Gene: TBX3

6926
TBX3-ISO|UMS|XHL
T-box 3
protein-coding
12q24.21
Ensembl:ENSG00000135111 MIM:601621 Vega:OTTHUMG00000169586 UniprotKB:O15119
NG_008315.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.047e-1 (AD)  3.696e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PEAR10.791
TINAGL10.77
DOCK60.768
FOXF10.768
ESAM0.761
TIE10.756
LEF10.748
CLDN50.74
MMRN20.734
LAMB20.733

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.473
MARCH4-0.429
KNCN-0.417
SLC7A4-0.416
PTPRR-0.415
PPEF1-0.414
HCRTR2-0.408
TAC1-0.401
SVOP-0.4
MYADML2-0.398

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TBX3 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TBX3 mRNA"19692669
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TBX3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TBX3 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of TBX3 mRNA29067470
C016601afimoxifenePD 173074 inhibits the reaction [afimoxifene results in increased expression of TBX3 protein]21098263
D000447AldehydesAldehydes results in increased expression of TBX3 mRNA25014914
D000638AmiodaroneAmiodarone results in increased expression of TBX3 mRNA23397585
D000640AmitroleAmitrole results in decreased expression of TBX3 mRNA23397585
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TBX3 mRNA24449571
C015001arsenitearsenite results in increased methylation of TBX3 promoter23974009
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of TBX3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TBX3 mRNA21802500|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBX3 mRNA22228805|2373587
D004958EstradiolEstradiol affects the expression of TBX3 mRNA22574217
D004958EstradiolEstradiol results in increased expression of TBX3 mRNA24424067
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TBX3 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of TBX3 mRNA20678512|2442406
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TBX3 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of TBX3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TBX3 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of TBX3 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TBX3 mRNA23397585
D002330CarmustineTBX3 mRNA affects the susceptibility to Carmustine16365179
D002509CephaloridineCephaloridine results in decreased expression of TBX3 mRNA18500788
D002922CiguatoxinsCiguatoxins affects the expression of TBX3 mRNA18353800
D002994ClofibrateClofibrate results in increased expression of TBX3 mRNA25270620
D019327Copper SulfateCopper Sulfate results in decreased expression of TBX3 mRNA19549813
D003471CuprizoneCuprizone affects the expression of TBX3 mRNA27523638
D003471CuprizoneCuprizone results in decreased expression of TBX3 mRNA26577399
C089595cylindrospermopsincylindrospermopsin results in increased expression of TBX3 mRNA24921660
C093628cyproconazolecyproconazole results in decreased expression of TBX3 mRNA22045034
C014347decitabinedecitabine results in increased expression of TBX3 mRNA16367923
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TBX3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TBX3 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of TBX3 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of TBX3 mRNA]20032058
D004008DiclofenacDiclofenac results in increased expression of TBX3 mRNA26934552
C000944dicrotophosdicrotophos results in increased expression of TBX3 mRNA28302478
D004041Dietary FatsDietary Fats affects the expression of TBX3 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of TBX3 mRNA22010203
D004041Dietary FatsTestosterone inhibits the reaction [Dietary Fats results in increased expression of TBX3 mRNA]22010203
D004117DimethoateDimethoate results in increased expression of TBX3 mRNA23397585
D004221DisulfiramDisulfiram results in decreased expression of TBX3 mRNA20530235
D004237DiuronDiuron results in increased expression of TBX3 mRNA21551480
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of TBX3 protein"28548306
D004365Drugs, Chinese Herbal"PPP2CA protein affects the reaction [Drugs, Chinese Herbal results in decreased expression of TBX3 protein]"28548306
C038939enzacameneenzacamene results in increased expression of TBX3 mRNA23397585
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TBX3 mRNA22079256
D004967EstrogensEstrogens affects the localization of TBX3 protein21098263
D004967EstrogensEstrogens results in increased expression of TBX3 protein21098263
D004967EstrogensFGF9 protein promotes the reaction [Estrogens results in increased expression of TBX3 protein]21098263
D004967EstrogensPD 173074 inhibits the reaction [Estrogens results in increased expression of TBX3 protein]21098263
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TBX3 mRNA17557909
C017690fenvaleratefenvalerate results in increased expression of TBX3 mRNA23397585
D004397FonofosFonofos results in increased methylation of TBX3 promoter22847954
