Gene: TBL1X

6907
EBI|SMAP55|TBL1
transducin beta like 1 X-linked
protein-coding
Xp22.31-p22.2
Ensembl:ENSG00000101849 MIM:300196 Vega:OTTHUMG00000021117 UniprotKB:O60907
NG_053005.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNA120.907
PPARA0.892
GPT20.888
TP53BP20.887
LRP100.884
SNX330.878
EPHX10.877
GOLIM40.875
CHDH0.875
PALLD0.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPEF1-0.482
ABCC12-0.473
DUSP27-0.468
TYRP1-0.465
MCHR1-0.46
NRG1-0.453
OR4F5-0.451
ADTRP-0.451
ADRA1D-0.446
ZNF860-0.441

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of TBL1X mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TBL1X mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TBL1X mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1X mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1X mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of TBL1X mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1X mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1X mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TBL1X mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of TBL1X mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TBL1X protein20106945
C103505AM 251AM 251 results in increased expression of TBL1X mRNA16500647
C068073Am 580Am 580 results in decreased expression of TBL1X mRNA16982809
C006632arsenic trioxidearsenic trioxide results in increased expression of TBL1X mRNA20458559
D001241AspirinAspirin results in decreased expression of TBL1X mRNA15928584
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBL1X mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBL1X mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TBL1X mRNA"19150397|2001819
C006780bisphenol Abisphenol A affects the methylation of TBL1X promoter27334623
C006780bisphenol Abisphenol A affects the expression of TBL1X mRNA25181051
D000069286BortezomibBortezomib results in increased expression of TBL1X mRNA20977926
C584509C646 compoundC646 compound results in increased expression of TBL1X mRNA26191083
C018021cobaltous chloridecobaltous chloride results in decreased expression of TBL1X mRNA19320972
D003375CoumestrolCoumestrol results in decreased expression of TBL1X mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of TBL1X mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of TBL1X mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TBL1X mRNA23914054
D002945CisplatinCisplatin results in decreased expression of TBL1X mRNA19561079
D002945CisplatinCisplatin results in increased expression of TBL1X mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of TBL1X mRNA28302478
D004237DiuronDiuron results in decreased expression of TBL1X mRNA25152437
D005047EtoposideEtoposide results in decreased expression of TBL1X mRNA25270620
D005557FormaldehydeFormaldehyde results in decreased expression of TBL1X mRNA23649840
C492448ICG 001ICG 001 results in increased expression of TBL1X mRNA26191083
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TBL1X mRNA23649840
C008493methylselenic acidmethylselenic acid results in increased expression of TBL1X mRNA18548127
C507134ON 01910ON 01910 results in increased expression of TBL1X mRNA22351695
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TBL1X mRNA25729387
C016030pantogabpantogab results in decreased expression of TBL1X mRNA17379144
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of TBL1X mRNA28973697
D010634PhenobarbitalPhenobarbital results in decreased expression of TBL1X mRNA23091169
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of TBL1X mRNA28903501
D011374ProgesteroneProgesterone affects the expression of TBL1X mRNA17251523
C089730rosiglitazonerosiglitazone results in decreased expression of TBL1X mRNA16982809
D012643SeleniumSelenium results in decreased expression of TBL1X mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TBL1X mRNA25351596
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBL1X mRNA21570461
D013849ThimerosalThimerosal results in decreased expression of TBL1X mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of TBL1X mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TBL1X mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TBL1X mRNA25729387
D014212TretinoinTretinoin results in decreased expression of TBL1X mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1X mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TBL1X mRNA26272509
D014635Valproic AcidValproic Acid results in decreased expression of TBL1X mRNA24935251|2627250
D014635Valproic AcidValproic Acid results in increased methylation of TBL1X gene29154799
D014635Valproic AcidValproic Acid affects the expression of TBL1X mRNA17292431
C025643vinclozolinvinclozolin affects the expression of TBL1X mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of TBL1X mRNA18042343
D014810Vitamin EVitamin E results in decreased expression of TBL1X mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1X mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of TBL1X mRNA27188386
D019287Zinc SulfateZinc Sulfate results in increased expression of TBL1X mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003714transcription corepressor activity-IDA12628926  
GO:0003714transcription corepressor activity-IGI15601853  
GO:0005515protein binding-IPI11931768  12628926  21044950  
GO:0008013beta-catenin binding-IPI18193033  
GO:0008022protein C-terminus binding-IPI18374649  
GO:0008134transcription factor binding-IPI18193033  
GO:0019904protein domain specific binding-IPI10809664  
GO:0042393histone binding-IDA15601853  
GO:0044212transcription regulatory region DNA binding-IDA18193033  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA12628926  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006508proteolysis-IMP18374649  
GO:0007605sensory perception of sound-IMP10330347  
GO:0016575histone deacetylation-IBA21873635  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA18193033  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA18193033  
GO:0050821protein stabilization-ISS-  
GO:0090263positive regulation of canonical Wnt signaling pathway-IMP18193033  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complex-IBA21873635  
GO:0000118histone deacetylase complexcolocalizes_withIDA18326024  
GO:0005634nucleus-IDA18193033  
GO:0005654nucleoplasm-TAS-  
GO:0005876spindle microtubule-IDA18326024  
GO:0017053transcriptional repressor complex-IDA12628926  15601853  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1368082RORA activates gene expressionTAS
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-157118Signaling by NOTCHIEA
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-1989781PPARA activates gene expressionIEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-3214815HDACs deacetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)IEA
R-HSA-400253Circadian ClockTAS
R-HSA-400253Circadian ClockIEA
R-HSA-4839726Chromatin organizationTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23665419Prenatal smoke exposure: effects on infant auditory system and placental gene expression. (2013 Jul-Aug)Katbamna BNeurotoxicol Teratol