Gene: TBX2

6909
-
T-box 2
protein-coding
17q23.2
Ensembl:ENSG00000121068 MIM:600747 Vega:OTTHUMG00000156986 UniprotKB:Q13207
NC_000017.11
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.413e-1 (AD)  1.149e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDUFA4L20.805
PEAR10.804
TINAGL10.785
TGFB1I10.774
KANK20.749
MYO1C0.746
COX4I20.746
COL6A20.743
GJA40.741
NOTCH30.736

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FSTL5-0.475
PTPRR-0.474
SMIM18-0.473
CSRNP3-0.468
KCNB2-0.464
EPHA5-0.463
GLRA3-0.459
SLC2A13-0.456
UNC5D-0.455
HOOK1-0.452

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TBX2 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TBX2 mRNA24449571
D001151ArsenicArsenic affects the methylation of TBX2 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBX2 mRNA26238291
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of TBX2 mRNA]22228805
D004958EstradiolEstradiol results in increased expression of TBX2 mRNA19484750
C006780bisphenol Abisphenol A affects the methylation of TBX2 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of TBX2 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of TBX2 mRNA25181051
C006780bisphenol Abisphenol A affects the methylation of TBX2 promoter27415467
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TBX2 promoter23359474
C584509C646 compoundC646 compound results in decreased expression of TBX2 mRNA26191083
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBX2 gene20938992
C480342clothianidinclothianidin results in increased expression of TBX2 mRNA29044138
D019327Copper SulfateCopper Sulfate results in decreased expression of TBX2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased methylation of TBX2 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of TBX2 mRNA23914054
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TBX2 promoter23359474
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TBX2 mRNA21266533
D004026DieldrinDieldrin results in decreased expression of TBX2 mRNA28385952
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TBX2 promoter23359474
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TBX2 mRNA"22485181
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of TBX2 mRNA"27840820
D004237DiuronDiuron results in increased expression of TBX2 mRNA21551480|2515243
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBX2 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of TBX2 mRNA19167457
D005947GlucoseGlucose results in increased expression of TBX2 mRNA21818840
D017313FenretinideFenretinide results in increased expression of TBX2 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of TBX2 mRNA26191083
C544151jinfukangjinfukang results in decreased expression of TBX2 mRNA27392435
C017461lead nitratelead nitrate affects the reaction [TBX2 affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [TBX2 affects the expression of MT2 mRNA]11891201
D018021Lithium ChlorideLithium Chloride results in decreased expression of TBX2 mRNA17506889
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBX2 gene20938992
C028007nickel monoxidenickel monoxide results in decreased expression of TBX2 mRNA27464988
C028007nickel monoxidenickel monoxide results in decreased expression of TBX2 protein27464988
C007350nitrofennitrofen results in decreased expression of TBX2 mRNA27833996
C007350nitrofennitrofen results in decreased expression of TBX2 protein27833996
D010705PhosgenePhosgene affects the expression of TBX2 mRNA16300373
D010938Plant OilsPlant Oils results in increased expression of TBX2 mRNA23370395
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of TBX2 mRNA16202921
C009166retinol acetateretinol acetate results in increased expression of TBX2 mRNA16772331
D012822Silicon DioxideSilicon Dioxide analog affects the expression of TBX2 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBX2 mRNA24058054
D014212TretinoinTretinoin results in increased expression of TBX2 mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TBX2 mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of TBX2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of TBX2 mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of TBX2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TBX2 mRNA24896083
C029297vinylidene chloridevinylidene chloride results in decreased expression of TBX2 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of TBX2 mRNA20044591
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX2 mRNA"27188386
D019287Zinc SulfateZinc Sulfate results in increased expression of TBX2 mRNA17506889

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11111039  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11111039  
GO:0003677DNA binding-TAS8530034  
GO:0005515protein binding-IPI22002537  
GO:0043565sequence-specific DNA binding-IDA11111039  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA11111039  
GO:0001947heart looping-ISS-  
GO:0003148outflow tract septum morphogenesis-ISS-  
GO:0003151outflow tract morphogenesis-ISS-  
GO:0003203endocardial cushion morphogenesis-ISS-  
GO:0003256regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007219Notch signaling pathway-IEA-  
GO:0007521muscle cell fate determination-ISS-  
GO:0007569cell aging-IDA11748239  
GO:0008016regulation of heart contraction-ISS-  
GO:0008284positive regulation of cell proliferation-IDA11748239  
GO:0035050embryonic heart tube development-ISS-  
GO:0035909aorta morphogenesis-ISS-  
GO:0036302atrioventricular canal development-ISS-  
GO:0042733embryonic digit morphogenesis-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA10468588  11111039  
GO:0048596embryonic camera-type eye morphogenesis-ISS-  
GO:0048738cardiac muscle tissue development-ISS-  
GO:0060021roof of mouth development-IEA-  
GO:0060045positive regulation of cardiac muscle cell proliferation-ISS-  
GO:0060465pharynx development-ISS-  
GO:0060560developmental growth involved in morphogenesis-IEA-  
GO:0060596mammary placode formation-IEA-  
GO:0090398cellular senescence-IDA22002537  
GO:1901208negative regulation of heart looping-ISS-  
GO:1901211negative regulation of cardiac chamber formation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15042700  
GO:0005667transcription factor complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29132311Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. (2017 Nov 13)Wang WBMC Genomics
25664048Association of TBX2 and P21 expression with clinicopathological features and survival of laryngeal squamous cell carcinoma. (2014)Huang YInt J Clin Exp Med
28978111TBX2 subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection. (2017 Sep 15)Khalil AAOncotarget