Gene: TBXA2R

6915
BDPLT13|TXA2-R
thromboxane A2 receptor
protein-coding
19p13.3
Ensembl:ENSG00000006638 MIM:188070 Vega:OTTHUMG00000180806 UniprotKB:P21731
NG_013363.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.325e-1 (AD)  8.237e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PGF0.687
TGFB1I10.674
SYDE10.671
KANK20.658
ORAI10.645
MYO1C0.638
ATP2A30.632
EHD20.631
NOTCH30.63
PCOLCE0.628

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAD2L1-0.411
ENPP5-0.396
KIF11-0.379
CDH8-0.378
ANO3-0.377
NEK10-0.374
C1orf146-0.373
KCNB2-0.373
LRRC7-0.371
ST6GALNAC5-0.371

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01207RidogrelSmall Molecule110140-89-1ApprovedTarget
DB06739SeratrodastSmall Molecule112665-43-7ApprovedTarget
DB09285MorniflumateSmall Molecule65847-85-0ApprovedTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of TBXA2R mRNA"26377693
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form"16499875
C09724015-deoxy-delta(12,14)-prostaglandin J2"PPARG protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form]"16499875
C0617507-(3-(3-hydroxy-4-(4'-iodophenoxy)-1-butenyl)-7-oxabicyclo(2.2.1)heptan-2-yl)-5-heptenoic acid7-(3-(3-hydroxy-4-(4'-iodophenoxy)-1-butenyl)-7-oxabicyclo(2.2.1)heptan-2-yl)-5-heptenoic acid binds to and results in increased activity of TBXA2R protein18158556
C0617507-(3-(3-hydroxy-4-(4'-iodophenoxy)-1-butenyl)-7-oxabicyclo(2.2.1)heptan-2-yl)-5-heptenoic acid7-(3-(3-hydroxy-4-(4'-iodophenoxy)-1-butenyl)-7-oxabicyclo(2.2.1)heptan-2-yl)-5-heptenoic acid binds to and results in increased activity of TBXA2R protein17997380
C0757508-epi-prostaglandin F2alpha8-epi-prostaglandin F2alpha binds to and results in increased activity of TBXA2R protein18158556
C0757508-epi-prostaglandin F2alphaTBXA2R protein affects the susceptibility to 8-epi-prostaglandin F2alpha22565502
D000082AcetaminophenAcetaminophen affects the expression of TBXA2R mRNA17562736
D000447AldehydesAldehydes results in increased expression of TBXA2R mRNA25014914
C010845aluminum chloridealuminum chloride results in increased expression of TBXA2R mRNA28826906
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TBXA2R mRNA16483693
D001151ArsenicArsenic affects the methylation of TBXA2R gene25304211
D001194AsbestosAsbestos results in increased expression of TBXA2R mRNA22398240
D001241AspirinTBXA2R gene SNP affects the susceptibility to Aspirin20485159
D001241AspirinTBXA2R polymorphism affects the susceptibility to Aspirin21070398
D001241AspirinTBXA2R SNP results in decreased susceptibility to Aspirin17245331
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TBXA2R mRNA22610609
C006780bisphenol Abisphenol A results in decreased expression of TBXA2R mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of TBXA2R mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of TBXA2R promoter22457795
D002118Calciumrosiglitazone inhibits the reaction [TBXA2R protein results in increased transport of Calcium]16499875
D002118CalciumTBXA2R protein results in increased transport of Calcium16499875
D002118Calciumtroglitazone inhibits the reaction [TBXA2R protein results in increased transport of Calcium]16499875
D002118CalciumML 7 promotes the reaction [TBXA2R protein affects the transport of Calcium]8867106
D002118CalciumW 7 promotes the reaction [TBXA2R protein affects the transport of Calcium]8867106
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TBXA2R mRNA22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of ADGRE1 mRNA]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of ADGRE1 protein]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of CCR2 mRNA]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of CCR2 protein]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of HGF mRNA]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of ITGAM mRNA]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of ITGAM protein]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the susceptibility to Carbon Tetrachloride22206755
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of TBXA2R mRNA18636392
C012843cinnamic aldehydecinnamic aldehyde binds to and results in decreased activity of TBXA2R protein17079160
D003471CuprizoneCuprizone results in increased expression of TBXA2R mRNA26577399
C051762daltrobandaltroban binds to and results in decreased activity of TBXA2R protein9218700
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TBXA2R mRNA23914054
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TBXA2R mRNA15620428
D004317Doxorubicin[Doxorubicin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA19643929
D004317Doxorubicin[Doxorubicin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein19643929
D004317DoxorubicinTBXA2R gene mutant form affects the susceptibility to Doxorubicin19643929
C118739entinostatentinostat results in increased expression of TBXA2R mRNA27188386
D005419FlavonoidsFlavonoids results in decreased expression of TBXA2R mRNA18035473
