Gene: TBX5

6910
HOS
T-box 5
protein-coding
12q24.21
Ensembl:ENSG00000089225 MIM:601620 Vega:OTTHUMG00000166191 UniprotKB:Q99593
NG_007373.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.662e-1 (AD)  1.051e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENDOU0.394
GH20.383
MAPKAPK30.377
AQP60.371
BANF20.37
RAB310.363
LCE1C0.361
ASCL10.352
PABPC30.349
PLA2G50.346

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AKR1C1-0.366
AK7-0.363
PABPC1L2A-0.359
NPY5R-0.351
SLC27A2-0.35
SLC7A3-0.345
SNRPN-0.344
HMGCLL1-0.344
STOX2-0.343
ITGBL1-0.343

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TBX5 gene27153756
C015001arsenitearsenite results in increased methylation of TBX5 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TBX5 mRNA"17331233
D001280AtrazineAtrazine results in increased expression of TBX5 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBX5 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of TBX5 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of TBX5 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of TBX5 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of TBX5 mRNA18579281
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TBX5 mRNA21266533
D000431EthanolEthanol results in decreased expression of TBX5 mRNA17676605
D004397FonofosFonofos results in increased methylation of TBX5 promoter22847954
C082359imidaclopridimidacloprid results in decreased expression of TBX5 mRNA27792329
C082359imidaclopridimidacloprid results in decreased expression of TBX5 protein27792329
C410337K 7174K 7174 results in decreased expression of TBX5 mRNA24086573
C007350nitrofennitrofen results in decreased expression of TBX5 mRNA27833996
C007350nitrofennitrofen results in decreased expression of TBX5 protein27833996
D010278ParathionParathion results in increased methylation of TBX5 promoter22847954
C415326phenoxyacetic acidphenoxyacetic acid affects the expression of TBX5 mRNA21621602
D010936Plant ExtractsPlant Extracts results in decreased expression of TBX5 mRNA23557933
D012834SilverSilver results in increased expression of TBX5 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of TBX5 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of TBX5 mRNA27862939
D053260SootSoot results in decreased expression of TBX5 mRNA26551751
C012568terbufosterbufos results in increased methylation of TBX5 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBX5 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBX5 mRNA26139165
D014635Valproic AcidValproic Acid results in increased expression of TBX5 mRNA20219112
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TBX5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA26926761  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA29174768  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-IDA16332960  
GO:0003700DNA-binding transcription factor activity-IDA11431700  12499378  16332960  
GO:0003700DNA-binding transcription factor activity-IMP11431700  
GO:0005515protein binding-IPI11431700  12499378  12845333  16332960  23245941  24000169  
26926761  29174768  
GO:0008134transcription factor binding-IPI11431700  
GO:0043565sequence-specific DNA binding-IDA11431700  12499378  
GO ID GO Term Qualifier Evidence PubMed
GO:0002009morphogenesis of an epithelium-IEA-  
GO:0003166bundle of His development-IEA-  
GO:0003181atrioventricular valve morphogenesis-IEA-  
GO:0003197endocardial cushion development-IEA-  
GO:0003218cardiac left ventricle formation-ISS-  
GO:0003281ventricular septum development-ISS-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007267cell-cell signaling-IDA11161571  
GO:0007389pattern specification process-IEA-  
GO:0007507heart development-IDA15138308  
GO:0007507heart development-IMP8988164  8988165  16183809  25963046  
GO:0008285negative regulation of cell proliferation-IDA11161571  12237100  
GO:0010719negative regulation of epithelial to mesenchymal transition-TAS20299672  
GO:0030324lung development-IEA-  
GO:0030326embryonic limb morphogenesis-IMP8988164  
GO:0030336negative regulation of cell migration-IDA15138308  
GO:0035115embryonic forelimb morphogenesis-IMP16183809  
GO:0035136forelimb morphogenesis-IMP8988164  8988165  
GO:0045893positive regulation of transcription, DNA-templated-IDA11431700  12499378  12845333  16332960  27035640  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA29174768  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP11431700  
GO:0051891positive regulation of cardioblast differentiation-IDA11431700  
GO:0055007cardiac muscle cell differentiation-IEA-  
GO:0060039pericardium development-IDA15138308  
GO:0060044negative regulation of cardiac muscle cell proliferation-IDA11161571  
GO:0060045positive regulation of cardiac muscle cell proliferation-IEA-  
GO:0060413atrial septum morphogenesis-IEA-  
GO:0060980cell migration involved in coronary vasculogenesis-TAS20299672  
GO:0072513positive regulation of secondary heart field cardioblast proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12237100  12499378  14519429  29174768  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA14519429  29174768  
GO:0005737cytoplasm-TAS20299672  
GO:0032991protein-containing complex-IDA26926761  
GO:0032993protein-DNA complex-IDA26926761  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578768Physiological factorsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28111280Inhibition of Gata4 and Tbx5 by Nicotine-Mediated DNA Methylation in Myocardial Differentiation. (2017 Feb 14)Jiang XYStem Cell Reports
26423011Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015 Oct)Wain LVLancet Respir Med