Gene: TBP

6908
GTF2D|GTF2D1|HDL4|SCA17|TFIID
TATA-box binding protein
protein-coding
6q27
Ensembl:ENSG00000112592 MIM:600075 Vega:OTTHUMG00000016084 UniprotKB:P20226
NG_008165.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.107e-1 (AD)  2.042e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPAIN0.925
FOXJ30.918
QRICH10.918
NRBP10.917
POLR3F0.916
PSMD110.916
GOLT1B0.916
SECISBP20.916
ARCN10.915
POLR3E0.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.62
OR4F29-0.578
MTRNR2L9-0.364
MTRNR2L10-0.332
MTRNR2L6-0.328
TTLL10-0.289
OR4F16-0.288
CSAG1-0.271
MTRNR2L2-0.266
MTRNR2L8-0.262

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TBP mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TBP mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TBP gene27153756
C006632arsenic trioxidearsenic trioxide affects the methylation of TBP promoter26046465
D001280AtrazineAtrazine results in increased expression of TBP mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TBP mRNA22228805
D004958EstradiolEstradiol results in increased expression of TBP mRNA17823450|1870914
C006780bisphenol Abisphenol A affects the methylation of TBP promoter27334623
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TBP mRNA24794047
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TBP mRNA23650126
C112125cladribine monophosphatecladribine monophosphate affects the activity of TBP protein17320040
C112125cladribine monophosphatecladribine monophosphate affects the reaction [TBP protein binds to GTF2B protein]17320040
D016572CyclosporineCyclosporine results in increased methylation of TBP promoter27989131
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of TBP mRNA18709148
D004041Dietary FatsDietary Fats results in decreased expression of TBP mRNA18042831
D007213IndomethacinIndomethacin results in increased expression of TBP mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBP mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TBP mRNA12057914
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TBP mRNA10975854
D008627Mercuric ChlorideMercuric Chloride affects the expression of TBP mRNA20353558
D000073878Palm OilPalm Oil results in decreased expression of TBP mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of TBP mRNA24642059
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of TBP mRNA21984479
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of TBP mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TBP mRNA18709148|2198447
C045362prochlorazprochloraz results in increased expression of TBP mRNA21470553
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBP mRNA21570461|2405805
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBP mRNA25613284
D014635Valproic AcidValproic Acid affects the expression of TBP mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TBP gene25560391
C025643vinclozolinvinclozolin results in decreased expression of TBP mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000987proximal promoter sequence-specific DNA binding-IDA16263792  
GO:0001016RNA polymerase III regulatory region DNA binding-IBA21873635  
GO:0001034RNA polymerase III transcription factor activity, sequence-specific DNA binding-IMP26638071  
GO:0001047core promoter binding-IDA9841876  
GO:0001093TFIIB-class transcription factor binding-IPI9841876  
GO:0001103RNA polymerase II repressing transcription factor binding-IEA-  
GO:0001129RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly-IDA9841876  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI1465435  7667268  7680771  7724559  7729427  7799929  
8006019  8423815  8504927  8551580  8626665  9045704  
9203586  9349482  9603525  9674425  9748258  9882311  
10391676  10567391  10619841  11029584  11438666  12040021  
12217962  12552007  15207618  16641295  17268553  17318177  
17884155  18391197  22761572  24418534  26496610  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-IPI7724559  8626665  9722567  11005381  12676957  
GO:0017162aryl hydrocarbon receptor binding-IPI15641800  
GO:0019899enzyme binding-IPI25336585  
GO:0044212transcription regulatory region DNA binding-IDA7933101  9027316  16540471  
GO:0070491repressing transcription factor binding-IPI18838386  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006359regulation of transcription by RNA polymerase III-IEA-  
GO:0006361transcription initiation from RNA polymerase I promoter-TAS-  
GO:0006363termination of RNA polymerase I transcription-TAS-  