C069837fullerene C60fullerene C60 results in increased expression of TBXA2R mRNA19167457
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein"7644563
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein"15792681|1982870
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"quercetin 3,7,3',4'-tetrasulfate inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein]"15792681
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"quercetin 3-acetyl-7,3',4'-trisulfate inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein]"15792681
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein] which results in increased expression of CCL2 mRNA"22206755
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein] which results in increased expression of CCR2 mRNA"22206755
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein] which results in increased expression of HGF mRNA"22206755
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein] which results in increased expression of IL6 mRNA"22206755
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein] which results in increased expression of TNF mRNA"22206755
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein"10919850
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"ifetroban inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein]"10919850
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"[SQ 29548 binds to and results in decreased activity of TBXA2R protein] which results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"15834289
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein"14660035|1513091
C078904ifetroban"ifetroban inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein]"10919850
D007854LeadLead results in decreased expression of TBXA2R mRNA19921347
D008555MelittenTBXA2R protein results in increased susceptibility to Melitten16524625
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TBXA2R mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TBXA2R mRNA24810058
C070571ML 7ML 7 affects the activity of TBXA2R protein8867106
C070571ML 7ML 7 promotes the reaction [TBXA2R protein affects the transport of Calcium]8867106
C070571ML 7ML 7 promotes the reaction [TBXA2R protein results in increased hydrolysis of Phosphatidylinositols]8867106
D009151Mustard GasMustard Gas results in increased expression of TBXA2R mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of TBXA2R mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TBXA2R mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TBXA2R mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of TBXA2R mRNA19167457
D009538NicotineNicotine results in increased activity of TBXA2R protein21316381
C012655nimesulideTBXA2R results in increased susceptibility to nimesulide15905461
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TBXA2R mRNA27935865
D009638Norepinephrine[SQ 29548 binds to and results in decreased activity of TBXA2R protein] which results in decreased susceptibility to Norepinephrine15834289
D019301Oleic AcidPhenolsulfonphthalein inhibits the reaction [Oleic Acid results in increased expression of TBXA2R mRNA]11263294
C049855ONO 3708ONO 3708 binds to and results in decreased activity of TBXA2R protein11444916
C049855ONO 3708ONO 3708 results in decreased activity of TBXA2R protein10888248
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of TBXA2R mRNA18636392
C046012pentanalpentanal results in increased expression of TBXA2R mRNA26079696
D010637PhenolsulfonphthaleinPhenolsulfonphthalein inhibits the reaction [Oleic Acid results in increased expression of TBXA2R mRNA]11263294
D010716PhosphatidylinositolsML 7 promotes the reaction [TBXA2R protein results in increased hydrolysis of Phosphatidylinositols]8867106
D010716PhosphatidylinositolsW 7 promotes the reaction [TBXA2R protein results in increased hydrolysis of Phosphatidylinositols]8867106
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of TBXA2R mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of TBXA2R mRNA17950772
D010936Plant ExtractsPlant Extracts results in decreased expression of TBXA2R mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of TBXA2R mRNA26079696
D011691Puromycin[Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA19643929
D011691Puromycin[Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein19643929
C503991quercetin 3,7,3',4'-tetrasulfate"quercetin 3,7,3',4'-tetrasulfate inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein]"15792681
C503992quercetin 3-acetyl-7,3',4'-trisulfate"quercetin 3-acetyl-7,3',4'-trisulfate inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein]"15792681
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TBXA2R mRNA19059307
C063119ramatrobanramatroban binds to and results in decreased activity of TBXA2R protein16979129
C063119ramatrobanramatroban binds to and results in decreased activity of TBXA2R protein16256979