C039281furanfuran results in decreased expression of TBX3 mRNA25539665|2738771
D017313FenretinideFenretinide results in increased expression of TBX3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TBX3 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TBX3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TBX3 mRNA28628672
D007480Iopanoic AcidIopanoic Acid results in increased expression of TBX3 mRNA23397585
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TBX3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TBX3 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of TBX3 mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of TBX3 mRNA]26733615
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TBX3 mRNA27432991
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of TBX3 mRNA]26733615
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of TBX3 mRNA25119042
C045463leflunomideleflunomide results in increased expression of TBX3 mRNA28988120
D008713MethimazoleMethimazole results in increased expression of TBX3 mRNA23397585
D008731MethoxychlorMethoxychlor results in increased expression of TBX3 mRNA23397585
D008748MethylcholanthreneMethylcholanthrene results in increased expression of TBX3 mRNA23397585
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TBX3 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride affects the expression of TBX3 mRNA21613230
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of TBX3 mRNA23397585
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of TBX3 mRNA23397585
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of TBX3 mRNA21664453
C500085muraglitazarmuraglitazar results in increased expression of TBX3 mRNA21515302
C058815N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamideN-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in decreased expression of TBX3 mRNA15255957
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TBX3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TBX3 mRNA"25554681
D009532NickelNickel results in decreased expression of TBX3 mRNA25583101
C118580octylmethoxycinnamateoctylmethoxycinnamate results in decreased expression of TBX3 mRNA23397585
D000073878Palm OilPalm Oil affects the expression of TBX3 mRNA19680557
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of TBX3 mRNA]26733615
C496932panobinostatpanobinostat affects the expression of TBX3 mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of TBX3 mRNA]26733615
C016030pantogabpantogab results in decreased expression of TBX3 mRNA17379144
D010278ParathionParathion results in increased methylation of TBX3 promoter22847954
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of TBX3 mRNA18593933
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of TBX3 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of TBX3 mRNA25119042
C115711PD 173074PD 173074 inhibits the reaction [afimoxifene results in increased expression of TBX3 protein]21098263
C115711PD 173074PD 173074 inhibits the reaction [Estrogens results in increased expression of TBX3 protein]21098263
C046012pentanalpentanal results in increased expression of TBX3 mRNA26079696
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of TBX3 mRNA28973697
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TBX3 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of TBX3 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of TBX3 mRNA19482888
D010795Phthalic AcidsPhthalic Acids results in decreased expression of TBX3 mRNA21061450
D010938Plant OilsPlant Oils results in increased expression of TBX3 mRNA23370395
C054694polyoxyethyleneaminepolyoxyethyleneamine results in increased expression of TBX3 mRNA28711546
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TBX3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TBX3 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of TBX3 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of TBX3 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of TBX3 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of TBX3 mRNA23397585
D011441PropylthiouracilPropylthiouracil results in decreased expression of TBX3 mRNA24780913
C043680ptaquilosideptaquiloside results in decreased expression of TBX3 mRNA23274088
D011794QuercetinQuercetin results in increased expression of TBX3 mRNA21632981
D012312RitodrineRitodrine results in decreased expression of TBX3 mRNA23370008
C089730rosiglitazonerosiglitazone results in increased expression of TBX3 mRNA21515302
D012822Silicon DioxideSilicon Dioxide results in increased expression of TBX3 mRNA25351596
D012834SilverSilver results in decreased expression of TBX3 mRNA26014281
D012906SmokeSmoke affects the expression of TBX3 mRNA23693141
C009277sodium arsenatesodium arsenate affects the methylation of TBX3 promoter20667999
C009277sodium arsenatesodium arsenate results in increased expression of TBX3 mRNA20667999|2179562
D018038Sodium SeleniteSodium Selenite results in decreased expression of TBX3 mRNA23274088