GO:0006366transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IC7729427  
GO:0006366transcription by RNA polymerase II-IDA7724559  
GO:0006366transcription by RNA polymerase II-IMP27193682  
GO:0006366transcription by RNA polymerase II-TAS-  
GO:0006367transcription initiation from RNA polymerase II promoter-IC7729427  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006383transcription by RNA polymerase III-IDA9027316  
GO:0006383transcription by RNA polymerase III-IMP26638071  
GO:0007283spermatogenesis-IEA-  
GO:0016032viral process-IEA-  
GO:0042795snRNA transcription by RNA polymerase II-TAS-  
GO:0045815positive regulation of gene expression, epigenetic-TAS-  
GO:0045893positive regulation of transcription, DNA-templated-IEA-  
GO:0051123RNA polymerase II transcriptional preinitiation complex assembly-IDA9841876  
GO:0070898RNA polymerase III transcriptional preinitiation complex assembly-IBA21873635  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000126transcription factor TFIIIB complex-IBA21873635  
GO:0000790nuclear chromatin-IDA24289924  
GO:0001939female pronucleus-IEA-  
GO:0001940male pronucleus-IEA-  
GO:0005634nucleus-IDA9841876  27007846  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0005669transcription factor TFIID complex-IBA21873635  
GO:0005669transcription factor TFIID complex-IDA7729427  14580349  27007846  27193682  
GO:0005672transcription factor TFIIA complex-IDA7724559  
GO:0005719nuclear euchromatin-IDA19861239  
GO:0005737cytoplasm-IEA-  
GO:0032991protein-containing complex-IMP15641800  
GO:0097550transcriptional preinitiation complex-IDA9841876  
KEGG ID KEGG Term
hsa03022Basal transcription factors
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162587HIV Life CycleIEA
R-HSA-162599Late Phase of HIV Life CycleIEA
R-HSA-162906HIV InfectionIEA
R-HSA-1643685DiseaseIEA
R-HSA-167161HIV Transcription InitiationIEA
R-HSA-167162RNA Polymerase II HIV Promoter EscapeIEA
R-HSA-167172Transcription of the HIV genomeIEA
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-427359SIRT1 negatively regulates rRNA expressionIEA
R-HSA-427413NoRC negatively regulates rRNA expressionIEA
R-HSA-5250913Positive epigenetic regulation of rRNA expressionTAS
R-HSA-5250924B-WICH complex positively regulates rRNA expressionTAS
R-HSA-5250941Negative epigenetic regulation of rRNA expressionIEA
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5663205Infectious diseaseIEA
R-HSA-674695RNA Polymerase II Pre-transcription EventsTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-6807505RNA polymerase II transcribes snRNA genesTAS
R-HSA-6807505RNA polymerase II transcribes snRNA genesIEA
R-HSA-73762RNA Polymerase I Transcription InitiationIEA
R-HSA-73762RNA Polymerase I Transcription InitiationTAS
R-HSA-73772RNA Polymerase I Promoter EscapeTAS
R-HSA-73776RNA Polymerase II Promoter EscapeTAS
R-HSA-73777RNA Polymerase I Chain ElongationTAS
R-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceIEA
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73863RNA Polymerase I Transcription TerminationTAS
R-HSA-73864RNA Polymerase I TranscriptionIEA
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-74158RNA Polymerase III TranscriptionIEA
R-HSA-74158RNA Polymerase III TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-749476RNA Polymerase III Abortive And Retractive InitiationIEA
R-HSA-75953RNA Polymerase II Transcription InitiationTAS
R-HSA-76042RNA Polymerase II Transcription Initiation And Promoter ClearanceTAS
R-HSA-76046RNA Polymerase III Transcription InitiationIEA
R-HSA-76046RNA Polymerase III Transcription InitiationTAS
R-HSA-76061RNA Polymerase III Transcription Initiation From Type 1 PromoterIEA
R-HSA-76061RNA Polymerase III Transcription Initiation From Type 1 PromoterTAS
R-HSA-76066RNA Polymerase III Transcription Initiation From Type 2 PromoterIEA
R-HSA-76066RNA Polymerase III Transcription Initiation From Type 2 PromoterTAS
R-HSA-76071RNA Polymerase III Transcription Initiation From Type 3 PromoterIEA
R-HSA-76071RNA Polymerase III Transcription Initiation From Type 3 PromoterTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25177835A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence. (2014 Oct)Faisal MComput Biol Med
29572047Contamination trends and factors affecting the transfer of hexabromocyclododecane diastereomers, tetrabromobisphenol A, and 2,4,6-tribromophenol to breast milk in Japan. (2018 Jun)Fujii YEnviron Pollut