C060219ridogrelridogrel binds to and results in decreased activity of TBXA2R protein2790215
C089730rosiglitazonerosiglitazone inhibits the reaction [TBXA2R protein results in increased transport of Calcium]16499875
C089730rosiglitazonerosiglitazone results in decreased activity of TBXA2R protein16499875
C089730rosiglitazonerosiglitazone results in decreased expression of TBXA2R mRNA alternative form16499875
C056566S 145S 145 binds to and results in decreased activity of TBXA2R protein8804153
C056566S 145S 145 binds to and results in decreased activity of TBXA2R protein7740511
C060230seratrodastseratrodast binds to and results in decreased activity of TBXA2R protein9707209
D012834SilverSilver results in increased expression of TBXA2R mRNA27131904
C045749SQ 29548SQ 29548 binds to and results in decreased activity of TBXA2R protein10846009
C045749SQ 29548SQ 29548 binds to and results in decreased activity of TBXA2R protein19828703
C045749SQ 29548SQ 29548 binds to and results in increased activity of TBXA2R protein18158556
C045749SQ 29548SQ 29548 binds to and results in decreased activity of TBXA2R protein15528449|1652462
C045749SQ 29548"[SQ 29548 binds to and results in decreased activity of TBXA2R protein] which results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"15834289
C045749SQ 29548[SQ 29548 binds to and results in decreased activity of TBXA2R protein] which results in decreased susceptibility to Norepinephrine15834289
C045749SQ 29548SQ 29548 binds to and affects the activity of TBXA2R protein22565502
C045749SQ 29548SQ 29548 binds to and results in decreased activity of TBXA2R protein15834289|1756285
C045749SQ 29548SQ 29548 results in decreased activity of TBXA2R protein16386349
C040624sulotrobansulotroban binds to and results in decreased activity of TBXA2R protein2790215
D013605T-2 ToxinT-2 Toxin results in increased expression of TBXA2R mRNA26141394
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of TBXA2R mRNA19059307
C501362terutrobanterutroban binds to and results in decreased activity of TBXA2R protein16380483
D013749TetrachlorodibenzodioxinTBXA2R protein results in increased susceptibility to Tetrachlorodibenzodioxin18952116
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBXA2R mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBXA2R mRNA16120747
D013853ThioacetamideThioacetamide results in increased expression of TBXA2R mRNA23411599
C057693troglitazonetroglitazone inhibits the reaction [TBXA2R protein results in increased transport of Calcium]16499875
C057693troglitazonetroglitazone results in decreased activity of TBXA2R protein16499875
C057693troglitazonetroglitazone results in decreased expression of TBXA2R mRNA alternative form16499875
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of TBXA2R protein18479249
D014635Valproic AcidValproic Acid affects the expression of TBXA2R mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TBXA2R mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of TBXA2R gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TBXA2R gene25560391
C017967W 7W 7 affects the activity of TBXA2R protein8867106
C017967W 7W 7 promotes the reaction [TBXA2R protein affects the transport of Calcium]8867106
C017967W 7W 7 promotes the reaction [TBXA2R protein results in increased hydrolysis of Phosphatidylinositols]8867106
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TBXA2R mRNA27935865
D019287Zinc SulfateZinc Sulfate results in decreased expression of TBXA2R mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004961thromboxane A2 receptor activity-TAS8119956  
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI17644091  19464661  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IBA21873635  
GO:0006954inflammatory response-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0019932second-messenger-mediated signaling-IEA-  
GO:0030194positive regulation of blood coagulation-IEA-  
GO:0033574response to testosterone-IEA-  
GO:0038193thromboxane A2 signaling pathway-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0045777positive regulation of blood pressure-IBA21873635  
GO:0045907positive regulation of vasoconstriction-IBA21873635  
GO:0045987positive regulation of smooth muscle contraction-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0090051negative regulation of cell migration involved in sprouting angiogenesis-IGI24558106  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS1825698  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-391903Eicosanoid ligand-binding receptorsTAS
R-HSA-391908Prostanoid ligand receptorsTAS
R-HSA-392518Signal amplificationTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-428930Thromboxane signalling through TP receptorTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25860557Correlation Between SNPs in Candidate Genes and VerifyNow-Detected Platelet Responsiveness to Aspirin and Clopidogrel Treatment. (2015 Apr)Cui HCardiovasc Drugs Ther