Gene: TAZ

6901
BTHS|CMD3A|EFE|EFE2|G4.5|LVNCX|Taz1
tafazzin
protein-coding
Xq28
Ensembl:ENSG00000102125 MIM:300394 Vega:OTTHUMG00000033190 UniprotKB:Q16635
NG_009634.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDK5RAP30.916
LRCH40.905
CLASRP0.898
ANKZF10.895
HSF40.895
SNRNP700.892
CCDC1300.891
CCNL20.889
LUC7L0.888
TSEN540.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.596
OR4F29-0.578
CALCR-0.229
GRPR-0.217
NDNF-0.21
ADAMTS5-0.205
PTGFR-0.205
FER1L6-0.198
FAM216B-0.198
AGTR1-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TAZ mRNA"27291303
D000082AcetaminophenAcetaminophen results in increased expression of TAZ mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of TAZ mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of TAZ mRNA19774075
D000638AmiodaroneAmiodarone results in increased expression of TAZ mRNA24489787
D001205Ascorbic Acid[Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of TAZ mRNA17692823
D001280AtrazineAtrazine affects the expression of TAZ mRNA25929836
D001280AtrazineAtrazine results in increased expression of TAZ mRNA22378314
C547126AZM551248AZM551248 results in increased expression of TAZ mRNA22323515
C031463beta-glycerophosphoric acid[Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of TAZ mRNA17692823
C006780bisphenol Abisphenol A affects the expression of TAZ mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TAZ mRNA25181051
C030583ceric oxideceric oxide analog results in decreased expression of TAZ mRNA24821434
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TAZ mRNA21266533
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of TAZ mRNA22985736
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of TAZ protein22985736
D004317DoxorubicinDoxorubicin results in decreased expression of TAZ mRNA28865727
C018063ethyl protocatechuateethyl protocatechuate inhibits the reaction [rosiglitazone results in increased ubiquitination of and results in increased degradation of TAZ protein]24338020
D005485FlutamideFlutamide results in decreased expression of TAZ mRNA24136188
D005897GlafenineGlafenine results in decreased expression of TAZ mRNA24136188
D007213IndomethacinIndomethacin results in increased expression of TAZ mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TAZ mRNA23086925
D008777MethyltestosteroneMethyltestosterone results in decreased expression of TAZ mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TAZ mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TAZ mRNA"25554681
C000621033napabucasinnapabucasin results in decreased expression of TAZ mRNA25605917
C089730rosiglitazoneethyl protocatechuate inhibits the reaction [rosiglitazone results in increased ubiquitination of and results in increased degradation of TAZ protein]24338020
C009277sodium arsenatesodium arsenate results in increased expression of TAZ mRNA23922661
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TAZ mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TAZ mRNA27255386
D002762Cholecalciferol[Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of TAZ mRNA17692823

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO:0008374O-acyltransferase activity-IBA21873635  
GO:0008374O-acyltransferase activity-TAS-  
GO:00471841-acylglycerophosphocholine O-acyltransferase activity-IDA12930833  
GO:00471841-acylglycerophosphocholine O-acyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-IMP17043667  
GO:0007007inner mitochondrial membrane organization-IBA21873635  
GO:0007507heart development-IBA21873635  
GO:0007507heart development-IMP17043667  
GO:0007519skeletal muscle tissue development-IMP17043667  
GO:0030097hemopoiesis-IMP17043667  
GO:0032049cardiolipin biosynthetic process-IMP11118295  16873891  17043667  19164547  
GO:0032981mitochondrial respiratory chain complex I assembly-IMP16857210  
GO:0035965cardiolipin acyl-chain remodeling-IBA21873635  
GO:0035965cardiolipin acyl-chain remodeling-TAS-  
GO:0042407cristae formation-IMP17043667  
GO:0042775mitochondrial ATP synthesis coupled electron transport-IDA15304507  
GO:0048738cardiac muscle tissue development-IMP17043667  
GO:0060048cardiac muscle contraction-IMP17043667  
GO:1900210positive regulation of cardiolipin metabolic process-IEA-  
GO:2001171positive regulation of ATP biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005739mitochondrion-IC16857210  
GO:0005739mitochondrion-IDA15304507  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005829cytosol-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0031224intrinsic component of membrane-IBA21873635  
GO:0031966mitochondrial membrane-IBA21873635  
KEGG ID KEGG Term
hsa00564Glycerophospholipid metabolism
Reactome ID Reactome Term Evidence
R-HSA-1268020Mitochondrial protein importTAS
R-HSA-1268020Mitochondrial protein importIEA
R-HSA-1430728MetabolismTAS
R-HSA-1482798Acyl chain remodeling of CLTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27628948The Emerging Role of the Hippo Pathway in Lung Cancers: Clinical Implications. (2017 Nov 30)Teoh SLCurr Drug Targets
29215705Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells. (2018 Jun)Chen PCJ Cell Physiol
28128737TAZ is an independent prognostic factor in non-small cell lung carcinoma: Elucidation at protein level. (2017)Malik SACancer Biomark