C105686SU 5402SU 5402 results in decreased expression of TBX3 mRNA15255957
D013467SulindacSulindac results in increased expression of TBX3 mRNA11906190
C013698tallowtallow affects the expression of TBX3 mRNA19680557
C047246temozolomideTBX3 mRNA affects the susceptibility to temozolomide16365179
C012568terbufosterbufos results in increased methylation of TBX3 promoter22847954
C501413tesaglitazartesaglitazar results in increased expression of TBX3 mRNA21515302
D013739TestosteroneTestosterone inhibits the reaction [Dietary Fats results in increased expression of TBX3 mRNA]22010203
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of TBX3 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBX3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBX3 mRNA16697128|1969266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBX3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBX3 mRNA24058054
D013893ThiramThiram results in decreased expression of TBX3 mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of TBX3 mRNA23131501
C009495titanium dioxidetitanium dioxide results in increased expression of TBX3 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TBX3 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of TBX3 mRNA20530235
D014212TretinoinTretinoin results in increased expression of TBX3 mRNA21934132|2372400
D014212TretinoinTretinoin results in increased expression of TBX3 mRNA16604517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TBX3 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of TBX3 mRNA17569031
D014520UrethaneUrethane results in increased expression of TBX3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX3 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of TBX3 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in decreased expression of TBX3 mRNA22045034
D014638VanadatesVanadates results in increased expression of TBX3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TBX3 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of TBX3 mRNA26682919
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of TBX3 mRNA18593933
D019287Zinc SulfateZinc Sulfate results in decreased expression of TBX3 mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11689487  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11689487  
GO:0001085RNA polymerase II transcription factor binding-ISS-  
GO:0001102RNA polymerase II activating transcription factor binding-ISS-  
GO:0005515protein binding-IPI22002537  25416956  
GO:0043565sequence-specific DNA binding-IDA11689487  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA11689487  
GO:0001501skeletal system development-IMP9207801  
GO:0001568blood vessel development-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0001947heart looping-IEA-  
GO:0003151outflow tract morphogenesis-IEA-  
GO:0003167atrioventricular bundle cell differentiation-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS9207801  
GO:0007569cell aging-IDA11689487  11748239  
GO:0008284positive regulation of cell proliferation-IDA11689487  11748239  12032820  
GO:0008595anterior/posterior axis specification, embryo-IMP9207801  
GO:0009887animal organ morphogenesis-IDA9207801  
GO:0010159specification of animal organ position-IEA-  
GO:0019827stem cell population maintenance-IEA-  
GO:0021761limbic system development-IEA-  
GO:0030539male genitalia development-IMP12116211  
GO:0030540female genitalia development-IMP12116211  
GO:0030857negative regulation of epithelial cell differentiation-IEA-  
GO:0030879mammary gland development-IMP12116211  
GO:0032275luteinizing hormone secretion-IMP12116211  
GO:0035115embryonic forelimb morphogenesis-IMP12116211  
GO:0035116embryonic hindlimb morphogenesis-IEA-  
GO:0035136forelimb morphogenesis-IDA9207801  
GO:0042733embryonic digit morphogenesis-IMP9207801  12116211  
GO:0043066negative regulation of apoptotic process-IDA12032820  
GO:0045662negative regulation of myoblast differentiation-IDA12032820  
GO:0045787positive regulation of cell cycle-IDA12032820  
GO:0045892negative regulation of transcription, DNA-templated-IDA10468588  11689487  
GO:0045893positive regulation of transcription, DNA-templated-IEA-  
GO:0046884follicle-stimulating hormone secretion-IMP12116211  
GO:0048332mesoderm morphogenesis-IMP9207801  
GO:0060021roof of mouth development-IEA-  
GO:0060412ventricular septum morphogenesis-IEA-  
GO:0060444branching involved in mammary gland duct morphogenesis-IEA-  
GO:0060596mammary placode formation-IEA-  
GO:0060923cardiac muscle cell fate commitment-IEA-  
GO:0060931sinoatrial node cell development-IEA-  
GO:0090398cellular senescence-IDA22002537  
GO:2000648positive regulation of stem cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11689487  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28521440T-box 3 overexpression is associated with poor prognosis of non-small cell lung cancer. (2017 May)Wu YOncol Lett