Gene: HNF1A

6927
HNF-1A|HNF1|HNF4A|IDDM20|LFB1|MODY3|TCF-1|TCF1
HNF1 homeobox A
protein-coding
12q24.31
Ensembl:ENSG00000135100 MIM:142410 Vega:OTTHUMG00000151015 UniprotKB:P20823
NG_011731.2
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.033e-1 (AD)  3.731e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC45A40.876
ANKRD34A0.863
FAM57B0.862
KCNJ120.847
SYT30.843
KLHL290.842
PLXNA40.841
KCNK120.84
KCNC10.837
KIF3C0.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.603
WWTR1-0.586
COPZ2-0.573
HEY2-0.569
YES1-0.568
SEPT10-0.561
SNHG18-0.56
IL18RAP-0.558
FAM114A1-0.555
MYL3-0.552

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04419D-norleucineSmall Molecule327-56-0ExperimentalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HNF1A mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HNF1A mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HNF1A mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HNF1A mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HNF1A mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HNF1A mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HNF1A protein results in increased expression of IL1B mRNA]15350541
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HNF1A mRNA"25510870
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of HNF1A mRNA14610520
D000082AcetaminophenAcetaminophen results in decreased expression of HNF1A mRNA29067470
D000082AcetaminophenAcetaminophen results in decreased expression of HNF1A protein29067470
D000082AcetaminophenAcetaminophen results in decreased activity of HNF1A protein25858767
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HNF1A mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HNF1A mRNA16483693
D001241AspirinAspirin results in decreased expression of HNF1A mRNA12800193
D001374AzacitidineAzacitidine results in decreased methylation of HNF1A promoter25953102
D001374AzacitidineAzacitidine results in increased expression of HNF1A mRNA25953102
D001374AzacitidineAzacitidine results in increased expression of HNF1A protein25953102
D001374AzacitidineHNF1A mutant form inhibits the reaction [Azacitidine results in increased expression of AQP9 mRNA]25953102
D004958EstradiolEstradiol results in decreased expression of HNF1A mRNA22946080
C006780bisphenol Abisphenol A affects the methylation of HNF1A promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of HNF1A mRNA22946080|2518105
D002084Butylated Hydroxytoluene[Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of HNF1A mRNA16272459
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of HNF1A mRNA15728792
C018475butyraldehydebutyraldehyde results in decreased expression of HNF1A mRNA26079696
D020148Butyric AcidButyric Acid affects the expression of HNF1A mRNA12800193
D002118CalciumHNF1A protein mutant form affects the abundance of Calcium21784843
D002220CarbamazepineCarbamazepine affects the expression of HNF1A mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HNF1A mRNA15056808
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased activity of HNF1A protein25858767
D002330CarmustineCarmustine results in decreased expression of HNF1A mRNA15980968
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of HNF1A mRNA11163329
C000543cyclopiazonic acidHNF1A protein mutant form results in increased susceptibility to cyclopiazonic acid21784843
C000543cyclopiazonic acidtauroursodeoxycholic acid inhibits the reaction [HNF1A protein mutant form results in increased susceptibility to cyclopiazonic acid]21784843
D003634DDT[DDT co-treated with Diethylnitrosamine] results in decreased expression of HNF1A mRNA15885732
D003634DDT[DDT co-treated with Diethylnitrosamine] results in increased expression of HNF1A mRNA15885732
C014347decitabineHNF1A protein promotes the reaction [decitabine results in increased expression of UGT1A1 mRNA]23401472
D003907DexamethasoneDexamethasone promotes the reaction [HNF1A protein binds to SLC4A2 promoter]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter alternative form]18188457
D003907DexamethasoneDexamethasone results in decreased expression of HNF1A mRNA20888898
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HNF1A mRNA15728792|2174549
D002945CisplatinCisplatin results in decreased expression of HNF1A mRNA27392435
D002945CisplatinCisplatin results in decreased expression of HNF1A mRNA18656965
D002945Cisplatin[Cisplatin results in decreased expression of HNF1A mRNA] which results in decreased expression of SLC5A1 mRNA18656965
D002945Cisplatin[Cisplatin results in decreased expression of HNF1A mRNA] which results in decreased expression of SLC5A2 mRNA18656965
D002945CisplatinHNF1A protein affects the reaction [Cisplatin results in decreased expression of TMEM27 mRNA]18656965
D004008DiclofenacDiclofenac affects the expression of HNF1A mRNA24752500
D004041Dietary FatsDietary Fats results in increased expression of HNF1A mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of HNF1A mRNA15728792
D004052Diethylnitrosamine[DDT co-treated with Diethylnitrosamine] results in decreased expression of HNF1A mRNA15885732
D004052Diethylnitrosamine[DDT co-treated with Diethylnitrosamine] results in increased expression of HNF1A mRNA15885732
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HNF1A mRNA22946080
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of HNF1A mRNA15728792
D000431EthanolEthanol results in decreased expression of HNF1A protein27989594
D000431Ethanolsalvianolic acid B inhibits the reaction [Ethanol results in decreased expression of HNF1A protein]27989594
D000431Ethanol[Zinc deficiency co-treated with Ethanol] results in increased expression of HNF1A mRNA24155903
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HNF1A mRNA27818225
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HNF1A protein27818225
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HNF1A mRNA17942748
D004997Ethinyl EstradiolHNF1A protein promotes the reaction [SRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 mRNA]]27818225
D004997Ethinyl EstradiolSRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of HNF1A mRNA]27818225
D004997Ethinyl EstradiolSRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of HNF1A protein]27818225
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HNF1A mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased activity of HNF1A protein12507762
D005839GentamicinsGentamicins results in decreased expression of HNF1A mRNA18656965
D005839Gentamicins[Gentamicins results in decreased expression of HNF1A mRNA] which results in decreased expression of SLC5A1 mRNA18656965
D005839Gentamicins[Gentamicins results in decreased expression of HNF1A mRNA] which results in decreased expression of SLC5A2 mRNA18656965
D005839GentamicinsHNF1A protein affects the reaction [Gentamicins results in decreased expression of TMEM27 mRNA]18656965
D005947GlucoseHNF1A gene mutant form affects the susceptibility to Glucose15787664
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HNF1A mRNA26752646
C410337K 7174K 7174 results in decreased expression of HNF1A mRNA24086573
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of HNF1A protein16002565
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [HNF1A protein binds to ALB promoter]14561216
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [HNF1A protein binds to GSTA2 promoter]14561216
D008095Lithocholic AcidLithocholic Acid results in decreased expression of HNF1A mRNA20888898
D008628MercuryMercury results in increased expression of HNF1A mRNA16823088
D008701MethapyrileneMethapyrilene results in decreased expression of HNF1A mRNA28013212
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HNF1A mRNA26011545
C064769N-acetylsphingosineN-acetylsphingosine results in decreased expression of and results in decreased activity of HNF1A protein15155840
C064769N-acetylsphingosineN-acetylsphingosine results in decreased ubiquitination of HNF1A protein15155840
C025256nonylphenolnonylphenol results in decreased expression of HNF1A mRNA22946080
C025589ochratoxin Aochratoxin A results in decreased expression of HNF1A mRNA23358140
C474055octylphenoloctylphenol results in decreased expression of HNF1A mRNA22946080
D010100OxygenHNF1A gene mutant form results in decreased susceptibility to Oxygen deficiency21994956
D010100Oxygen[Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of HNF1A mRNA16272459
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HNF1A mRNA"25510870
C023036perfluorooctanoic acid[perfluorooctanoic acid results in decreased activity of HNF4A protein] which results in decreased expression of HNF1A mRNA22609092
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HNF1A mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HNF1A protein22609092
D010795Phthalic AcidsPhthalic Acids results in decreased expression of HNF1A mRNA21061450
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of HNF1A mRNA20888898
C005556propionaldehydepropionaldehyde results in decreased expression of HNF1A mRNA26079696
C043680ptaquilosideptaquiloside results in decreased expression of HNF1A mRNA23274088
C059514resveratrolresveratrol results in increased expression of HNF1A mRNA21163946
C488333Ro 65-7199Ro 65-7199 affects the expression of HNF1A mRNA14610520
C076944salvianolic acid Bsalvianolic acid B inhibits the reaction [Ethanol results in decreased expression of HNF1A protein]27989594
D012822Silicon DioxideSilicon Dioxide results in decreased expression of HNF1A mRNA23623845
D019821SimvastatinSimvastatin results in increased expression of HNF1A mRNA22160096
C017947sodium arsenitesodium arsenite results in decreased expression of HNF1A23052196
C525422SRT1720HNF1A protein promotes the reaction [SRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 mRNA]]27818225
C525422SRT1720SRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of HNF1A mRNA]27818225
C525422SRT1720SRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of HNF1A protein]27818225
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [HNF1A protein mutant form results in increased susceptibility to cyclopiazonic acid]21784843
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HNF1A mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HNF1A mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HNF1A gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HNF1A mRNA28213091
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of HNF1A mRNA19042947
D014520UrethaneUrethane results in decreased expression of HNF1A mRNA28818685
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter alternative form]18188457
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid promotes the reaction [HNF1A protein binds to SLC4A2 promoter]18188457
D014635Valproic AcidValproic Acid results in decreased expression of HNF1A mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of HNF1A mRNA17963808
D015032ZincZinc deficiency affects the expression of HNF1A mRNA24155903
D015032Zinc[Zinc deficiency co-treated with Ethanol] results in increased expression of HNF1A mRNA24155903

