Gene: HNF1B

6928
FJHN|HNF-1-beta|HNF-1B|HNF1beta|HNF2|HPC11|LF-B3|LFB3|MODY5|TCF-2|TCF2|VHNF1
HNF1 homeobox B
protein-coding
17q12
Ensembl:ENSG00000275410 MIM:189907 Vega:OTTHUMG00000188478 UniprotKB:P35680
NG_013019.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.169e-1 (AD)  1.537e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21250756chr17:36077300HNF1BGene body5.854e-4Alcohol use disorders26763658

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELP60.423
PIN40.409
IFI27L10.391
HDDC30.386
ATOX10.384
NUDT20.38
LSM30.378
COMMD10.376
NDUFA20.373
TRAPPC2L0.373

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BAIAP2L1-0.271
SLC22A3-0.263
CXCR6-0.263
EBF1-0.261
PDGFRB-0.26
NOTCH3-0.254
GPR171-0.252
QRFP-0.25
COL4A3-0.249
FHL5-0.245

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HNF1B mRNA"27291303
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HNF1B mRNA16288212
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HNF1B mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HNF1B mRNA"20816883
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of HNF1B mRNA25088246
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of HNF1B mRNA17011747
D000082AcetaminophenAcetaminophen results in decreased expression of HNF1B mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of HNF1B mRNA28959563
C015001arsenitearsenite results in increased methylation of HNF1B promoter23974009
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of HNF1B mRNA18804290
C018475butyraldehydebutyraldehyde results in decreased expression of HNF1B mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the expression of HNF1B mRNA18804290
C018021cobaltous chloridecobaltous chloride results in decreased expression of HNF1B mRNA24386269
D003471CuprizoneCuprizone results in decreased expression of HNF1B mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of HNF1B mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of HNF1B mRNA22416070
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]18188457
D003976DiazinonDiazinon results in increased methylation of HNF1B gene22964155
D002945CisplatinCisplatin affects the expression of HNF1B protein28119452
D002945CisplatinCisplatin results in decreased expression of HNF1B mRNA18656965
D002945CisplatinHNF1B protein inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]28119452
D002945CisplatinHNF1B protein inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]28119452
D002945CisplatinMIR375 mRNA promotes the reaction [Cisplatin results in decreased expression of HNF1B protein]28119452
C000944dicrotophosdicrotophos results in increased expression of HNF1B mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of HNF1B mRNA26924002
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HNF1B mRNA17011747
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HNF1B mRNA17011747
D005839GentamicinsGentamicins results in decreased expression of HNF1B mRNA18656965
D005839GentamicinsHNF1B protein affects the reaction [Gentamicins results in decreased expression of TMEM27 mRNA]18656965
D017313FenretinideFenretinide results in increased expression of HNF1B mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HNF1B mRNA26752646|2708169
C008261lead acetatelead acetate results in decreased expression of HNF1B mRNA22609695
C045463leflunomideleflunomide results in increased expression of HNF1B mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HNF1B mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of HNF1B mRNA26924002
D009532NickelNickel affects the expression of HNF1B mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of HNF1B mRNA]14575637
D010416PentachlorophenolPentachlorophenol results in decreased expression of HNF1B mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of HNF1B mRNA23091169
D011192Potassium DichromatePotassium Dichromate results in decreased expression of HNF1B mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of HNF1B mRNA23012394
C059514resveratrolresveratrol results in decreased expression of HNF1B mRNA15280659
D012643SeleniumSelenium results in increased expression of HNF1B mRNA28810182
D016559TacrolimusTacrolimus results in decreased expression of HNF1B mRNA22416070
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HNF1B mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HNF1B mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of HNF1B mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HNF1B mRNA21889950|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HNF1B mRNA21215274
D013792ThalidomideThalidomide results in increased expression of HNF1B mRNA28892372
D014212TretinoinTretinoin results in increased expression of HNF1B mRNA16102743
D014212TretinoinTretinoin results in increased expression of HNF1B mRNA16604517
D014212TretinoinTretinoin results in increased expression of HNF1B mRNA20488242
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of HNF1B mRNA]14575637
C057693troglitazonetroglitazone results in decreased expression of HNF1B mRNA28973697
D014520UrethaneUrethane results in decreased expression of HNF1B mRNA28818685
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]18188457
D014635Valproic AcidValproic Acid affects the expression of HNF1B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HNF1B mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of HNF1B gene29154799
D014635Valproic AcidValproic Acid affects the expression of HNF1B mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HNF1B gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000987proximal promoter sequence-specific DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA16297991  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0005515protein binding-IPI21281489  
GO:0042803protein homodimerization activity-IEA-  
GO:0044877protein-containing complex binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001714endodermal cell fate specification-IEA-  
GO:0001822kidney development-IDA21281489  
GO:0001822kidney development-IMP10720943  
GO:0001826inner cell mass cell differentiation-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0007219Notch signaling pathway-IEA-  
GO:0009749response to glucose-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0014070response to organic cyclic compound-IEA-  
GO:0030073insulin secretion-IEA-  
GO:0030111regulation of Wnt signaling pathway-IEA-  
GO:0030902hindbrain development-IEA-  
GO:0032922circadian regulation of gene expression-IEA-  
GO:0035565regulation of pronephros size-IMP15355349  
GO:0039020pronephric nephron tubule development-IGI15355349  
GO:0042493response to drug-IEA-  
GO:0042663regulation of endodermal cell fate specification-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IBA21873635  
GO:0045893positive regulation of transcription, DNA-templated-IDA16297991  21281489  
GO:0048557embryonic digestive tract morphogenesis-IEA-  
GO:0048754branching morphogenesis of an epithelial tube-IEA-  
GO:0048793pronephros development-IMP15355349  
GO:0050673epithelial cell proliferation-IEA-  
GO:0060261positive regulation of transcription initiation from RNA polymerase II promoter-IDA15355349  
GO:0060677ureteric bud elongation-IEA-  
GO:0061017hepatoblast differentiation-IEA-  
GO:0061296negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis-IEA-  
GO:0065004protein-DNA complex assembly-IEA-  
GO:0070365hepatocyte differentiation-IEA-  
GO:0072095regulation of branch elongation involved in ureteric bud branching-IEA-  
GO:0072181mesonephric duct formation-IEA-  
GO:1900212negative regulation of mesenchymal cell apoptotic process involved in metanephros development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA15355349  
GO:0005654nucleoplasm-IDA-  
GO:0005667transcription factor complex-IEA-  
KEGG ID KEGG Term
hsa04950Maturity onset diabetes of the young
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-186712Regulation of beta-cell developmentIEA
R-HSA-210744Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsIEA
R-HSA-210747Regulation of gene expression in early pancreatic precursor cellsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22299039HNF1B and endometrial cancer risk: results from the PAGE study. (2012)Setiawan VWPLoS One
28737528Genetic variants of increased waist circumference in psychosis. (2017 Dec)Hukic DSPsychiatr Genet