Gene: TCF4

6925
E2-2|FECD3|ITF-2|ITF2|PTHS|SEF-2|SEF2|SEF2-1|SEF2-1A|SEF2-1B|SEF2-1D|TCF-4|bHLHb19
transcription factor 4
protein-coding
18q21.2
Ensembl:ENSG00000196628 MIM:602272 Vega:OTTHUMG00000132713 UniprotKB:P15884
NG_011716.2
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.788e-2 (AD)  9.512e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF120.912
PUM20.911
GNAQ0.906
RBBP40.904
WDR480.895
XPO70.892
TRAK10.891
TMOD20.89
FAM168A0.889
ZMYM40.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.738
OR4F29-0.685
NANOGNB-0.324
CRNDE-0.285
TNFRSF13B-0.279
ISL1-0.278
IRX1-0.276
SH2D1A-0.264
IRX2-0.263
CD8B-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TCF4 protein"21705713
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TCF4 mRNA"19114083
C4881752-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester inhibits the reaction [TCF4 protein binds to CTNNB1 protein]14566053
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of TCF4 mRNA25716159
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF4 mRNA"27188386
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of TCF4 mRNA17011747
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF4 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TCF4 mRNA19770486
C010845aluminum chloridealuminum chloride results in decreased expression of TCF4 mRNA26474975
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TCF4 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of TCF4 mRNA15761015
D001241AspirinAspirin results in decreased activity of TCF4 protein11593435
D001241AspirinTCF4 protein promotes the reaction [Aspirin results in increased susceptibility to TNFSF10 protein]21171083
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of TCF4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TCF4 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TCF4 mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TCF4 mRNA21839799
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of TCF4 mRNA17404688
D004958EstradiolEstradiol results in decreased expression of TCF4 mRNA20068009
D001663BilirubinBilirubin results in decreased expression of TCF4 mRNA20196124
C495703bis(2-chloroethoxy)methanebis(2-chloroethoxy)methane affects the expression of TCF4 mRNA16844662
C006780bisphenol Abisphenol A affects the methylation of TCF4 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of TCF4 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of TCF4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TCF4 gene28505145
D000069286BortezomibBortezomib results in increased expression of TCF4 mRNA17895889
C471992bosutinibbosutinib inhibits the reaction [CTNNB1 protein binds to TCF4 protein]16489032
C027561butylbenzyl phthalatebutylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]22552774
C027561butylbenzyl phthalateHDAC6 mutant form inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
C027561butylbenzyl phthalatetrichostatin A inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TCF4 mRNA15336504
D002104Cadmium[Cadmium affects the localization of CTNNB1 protein] promotes the reaction [CTNNB1 protein binds to TCF4 protein]24798214
D019256Cadmium ChlorideCadmium Chloride affects the localization of TCF4 protein20459685
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [DDIT3 protein binds to TCF4 protein]20459685
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [TCF4 protein binds to ABCB1 promoter]20459685
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [TCF4 protein binds to CCND1 promoter]20459685
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [TCF4 protein binds to CTNNB1 protein]20459685
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TCF4 mRNA20459685
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TCF4 protein20459685
D019256Cadmium ChlorideDactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of TCF4 mRNA]20459685
D019256Cadmium ChlorideTCF4 promotes the reaction [Cadmium Chloride results in increased expression of MYC mRNA]20459685
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TCF4 mRNA16239168
D002737ChloropreneChloroprene results in increased expression of TCF4 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TCF4 mRNA18668222
C074702chromium hexavalent ionchromium hexavalent ion promotes the reaction [[CTNNB1 protein co-treated with TCF4 protein] binds to MYC promoter]27323401
C074702chromium hexavalent ionchromium hexavalent ion promotes the reaction [[CTNNB1 protein co-treated with TCF4 protein] binds to PLAUR promoter]27323401
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of TCF4 protein27323401
C018021cobaltous chloridecobaltous chloride results in decreased expression of TCF4 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of TCF4 mRNA24386269
D003042CocaineCocaine affects the expression of TCF4 mRNA20187946
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of TCF4 mRNA20971185
D003300CopperMT1 affects the reaction [Copper results in increased expression of TCF4 mRNA]16629173
D003300CopperMT2 affects the reaction [Copper results in increased expression of TCF4 mRNA]16629173
D003471CuprizoneCuprizone results in decreased expression of TCF4 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of TCF4 mRNA20106945
D003609DactinomycinDactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of TCF4 mRNA]20459685
C014347decitabinedecitabine affects the expression of TCF4 mRNA23300844
C107676deguelindeguelin results in increased expression of TCF4 mRNA19861542
C040424destruxin Bdestruxin B affects the localization of and results in decreased expression of TCF4 protein22465936
C040424destruxin Bdestruxin B results in decreased activity of [TCF4 protein co-treated with CTNNB1 protein]22465936
