses. (2011 Nov)	El-Hage N	J Virol
14574230	Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1. (2003 Oct)	Vagts AJ	Alcohol Clin Exp Res
9134645	Thrombin generation markers and coronary heart disease risk factors in a Polish population sample. (1997 Apr)	Musial J	Thromb Haemost
12917829	Exercise in claudicants is accompanied by excessive thrombin generation. (2003 Aug)	Burns P	Eur J Vasc Endovasc Surg
24694769	Cilostazol eliminates adverse smoking outcome in patients with drug-eluting stent implantation. (2014)	Kim HL	Circ J
15714993	[Clinical classification for lacunar infarct. An investigation of 130 consecutive cases of lacunar infarctions]. (2005 Jan)	Ohara T	Rinsho Shinkeigaku
9484989	Physical exertion induces thrombin formation and fibrin degradation in patients with peripheral atherosclerosis. (1998 Feb)	Mustonen P	Arterioscler Thromb Vasc Biol
29206302	Network Analysis of Hippocampal Neurons by Microelectrode Array in the Presence of HIV-1 Tat and Cocaine. (2017 Dec 5)	Ahooyi TM	J Cell Physiol
17920310	Activated coagulation in patients with shock due to ruptured abdominal aortic aneurysm. (2008 Jan)	Skagius E	Eur J Vasc Endovasc Surg
23682308	A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities. (2013 May 1)	Yuan Y	Medchemcomm
21425908	Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine. (2011)	El-Hage N	Immunol Invest
29146238	CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward. (2018 Mar)	Gonek M	Brain Behav Immun
26150803	Intra-ventral tegmental area HIV-1 Tat1-86 attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats. (2015)	Zhu J	Front Microbiol
22036089	Establishing an EGFR mutation screening service for non-small cell lung cancer - sample quality criteria and candidate histological predictors. (2012 Jan)	Leary AF	Eur J Cancer
26441868	Interactive effects of cocaine on HIV infection: implication in HIV-associated neurocognitive disorder and neuroAIDS. (2015)	Dahal S	Front Microbiol
18716423	Association between anxiety and factors of coagulation and fibrinolysis. (2008)	Geiser F	Psychother Psychosom
19269021	Haemostatic markers in patients with abdominal aortic aneurysm and the impact of aneurysm size. (2009 Sep)	Wallinder J	Thromb Res
24724747	Routine implementation of EGFR mutation testing in clinical practice in Flanders: 'HERMES' project. (2014 Apr)	Janssens A	Acta Clin Belg
29789655	Cigarette smoke promotes HIV infection of primary bronchial epithelium and additively suppresses CFTR function. (2018 May 22)	Chinnapaiyan S	Sci Rep
2150727	Impact of smoking, physical training and weight reduction on FVII, PAI-1 and hemostatic markers in sedentary men. (1990 Dec 28)	Gris JC	Thromb Haemost
26884960	VKORC1 and CD-14 genetic polymorphisms associate with susceptibility to cardiovascular and cerebrovascular diseases. (2015)	Du J	Int J Clin Exp Med
18752144	Increased level of platelet microparticles in survivors of myocardial infarction. (2008)	Michelsen AE	Scand J Clin Lab Invest
21998007	A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women. (2011 Dec)	Kranzler HR	Am J Med Genet B Neuropsychiatr Genet
25760046	Opiate addiction therapies and HIV-1 Tat: interactive effects on glial [Ca(2)(+)]i, oxyradical and neuroinflammatory chemokine production and correlative neurotoxicity. (2014)	Fitting S	Curr HIV Res
16284380	Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case-control study. (2005 Nov)	Matullo G	Cancer Epidemiol Biomarkers Prev
15091342	Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking. (2004 Apr 22)	Bowers MS	Neuron
8760709	Coagulation and fibrinolysis in smoking and nonsmoking pregnant women. (1996 Aug)	Mercelina-Roumans PE	Br J Obstet Gynaecol