Gene info: ID 6929

Gene: TCF3

GENE ID: 6929

Synonyms: AGM8|E2A|E47|ITF1|TCF-3|VDIR|bHLHb21|p75

Description: transcription factor 3

Gene type: protein-coding

Location: 19p13.3

dbXrefs: Ensembl:ENSG00000071564 MIM:147141 Vega:OTTHUMG00000180031 UniprotKB:P15923

RefSeq: NG_029953.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.470e-1 (AD) 2.518e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
INPPL1	0.859
PTBP1	0.855
ARAF	0.839
TLN1	0.835
PLXNB2	0.835
ABL1	0.833
ECE1	0.828
PAK4	0.826
RAVER1	0.826
MOB3A	0.825

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.592
OR4F29	-0.559
PPEF1	-0.29
SMIM18	-0.29
NMU	-0.287
TYRP1	-0.283
IL1RAPL2	-0.282
RAB3B	-0.276
SPHKAP	-0.271
CHRM2	-0.268

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TCF3 mRNA"	21346803
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of TCF3 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF3 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of TCF3 mRNA	12419474
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF3 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of TCF3 mRNA	22230336
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TCF3 mRNA	21641981
D001151	Arsenic	Arsenic affects the methylation of TCF3 gene	25304211
D001280	Atrazine	Atrazine results in decreased expression of TCF3 mRNA	25929836
C012765	bakuchiol	bakuchiol promotes the reaction [MYOD1 protein binds to TCF3 protein]	26902638
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the activity of TCF3 protein	20624995
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TCF3 mRNA	20064835\|2623829
D001564	Benzo(a)pyrene	AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of TCF3 mRNA]	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TCF3 mRNA	20713471
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TCF3 mRNA	15034205
C044887	beta-methylcholine	beta-methylcholine affects the expression of TCF3 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of TCF3 mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of TCF3 mRNA	12419474\|1533650
C584509	C646 compound	C646 compound results in decreased expression of TCF3 mRNA	26191083
D002220	Carbamazepine	Carbamazepine affects the expression of TCF3 mRNA	24752500
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TCF3 mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in increased expression of TCF3 mRNA	19376846
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of TCF3 mRNA	20971185
D003300	Copper	Copper deficiency results in increased expression of TCF3 mRNA	26033743
D003471	Cuprizone	Cuprizone results in increased expression of TCF3 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in increased expression of TCF3 mRNA	20106945
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of TCF3 mRNA	23640034
C014347	decitabine	decitabine results in decreased methylation of TCF3 gene	17581917
D002945	Cisplatin	Cisplatin results in decreased expression of TCF3 mRNA	22023808
D004008	Diclofenac	Diclofenac affects the expression of TCF3 mRNA	24752500
C000944	dicrotophos	dicrotophos results in increased expression of TCF3 mRNA	28302478
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of TCF3 mRNA	26033743
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of TCF3 mRNA	15171707
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of TCF3 mRNA	21658437
D004317	Doxorubicin	TCF3 protein results in decreased susceptibility to Doxorubicin	16886622
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of TCF3 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TCF3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TCF3 mRNA	17942748
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of TCF3 mRNA	23649840
D005419	Flavonoids	Flavonoids results in decreased expression of TCF3 mRNA	15465739
D005419	Flavonoids	Flavonoids results in decreased expression of TCF3 mRNA	18035473
D005485	Flutamide	Flutamide results in decreased expression of TCF3 mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in decreased expression of TCF3 mRNA	23649840
D017313	Fenretinide	Fenretinide results in increased expression of TCF3 mRNA	28973697
D006861	Hydrogen Peroxide	[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TCF3 protein	18951874
D000068877	Imatinib Mesylate	Imatinib Mesylate promotes the reaction [TCF3 protein binds to CDK6 promoter]	21536647
D000068877	Imatinib Mesylate	Imatinib Mesylate results in increased activity of TCF3 protein	21536647
D000068877	Imatinib Mesylate	Imatinib Mesylate results in increased expression of TCF3 mRNA	21536647
D007545	Isoproterenol	Isoproterenol results in decreased expression of TCF3 mRNA	20003209
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TCF3 mRNA	23086925
D008628	Mercury	Mercury results in decreased expression of TCF3 mRNA	19937285
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of TCF3 mRNA	23649840
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of TCF3 mRNA	26518055
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of TCF3 mRNA	19812364
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of TCF3 mRNA	20971185
C042670	N-vinyl-2-pyrrolidinone	[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TCF3 mRNA	22037397
C025589	ochratoxin A	ochratoxin A results in increased methylation of TCF3 gene	26431795
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of TCF3 mRNA	17097637
D010634	Phenobarbital	Phenobarbital results in increased expression of TCF3 mRNA	12832660\|2203739
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of TCF3 mRNA	26272509
D010894	Piroxicam	Piroxicam results in decreased expression of TCF3 mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in decreased expression of TCF3 mRNA	15465739\|2355793
D059808	Polyphenols	Polyphenols results in decreased expression of TCF3 mRNA	15465739
D011441	Propylthiouracil	Propylthiouracil affects the expression of TCF3 mRNA	24780913
D053260	Soot	Soot results in increased expression of TCF3 mRNA	26551751
D013629	Tamoxifen	Tamoxifen affects the expression of TCF3 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TCF3 mRNA]	15034205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TCF3 mRNA	24058054
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TCF3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TCF3 mRNA	15034205
D019284	Thapsigargin	Thapsigargin results in decreased expression of TCF3 protein	24648495
D013806	Theophylline	[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TCF3 protein	18951874
D019772	Topotecan	TCF3 protein affects the susceptibility to Topotecan	16217747
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF3 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of TCF3 mRNA	24935251\|2627250
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of TCF3 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TCF3 mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in decreased expression of TCF3 mRNA	22378314
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of TCF3 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased methylation of TCF3 gene	28853863\|2915479
D014635	Valproic Acid	Valproic Acid affects the expression of TCF3 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of TCF3 gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of TCF3 mRNA	18042343
C111237	vorinostat	vorinostat results in decreased expression of TCF3 mRNA	27188386
D015032	Zinc	Zinc deficiency results in decreased expression of TCF3 mRNA	18356318