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0003677DNA binding-IDA1989880  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA1989880  11980910  
GO:0005515protein binding-IPI11980910  14500717  17353931  19264593  21988832  
GO:0044212transcription regulatory region DNA binding-IDA12453420  15961790  
GO:0046983protein dimerization activity-IPI12453420  
GO ID GO Term Qualifier Evidence PubMed
GO:0001779natural killer cell differentiation-IDA11301190  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IDA10330009  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0035565regulation of pronephros sizeNOTIMP15355349  
GO:0035623renal glucose absorption-IMP11269503  
GO:0042593glucose homeostasis-IMP11269503  15277395  
GO:0045893positive regulation of transcription, DNA-templated-IBA21873635  
GO:0045893positive regulation of transcription, DNA-templated-IDA1989880  11980910  12453420  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0046323glucose import-IMP11269503  
GO:0060261positive regulation of transcription initiation from RNA polymerase II promoter-IGI15355349  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA15355349  
GO:0005737cytoplasm-IDA15355349  
GO:0032991protein-containing complex-IDA11980910  
KEGG ID KEGG Term
hsa04950Maturity onset diabetes of the young
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-186712Regulation of beta-cell developmentIEA
R-HSA-210745Regulation of gene expression in beta cellsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28035729Association of the HNF1A polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke. (2017 Jan)Zhou YJJ Gene Med
21208426HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study. (2011 Jan 5)Ley SHBMC Med Genet
20546258Increased all-cause and cardiovascular mortality in monogenic diabetes as a result of mutations in the HNF1A gene. (2010 Feb)Steele AMDiabet Med