C040424destruxin Bdestruxin B results in decreased expression of TCF4 protein24434019
D003993Dibutyl PhthalateDibutyl Phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]22552774
D003993Dibutyl PhthalateHDAC6 mutant form inhibits the reaction [Dibutyl Phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
D003993Dibutyl Phthalatetrichostatin A inhibits the reaction [Dibutyl Phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TCF4 mRNA21266533
D002945CisplatinCisplatin affects the expression of TCF4 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TCF4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TCF4 mRNA27392435|2759478
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TCF4 mRNA17011747
D004221DisulfiramDisulfiram results in decreased expression of TCF4 mRNA20530235
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TCF4 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TCF4 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TCF4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TCF4 mRNA17557909
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TCF4 mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of TCF4 mRNA18035473
C069837fullerene C60fullerene C60 results in decreased expression of TCF4 mRNA19167457
D019833GenisteinGenistein results in decreased expression of TCF4 mRNA15256057
D005839GentamicinsGentamicins results in increased expression of TCF4 mRNA22061828
C010176halofuginonehalofuginone results in increased expression of TCF4 mRNA17180598
D017313FenretinideFenretinide results in increased expression of TCF4 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TCF4 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of TCF4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TCF4 mRNA24796395
D007657Ketone BodiesKetone Bodies results in increased expression of TCF4 mRNA16807920
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of TCF4 gene21212295
D018021Lithium ChlorideLithium Chloride results in increased activity of [TCF4 protein co-treated with CTNNB1 protein]22935447
D018021Lithium Chlorideresveratrol inhibits the reaction [Lithium Chloride results in increased activity of [TCF4 protein co-treated with CTNNB1 protein]]22935447
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TCF4 mRNA21641980
D008694MethamphetamineMethamphetamine results in increased expression of TCF4 mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TCF4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TCF4 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TCF4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TCF4 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of TCF4 mRNA19812364
C498045NCX 4040NCX 4040 inhibits the reaction [TCF4 protein binds to CTNNB1 protein]14566053
C498045NCX 4040NCX 4040 results in decreased activity of TCF414566053
C498045NCX 4040NCX 4040 results in decreased expression of TCF4 mRNA19576865
C029938nickel sulfatenickel sulfate results in decreased expression of TCF4 mRNA16780908
C029938nickel sulfatenickel sulfate results in increased expression of TCF4 mRNA22714537
C102148nitroaspirinnitroaspirin affects the expression of TCF4 mRNA19576865
C102148nitroaspirinnitroaspirin affects the reaction [TCF4 protein binds to CTNNB1 protein]14566053
C007350nitrofennitrofen results in decreased expression of TCF4 mRNA27665494
C007350nitrofennitrofen results in decreased expression of TCF4 protein27665494
D005996NitroglycerinNitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]17030184
D005996NitroglycerinTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]17030184
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of TCF4 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TCF4 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of TCF4 mRNA22629407
D010100OxygenOxygen promotes the reaction [Oxygen deficiency results in decreased expression of TCF4 mRNA]22629407
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of TCF4 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of TCF4 mRNA19429403
D010634PhenobarbitalPhenobarbital affects the expression of TCF4 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the methylation of TCF4 gene19233941
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TCF4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TCF4 mRNA22079256
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of TCF4 mRNA17404688
D011794QuercetinQuercetin affects the expression of TCF4 protein15670774
D011794QuercetinQuercetin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]15670774
D011794QuercetinQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA]23117658
D011794QuercetinQuercetin inhibits the reaction [Warfarin results in increased expression of TCF4 mRNA]23117658
C059514resveratrolresveratrol inhibits the reaction [Lithium Chloride results in increased activity of [TCF4 protein co-treated with CTNNB1 protein]]22935447
C059514resveratrolresveratrol inhibits the reaction [TCF4 protein binds to CTNNB1 protein]22935447
C059514resveratrolresveratrol results in decreased activity of [TCF4 protein co-treated with CTNNB1 protein]22935447
C059514resveratrolresveratrol inhibits the reaction [TCF4 protein binds to CTNNB1 protein]22935447
C059514resveratrolresveratrol inhibits the reaction [WNT3A protein promotes the reaction [TCF4 protein binds to CTNNB1 protein]]22935447
C541923sandostatinLARsandostatinLAR results in increased expression of TCF4 mRNA17210224
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TCF4 mRNA19073995
C009277sodium arsenatesodium arsenate results in increased expression of TCF4 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of TCF4 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of TCF4 mRNA22714537
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TCF4 mRNA21641980