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	14576336
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	14576336
GO:0003677	DNA binding	-	IDA	10958665
GO:0003677	DNA binding	-	NAS	2105528
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0003700	DNA-binding transcription factor activity	-	IDA	2105528
GO:0003700	DNA-binding transcription factor activity	-	NAS	2493990
GO:0003713	transcription coactivator activity	-	IDA	14752053
GO:0005515	protein binding	-	IPI	7568177 9824680 10903890 11940670 14752053 19497860 21179004 21828274 25416956 25466284
GO:0008134	transcription factor binding	-	IPI	21828274
GO:0031435	mitogen-activated protein kinase kinase kinase binding	-	IPI	19801649
GO:0035326	enhancer binding	-	IC	21828274
GO:0042803	protein homodimerization activity	-	IBA	21873635
GO:0042803	protein homodimerization activity	-	IDA	10958665 14752053
GO:0043425	bHLH transcription factor binding	-	IBA	21873635
GO:0043425	bHLH transcription factor binding	-	IPI	10545951 10775504 21828274
GO:0046982	protein heterodimerization activity	-	IBA	21873635
GO:0046982	protein heterodimerization activity	-	IDA	10775504 14752053 19323994
GO:0046982	protein heterodimerization activity	-	IPI	10545951
GO:0046982	protein heterodimerization activity	-	NAS	2105528
GO:0070491	repressing transcription factor binding	-	IPI	12493738
GO:0070644	vitamin D response element binding	-	IDA	17426122
GO:0070888	E-box binding	-	IDA	7933101
GO:0070888	E-box binding	contributes_to	IDA	10775504
GO:0070888	E-box binding	contributes_to	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	14576336
GO:0002326	B cell lineage commitment	-	NAS	12435739
GO:0006351	transcription, DNA-templated	-	IDA	10775504
GO:0006355	regulation of transcription, DNA-templated	-	NAS	2493990
GO:0030183	B cell differentiation	-	NAS	12435739
GO:0033152	immunoglobulin V(D)J recombination	-	IBA	21873635
GO:0033152	immunoglobulin V(D)J recombination	-	IDA	16428437
GO:0045666	positive regulation of neuron differentiation	-	IBA	21873635
GO:0045666	positive regulation of neuron differentiation	-	ISS	-
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	2105528
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	16428437 19362560
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IDA	14752053
GO:0051149	positive regulation of muscle cell differentiation	-	TAS	-
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000790	nuclear chromatin	-	IDA	21828274
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	10775504 12493738 21828274
GO:0005634	nucleus	-	NAS	2493990
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IBA	21873635
GO:0005667	transcription factor complex	-	IDA	10775504
GO:0005737	cytoplasm	-	IDA	21828274
GO:0016607	nuclear speck	-	IDA	-
GO:0090575	RNA polymerase II transcription factor complex	-	IDA	10545951

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1266738	Developmental Biology	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-375170	CDO in myogenesis	IEA
R-HSA-375170	CDO in myogenesis	TAS
R-HSA-525793	Myogenesis	IEA
R-HSA-525793	Myogenesis	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20217071	Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function. (2010 Apr)	Pan F	Immunogenetics
28592245	In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)	El-Aarag SA	BMC Med Genomics