D013467SulindacSulindac results in decreased activity of TCF4 protein11593435
D013467SulindacTCF4 protein promotes the reaction [Sulindac results in increased susceptibility to TNFSF10 protein]21171083
D013629TamoxifenTamoxifen affects the expression of TCF4 mRNA17555576
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of TCF4 mRNA20189893
C004648testosterone enanthatetestosterone enanthate results in increased expression of TCF4 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TCF4 mRNA16611356|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TCF4 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of TCF4 gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TCF4 mRNA15328365|1817288
D013893ThiramThiram results in decreased expression of TCF4 mRNA20530235
D014028Tobacco Smoke PollutionGSK3B protein inhibits the reaction [Tobacco Smoke Pollution results in increased activity of [CTNNB1 protein binds to TCF4 protein]]19429245
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased activity of [CTNNB1 protein binds to TCF4 protein]19429245
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TCF4 mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TCF4 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TCF4 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of TCF4 mRNA23228038
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]17030184
D014212TretinoinTretinoin results in decreased expression of TCF4 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of TCF4 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF4 mRNA"27188386
C012589trichostatin Atrichostatin A inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
C012589trichostatin Atrichostatin A inhibits the reaction [Dibutyl Phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
C012589trichostatin Atrichostatin A results in decreased expression of TCF4 mRNA26272509
C057693troglitazonetroglitazone results in decreased expression of TCF4 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of TCF4 mRNA22378314
C022884undecaneundecane results in increased expression of TCF4 protein17337753
D014635Valproic AcidValproic Acid results in decreased expression of TCF4 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of TCF4 gene28853863
D014638VanadatesVanadates results in decreased expression of TCF4 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TCF4 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of TCF4 mRNA25423262
D014800VitalliumVitallium analog results in decreased expression of TCF4 mRNA23825117
D014812Vitamin KQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA]23117658
D014812Vitamin K[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA23117658
D014859WarfarinQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA]23117658
D014859WarfarinQuercetin inhibits the reaction [Warfarin results in increased expression of TCF4 mRNA]23117658
D014859Warfarin[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA23117658
D014859WarfarinWarfarin results in increased expression of TCF4 mRNA23117658
D015032ZincZinc deficiency results in increased expression of TCF4 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA12651860  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-ISS8978694  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISS8978694  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001011transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting-ISS8978694  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-ISS8978694  
GO:0001093TFIIB-class transcription factor binding-ISS8978694  
GO:0003677DNA binding-IDA1681116  16950124  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA2105528  11802795  
GO:0005515protein binding-IPI10903890  17318191  17875931  17983804  21103407  21743491  
21988832  22699938  25402006  25416956  25466284  25609649  
GO:0008022protein C-terminus binding-IPI10903890  
GO:0042802identical protein binding-IPI10903890  25609649  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0043425bHLH transcription factor binding-IBA21873635  
GO:0046982protein heterodimerization activity-IBA21873635  
GO:0046982protein heterodimerization activity-ISS-  
GO:0046982protein heterodimerization activity-NAS2105528  
GO:0070888E-box binding-ISS8978694  
GO ID GO Term Qualifier Evidence PubMed
GO:0006352DNA-templated transcription, initiation-ISS8978694  
GO:0006367transcription initiation from RNA polymerase II promoter-ISS8978694  
GO:0045666positive regulation of neuron differentiation-IBA21873635  
GO:0045666positive regulation of neuron differentiation-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA2105528  12651860  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS8978694  
GO:0065004protein-DNA complex assembly-ISS8978694  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA21880741  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA1681116  21828274  
GO:0005667transcription factor complex-IBA21873635  
GO:0005667transcription factor complex-ISS8978694  
GO:0070369beta-catenin-TCF7L2 complex-IDA12651860  
GO:1990907beta-catenin-TCF complex-IPI11955446  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-375170CDO in myogenesisIEA
R-HSA-375170CDO in myogenesisTAS
R-HSA-525793MyogenesisIEA
R-HSA-525793MyogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24917144Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy. (2014 Jun 10)Li YJInvest Ophthalmol Vis Sci
19174556WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. (2009 Feb)Tang YMol Cancer Ther
24413739Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective. (2014 Aug)Quednow BBCell Mol Life Sci
22451930Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating. (2012 Apr 17)Quednow BBProc Natl Acad Sci U S A